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1. Phosphorylation of the regulatory subunit of type II-beta cAMP-dependent protein kinase by cyclin B/p34 cdc2 kinase impairs its binding to microtubule-associated protein 2

Author

Keryer, Guy, Zhijun Luo, Cavadore, Jean Claude, Erlichman, Jack, and Bornens, Michel

Subjects
Protein kinases -- Usage, Science and technology
Abstract

Researchers used truncated NH2-terminal RII beta fusion proteins expressed in Escherichia Coli and the mitotic protein kirase p34 cdc2 isolated from HcLa cells or starfish oocytes to examine the in-vitro phosphorylation of regulatory submit (RII) beta by these kinases. The study analyzed the importance of the putative area for phosphorylation by the mitotic kinases, which is Thr-69 in the NH2-terminal domain of RII beta.

Published
1993

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