1. Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders.
- Author
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Aghdassi AA, Pham C, Zierke L, Mariaule V, Korkmaz B, and Rhimi M
- Subjects
- Humans, Cathepsin C genetics, Myeloblastin, Mutation, Neutrophils, Papillon-Lefevre Disease genetics, Papillon-Lefevre Disease drug therapy, Lung Diseases
- Abstract
Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase expressed in several tissues including inflammatory cells. This enzyme is important for maintaining multiple cellular functions and for processing immune cell-derived proteases. While mutations in the CatC gene were reported in Papillon-Lefèvre syndrome, a rare autosomal recessive disorder featuring hyperkeratosis and periodontitis, evidence from clinical and preclinical studies points toward pro-inflammatory effects of CatC in various disease processes that are mainly mediated by the activation of neutrophil serine proteinases. Moreover, tumor-promoting effects were ascribed to CatC. The aim of this review is to highlight current knowledge of the CatC as a potential therapeutic target in inflammatory disorders., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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