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Within fluid mechanics, the flow of hybrid nanofluids over a stretching surface has been extensively researched due to their influence on the flow and heat transfer properties. Expanding on this concept by introducing porous media, the current study explore the flow and heat and mass transport characteristics of hybrid nanofluid. This investigation includes the effect of magnetohydrodynamic (MHD) with chemical reaction, thermal radiation, and slip effects. The nanoparticles, copper, and alumina are combined with water for the formation of a hybrid nanofluid. Using the self-similar method for the reduction of Partial differential equations (PDEs) to the system of Ordinary differential equations (ODEs). These nonlinear equation systems are solved numerically using the bvp4c (boundary value solver) technique. The effect of the different physical non-dimensional flow parameters on different flow profiles such as velocity, temperature, concentration, skin friction, Nusselt and mass transfer rate are depicted through graphs and tables. The velocity profiles diminish with the effect of magnetic and slip parameters. The temperature and concentration slip parameters reduce the temperature and concentration profile respectively. The higher values of magnetic factor lessened the skin friction coefficient for both slip and no-slip conditions. An elevation in the thermal slip parameter reduced the boundary layer thickness and the heat transfer from the surface to the fluid. The Nusselt number amplified with the climbing values of the radiation parameter. The mass transfer rate depressed with the solutal slip parameter. Comparison is made with the published work in the literature and there is excellent agreement between them., (© 2024. The Author(s).)