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The computer-aided diagnosis has become one of the major research topics in medical diagnostics. In this research paper, we focus on designing an automated computer diagnosis by combining two major methodologies, namely the fuzzy base systems and the evolutionary genetic algorithms and applying them to the Saudi Arabian breast cancer diagnosis database, to be employed for assisting physicians in the early detection of breast cancers, and hence obtaining an early-computerized diagnosis complementary to that by physicians. Our hybrid algorithm, the genetic-fuzzy algorithm, has produced optimized diagnosis systems that attain high classification performance, in fact, our best three rule system obtained a 97% accuracy, with simple and well interpretive rules, and with a good degree of confidence of 91%., (Copyright © 2017 Elsevier Inc. All rights reserved.)