13 results on '"Almeida, Eros Antonio de"'
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2. Correction: Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions".
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Shikanai-Yasuda MA, Mediano MFF, Novaes CTG, Sousa AS, Sartori AMC, Santana RC, Correia D, Castro CN, Severo MMDS, Hasslocher-Moreno AM, Fernandez ML, Salvador F, Pinazo MJ, Bolella VR, Furtado PC, Corti M, Pinto AYN, Fica A, Molina I, Gascon J, Viñas PA, Cortez-Escalante J, Jr ANR, and Almeida EA
- Abstract
[This corrects the article DOI: 10.1371/journal.pntd.0009809.]., (Copyright: © 2023 Shikanai-Yasuda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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3. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions".
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Shikanai-Yasuda MA, Mediano MFF, Novaes CTG, Sousa AS, Sartori AMC, Santana RC, Correia D, Castro CN, Severo MMDS, Hasslocher-Moreno AM, Fernandez ML, Salvador F, Pinazo MJ, Bolella VR, Furtado PC, Corti M, Neves Pinto AY, Fica A, Molina I, Gascon J, Viñas PA, Cortez-Escalante J, Ramos AN Jr, and Almeida EA
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- Acquired Immunodeficiency Syndrome complications, Acquired Immunodeficiency Syndrome mortality, Adult, Brazil epidemiology, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Chagas Disease parasitology, Coinfection parasitology, Cross-Sectional Studies, Data Management, Female, HIV Infections complications, Humans, Male, Middle Aged, Retrospective Studies, Trypanosoma cruzi, Viral Load, Chagas Disease mortality, Coinfection mortality, Delivery of Health Care, HIV Infections mortality, Immunosuppression Therapy
- Abstract
Objective: Chagas disease (CD) globalization facilitated the co-infection with Human Immunodeficiency Virus (HIV) in endemic and non-endemic areas. Considering the underestimation of Trypanosoma cruzi (T. cruzi)-HIV co-infection and the risk of life-threatening Chagas Disease Reactivation (CDR), this study aimed to analyze the major co-infection clinical characteristics and its mortality rates., Methods: This is a cross-sectional retrospective multicenter study of patients with CD confirmed by two serological or one parasitological tests, and HIV infection confirmed by immunoblot. CDR was diagnosed by direct microscopy with detection of trypomastigote forms in the blood or other biological fluids and/or amastigote forms in inflammatory lesions., Results: Out of 241 patients with co-infection, 86.7% were from Brazil, 47.5% had <200 CD4+ T cells/μL and median viral load was 17,000 copies/μL. Sixty CDR cases were observed. Death was more frequent in patients with reactivation and was mainly caused by CDR. Other causes of death unrelated to CDR were the manifestation of opportunistic infections in those with Acquired Immunodeficiency Syndrome. The time between the co-infection diagnosis to death was shorter in patients with CDR. Lower CD4+ cells count at co-infection diagnosis was independently associated with reactivation. Similarly, lower CD4+ cells numbers at co-infection diagnosis and male sex were associated with higher lethality in CDR. Additionally, CD4+ cells were lower in meningoencephalitis than in myocarditis and milder forms., Conclusion: This study showed major features on T. cruzi-HIV co-infection and highlighted the prognostic role of CD4+ cells for reactivation and mortality. Since lethality was high in meningoencephalitis and all untreated patients died shortly after the diagnosis, early diagnosis, immediate antiparasitic treatment, patient follow-up and epidemiological surveillance are essentials in T. cruzi/HIV co-infection and CDR managements., Competing Interests: The authors have declared that no competing interests exist.
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- 2021
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4. 2 nd Brazilian Consensus on Chagas Disease, 2015.
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Dias JC, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, Torres RM, Melo JR, Almeida EA, Oliveira W Jr, Silveira AC, Rezende JM, Pinto FS, Ferreira AW, Rassi A, Fragata AA Filho, Sousa AS, Correia D, Jansen AM, Andrade GM, Britto CF, Pinto AY, Rassi A Jr, Campos DE, Abad-Franch F, Santos SE, Chiari E, Hasslocher-Moreno AM, Moreira EF, Marques DS, Silva EL, Marin-Neto JA, Galvão LM, Xavier SS, Valente SA, Carvalho NB, Cardoso AV, Silva RA, Costa VM, Vivaldini SM, Oliveira SM, Valente VD, Lima MM, and Alves RV
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- Brazil epidemiology, Humans, Chagas Disease diagnosis, Chagas Disease epidemiology, Chagas Disease therapy, Chagas Disease transmission, Consensus
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Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research .
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- 2016
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5. [Brazilian Consensus on Chagas Disease, 2015].
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Dias JC, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, Torres RM, Melo JR, Almeida EA, Oliveira W Jr, Silveira AC, Rezende JM, Pinto FS, Ferreira AW, Rassi A, Fragata AA Filho, Sousa AS, Correia D Filho, Jansen AM, Andrade GM, Britto CF, Pinto AY, Rassi A Jr, Campos DE, Abad-Franch F, Santos SE, Chiari E, Hasslocher-Moreno AM, Moreira EF, Marques DS, Silva EL, Marin-Neto JA, Galvão LM, Xavier SS, Valente SA, Carvalho NB, Cardoso AV, Silva RA, Costa VM, Vivaldini SM, Oliveira SM, Valente VD, Lima MM, and Alves RV
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- Brazil epidemiology, Chagas Disease mortality, Chagas Disease transmission, Chronic Disease, Consensus, Disease Management, Humans, Neglected Diseases mortality, Neglected Diseases prevention & control, Public Health, Tropical Medicine, Chagas Disease diagnosis, Chagas Disease therapy, Neglected Diseases diagnosis, Neglected Diseases therapy
- Abstract
Chagas disease is a neglected chronic condition that presents high morbidity and mortality burden, with considerable psychological, social, and economic impact. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on collaboration and contribution of renowned Brazilian experts with vast knowledge and experience on various aspects of the disease. It is the result of close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. This document shall strengthen the development of integrated control measures against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research.
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- 2016
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6. Neural mechanisms and delayed gastric emptying of liquid induced through acute myocardial infarction in rats.
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Nunez WR, Ozaki MR, Vinagre AM, Collares EF, and Almeida EA
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- Adrenergic alpha-1 Receptor Antagonists pharmacology, Animals, Baclofen pharmacology, GABA-B Receptor Agonists pharmacology, Gastroparesis physiopathology, Male, Myocardial Infarction complications, Prazosin pharmacology, Rats, Wistar, Time Factors, Vagotomy, Gastric Emptying physiology, Myocardial Infarction physiopathology, Paraventricular Hypothalamic Nucleus physiopathology, Receptors, Adrenergic, alpha-1 physiology, Receptors, GABA-B physiology, Vagus Nerve physiopathology
- Abstract
Background: In pathological situations, such as acute myocardial infarction, disorders of motility of the proximal gut can trigger symptoms like nausea and vomiting. Acute myocardial infarction delays gastric emptying (GE) of liquid in rats., Objective: Investigate the involvement of the vagus nerve, α 1-adrenoceptors, central nervous system GABAB receptors and also participation of paraventricular nucleus (PVN) of the hypothalamus in GE and gastric compliance (GC) in infarcted rats., Methods: Wistar rats, N = 8-15 in each group, were divided as INF group and sham (SH) group and subdivided. The infarction was performed through ligation of the left anterior descending coronary artery. GC was estimated with pressure-volume curves. Vagotomy was performed by sectioning the dorsal and ventral branches. To verify the action of GABAB receptors, baclofen was injected via icv (intracerebroventricular). Intravenous prazosin was used to produce chemical sympathectomy. The lesion in the PVN of the hypothalamus was performed using a 1 mA/10 s electrical current and GE was determined by measuring the percentage of gastric retention (% GR) of a saline meal., Results: No significant differences were observed regarding GC between groups; vagotomy significantly reduced % GR in INF group; icv treatment with baclofen significantly reduced %GR. GABAB receptors were not conclusively involved in delaying GE; intravenous treatment with prazosin significantly reduced GR% in INF group. PVN lesion abolished the effect of myocardial infarction on GE., Conclusion: Gastric emptying of liquids induced through acute myocardial infarction in rats showed the involvement of the vagus nerve, alpha1- adrenergic receptors and PVN.
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- 2015
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7. Effect of pitavastatin on vascular reactivity in hypercholesterolemic rabbits.
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Almeida EA and Ozaki MR
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- Animal Experimentation, Animals, Aorta, Thoracic drug effects, Cholesterol blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, Hypercholesterolemia blood, Lipid Peroxidation drug effects, Male, Quinolines administration & dosage, Rabbits, Triglycerides blood, Endothelium, Vascular drug effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Hypercholesterolemia drug therapy, Quinolines pharmacology
- Abstract
Background: Pitavastatin is the newest statin available in Brazil and likely the one with fewer side effects. Thus, pitavastatin was evaluated in hypercholesterolemic rabbits in relation to its action on vascular reactivity., Objective: To assess the lowest dose of pitavastatin necessary to reduce plasma lipids, cholesterol and tissue lipid peroxidation, as well as endothelial function in hypercholesterolemic rabbits., Methods: Thirty rabbits divided into six groups (n = 5): G1 - standard chow diet; G2 - hypercholesterolemic diet for 30 days; G3 - hypercholesterolemic diet and after the 16th day, diet supplemented with pitavastatin (0.1 mg); G4 - hypercholesterolemic diet supplemented with pitavastatin (0.25 mg); G5 - hypercholesterolemic diet supplemented with pitavastatin (0.5 mg); G6 - hypercholesterolemic diet supplemented with pitavastatin (1.0 mg). After 30 days, total cholesterol, HDL, triglycerides, glucose, creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT) were measured and LDL was calculated. In-depth anesthesia was performed with sodium thiopental and aortic segments were removed to study endothelial function, cholesterol and tissue lipid peroxidation. The significance level for statistical tests was 5%., Results: Total cholesterol and LDL were significantly elevated in relation to G1. HDL was significantly reduced in G4, G5 and G6 when compared to G2. Triglycerides, CK, AST, ALT, cholesterol and tissue lipid peroxidation showed no statistical difference between G2 and G3-G6. Significantly endothelial dysfunction reversion was observed in G5 and G6 when compared to G2., Conclusion: Pitavastatin starting at a 0.5 mg dose was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.
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- 2014
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8. Co-infection Trypanosoma cruzi/HIV: systematic review (1980-2010).
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Almeida EA, Ramos Júnior AN, Correia D, and Shikanai-Yasuda MA
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- Acute Disease, Adult, Aged, Antiretroviral Therapy, Highly Active, Chagas Disease drug therapy, Chagas Disease immunology, Chronic Disease, Female, HIV Infections drug therapy, HIV Infections immunology, Humans, Immunocompromised Host, Male, Middle Aged, Nitroimidazoles therapeutic use, Parasitemia drug therapy, Parasitemia immunology, Trypanocidal Agents therapeutic use, Young Adult, Chagas Disease complications, Coinfection drug therapy, Coinfection immunology, HIV Infections complications
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Introduction: The co-infection Trypanosoma cruzi/HIV has been described as a clinical event of great relevance. The objective of this study was to describe clinical and epidemiological aspects published in literature., Methods: It is a systematic review of a descriptive nature from the databases Medline, Lilacs, SciELO, Scopus, from 1980 to 2010., Results: There were 83 articles (2.8 articles/year) with a total of 291 cases. The co-infection was described in 1980 and this situation has become the defining AIDS clinical event in Brazil. This is the country with the highest number of publication (51.8%) followed by Argentina (27.7%). The majority of cases are amongst adult men (65.3%) native or from endemic regions with serological diagnosis in the chronic stage (97.9%) and indeterminate form (50.8%). Both diseases follow the normal course, but in 41% the reactivation of the Chagas disease occurs. The most severe form is the meningoencephalitis, with 100% of mortality without specific and early treatment of the T. cruzi. The medication of choice was the benznidazole on doses and duration normally used for the acute phase. The high parasitemia detected by direct or indirect quantitative methods indicated reactivation and its elevation is the most important predictive factor. The lower survival rate was related to the reactivation of the Chagas disease and the natural complications of both diseases. The role of the antiretroviral treatment on the co-infection cannot yet be defined by the knowledge currently existent., Conclusions: Despite the relevance of this clinical event there are still gaps to be filled.
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- 2011
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9. [Brazilian Network of Attention and Studies on Trypanosoma cruzi/HIV Co-infection and others immunossupression conditions].
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Almeida EA, Ramos Junior AN, Correia D, and Shikanai-Yasuda MA
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- Brazil, Humans, Chagas Disease complications, Delivery of Health Care organization & administration, HIV Infections complications
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- 2009
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10. [Fatal evolution of Chagas'disease/Aids co-infection: diagnostic difficulties between myocarditis reactivation and chronic chagasic myocardiopathy].
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Almeida EA, Silva EL, Guariento ME, Souza ML, Aoki FH, and Pedro Rde J
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- Acute Disease, Adult, Chagas Cardiomyopathy complications, Chronic Disease, Diagnosis, Differential, Fatal Outcome, Humans, Male, Nitroimidazoles therapeutic use, Trypanocidal Agents therapeutic use, Acquired Immunodeficiency Syndrome complications, Chagas Cardiomyopathy diagnosis, Myocarditis diagnosis
- Abstract
Chagas disease is a type of parasitosis caused by the protozoan Trypanosoma cruzi, and it is transmitted by triatomine insects. This disease is found between the southern United States to Argentina and approximately 14 million people in Latin America are believed to be infected, predominantly with the chronic form of the disease. Reactivation of Chagas disease can occur among immunosuppressed patients, as has been observed among AIDS patients. In one such case, we observed cardiac decompensation with severe ventricular dysfunction and arrhythmias. This case was thought to be reactivation of Chagas disease in the myocardium, since the xenodiagnosis was positive. Specific treatment for Trypanosoma cruzi was administered, consisting of benznidazole, but the course of treatment was not completed because the patient died due to cardiopathic complications. The necropsy showed the usual stigmas of chronic Chagas cardiopathy, such as fibrosing myocarditis and a decreased number of neurons in the digestive system. There were no amastigote forms of Trypanosoma cruzi in any of the tissue samples studied. Therefore, reactivation of Chagas disease was not demonstrated but, rather, the natural evolution of chronic Chagas cardiopathy was demonstrated.
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- 2009
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11. [Clinical and laboratory characterization of hypertensive Chagas disease patients without evident heart failure].
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Bertanha L, Guariento ME, Magna LA, and Almeida EA
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- Age Factors, Chagas Cardiomyopathy complications, Chagas Cardiomyopathy physiopathology, Chagas Disease physiopathology, Chronic Disease, Female, Humans, Hypertension diagnosis, Hypertension physiopathology, Male, Middle Aged, Retrospective Studies, Risk Factors, Chagas Disease complications, Hypertension complications
- Abstract
This study evaluated the characteristics of 125 Chagas disease patients aged > 25 years or over who were attended at the Clinical Hospital of the State University of Campinas, State of São Paulo. Arterial pressure, age, gender, skin color, heart disease, body mass index, lipid profile, blood glucose level, alcohol and tobacco dependence, dyslipidemia, diabetes, anxiety disorders and obesity were investigated. It was found that the hypertensive Chagas disease patients were older than the non-hypertensive ones (p = 0.028). Among the hypertensive patients, there were more women (p = 0.015); higher blood glucose, LDL cholesterol and total cholesterol levels (p = 0.005, p = 0.024 and p = 0.017); more diabetics (p = 0.006); and more cardiac damage (p = 0.04) and left ventricular hypertrophy (p = 0.003). Only the age of patients with cardiac damage was shown to be higher (p = 0.003). The hypertensive Chagas disease patients presented clinical and laboratory characteristics that were similar to those of the general hypertensive population. This association may compound the harmful effects on the cardiovascular system.
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- 2008
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12. Frequency of hypertension in patients with chronic Chagas disease and its consequences on the heart: a clinical and pathological study.
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Gurgel CB and Almeida EA
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- Adolescent, Adult, Age Factors, Aged, 80 and over, Autopsy, Brazil epidemiology, Chagas Disease pathology, Chronic Disease, Coronary Artery Disease epidemiology, Coronary Artery Disease etiology, Coronary Artery Disease pathology, Electrocardiography, Epidemiologic Methods, Female, Humans, Hypertension complications, Hypertension pathology, Male, Myocardial Infarction epidemiology, Myocardial Infarction etiology, Myocardial Infarction pathology, Stroke epidemiology, Stroke etiology, Stroke pathology, White People statistics & numerical data, Chagas Disease complications, Hypertension epidemiology
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Background: Data from the literature on the frequency of concomitant Chagas disease and hypertension are controversial and, when available, do not mention the consequences of this concomitance in the natural history of either Chagas disease or of hypertension., Objective: To assess the frequency of concomitant Chagas disease and hypertension and the clinical and anatomopathological consequences of this association., Methods: The cases were selected from necropsies performed in the Department of Pathological Anatomy of Hospital e Maternidade Celso Pierrô of Pontifícia Universidade Católica de Campinas and divided into three groups: CH + SH group, of patients with Chagas disease plus hypertension; CH group, of patients with Chagas disease without hypertension; and SH group, of patients with hypertension without Chagas disease. The variables of gender, age, race, clinical forms of Chagas disease, and electrocardiographic and anatomopathological findings were statistically analyzed., Results: In this assessment, a total of 101 (2.9%) cases of patients with Chagas disease was found, and 33 (32.7%) of them also had hypertension. A slight predominance of the male gender was observed; racial distribution and mean age were similar in the three groups. Severe hypertension was not frequently found among chagasic patients. When present, hypertension did not change the clinical and anatomopathological findings compatible with Chagas disease., Conclusion: The frequency of hypertension in chagasic patients was similar to that observed in the general population. Hypertension, when present in chagasic patients, occurred in those with a higher mean age. The concomitance of hypertension and Chagas disease did not change the natural history of either one of the two diseases.
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- 2007
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13. [Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits].
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Jorge PA, Almeida EA, Ozaki MR, Jorge M, and Carneiro A
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- Animals, Aortic Diseases metabolism, Aortic Diseases physiopathology, Arteriosclerosis metabolism, Arteriosclerosis physiopathology, Atorvastatin, Cholesterol blood, Cholesterol, LDL blood, Cholesterol, LDL drug effects, Endothelium, Vascular metabolism, Endothelium, Vascular physiopathology, Fatty Acids, Monounsaturated pharmacology, Fluvastatin, Heptanoic Acids pharmacology, Hypercholesterolemia metabolism, Hypercholesterolemia physiopathology, Indoles pharmacology, Male, Malondialdehyde analysis, Pravastatin pharmacology, Pyrroles pharmacology, Rabbits, Simvastatin pharmacology, Anticholesteremic Agents pharmacology, Aortic Diseases drug therapy, Arteriosclerosis drug therapy, Endothelium, Vascular drug effects, Hypercholesterolemia drug therapy, Lipid Peroxidation drug effects
- Abstract
Objective: To compare the effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, aortic atherosclerosis, and the content of malondialdehyde (MDA) in native and oxidized LDL and in the arterial wall of hypercholesterolemic rabbits after adjusting the dosages of those statins to reduce total serum cholesterol levels to similar values., Methods: Male rabbits were divided into the following 6 groups of 10 animals (n=10): 1) GH (control)--hypercholesterolemic animals; 2) GA--atorvastatin; 3) GF--fluvastatin; 4) GP--pravastatin; 5) GS--simvastatin; and 6) GN--normal. The animals were fed a standard food preparation enriched with 0.5% cholesterol and 2% coconut oil for 45 days. Fifteen days after beginning the experiment, atorvastatin, fluvastatin, pravastatin and simvastatin were administered for 15 days through gavage, and the dosages were adjusted to obtain similar cholesterol values in each group. At the end of the experiment, a blood sample was withdrawn for determining total cholesterol and separating the lipoproteins, and a segment of the thoracic aorta was removed to be used for studying endothelial function and lipid peroxidation, and for measuring aortic atherosclerosis in histological sections., Results: The statins significantly reduced total serum cholesterol levels, LDL-cholesterol levels, and aortic atherosclerosis. The MDA content was also significantly reduced in native and oxidized LDL, as well as in the arterial wall. Endothelium-dependent relaxation was significantly greater in the treated group compared with that in the hypercholesterolemic group., Conclusion: The statins, at dosages adjusted, had a significant and similar effect in reducing lipid peroxidation in native and oxidized LDL-C and in arterial walls, in decreasing aortic atherosclerosis, and in reverting endothelial dysfunction.
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- 2005
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