1. Impact of Disease-modifying Therapies on Respiratory Function in People with Neuromuscular Disorders.
- Author
-
Xiao L and Amin R
- Subjects
- Humans, Muscular Atrophy, Spinal drug therapy, Muscular Atrophy, Spinal physiopathology, Neuromuscular Diseases drug therapy, Neuromuscular Diseases physiopathology, Neuromuscular Diseases therapy, Muscular Dystrophy, Duchenne drug therapy, Muscular Dystrophy, Duchenne physiopathology, Muscular Dystrophy, Duchenne complications
- Abstract
Spinal muscular atrophy (SMA) and Duchenne muscular dystrophy (DMD) are neuromuscular disorders that affect muscular function. The most common causes of morbidity and mortality are respiratory complications, including restrictive lung disease, ineffective cough, and sleep-disordered breathing. The paradigm of care is changing as new disease-modifying therapies are altering disease trajectory, outcomes, expectations, as well as patient and caregiver experiences. This article provides an overview on therapeutic advances for SMA and DMD in the last 10 years, with a focus on the effects of disease-modifying therapies on respiratory function., Competing Interests: Disclosure Dr R. Amin is a committee member of the American College of Chest Physicians and a pediatrics committee member of the American Thoracic Society. R. Amin holds research grants from Canadian Institutes of Health Research, Canada, Cure SMA Canada, Canada, Muscular Dystrophy Canada, Canada, VHA Home Healthcare, Canada, Boehringer-Ingelheim, Germany, Medigas, Canada, ProResp, Canada, Baxter Corporation Endowment Fund for Home Care, United States, and Ontario Ministry of Health and Long-Term Care, Canada. Dr L. Xiao is a committee member of the American College of Chest Physicians. Dr. Xiao holds research grants from Muscular Dystrophy Canada, Baxter Corporation Endowment Fund for Home Care, International Pediatric Sleep Association, United States, and the Sleep Research Society Foundation, United States., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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