1. Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats.
- Author
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Grujić-Milanović JD, Miloradović ZZ, Mihailović-Stanojević ND, Banjac VV, Vidosavljević S, Ivanov MS, Karanović DJ, Vajić UV, and Jovović DM
- Subjects
- Animals, Biomarkers metabolism, C-Reactive Protein metabolism, Diet, High-Fat adverse effects, Dietary Fats adverse effects, Interleukin-6 metabolism, Liver metabolism, Male, Peroxidase metabolism, Rats, Rats, Wistar, Serum Amyloid P-Component metabolism, Soybean Oil adverse effects, Fatty Acids, Unsaturated administration & dosage, Inflammation chemically induced, Inflammation metabolism, Oxidative Stress physiology
- Abstract
Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage., (Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2021
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