1. Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa.
- Author
-
Cardozo C, Rico V, Agüero D, and Soriano A
- Subjects
- Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents pharmacology, Cross Infection microbiology, Drug Resistance, Bacterial drug effects, Drug Resistance, Bacterial genetics, Humans, Microbial Sensitivity Tests, Pseudomonas Infections microbiology, Anti-Bacterial Agents therapeutic use, Cross Infection drug therapy, Pseudomonas Infections drug therapy, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa genetics
- Abstract
Pseudomonas aeruginosa is characterized by an important intrinsic resistance to antibiotics and it possess an extraordinary ability to develop resistance to nearly all available antimicrobials through selection of mutations. We review some of the pharmacodynamic principles of antibiotics predicting efficacy, clinical experience with monotherapy and combination therapy, and principles for antibiotic treatment for empirical and directed treatment of P. aeruginosa invasive infections.
- Published
- 2019