A smart mask integrated with a remote, noncontact multiplexed sensor system, or "Lab-on-Mask" (LOM) is designed for monitoring respiratory diseases, such as the COVID-19. This LOM can monitor the heart rate, blood oxygen saturation, blood pressure, and body temperature associated with symptoms of pneumonia caused by coronaviruses in real time. Because of this remote monitoring system, frontline healthcare staff can minimize the exposure they face from close contact with the patients and reduce the risks of being infected., Competing Interests: The authors declare no competing financial interest., (Copyright © 2020 American Chemical Society.)