1. Real life experience of apremilast in psoriasis and arthritis psoriatic patients: Preliminary results on metabolic biomarkers.
- Author
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Mazzilli S, Lanna C, Chiaramonte C, Cesaroni GM, Zangrilli A, Palumbo V, Cosio T, Dattola A, Gaziano R, Galluzzo M, Chimenti MS, Gisondi P, Bianchi L, and Campione E
- Subjects
- Aged, Aged, 80 and over, Arthritis, Psoriatic blood, Arthritis, Psoriatic epidemiology, Arthritis, Psoriatic metabolism, Biomarkers blood, Biomarkers metabolism, Comorbidity, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 metabolism, Female, Follow-Up Studies, Humans, Male, Middle Aged, Phosphodiesterase 4 Inhibitors adverse effects, Psoriasis blood, Psoriasis epidemiology, Psoriasis metabolism, Thalidomide administration & dosage, Thalidomide adverse effects, Treatment Outcome, Arthritis, Psoriatic drug therapy, Diabetes Mellitus, Type 2 drug therapy, Phosphodiesterase 4 Inhibitors administration & dosage, Psoriasis drug therapy, Thalidomide analogs & derivatives
- Abstract
Psoriasis is a common inflammatory skin condition, affecting 2-4% of the worldwide population. Psoriasis remains an important public health challenge because there are many clinical forms of psoriasis in particular sites, probably related to the dysregulation of different cytokines. Therefore, there is a continuous need to improve treatment options with mechanisms of action different from those of the currently known therapies. Advances in knowledge of the molecular bases of pathogenesis lead to a better understanding of the disease, thus influencing the development and management of effective treatments. Moreover, data from recent published work indicate that psoriasis coexists with cardiovascular diseases, metabolic syndrome, diabetes mellitus and psychiatric disorders. We present results from our 52-week open-label trial in a cohort of psoriatic and psoriatic arthritis patients treated with daily p.o. doses of apremilast 60 mg. We confirmed the efficacy and safety of the drug in favoring the improvement of skin and joint disease as well as the modulation of metabolic biomarkers in diabetic and non-diabetic psoriatic patients. Apremilast could be used successfully in psoriatic patients affected by cardiometabolic comorbidities, ensuring an improvement in both diseases., (© 2020 Japanese Dermatological Association.)
- Published
- 2020
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