1. GVHD: biology matters.
- Author
-
Ferrara JLM and Chaudhry MS
- Subjects
- Acute Disease, Biomarkers metabolism, Humans, Gastrointestinal Diseases metabolism, Gastrointestinal Diseases microbiology, Gastrointestinal Diseases pathology, Gastrointestinal Diseases prevention & control, Gastrointestinal Microbiome, Graft vs Host Disease metabolism, Graft vs Host Disease microbiology, Graft vs Host Disease pathology, Graft vs Host Disease prevention & control, Stem Cells metabolism, Stem Cells pathology
- Abstract
Acute graft-versus-host disease (GVHD) targets the crypts in the gastrointestinal (GI) tract that are responsible for the self-renewal of the intestinal mucosa. Recent advances in the identification and culture of intestinal stem cells have improved our understanding of the interactions between the microbiome and the immune system (both innate and adaptive) that are key to the pathophysiology of GVHD. The identification of serum biomarkers that best predict long-term GVHD outcomes derive from the GI tract and have focused attention on cellular elements that act as shields against GVHD as well as its targets. These biomarkers have illuminated new mechanisms of crypt biology and provided insights that should prove useful both in the design of clinical trials and as guides to GVHD prevention and treatment., Competing Interests: Conflicts-of-interest disclosure: J.L.M.F. is a coinventor on a graft-versus-host disease biomarker patent. M.S.C declares no competing financial interest., (© 2018 by The American Society of Hematology. All rights reserved.)
- Published
- 2018
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