1. Combining a novel leucocyte-platelet-concentrated membrane and an injectable collagen scaffold in a single-step AMIC procedure to treat chondral lesions of the knee: a preliminary retrospective study.
- Author
-
D'Antimo C, Biggi F, Borean A, Di Fabio S, and Pirola I
- Subjects
- AC133 Antigen metabolism, Adolescent, Adult, Antigens, CD34 metabolism, Blood Platelets, Cartilage, Articular injuries, Chondrogenesis, Collagen administration & dosage, Female, Fibrinogen metabolism, Humans, Injections, Intra-Articular, Macrophages metabolism, Male, Monocytes metabolism, Pain Measurement, Retrospective Studies, Vascular Endothelial Growth Factor Receptor-2 metabolism, Young Adult, Cartilage, Articular surgery, Collagen therapeutic use, Knee Joint physiopathology, Membranes, Artificial, Tissue Scaffolds
- Abstract
Background: Different surgical approaches are currently available to treat knee chondral defects. Microfracture is the most commonly applied, but it often leads to a mechanically inferior fibrocartilaginous tissue. To overcome this shortcoming, the Autologous, Matrix-Induced Chondrogenesis (AMIC) technique has been proposed. To further enhance the outcome of AMIC, the addition of haemoderivatives containing growth factors that stimulate cartilage healing has emerged as a new treatment method. Recently, a novel leucocyte-platelet-concentrated membrane (CLP-MB), highly enriched in platelets, monocytes/macrophages, fibrinogen, CD34
+ and CD34+ VEGFR-2+ CD133+ cells, has been developed. Additionally, an injectable collagen scaffold (Cartifill) has been proposed as a replacement of the AMIC standard collagen membrane., Aims: This preliminary study is aimed to evaluate the short-term safety and efficacy of the use of the CLP-MB membrane and injectable collagen scaffold when combined in single-step AMIC procedures for the treatment of knee chondral lesions., Methods: Medical records of patients who underwent an AMIC procedure with the CLP-MB membrane combined with Cartifill were reviewed retrospectively. Follow-up assessments were conducted at 6 and 12 months after surgery. Clinical function was assessed on the basis of the International Knee Documentation Committee (IKDC) score. Pain was evaluated using the visual analogue scale (VAS)., Results: Twenty-five patients were identified as meeting the inclusion criteria. Mean IKDC and VAS scores significantly improved during the follow-up time. The postoperative course was uneventful., Conclusions: AMIC combined with the CLP-MB membrane, and Cartifill seems to be a promising approach to treat knee chondral defects.- Published
- 2017
- Full Text
- View/download PDF