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Let X → P 1 be an elliptically fibered K 3 surface, admitting a sequence ω i of Ricci-flat metrics collapsing the fibers. Let V be a holomorphic SU ( n ) bundle over X , stable with respect to ω i . Given the corresponding sequence Ξ i of Hermitian-Yang-Mills connections on V , we prove that, if E is a generic fiber, the restricted sequence Ξ i | E converges to a flat connection A 0 . Furthermore, if the restriction V | E is of the form ⊕ j = 1 n O E ( q j - 0 ) for n distinct points q j ∈ E , then these points uniquely determine A 0 ., (© The Author(s) 2022.)

Adoptive immunotherapy retargeting T cells to CD19 via a chimeric antigen receptor (CAR) is an investigational treatment capable of inducing complete tumor regression of B-cell malignancies when there is sustained survival of infused cells. T-memory stem cells (T SCM ) retain superior potential for long-lived persistence, but challenges exist in manufacturing this T-cell subset because they are rare among circulating lymphocytes. We report a clinically relevant approach to generating CAR + T cells with preserved T SCM potential using the Sleeping Beauty platform. Because IL-15 is fundamental to T-cell memory, we incorporated its costimulatory properties by coexpressing CAR with a membrane-bound chimeric IL-15 (mbIL15). The mbIL15-CAR T cells signaled through signal transducer and activator of transcription 5 to yield improved T-cell persistence independent of CAR signaling, without apparent autonomous growth or transformation, and achieved potent rejection of CD19 + leukemia. Long-lived T cells were CD45RO neg CCR7 + CD95 + , phenotypically most similar to T SCM , and possessed a memory-like transcriptional profile. Overall, these results demonstrate that CAR + T cells can develop long-term persistence with a memory stem-cell phenotype sustained by signaling through mbIL15. This observation warrants evaluation in clinical trials., Competing Interests: Some of the technology described was advanced through research conducted at the M. D. Anderson Cancer Center by L.J.N.C. The M. D. Anderson Cancer Center, L.J.N.C., L.V.H., K.C.S., H.S., T.M., S.M., S.O., B.R., M.-A.F., H.H., A.M.N., R.E.C., and D.A.L. all have or had a financial interest in ZIOPHARM Oncology, Inc., and Intrexon Corporation. On May 7, 2015, L.J.N.C. was appointed as the Chief Executive Officer at ZIOPHARM. L.J.N.C. is now a Visiting Scientist at the M. D. Anderson Cancer Center. A patent application based on this manuscript has been filed.

An earlier measurement on the 4+ to 2+ radiative transition in 8Be provided the first electromagnetic signature of its dumbbell-like shape. However, the large uncertainty in the measured cross section does not allow a stringent test of nuclear structure models. This Letter reports a more elaborate and precise measurement for this transition, via the radiative capture in the 4He + 4He reaction, improving the accuracy by about a factor of 3. Ab initio calculations of the radiative transition strength with improved three-nucleon forces are also presented. The experimental results are compared with the predictions of the alpha cluster model and ab initio calculations.

The damping of the nuclear shell effect with excitation energy has been measured through an analysis of the neutron spectra following the triton transfer in the (7)Li induced reaction on (205)Tl. The measured neutron spectra demonstrate the expected large shell correction energy for the nuclei in the vicinity of doubly magic (208)Pb and a small value around (184)W. A quantitative extraction of the allowed values of the damping parameter γ, along with those for the asymptotic nuclear level density parameter ã, has been made for the first time.

Electromagnetic transition rates provide an important test for nuclear structure models. The nucleus 8Be exhibits a pronounced alpha-cluster structure and is a building block for more complex cluster nuclei. Here we report on the first observation of the gamma transition between the 4(+) and 2(+) states of 8Be in the 4He+4He reaction. The measured on-resonance cross section of 165+/-54 nb leads to a B(E2) of25+/-8e(2) fm(4), in good agreement with alpha-cluster models and sophisticated ab initio structure calculations.