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Astrocytes are essential to virtually all brain processes, from ion homeostasis to neurovascular coupling to metabolism, and even play an active role in signaling and plasticity. Astrocytic dysfunction can be devastating to neighboring neurons made inherently vulnerable by their polarized, excitable membranes. Therefore, correcting astrocyte dysfunction is an attractive therapeutic target to enhance neuroprotection and recovery following acquired brain injury. However, the translation of such therapeutic strategies is hindered by a knowledge base dependent almost entirely on rodent data. To facilitate additional astrocytic research in the translatable pig model, we present a review of astrocyte findings from pig studies of health and disease. We hope that this review can serve as a road map for intrepid pig researchers interested in studying astrocyte biology.

The present work concerns the measurements obtained with the Tungsten (W) Environment in Steady-state Tokamak (WEST) visible spectroscopy system during the first experimental campaign. This system has been developed in the framework of the WEST project that equipped the existing Tore Supra device with a tungsten divertor in order to test actively cooled tungsten Plasma Facing Components (PFC) in view of preparing for ITER operation. The goal of this diagnostic is to measure the PFC sources and the deuterium recycling with spectral, spatial, and temporal resolution adapted to the predicted power deposition profiles on the objects observed. Three kinds of PFCs are monitored: the Ion Cyclotron Resonance Heating (ICRH) antenna and Low Hybrid Current Drive (LHCD) launcher W limiters; one of the 6 W inner bumpers; and the upper and lower W divertors. Large-aperture in-vessel actively cooled optical systems (f-number ∼ 3) were installed for each view and connected to optical fibres. A total of 240 optical fibers can be distributed on various detection systems including a fast response-time, multi-channel, filtered photodetector-based "Filterscope" system, developed by Oak Ridge National Laboratory (USA) as well as grating spectrometers optimized for multi-sightline analysis. The first WEST experimental campaign conducted in 2017 has been dedicated to plasma start-up development during which the visible spectroscopy system has provided crucial information related to the impurity content first and then impurity sources. The diagnostic setup for that first experimental campaign was limited to the inner bumper and outer limiters but was sufficient to demonstrate that the optical setup was in accordance with the specifications. The radiance calibration procedure allowed us to estimate fluxes from the main limiter of about 8 × 10 18 atoms/(s m 2 ) and to show a first W source radial profile along the outboard limiter.

This paper presents the current wall-embedded Langmuir probe system installed on the Tokamak à Configuration Variable (TCV), as well as the analysis tool chain used to interpret the current-voltage characteristic obtained when the probes are operated in swept-bias conditions. The analysis is based on a four-parameter fit combined with a minimum temperature approach. In order to reduce the effect of plasma fluctuations and measurement noise, several current-voltage characteristics are usually averaged before proceeding to the fitting. The impact of this procedure on the results is investigated, as well as the possible role of finite resistances in the circuitry, which could lead to an overestimation of the temperature. We study the application of the procedure in a specific regime, the plasma detachment, where results from other diagnostics indicate that the electron temperature derived from the Langmuir probes might be overestimated. To address this issue, we explore other fitting models and, in particular, an extension of the asymmetric double probe fit, which features effects of sheath expansion. We show that these models yield lower temperatures (up to approximately 60%) than the standard analysis in detached conditions, particularly for a temperature peak observed near the plasma strike point, but a discrepancy with other measurements remains. We explore a possible explanation for this observation, the presence of a fast electron population, and assess how robust the different methods are in such conditions.

Fluorocarbon thin-film deposition is studied, which shows an anomalous high dynamic growth exponent and therefore does not fit in any universal class of fractal surface growth models. A detailed analysis of the nonlinear behavior of the surface morphology evolution is carried out, quantifying several features of the shadowing instability. A synergy effect with the Kardar-Parisi-Zhang nonlinearity, which couple the large scales induced by shadowing with intermediate scales, may explain the anomalous high growth exponent.

We compare measurements of radially sheared azimuthal plasma flow based on time delay estimation (TDE) between two spatially separated Langmuir probes, Mach probes and laser induced fluorescence (LIF). TDE measurements cannot distinguish between ion fluid velocities and phase velocities. TDE and Mach probes are perturbative, so we compare the results against LIF, a non-perturbative, spatially resolved diagnostic technique that provides direct measurements of the ion velocity distribution functions. The bulk ion flow is determined from the Doppler shift of the Argon absorption line at 668.6139 nm. We compare results from all the three diagnostics, at various magnetic fields, which acts as a control knob for development of drift wave turbulence. We find that while Mach probes and LIF give similar profiles, TDE measurements typically overestimate the velocities and are also sensitive to the drift wave modes being investigated.

The absolute rate of nonlinear energy transfer among broadband turbulence, low-frequency zonal flows (ZFs) and geodesic acoustic modes (GAMs) was measured for the first time in fusion-grade plasmas using two independent methods across a range of heating powers. The results show that turbulent kinetic energy from intermediate frequencies (20-80 kHz) was transferred into ZFs and GAMs, as well as into fluctuations at higher frequencies (>80  kHz). As the heating power was increased, the energy transfer from turbulence into GAMs and the GAM amplitudes increased, peaked and then decreased, while the energy transfer into the ZFs and the ZFs themselves increased monotonically with heating power. Thus there exists a competition between ZFs and GAMs for the transfer of turbulent energy, and the transfer into ZFs becomes dominant as the heating power is increased. The poloidal-radial Reynolds stress and the mean radial electric field profiles were also measured at different heating powers and found to be consistent with the energy transfer measurement. The results suggest that ZFs play an important role in the low-to-high (L-H) plasma confinement transition.

Using fast-camera measurements the generation mechanism of plasma blobs is investigated in the linear device CSDX. During the ejection of plasma blobs the plasma is dominated by an m=1 mode, which is a counterrotating vortex pair. These flows are known to be subject to the cooperative elliptic instability, which is characterized by a cooperative disturbance of the vortex cores and results in a three-dimensional breakdown of two-dimensional flows. The first experimental evidence of a cooperative elliptic instability preceding the blob-ejection is provided in terms of the qualitative evolution of the vortex geometries and internal wave patterns.