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1. Case report: somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma.

Author

Gregersen G, Holst JJ, Trankjaer A, Stadil F, and Mogensen AM

Subjects
Female, Humans, Hyperglycemia etiology, Hypoglycemia etiology, Middle Aged, Teratoma complications, Blood Glucose metabolism, Multiple Endocrine Neoplasia pathology, Ovarian Neoplasms metabolism, Somatostatin biosynthesis, Somatostatinoma pathology, Teratoma metabolism
Abstract

A 54-year-old woman presented with extremely fluctuating and symptomatic blood glucose levels. Very high levels of somatostatin and low levels of insulin, C-peptide, gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) in peripheral blood were constantly present. A benign somatostatinoma was localized by meta-iodobenzyl guanidine iodine 123 (MIBG-I(123)) scintigraphy and successfully removed encapsulated in an ovarian teratoma. The patient made a complete recovery. The case described is unique with regard to clinical symptomatology and anatomic localization of the tumor., (Copyright 2002, Elsevier Science (USA). All rights reserved.)

Published
2002
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