1. Resveratrol by elevating the SIRT1 BDNF, GDNF and PSD95 levels reduce heroin addiction related behaviors.
- Author
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Liu M, Li C, Li R, Yin D, Hong Y, Lu M, Xia B, and Li Y
- Subjects
- Animals, Male, Substance Withdrawal Syndrome metabolism, Substance Withdrawal Syndrome drug therapy, Substance Withdrawal Syndrome psychology, Maze Learning drug effects, Behavior, Animal drug effects, Brain-Derived Neurotrophic Factor metabolism, Brain-Derived Neurotrophic Factor drug effects, Sirtuin 1 metabolism, Disks Large Homolog 4 Protein metabolism, Heroin Dependence drug therapy, Heroin Dependence metabolism, Heroin Dependence psychology, Glial Cell Line-Derived Neurotrophic Factor metabolism, Resveratrol pharmacology, Resveratrol administration & dosage
- Abstract
Objective: To study the effects of resveratrol on heroin addiction-related behaviors and to preliminarily explore the possible intervention mechanism of resveratrol in heroin dependence., Methods: The effects of resveratrol on heroin withdrawal symptoms were observed by naloxone; The effect of resveratrol on heroin reward memory acquisition was detected by CPP paradigm; The effect of resveratrol on the mental excitability of heroin was tested by open field experiment; The effect of resveratrol on heroin spatial learning and memory was tested by water maze test. Western blot was used to detect Sirtuin 1 (SIRT1) Expression of brain-derived neurotrophic factor (BDNF), glial cell derived neurotrophic factor (GDNF), and postsynaptic density protein (PSD95)., Results: The behavioral results showed that the withdrawal behavior of the resveratrol intervention group was reduced compared with the heroin chronic dependence group (P<0.05), and the shift score of the conditioned place preference test of the resveratrol intervention group was reduced compared with the heroin chronic dependence group (P<0.05) The spatial learning and memory ability of the water maze in the resveratrol intervention group was improved compared with the heroin chronic dependence group (P<0.05), and the mental excitability of the resveratrol intervention group was lower than that of the heroin chronic dependence group (P<0.05), but higher than that of the saline group (P<0.05); SIRT1 The expression levels of BDNF, GDNF and PSD95 protein were significantly increased (P<0.05)., Conclusion: The behavioral results of this study suggest that resveratrol can be used as a potential drug to treat heroin dependence. At the same time, SIRT1 The expression of BDNF, GDNF, and PSD95 increased; SIRT1, BDNF, GDNF, and PSD95 play an essential role in heroin addiction., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
- Published
- 2024
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