1. Local immune response to food antigens drives meal-induced abdominal pain.
- Author
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Aguilera-Lizarraga J, Florens MV, Viola MF, Jain P, Decraecker L, Appeltans I, Cuende-Estevez M, Fabre N, Van Beek K, Perna E, Balemans D, Stakenborg N, Theofanous S, Bosmans G, Mondelaers SU, Matteoli G, Ibiza Martínez S, Lopez-Lopez C, Jaramillo-Polanco J, Talavera K, Alpizar YA, Feyerabend TB, Rodewald HR, Farre R, Redegeld FA, Si J, Raes J, Breynaert C, Schrijvers R, Bosteels C, Lambrecht BN, Boyd SD, Hoh RA, Cabooter D, Nelis M, Augustijns P, Hendrix S, Strid J, Bisschops R, Reed DE, Vanner SJ, Denadai-Souza A, Wouters MM, and Boeckxstaens GE
- Subjects
- Abdominal Pain etiology, Abdominal Pain microbiology, Adult, Animals, Citrobacter rodentium immunology, Diarrhea immunology, Diarrhea microbiology, Diarrhea pathology, Enterobacteriaceae Infections complications, Enterobacteriaceae Infections immunology, Enterobacteriaceae Infections microbiology, Female, Food Hypersensitivity complications, Food Hypersensitivity microbiology, Food Hypersensitivity pathology, Glutens immunology, Humans, Immunoglobulin E immunology, Intestinal Mucosa immunology, Intestinal Mucosa microbiology, Intestinal Mucosa pathology, Intestines microbiology, Intestines pathology, Irritable Bowel Syndrome etiology, Irritable Bowel Syndrome microbiology, Irritable Bowel Syndrome pathology, Male, Mast Cells immunology, Mice, Mice, Inbred BALB C, Middle Aged, Milk immunology, Ovalbumin immunology, Quality of Life, Receptors, Histamine H1 metabolism, Soybean Proteins immunology, Triticum immunology, Abdominal Pain immunology, Abdominal Pain pathology, Allergens immunology, Food adverse effects, Food Hypersensitivity immunology, Intestines immunology, Irritable Bowel Syndrome immunology
- Abstract
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal
1 , leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific and lay communities in this issue has increased markedly in recent years, with the worldwide introduction of gluten-free and other diets, the underlying mechanisms of food-induced abdominal complaints remain largely unknown. Here we show that a bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine. Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain. This aberrant pain signalling resulted from histamine receptor H1 -mediated sensitization of visceral afferents. Moreover, injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation. Our results identify and characterize a peripheral mechanism that underlies food-induced abdominal pain, thereby creating new possibilities for the treatment of irritable bowel syndrome and related abdominal pain disorders.- Published
- 2021
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