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Aorto-ostial lesions pose complex technical challenges in percutaneous revascularization procedures. The successful use of the ostial positioning system OstialPro has been reported in coronary arteries. This nitinol device has self expanding legs that open just distal to the guide catheter. This allows the stent to be deployed in the ostium of the vessel with the guide catheter positioned in the aorta and allows for accurate anatomic visualization of the plane between the ostium and the aorta. Besides coronary interventions, the OstialPro could be useful in peripheral vascular interventions for ostial renal, mesenteric or vertebral arteries stenoses. We report the case of a patient with a significant ostial renal artery stenosis who underwent a successful percutaneous intervention using the OstialPro device.