1. Methylenetetrahydrofolate reductase and glutathione S-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: a case report.
- Author
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Skoric D, Ivana J, Tanja R, Jovana J, Petar I, and Tatjana S
- Subjects
- Acute Disease, Child, Flow Cytometry, Genotype, Glutathione S-Transferase pi genetics, Humans, Leukemia drug therapy, Male, Neoplasms, Second Primary drug therapy, Phenotype, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Prognosis, Remission Induction, Biomarkers, Tumor genetics, Glutathione Transferase genetics, Leukemia genetics, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Neoplasms, Second Primary genetics, Polymorphism, Genetic genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
- Abstract
Background: Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy., Observation: We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia., Conclusions: Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive.
- Published
- 2014
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