1. Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods.
- Author
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Rane Levendovszky S, Flores J, Peskind ER, Václavů L, van Osch MJ, and Iliff J
- Subjects
- Humans, Male, Female, Adult, Aged, Young Adult, Aging physiology, Glymphatic System diagnostic imaging, Sleep Deprivation diagnostic imaging, Sleep Deprivation physiopathology, Sleep physiology, Cerebrospinal Fluid physiology, Middle Aged, Cerebrovascular Circulation physiology, Magnetic Resonance Imaging methods, Subarachnoid Space diagnostic imaging
- Abstract
We discuss two potential non-invasive MRI methods to study phenomena related to subarachnoid cerebrospinal fluid (CSF) motion and perivascular fluid transport, and their association with sleep and aging. We apply diffusion-based intravoxel incoherent motion (IVIM) imaging to evaluate pseudodiffusion coefficient, D* , or CSF movement across large spaces like the subarachnoid space (SAS). We also performed perfusion-based multi-echo, Hadamard encoded arterial spin labeling (ASL) to evaluate whole brain cortical cerebral blood flow (CBF) and trans-endothelial exchange ( T
ex ) of water from the vasculature into the perivascular space and parenchyma. Both methods were used in young adults (N = 9, 6 F, 23 ± 3 years old) in the setting of sleep and sleep deprivation. To study aging, 10 older adults (6 F, 67 ± 3 years old) were imaged after a night of normal sleep and compared with the young adults. D* in SAS was significantly (p < 0.05) reduced with sleep deprivation (0.016 ± 0.001 mm2 /s) compared to normal sleep (0.018 ± 0.001 mm2 /s) and marginally reduced with aging (0.017 ± 0.001 mm2 /s, p = 0.029). Cortical CBF and Tex were unchanged with sleep deprivation but significantly lower in older adults (37 ± 3 ml/100 g/min, 578 ± 61 ms) than in young adults (42 ± 2 ml/100 g/min, 696 ± 62 ms). IVIM was sensitive to sleep physiology and aging, and multi-echo, multi-delay ASL was sensitive to aging., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.- Published
- 2024
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