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Endothelial dysfunction (ED) is defined as an impairment in the vasodilatory, anti-thrombotic, and anti-inflammatory properties of the cells that make up the lining of blood vessels. ED is considered a key step in the development of atherosclerotic cardiovascular disease. The association between ED and systemic inflammatory diseases is well established. However, the prevalence and clinical significance of ED in psoriatic arthritis (PsA) have been investigated to a lesser extent. This review aims to explore the link between ED and PsA, including ED in macro- and microcirculation, as well as risk factors for its occurrence in PsA and its relationship with atherosclerosis in PsA. Furthermore, the ED in PsA was compared with that of rheumatoid arthritis (RA). Regarding ED in the microcirculation, the coronary flow reserve was found to be significantly reduced in individuals with PsA. The relationship between PsA and macrovascular ED is more pronounced, along with more advanced atherosclerosis detected in patients with PsA. These results are consistent with those obtained in RA studies. On the other hand, arterial stiffness and signs of vascular remodeling were found more frequently in RA than in PsA, with the potential role of efficient anti-TNF treatment in patients with PsA and psoriasis explaining this finding. The impact of ED on cardiovascular diseases and the burden of this risk caused independently by PsA have not yet been precisely established, however, this group of patients requires special attention with regard to cardiovascular events., (© 2024. The Author(s).)

Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective selective treatments that could improve the 5-year survival rate. Consequently, the pathophysiological processes within leukemia cells are the focus of critical research. Enzymes such as cystathionine beta-synthase and sulfurtransferases like thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cystathionine gamma-lyase play a vital role in cellular sulfur metabolism. These enzymes are essential to maintaining cellular homeostasis, providing robust antioxidant defenses, and supporting cell division. Numerous studies have demonstrated that cancerous processes can alter the expression and activity of these enzymes, uncovering potential vulnerabilities or molecular targets for cancer therapy. Recent laboratory research has indicated that certain leukemia cell lines may exhibit significant changes in the expression patterns of these enzymes. Analysis of the scientific literature and online datasets has confirmed variations in sulfur enzyme function in specific leukemic cell lines compared to normal leukocytes. This comprehensive review collects and analyzes available information on sulfur enzymes in normal and leukemic cell lines, providing valuable insights and identifying new research pathways in this field.

Infectious skin diseases constitute a significant public health problem. Despite the systematic development of many modern diagnostic and therapeutic tools, they still pose a serious challenge for clinicians. Due to their prevalence and mild course in most cases, they are often marginalized, which can delay their diagnosis and treatment initiation. Such an approach in more clinically advanced cases can have serious consequences, sometimes leading to tragic outcomes. This work presents a series of four cases of common infectious skin diseases with an unusually atypical clinical picture: the history of a 49-year-old female patient with recurrent erysipelas of the right lower leg co-occurring with a SARS-CoV-2 infection, a 75-year-old male patient with a generalized form of herpes zoster, a 38-year-old female patient with a complicated severe course of head lice, and a 34-year-old male patient with a severe form of post-steroid mycosis. In each of these cases, difficulties in making the correct diagnosis were highlighted, even though they represent some of the most common bacterial, viral, parasitic, and fungal dermatoses. The paper discusses the risk factors for these diseases, the pathophysiology of their atypical course, the effects and challenges in the therapeutic approach conducted. Infectious skin dermatoses require aggressive treatment and should never be underestimated.

Nowadays, there is an increasing emphasis on the need to alleviate the chronic inflammatory response to effectively treat hypertension. However, there are still gaps in our understanding on how to achieve this. Therefore, research on interaction of antihypertensive drugs with the immune system is extremely interesting, since their therapeutic effect could partly result from amelioration of hypertension-related inflammation, in which macrophages seem to play a pivotal role. Thus, current comprehensive studies have investigated the impact of repeatedly administered hypotensive drugs (captopril, olmesartan, propranolol, carvedilol, amlodipine, verapamil) on macrophage functions in the innate and adaptive immunity, as well as if drug-induced effects are affected by a high-sodium diet (HSD), one of the key environmental risk factors of hypertension. Although the assayed medications increased the generation of reactive oxygen and nitrogen intermediates by macrophages from standard fed donors, they reversed HSD-induced enhancing effects on macrophage oxidative burst and secretion of pro-inflammatory cytokines. On the other hand, some drugs increased macrophage phagocytic activity and the expression of surface markers involved in antigen presentation, which translated into enhanced macrophage ability to activate B cells for antibody production. Moreover, the assayed medications augmented macrophage function and the effector phase of contact hypersensitivity reaction, but suppressed the sensitization phase of cell-mediated hypersensitivity under HSD conditions. Our current findings contribute to the recognition of mechanisms, by which excessive sodium intake affects macrophage immune activity in hypertensive individuals, and provide evidence that the assayed medications mitigate most of the HSD-induced adverse effects, suggesting their additional protective therapeutic activity., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Purpose: Androgen receptor (AR) can serve as a new therapeutic target since it was shown to play a proliferative role in several breast cancer (BC) subtypes. Moreover, AR positivity has been suggested to reflect the metastatic potential of tumor cells in some BC subtypes. The aim of this study was to determine the AR expression on disseminated tumor cells (DTCs) as a surrogate marker of minimal residual disease (MRD) and potential precursor of metastasis in early BC., Methods: Bone marrow (BM) aspirates from 62 DTC-positive early BC patients were included into this study and analyzed by immunofluorescence staining for the presence of AR-positive DTCs. CK-positive, CD45-negative cells containing an intact nucleus (DAPI positive) were identified as DTCs. AR expression of the primary tumor (PT) was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tumor sections from core biopsies and surgical specimens., Results: AR status of DTCs could be determined in 21 patients. We detected AR-positive DTCs in nine samples (43%). AR expression of DTCs and corresponding PT showed a concordance rate of 33%. The DTC-AR status did not correlate with clinicopathological factors, nor did we observe a significant correlation between the AR status of the PT and other established prognostic factors for BC., Conclusion: AR-positive DTCs can be detected in BM of early BC patients with a marked discordance of the AR status between DTCs and corresponding PTs. The clinical significance of these findings needs further investigation., (© 2023. The Author(s).)

Among various factors influencing the course of SARS-CoV-2 infection in humans, macrophage overactivation is considered the main cause of the cytokine storm that leads to severe complications of COVID-19. Moreover, the increased expression of angiotensin converting enzyme 2 (ACE2), an obligatory entry receptor of the coronavirus, caused by treatment with ACE inhibitors (ACEI) lowered overall confidence in the safety of these drugs. However, analysis of the course of coronavirus infection in patients treated with ACEI does not support these concerns. Instead, the beneficial effect of ACEI on macrophages has increasingly been emphasized. This includes their anti-inflammatory activation and the consequent reduction in the risk of severe disease and life-threatening complications. Herein, we summarize the current knowledge and understanding of the dual role of macrophages in SARS-CoV-2 infection, with a special focus on the postulated mechanisms underlying the beneficial effects of macrophage targeting by ACEI. These seem to involve the stimulation of macrophage angiotensin II type 2 and Mas receptors by angiotensin 1-7, intensively produced due to the up-regulation of ACE2 expression on macrophages, as well as the direct inhibition of macrophage hyper-responsiveness by ACEI. The impact of ACEI on macrophages may also lead to the activation of an effective antiviral response due to the increased expression of ACE2., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

Objectives: Possible correlations between wisdom and wellbeing among older people have been extensively debated in psychology. At the same time, researchers emphasize that the effect of older adults' wisdom on their wellbeing depends on numerous mediators. A review of the literature suggests that forgiveness might be one such variable. Thus, this study aimed to investigate whether forgiveness mediated the relationship between wisdom and wellbeing in late adulthood., Method: In total, 481 participants aged from 60 to 92 years ( M = 68.84; SD = 6.31) were involved in the study. All older people participating in the study lived independently in their households. Four psychological instruments were used: (1) the Self-Assessed Wisdom Scale; (2) the Heartland Forgiveness Scale; (3) the Psychological Wellbeing Scale; and (4) the Satisfaction with Life Scale. Therefore, the measurement of the analyzed variables was self-reported., Results: The results showed that forgiveness mediated the relationships between wisdom and wellbeing in the older population. The indirect effects demonstrated that forgiveness mediated the relationships between wisdom and wellbeing. Wisdom related to higher forgiveness (β = 0.21; p < 0.01), which, in turn, was related to a higher level of psychological (β = 0.48; p < 0.01) and subjective (β = 0.36; p < 0.01) wellbeing., Conclusion: These findings suggest that forgiveness is an important element of wisdom and wellbeing. The greater the wisdom the participants showed, the stronger the tendency to forgive and the better wellbeing they reported., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Brudek, Steuden and Kaleta.)

Drug-abuse detection tests are becoming increasingly commonplace in patient care today and provide a rapid and effective method for identifying illicit substances. Occasionally, they may yield a positive result, indicating the presence of a substance, even though the individual has not consumed the suspected drug what sometimes can significantly impact both medical and legal decisions. The study outlines the substances that can lead to false-positive drug test results for amphetamines, cannabinoids, and benzodiazepines. The study's findings have revealed pivotal insights for patients receiving chronic treatment and their primary care physicians. Notably, amphetamine assays appear to be most prone to cross-reactivity with other substances. The beta-blocker group of medications, confirmed by various studies to interfere with amphetamine assays, could pose a substantial challenge in drug screening given its widespread use. Efavirenz also warrants mention, as it frequently triggers positive results for both benzodiazepine and cannabinoid assays among its users. This research helps highlight new areas for further investigation and aims to guide clinicians in their daily practice, especially when interpreting questionable positive drug-abuse test results. This comprehensive review serves as a valuable resource for clinicians to navigate false-positive scenarios effectively and maintain the highest standard of patient care.

Background: The current study assessed forgiveness (positive forgiveness and reduced unforgiveness), self-consciousness (rumination and reflection), and physical and mental health. The aim of the study was to check if self-consciousness mediates the relationship between dispositional forgiveness and health., Methods: To address this link, we conducted 2 studies ( N = 484 in Study 1 and N = 249 in Study 2). Data were collected separately for Study 1, as well as Study 2. We used in both studies the Heartland Forgiveness Scale and the Rumination-Reflection Questionnaire, and additionally, the General Health Questionnaire-28 in Study 1 and the Scales of Psychological Well-Being in Study 2., Results: The results indicated that rumination was an effective mediator between positive forgiveness and mental health (B = 0.14, CI 95% = [0.064, 0.234]), reduced unforgiveness and physical health (B = -0.13, CI 95% = [-0.182, -0.088]), and both rumination and reflection between reduced unforgiveness and mental health (B = 0.13 CI 95% = [0.051, 0.226]), positive forgiveness (B = -0.09 CI 95% = [-0.135, -0.052]), and physical health., Conclusion: The mediating role of ruminations was more frequently observed in females. The study highlighted the indirect effect between forgiveness and health. Rumination and reflection are mediators between forgiveness and health.

Prior research has mainly examined non-adaptive responses to divorce, with less attention being paid to positive changes following the adversity of marital dissolution, especially posttraumatic growth and its consequences. The aim of this paper was to analyse the relationship between posttraumatic growth and subjective well-being, as well as the mediating and moderating role of self-esteem in this relationship among divorced men and women. The sample consisted of 209 divorcees (143 females, 66 males) aged 23-80 ( M = 41.97, SD = 10.72). The Posttraumatic Growth Inventory (PTGI), the Oxford Happiness Questionnaire (OHQ) and the Rosenberg Self-Esteem Scale (SES) were used in the study. Positive associations between overall posttraumatic growth, specific growth dimensions, subjective well-being and self-esteem were found. Self-esteem was confirmed as a mediator in the relationships between changes in perception of self and subjective well-being (SWB), between changes in relating to others and SWB and between appreciation for life and SWB. Self-esteem moderated the association between spiritual changes and subjective well-being; namely, changes in spirituality were positively related to happiness in individuals with lower and average self-esteem but not with high self-esteem. We found no differences between women and men in the obtained results. Self-esteem might be considered a possible psychological (mediating rather than moderating) mechanism in the transmission of PTG onto SWB in divorcees, regardless of their gender.

Competing Interests: The authors declare no conflict of interest.

Purpose/objective: To investigate whether there is a relationship between posttraumatic growth (PTG) and forgiveness in people with physical disabilities, and whether contextual factors moderate the association., Research Method/design: Two hundred and sixty seven persons with physical disabilities completed Polish versions of three inventories: Posttraumatic Growth Inventory (PTGI), Decision to Forgive Scale (DTFS), and Emotional Forgiveness Scale (EFS). The participants also assessed contextual factors of offenses, such as transgression severity, apology being offered, and quality of the relationship with the offender. The associations between the variables were examined using correlation and moderation analyses. In the moderation model, PTG was posited as a predictor, offence-specific factors as subsequent moderators, and forgiveness (decisional and emotional) as outcome variables., Results: PTG was positively associated with decisional and emotional forgiveness, and not related to contextual factors. Transgression severity, apology, and relationship quality were correlated with forgiveness. The quality of the victim-offender relationship was the only contextual variable to moderate the association between PTG and emotional forgiveness., Conclusion/implications: PTG and forgiveness are positively related and their association is moderated by the context of the transgression to a minor extent. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Background: Atrophic papulosis is a very rare vascular disease of unknown pathogenesis, mostly described by case reports., Objective: To assess demographic data and prognosis in patients with atrophic papulosis., Methods: A single-centre study was performed on a series of 105 patients with atrophic papulosis, diagnosed 2000-2021. Patients were referred and diagnosed at the evaluation centre and patients' clinical data were provided by the Degos Support Network and evaluated by the authors for confirming the diagnosis of skin lesions and fulfilling the diagnostic criteria for a malignant subset. A unique set of variables were collected from all patients., Results: The mean age of disease onset was 33.3 ± 18.3 years and the male-to-female ratio was 1:1.6. The family history rate was 8.1%. The classification into a benign, merely cutaneous disease (benign atrophic papulosis), and malignant atrophic papulosis, associating cutaneous and visceral lesions was confirmed due to their striking prognostic difference. Benign atrophic papulosis was detected in 41% of the patients with no deaths occurring throughout the follow-up period (median 3.00 years; range 0.13-23). Malignant atrophic papulosis was reported in 59% of patients with 47.5% multisystemic involvement and a median skin lesion onset to systemic symptoms duration of 0.54 years (-6 to 20). The gastrointestinal tract and central nervous system were equally involved; however, the neurological involvement-caused death rate was slightly higher. The disease-specific mortality rate of malignant atrophic papulosis was 22.6%., Conclusions: Atrophic papulosis presents with a striking prognostic difference of benign - merely cutaneous - involvement or quickly developing - into less than 1 year - malignant subset, associating cutaneous and visceral lesions and multiorgan involvement in 1/2 of the patients, which leads to premature, disease-specific mortality in 1/4 of the cases. Central nervous system and gastrointestinal tract complications are the major reasons for disease-specific death. Over the years, the diagnosis of severe nervous system involvement has become more common., (© 2022 European Academy of Dermatology and Venereology.)

Hypertension remains the leading preventable risk factor for stroke and coronary artery disease, significantly contributing to all-cause global mortality and predisposing patients to renal and heart failure, as well as peripheral vascular disease. Due to the widespread usage of antihypertensive drugs, global mean blood pressure has remained unchanged or even slightly decreased over the past four decades. However, considering the broad spectrum of mechanisms involved in the action of antihypertensive drugs and the prevalence of their target receptors on immune cells, possible immunomodulatory effects which may exert beneficial effects of lowering blood pressure but also potentially alter immune function should be considered. In this review, we attempt to assess the consequences to immune system function of administering the five most commonly prescribed groups of antihypertensive drugs and to explain the mechanisms behind those interactions. Finally, we show potential gaps in our understanding of the effects of antihypertensive drugs on patient health. With regard to the widespread use of these drugs in the adult population worldwide, the discussed results may be of vital importance to evidence-based decision-making in daily clinical practice., Competing Interests: Conflict of interest statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Although women are believed to be more forgiving than men, the results of many studies comparing women with men vary. Moreover, little is known about unique correlates or differential patterns of experiencing forgiveness by gender. In the present study, we compared men and women in terms of their level of dispositional forgiveness and its emotional correlates, namely positive and negative affect, anxiety, and emotional control. The sample consisted of 625 individuals aged 19-69, of whom 478 (76.5%) were women and 147 (23.5%) were men. Polish versions of the Heartland Forgiveness Scale (HFS), the Positive and Negative Affect Schedule (PANAS), the Courtauld Emotional Control Scale (CECS), and the State-Trait Anxiety Inventory (STAI) were used. Men showed a higher level of general forgiveness and greater willingness to overcome unforgiveness than women, but there was no significant difference in positive facets of the disposition to forgive. In both genders negative affect, anxiety, and control of anger and of depression were negatively related to dimensions of dispositional forgiveness, and positive affect was positively associated with forgiveness. In females control of anxiety was negatively and in males it was positively related to facets of forgiveness. Gender moderated a number of links between affective traits and forgiveness of self and of situations beyond control, but not forgiveness of others., (© 2021. The Author(s).)

This study explores gender and age differences in forgivingness using the crosscultural and stress-and-coping perspective. Polish and Italian versions of the Heartland Forgiveness scale (HFS) were used. The sample consisted of 1957 individuals aged 18-80 (61% females and 39% males). A 3-way between groups ANOVA was used to examine the main effects and interactions of country, age and gender as they relate to total HFS score. Post-hoc analyses were performed where appropriate. The results revealed that Polish and Italian respondents did not differ in the level of the general tendency to forgive. Gender differences in trait forgiveness were reported in whole sample and in Italian subsample, showing males to be more forgiving than females. Further, our results for all study participants, in Polish subsample and among Italian males showed that older adults were more forgiving than young respondents, which is consistent with the previous findings showing an increase in forgivingness with age., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s).)

(1) Background: Cyberhate is becoming increasingly prevalent, just as Internet addiction. One way to deal with hate speech may be to make a decision to forgive the offence. However, addiction to the Internet, due to cognitive changes caused, can play a role in the making of this decision. (2) Methods: A total of N = 246 participants completed the Online Cognitive Scale (OCS), Decision to Forgive Scale (DTFS), and a single-item scale to assess cyberhate severity. In our cross-sectional study, we tested the moderating role of Internet addiction in the relationship between the severity of cyberhate and decisional forgiveness. (3) Results: The results of our study show an inverse correlation between cyberhate severity and decisional forgiveness. We found that Internet addiction moderated the relationship between the perceived severity of cyberhate and forgiveness. In case of a high level of Internet addiction, the transgression severity-forgiveness link is not significant. (4) Conclusions: These results are in accordance with the studies that showed the negative effects of Internet addiction on cognitive processes.

Competing Interests: The authors declare no conflict of interest.

Introduction: Primary cicatricial alopecia (PCA) encompasses a heterogeneous group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. Discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) are the most common causes of scarring alopecia. The distinction between both entities is often challenging because of significant clinical and histopathological overlap., Aim: We hypothesized that dendritic cells which are implicated in PCA pathogenesis can provide a reliable histopathological clue to distinguish between these two entities., Material and Methods: In a retrospective cohort study including 51 patients diagnosed with LPP and DLE we mapped and quantified the distribution of dendritic cells. Cell count in lesional skin was performed on immunohistochemistry by using characteristic monoclonal antibodies to specific subpopulations of dendritic cells., Results: We demonstrated that almost all subpopulations of dendritic cells were highly expressed in lesional skin of discoid lupus erythematosus patients in comparison with lichen planopilaris ones., Conclusions: In the light of this observation, dendritic cells might be used as an additional clue in differential diagnosis of PCA., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2022 Termedia Sp. z o. o.)

Hidradenitis suppurativa/acne inversa (HS) has a multifactorial pathogenesis. In addition to a sporadic form, a familial form is reported in around 40% of patients, for whom an autosomal dominant (AD) inheritance with reduced gene penetrance is assumed. The phenotype of the disease with inflammatory nodules, abscesses and secreting sinus tracts suggests an infectious origin, but the exact role of the bacteria detected in HS pathogenesis remains unclear. Smoking and metabolic syndrome are regarded as important trigger factors in HS, with obesity and hormonal changes playing a pathogenic role in the latter. Ultimately, Toll-like receptors, antimicrobial peptides, immune cells and key cytokines are involved in the excessive inflammatory reaction of HS and are also the targets of future therapies., (© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)

Purpose: To assess the time course changes in corneal topographic parameters during the one-year follow-up after Descemet membrane endothelial keratoplasty (DMEK) surgery., Materials and Methods: Twenty-one patients (24 eyes) who underwent DMEK surgery were evaluated. Best corrected visual acuity (BCVA), endothelial cell count (ECC), central corneal thickness (CCT), mean keratometry (MK), mean astigmatism (MA), astigmatism asymmetry (AA), and higher-order aberration (HOA) were assessed at baseline and 1, 3, 6 and 12 months after the surgery using CASIA2 anterior segment swept-source OCT (Tomey, Japan)., Results: In patients who underwent DMEK surgery, BCVA improved gradually at the subsequent visits during the 12-month follow-up. A significant reduction in ECC and CCT at the 1st month was noted, which remained stable until the 6th month postoperatively. Anterior and total MK values remained unchanged, whereas changes in posterior keratometry were noticeable until the 6th month after surgery. A significant reduction in the anterior, posterior, and total astigmatism magnitude as well as astigmatism asymmetry was observed during the first 6 months after surgery. A gradual anterior, posterior, and total HOA decrease was documented until the 12th month after surgery. Negative correlations between baseline values of CCT, MK, MA, AA, and HOA and postoperative variations in those parameters at consecutive follow-up time points were observed. Accordingly, negative correlations between baseline CCT and postoperative changes in corneal topographic parameters after surgery were found., Conclusion: The stabilization of most corneal topographic parameters takes place within 6 months after the procedure, whereas HOA reduction and BCVA improvement gradually occur during the first year after surgery. Preoperative values of corneal topographic parameters strongly determine their changes detected after DMEK surgery, which may suggest that early therapeutic intervention results in better visual outcomes., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2021 Anna Machalińska et al.)

Study Design: This is a cross-sectional study using questionnaires., Objectives: This paper investigates the correlation between forgiveness and acceptance of disability and mediation effects of appraisal of disability in people with traumatic spinal cord injury (T-SCI)., Setting: Community-dwelling people with T-SCI in Poland., Methods: The study assessed forgiveness, appraisal of disability, and acceptance of disability. The association between all the variables was examined by Pearson correlation analysis, and multiple mediation macro Preacher and Hayes' (Behav Res Methods 40:879-91, 2008)-model 4, including appraisals of disability as a mediator on the relationship between forgiveness and acceptance of disability., Results: Participants were 163 adults with T-SCI (63 females and 100 males, the average age of the sample was 39.6, SD = 9.38). Forgiveness showed a significant relationship with all dimensions of acceptance of disability. In addition, appraisal of disability, especially determined resolve, overwhelming disbelief, and negative perceptions of disability were mediators between forgiveness and all dimensions of acceptance of disability. In case of acceptance of disability as a subordinating physique relative to other values, full mediation was observed., Conclusions: Forgiveness along with appraisal of disability is important for explaining disability acceptance. Promoting forgiveness and positive assessments of disability at the same time weakening negative assessments of disability can be favorable for making necessary changes in values, and as a result, for strengthened mental health and successful psychosocial adaptation in individuals with T-SCI.

Competing Interests: The authors declare no conflict of interest.

Although hope and forgiveness have been both negatively correlated with depression, actual relationships between all three variables have never been investigated. The aim of the study was to examine a theoretical model in which forgiveness mediates the relationship between basic hope and depressive symptoms. The sample was composed of 77 psychotherapy outpatients. Polish adaptations of the Basic Hope Inventory, the Beck Depression Inventory, and the Heartland Forgiveness Scale were used. Negative and positive aspects of dispositional forgiveness of self, others, and situations beyond anyone's control were applied. Results indicated that the general level of forgiveness, as well as overcoming unforgiveness, fully mediated the relationship between basic hope and depression symptoms, while positive dimension of forgiveness partially mediated the links between the variables. The findings demonstrate that the tendency to forgive might be a mechanism via which basic hope reduces odds of depression.

Competing Interests: The authors declare no conflict of interest.

The time evolution of random variables with Lévy statistics has the ability to develop jumps, displaying very different behaviors from continuously fluctuating cases. Such patterns appear in an ever broadening range of examples including random lasers, non-Gaussian kinetics, or foraging strategies. The penalizing or reinforcing effect of the environment, however, has been little explored so far. We report a new phenomenon which manifests as a qualitative transition in the spatial decay behavior of the stationary measure of a jump process under an external potential, occurring on a combined change in the characteristics of the process and the lowest eigenvalue resulting from the effect of the potential. This also provides insight into the fundamental question of what is the mechanism of the spatial decay of a ground state.

Objectives: Although there have been studies linking personality to selected aspects of functioning at work, Polish literature reports a shortage of detailed analyses considering, e.g., specific professional groups or certain variables. The aim of our study was to explore the links between personality traits and emotional labor, work engagement and job satisfaction among service workers., Material and Methods: The study was based on a cross-sectional, self-report survey of 137 workers representing different service industries in Poland. Each participant received a demographic data sheet and a set of questionnaires: NEO Five-Factor Inventory, the Deep Acting and Surface Acting Scale, the Job Satisfaction Scale and the Utrecht Work Engagement Scale - all in their Polish versions., Results: A correlation analysis revealed numerous relationships between the examined variables. However, results of the regression analysis showed that only some personality traits were related with individual aspects of functioning at work. Neuroticism accounted for the phenomenon of faking emotions. Conscientiousness was significantly related to general work engagement, vigor and dedication. Agreeableness and neuroticism significantly predicted job satisfaction., Conclusions: Individual personality traits account for various aspects of work functioning. Int J Occup Med Environ Health 2016;29(5):767-782., (This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.)

The reaction of different metallocene fragments [Cp(2)M] (Cp=η(5)-cyclopentadienyl, M=Ti, Zr) with diferrocenylacetylene and 1,4-diferrocenylbuta-1,3-diyne is described. The titanocene complexes form the highly strained three- and five-membered ring systems [Cp(2)Ti(η(2)-FcC(2)Fc)] (1) and [Cp(2)Ti(η(4)-FcC(4)Fc)](2) (Fc=[Fe(η(5)-C(5)H(4))(η(5)-C(5)H(5))]) by addition of the appropriate alkyne or diyne to Cp(2)Ti. Zirconocene precursors react with diferrocenyl- and ferrocenylphenylacetylene under C-C bond coupling to yield the metallacyclopentadienes [Cp(2)Zr(C(4)Fc(4))](3) and [Cp(2)Zr(C(4)Fc(2)Ph(2))](5), respectively. The exchange of the zirconocene unit in 3 by hydrogen atoms opens the route to the super-crowded ferrocenyl-substituted compound tetraferrocenylbutadiene (4). On the other hand, the reaction of 1,4-diferrocenylbuta-1,3-diyne with zirconocene complexes afforded a cleavage of the central C-C bond, and thus, dinuclear [{Cp(2)Zr(μ-η(1):η(2)-C≡CFc)}(2)] (6) that consists of two zirconocene acetylide groups was formed. Most of the complexes were characterized by single-crystal X-ray crystallography, showing attractive multinuclear molecules. The redox properties of 3, 5, and 6 were studied by cyclic voltammetry. Upon oxidation to 3(n+), 5(n+), and 6(n+) (n=1-3), decomposition occured with in situ formation of new species. The follow-up products from 3 and 5 possess two or four reversible redox events pointing to butadiene-based molecules. However, the dinuclear complex 6 afforded ethynylferrocene under the measurement conditions., (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

The reaction of the low-valent metallocene(II) sources Cp(2)Ti(η(2)-Me(3)SiC(2)SiMe(3)) (7) and Cp(2)Zr(py)(η(2)-Me(3)SiC(2)SiMe(3)) (11, Cp = η(5)-cyclopentadienyl, py = pyridine) with carbodiimides RN═C═NR (R = Cy, i-Pr, p-Tol) leads to the formation of five membered hetero-metallacycloallenes Cp(2)M{Me(3)SiC═C═C[N(SiMe(3))(R)]-N(R)} (9M-R) (M = Ti, R = i-Pr; M = Zr, R = Cy, i-Pr, p-Tol). Elimination of the alkyne (as the hitherto known reactivity of titanocene and zirconocene alkyne complexes would suggest) was not observed. The molecular structures of the obtained complexes were confirmed by X-ray studies. Moreover, the structure and bonding of the complexes 9Zr-Cy and 9Zr-p-Tol was investigated by DFT calculations., (© 2011 American Chemical Society)

The title compound, [Zr(C(5)H(5))(2)(C(4)H(9)N)(C(5)H(5)N)], was obtained from the reaction of (C(5)H(5))(2)Zr(py)(η(2)-Me(3)SiC(2)SiMe(3)) (py is pyridine) and (t)BuN=C=N(t)Bu alongside the formation of (C(5)H(5))(2)Zr(CN(t)Bu)(η(2)-Me(3)SiC(2)SiMe(3)). The zirconium atom is coordinated in a distorted tetra-hedral geometry by two cyclo-penta-dienyl ligands, a pyridine ligand, and a tert-butyl-imido ligand via a Zr=N double bond. The tert-butyl group is disordered over two positions in a 0.634 (5):0.366 (5) ratio.

Aza-analogues of Acyclovir were obtained from N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-p-toluenesulfonamide via a one-pot base silylation/nucleoside coupling procedure. The antiviral activities of all aza-nucleosides in vitro against a variety of viruses were evaluated. None of these compounds displayed any specific antiviral effects.

The aim of this investigation was to evaluate effectiveness of RM-33, a new isoxazolotriazepine, in the model of carrageenan-induced inflammation in rats. Wistar rats were pretreated with intraperitoneal (ip) or oral (po) doses of RM-33, at daily doses ranging from 250 to 1000 microg, administered 1-3 days before elicitation of the carrageenan reaction. We showed that both routes of RM-33 administration were effective in significantly diminishing the footpad edema. The effects were dose-dependent and better pronounced at the ip administration of the compound. We found a lower production of tumor necrosis factor alpha (TNF-alpha) by mitogen-stimulated splenocytes isolated from rats pretreated with RM-33 and injected with carrageenan, as well as lower serum TNF-alpha levels in these rats, as compared to the respective control. Histological analysis of the skin reaction site revealed that in the rats pretreated with RM-33, the carrageenan-induced inflammation was reduced, as reflected by a lesser damage of mast cells, smaller infiltration by macrophages and a diminished edema of the connective tissue. Together with our previous data, indicating the antagonistic action of RM-33 in the adjuvant-induced footpad inflammation in mice, the present results confirm the anti-inflammatory activity of RM-33 compound.