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Start Over Author "Kharchenko, Sergiy G." Database MEDLINE
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1. Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B.

Author

Trush VV, Kharchenko SG, Tanchuk VY, Kalchenko VI, and Vovk AI

Subjects
Calixarenes chemistry, Catalytic Domain, Enzyme Inhibitors chemistry, Esters chemistry, Humans, Inhibitory Concentration 50, Kinetics, Models, Molecular, Organophosphonates chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 1 metabolism, Serum Albumin metabolism, Temperature, Calixarenes pharmacology, Enzyme Inhibitors pharmacology, Esters pharmacology, Organophosphonates pharmacology, Protein Tyrosine Phosphatase, Non-Receptor Type 1 antagonists & inhibitors
Abstract

Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.

Published
2015
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