Search

Background: The purpose of this study was to evaluate the safety and outcome of rechallenge [ 177 Lu]Lu-PSMA-I&T in newly progressed mCRPC patients after response to initial [ 177 Lu]Lu-PSMA radioligand therapy (PRLT)., Methods: We retrospectively included 18 patients who underwent rechallenge with [ 177 Lu]Lu-PSMA-I&T. All patients presented with (i) newly progressed disease after response to initial PRLT; (ii) a [ 68 Ga]Ga-PSMA-11 PET/CT confirming the presence of PSMA-positive metastases; iii) ECOG performance status 0-1. Adverse events were graded according to CTCAE v5.0. Response was assessed by PSA and classified according to PCWG3 recommendations. For patients who underwent restaging with [ 68 Ga]Ga-PSMA-11 PET/CT, imaging response was categorised according to adapted PERCIST v1.0. In patients with discordant [ 68 Ga]Ga-PSMA-11 PET/CT and PSA, other available imaging modalities were evaluated to confirm disease status. Overall survival (OS) was calculated from the first cycle of initial PRLT and rechallenge PRLT, respectively, until last patient contact or death., Results: Patients were initially treated with a median of 5 cycles (range 4-7) and were rechallenged after a median of 9 months (range 3-13). Each patient received a median of 4 (range 2-7) rechallenge cycles (median cumulative activity 26.1 GBq). None of the patients experienced life-threatening G4 adverse events during either treatment period. Grade 3 adverse events included one case of anaemia, one case of thrombocytopenia, and one case of renal failure. In 8/18 patients long-term toxicities were evaluated. Serious toxicities (≥ Grade 3) occurred in 3/8 patients (n = 1 G4 thrombocytopenia, n = 1 G4 renal failure and n = 1 pancytopenia and G4 renal failure). Best PSA50%-response was observed in 44% of patients and PSA-disease control was confirmed in 56% of patients at the last cycle. Of the 12/18 patients restaged by imaging, 6/12 (50%) patients had disease control (partial response/stable disease), 1/12 had a mixed response, and 5/12 had progression. After a median follow-up time of 25 months (range 14-44), 10 patients had died, 7 were still alive, and one patient was lost at follow-up. The median OS was 29 months (95%CI, 14.3-43.7 months) for the initial treatment and 11 months (95%CI, 8.1-13.8 months) for the first rechallenge course., Conclusion: More than half of patients benefit from rechallenge PRLT. Our analysis suggests that rechallenge may prolong survival in selected patients, with an acceptable safety profile., Competing Interests: Declarations. Ethical approval: All procedures performed in this study were in accordance with the principles of the 1964 Declaration of Helsinki and its subsequent amendments. [177Lu]Lu-PSMA-I&T was prepared according to the Austrian Medicinal Products Act AMG § 8 and § 62 and all regulations of the Austrian Agency for Radiation Protection were observed. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: All authors have nothing to disclose., (© 2024. The Author(s).)

Greenbeards facilitate cooperation by encoding a perceptible signal, the ability to detect it, and a tendency to help others that display it. Falsebeards are hypothetical cheaters that display the signal without being altruistic. Despite many examples of greenbeards, evidence for falsebeards is scarce. The Dictyostelium discoideum tgrB1-tgrC1 allorecognition pathway encodes a greenbeard. It allows development, which yields fruiting bodies with altruistic stalks that increase spore dispersal. Here we show that cells lacking rapgapB , a tgrB1-tgrC1 signaling element, cheat by avoiding the stalk fate and generating more spores in chimeras than in pure populations. rapgapB - cells cheat only on partners with compatible tgrB1-tgrC1 allotypes, suggesting that beard display and recognition are intact but decoupled from altruism. The rapgapB - falsebeard provides a model to study greenbeard maintenance and subversion., Competing Interests: The authors declare no competing interests., (© 2024 The Author(s).)

Casimir force densities, i.e., force per area, become very large if two solid material surfaces come closer together to each other than 10 nm. In most cases, the forces are attractive. In some cases, they can be repulsive depending on the solid materials and the fluid medium in between. This review provides an overview of experimental and theoretical studies that have been performed and focuses on four main aspects: (i) the combinations of different materials, (ii) the considered geometries, (iii) the applied experimental measurement methodologies and (iv) a novel self-assembly methodology based on Casimir forces. Briefly reviewed is also the influence of additional parameters such as temperature, conductivity, and surface roughness. The Casimir effect opens many application possibilities in microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS), where an overview is also provided. The knowledge generation in this fascinating field requires interdisciplinary approaches to generate synergetic effects between technological fabrication metrology, theoretical simulations, the establishment of adequate models, artificial intelligence, and machine learning. Finally, multiple applications are addressed as a research roadmap.

Background: Adverse childhood experiences (ACEs) represent a key risk factor for suicidal thoughts and behaviors among adolescents. However, the intervening mechanisms linking ACEs and suicidality, and whether such processes vary by gender, remain underexplored., Objective: The present study examines whether the relationships between ACEs and the likelihood of experiencing suicidal thoughts and attempting suicide are indirect through depressive symptoms and low self-control. This study also investigates whether these direct and indirect paths might be moderated by gender., Participants and Setting: The analyses make use of data on a statewide representative sample of students enrolled in public high schools in Florida (N = 23,078) from the 2022 Florida Youth Substance Abuse Survey (FYSAS)., Methods: Generalized structural equation modeling (GSEM) was used to estimate the direct and indirect effects of ACEs on the likelihood of suicidal thoughts and attempting suicide. The indirect effects were assessed using bootstrapping, and between-gender differences in the coefficients were tested., Results: ACEs has direct associations with depressive symptoms, low self-control, and both suicidality outcomes. The effects of ACEs on suicidal thoughts are indirect through both depressive symptoms and low self-control, and the effects of ACEs on suicide attempts are indirect through depressive symptoms. Limited gender differences in these pathways emerge., Conclusions: For male and female youth, ACEs are associated with heightened depression symptoms and reduced self-control, and both of these factors partially explain the previously established relationship between ACEs and suicidality., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Greenbeard genetic elements encode rare perceptible signals, signal recognition ability, and altruism towards others that display the same signal. Putative greenbeards have been described in various organisms but direct evidence for all the properties in one system is scarce. The tgrB1-tgrC1 allorecognition system of Dictyostelium discoideum encodes two polymorphic membrane proteins which protect cells from chimerism-associated perils. During development, TgrC1 functions as a ligand-signal and TgrB1 as its receptor, but evidence for altruism has been indirect. Here, we show that mixing wild-type and activated tgrB1 cells increases wild-type spore production and relegates the mutants to the altruistic stalk, whereas mixing wild-type and tgrB1-null cells increases mutant spore production and wild-type stalk production. The tgrB1-null cells cheat only on partners that carry the same tgrC1-allotype. Therefore, TgrB1 activation confers altruism whereas TgrB1 inactivation causes allotype-specific cheating, supporting the greenbeard concept and providing insight into the relationship between allorecognition, altruism, and exploitation., (© 2024. The Author(s).)

The prevalence of suicidal thoughts and behaviors across distinct intersections of race/ethnicity and gender among adolescents remains understudied. The current study seeks to address this important gap in suicide scholarship using a statewide representative sample of U.S. Florida middle school and high school adolescents. Data drawn from the 2022 Florida Youth Substance Abuse Survey (FYSAS) ( N  = 41,764) were analyzed to examine disparities in suicidal thoughts and suicide attempts among 26 racial/ethnic and gender subgroups of middle school and high school aged adolescents. Survey-weighted prevalence estimates for both suicidality outcomes were generated, and binary contrasts were used to assess the statistical significance of the differences in the probabilities between members of each subgroup and youth belonging to all other subgroups. Our results indicate that the prevalence of suicidal thoughts and attempts was highly gendered and varied according to racial/ethnic subgroups. Native American girls reported more suicidal thoughts (49.9%) and attempts (16.5%) in the past 12 months than any race/gender group. Other racial/ethnic and gender groups that reported particularly high rates of suicidal thoughts and attempts were West Indian/Caribbean female adolescents (48.8% and 13.4%, respectively), Puerto Rican female adolescents (48.5% and 14.7%, respectively), and Black/non-Hispanic female adolescents (19.9% and 15.6%, respectively). Because certain gender and race/ethnic subgroups are at an increased risk for suicidality, more research is needed to better understand the risk and protective factors to determine which suicide prevention strategies might best serve each group., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Inc.)

The depth discrimination in confocal microscopy is based on the digital analysis of depth response signals obtained by each camera pixel during measurement. Various signal-processing algorithms are used for this purpose. The accuracy of these algorithms is inter alia restricted by the axial symmetry of the signals. However, in practice response signals are rather asymmetrical especially in case of measurement objects with critical surface structures such as edges or steep flanks. We present a novel signal-processing algorithm based on an exponential function with a cubic argument to handle asymmetrical and also symmetrical depth response signals. Results obtained by this algorithm are compared to those of commonly used signal processing algorithms. It turns out that the novel algorithm is more robust, more accurate and exhibits a repeatability of a similar order compared to other algorithms. RESEARCH HIGHLIGHTS: A novel, more robust algorithm with improved accuracy in peak extraction especially for asymmetrical response signals in confocal microscopy is introduced and validated. Improved accuracy is demonstrated for height and layer thickness measurements., (© 2023 The Authors. Microscopy Research and Technique published by Wiley Periodicals LLC.)

Purpose: The prevalence of exposure to adverse childhood experiences (ACEs) across distinct intersections of race/ethnicity and gender among adolescents remains relatively unknown. The current study seeks to address this important gap in the literature using a statewide representative sample of Florida high school students., Methods: Data drawn from the 2020 Florida Youth Substance Abuse Survey (FYSAS) (N = 20,438) were analyzed to examine differences in ACE exposure among 26 racial/ethnic and gender subgroups of high-school aged youth. Lifetime exposure to ACEs was constructed using 10 different ACE categories to measure ACEs prevalence as reported exposure to 1+ ACEs and 4+ ACEs., Results: Exposure to ACEs was highly gendered and varied according to racial/ethnic subgroup. While notable differences across gender and racial/ethnic groups emerged when measuring prevalence as exposure to 1+ ACEs, several of these disparities were further amplified when prevalence was measured as exposure to 4+ ACEs. Native American female adolescents represented the group at greatest risk of high exposure to ACEs, with more than 50% of such youth reporting exposure to 4+ ACEs., Discussion: The prevalence of ACE exposure varies significantly across race/ethnic and gender subgroups of youth. These intersections should be considered for prevention efforts and clinical treatments of trauma exposure as ACEs may be linked to certain outcomes or behaviors based on high exposure in certain subpopulations of youth., (Copyright © 2022 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)

Objective: Prior research consistently demonstrates that defendants convicted at trial are sentenced more harshly than those who plead guilty. Additionally, a vast literature has shown that Black and Hispanic defendants, and especially young minority males, are particularly disadvantaged in sentencing, though these effects may be conditional on various legal and case-processing factors. However, it remains unclear how the mode of conviction might moderate these inequalities according to offenders' combined race/ethnicity, gender, and age., Hypotheses: I expected that mode of conviction would moderate the joint effects of race/ethnicity, gender, and age on the imposition of a sentence to prison and on sentence length such that young minority males convicted at trial would receive more severe punishments than members of other subgroups., Method: The analyses made use of data on defendants sentenced for noncapital felony crimes in Florida circuit courts over a 12-year period (N = 1,076,500). Hurdle regression models and marginal effects analysis were used., Results: Greater sentencing disparities in absolute as well as relative terms between young minority males and other race/ethnicity, gender, and age subgroups were found among trial cases than among plea cases. Further, Black and Hispanic males were subjected to trial taxes that were substantially larger than those of other subgroups., Conclusions: These findings suggest that defendants who plead guilty are generally sentenced according to predictable and standardized "going rates" of punishment, whereas the enhanced discretion afforded judges in trial cases as well as racialized "bad facts" about defendants that emerge at trial may drive inequalities in punishment. Thus, extralegal sentencing disparities tied to mode of conviction are an area in which criminal justice reform efforts might be directed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

The representation of land surface processes in hydrological and climatic models critically depends on the soil water characteristics curve (SWCC) that defines the plant availability and water storage in the vadose zone. Despite the availability of SWCC datasets in the literature, significant efforts are required to harmonize reported data before SWCC parameters can be determined and implemented in modeling applications. In this work, a total of 15,259 SWCCs from 2,702 sites were assembled from published literature, harmonized, and quality-checked. The assembled SWCC data provide a global soil hydraulic properties (GSHP) database. Parameters of the van Genuchten (vG) SWCC model were estimated from the data using the R package 'soilhypfit'. In many cases, information on the wet- or dry-end of the SWCC measurements were missing, and we used pedotransfer functions (PTFs) to estimate saturated and residual water contents. The new database quantifies the differences of SWCCs across climatic regions and can be used to create global maps of soil hydraulic properties., (© 2022. The Author(s).)

Research consistently finds that unstructured socializing with peers and low self-control are both positively associated with substance use among adolescents. However, largely absent from the literature is a consideration of whether unstructured socializing with peers and low self-control have differential and interactive effects when predicting usage of different classifications of drugs. The current study addresses these issues using data collected on a statewide sample of middle school and high school students who participated in the 2017 Florida Youth Substance Abuse Survey. Results indicate that (1) unstructured socializing with peers is a stronger predictor of soft drug use than low self-control, (2) low self-control is a stronger predictor of hard drug use than unstructured socializing with peers, and (3) the effect of unstructured socializing on both soft and hard drug use is diminished among adolescents who are lower in self-control.

Three-dimensional (3D) transfer functions build the basis for a comprehensive characterization of optical imaging systems in the spatial frequency domain. Utilizing the projection-slice theorem, the 2D modulation transfer function of an incoherent imaging system can be derived from a 3D transfer function by integration with respect to the axial spatial frequency. For a diffraction limited microscope with homogeneous incoherent pupil illumination, the modulation transfer function equals the 2D autocorrelation function of a circular disc. However, until now to the best of our knowledge no 3D transfer function has been published, which exactly leads to the 2D modulation transfer function of a diffraction limited microscope in reflection mode. In this article, we derive a formula, which after integration with respect to the axial spatial frequency coordinate perfectly fits to the diffraction limited 2D modulation transfer function. The inverse three-dimensional Fourier transform of the 3D transfer function results in a complex-valued 3D point spread function, from which the depth of field, the lateral resolution and, in addition, the corresponding 3D point spread function of both, a conventional and an interference microscope, can be obtained., (© 2021 The Authors. Journal of Microscopy published by John Wiley & Sons Ltd on behalf of Royal Microscopical Society.)

Dryland vegetation productivity is strongly modulated by water availability. As precipitation patterns and variability are altered by climate change, there is a pressing need to better understand vegetation responses to precipitation variability in these ecologically fragile regions. Here we present a global analysis of dryland sensitivity to annual precipitation variations using long-term records of normalized difference vegetation index (NDVI). We show that while precipitation explains 66% of spatial gradients in NDVI across dryland regions, precipitation only accounts for <26% of temporal NDVI variability over most (>75%) dryland regions. We observed this weaker temporal relative to spatial relationship between NDVI and precipitation across all global drylands. We confirmed this result using three alternative water availability metrics that account for water loss to evaporation, and growing season and precipitation timing. This suggests that predicting vegetation responses to future rainfall using space-for-time substitution will strongly overestimate precipitation control on interannual variability in aboveground growth. We explore multiple mechanisms to explain the discrepancy between spatial and temporal responses and find contributions from multiple factors including local-scale vegetation characteristics, climate and soil properties. Earth system models (ESMs) from the latest Coupled Model Intercomparison Project overestimate the observed vegetation sensitivity to precipitation variability up to threefold, particularly during dry years. Given projections of increasing meteorological drought, ESMs are likely to overestimate the impacts of future drought on dryland vegetation with observations suggesting that dryland vegetation is more resistant to annual precipitation variations than ESMs project., (© 2021 John Wiley & Sons Ltd.)

Despite the fact that optical profilers, such as coherence scanning interferometers, are frequently used for fast and contactless topography measurements in various fields of application, measured profiles still suffer from the wave characteristics of light, which leads to systematic deviations that are still not sufficiently investigated. In order to analyze these systematic deviations and their physical relations, we apply a rigorous simulation model considering both the transfer characteristics of the measurement instrument as well as the geometry and material of different measurement objects. Simulation results are compared to measurement results for different polarizations, wavelengths and interferometer types, considering surface structures including edges, slopes and different materials as the main reasons for those deviations. Compared to former publications, a full three-dimensional (3D) modeling of the image formation with regard to two-dimensional (2D) surface structures is provided. The advantages of 3D modeling in contrast to a time efficient 2D approach are discussed. Further, an extract of an atomic force microscope (AFM) measurement result is used as the basis for the FEM simulation in one example in order to achieve most realistic simulation results.

GoldenBraid is a rapid, modular, and robust cloning system used to assemble and combine genetic elements. Dictyostelium amoebae represent an intriguing synthetic biological chassis with tractable applications in development, chemotaxis, bacteria-host interactions, and allorecognition. We present GoldenBraid as a synthetic biological framework for Dictyostelium, including a library of 250 DNA parts and assemblies and a proof-of-concept strain that illustrates cAMP-chemotaxis with four fluorescent reporters coded by one plasmid., (© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Improving the lateral resolution is a key focus of the research on optical measuring systems to expand the fields of application for optical metrology. By means of microspheres put on an object in a microscope, and therefore used as a near-field support, it has already been shown that a superresolution of structures below Abbe's diffraction limit is possible. The following investigations give more detailed theoretical and experimental insight into the physical mechanisms responsible for the transition of near-field information to the far field. In particular, the effects of microspheres as near-field support on the behavior of phase-evaluating interference microscopes close to the optical resolution limit are studied experimentally as well as with numerical simulations. Special attention is drawn to measured data taken with a Linnik microscope of high numerical aperture. Finally, the measurement results of grating structures with a period below Abbe's diffraction limit are presented.

Tailored 3D microparticles and nanostructures lead to increasing possibilities in semiconductor industry or biomedical applications. In an interdisciplinary study we investigate the parallel production of such particles by using nanoimprint lithography in combination with their characterization based on interference microscopy. In this Letter we report on a metrological inspection, which tends to a universal measurement solution comparing the sample optically to a master object produced in the same way as the sample.

This contribution introduces a novel image recording approach for phase retrieval in a RGB-interferometer setup with pulsed LED illumination and an oscillating reference mirror. The effective acquisition time of the interference images is below 100 μs with a repetition rate of 10 frames per second. The pulsed illumination is synchronized with the exposure gap of a Bayer-Pattern CMOS RGB camera to enable the recording of two π/2 phase shifted images with a short delay compared to the camera exposure time. The proposed quadrature method enables surface phase retrieval with a standard deviation of ≈ [3 nm, · · ·, 5 nm], depending on phase noise and actuator precision. The applicability of the reconstructed phase data to unambiguity range extension algorithms based on the exact fraction method is considered. Experimental results demonstrate the feasibility of the setup to measure the topography of samples in motion or oscillating by mechanical vibrations.

In this paper, we present a practical approach for phase analysis of sinusoidally phase shifted interference signals, which are generally used to detect optical path length changes in one arm of the interferometer based on an algorithm introduced by de Groot. We describe the original algorithm from our point of view and try to emphasize the limitations and some details that need to be known for practical implementation. We introduce methods for how to overcome these limitations, and in addition, we provide an extension of the algorithm to a temporal high-resolution mode, which provides a possibility to calculate a phase value for each sampled point of an interference signal and opens new applications for the existing measurement devices without any hardware changes. Simulated and experimental results verify our extensions.

This exploratory study employs discourse and narrative analysis to assess men's ( n = 45) responses to a writing assignment completed at the end of a solution-focused voluntary batterer intervention program. The study finds that the men primarily use the assignment to reassure themselves of their future success, defined through traditionally male paradigms. The narrative analysis then divides the letters according to type: Participants (22.7%) use a "transformative" discourse of behavior change and intimate partner violence (IPV)-sustaining discourse (18.2%), but the plurality (38.6%) use both simultaneously. The ideological conflict demonstrated in these responses highlights how IPV-sustaining discourse is embedded within broader sociocultural discursive structures.

Snow is a heterogeneous material with strain- and/or load-rate-dependent strength. In particular, a transition from ductile-to-brittle failure behavior with increasing load rate is observed. The rate-dependent behavior can partly be explained with the existence of a unique healing mechanism in snow that stems from its high homologous temperature (temperature close to melting point). As soon as broken elements in the ice matrix get in contact, they start sintering and the structure may regain strength. Moreover, the ice matrix is subjected to viscous deformation, inducing a relaxation of local load concentrations and, therefore, further counteracting the damage process. Ideal tools for studying the failure process of heterogeneous materials are the fiber-bundle models (FBMs), which allow investigating the effects of basic microstructural characteristics on the general macroscopic failure behavior. We present an FBM with two concurrent time-dependent healing mechanisms: sintering of broken fibers and relaxation of load inhomogeneities. Sintering compensates damage by creating additional intact, load-supporting fibers which lead to an increase of the bundle strength. However, the character of the failure is not changed by sintering alone. With combined sintering and load relaxation, load is distributed from old stronger fibers to new fibers that carry fewer load. So as we additionally incorporated load redistribution to the FBM, the failure occurred suddenly without decrease of the order parameter-describing the amount of damage in the bundle-and without divergence of the fiber failure rate. Moreover, the b value, i.e., the power-law exponent of frequency-magnitude statistics of fibers breaking in load redistribution steps, at failure converged to b≈2, a value higher than that of a classical FBM without healing (b=3/2). These results indicate that healing, as the combined effect of sintering and load relaxation, changes the type of the phase transition at failure. This change of the phase transition is important for quantifying or predicting the failure (e.g., by monitoring acoustic emissions) of snow or other materials for which healing plays an important role.

To get physical insight into the 3D transfer characteristics of interference microscopy at high numerical apertures we study reflecting rectangular grating structures. In general, the height obtained from phase information seems to be reduced, whereas height values resulting from coherence scanning sometimes seem to be systematically overestimated. Increasing the numerical aperture of an interference microscope broadens the spectra of the resulting interference signals, thus offering a broad variety of wavelength contributions to be analyzed. If phase analysis of a measured far-field interference wavefront is performed at very short wavelengths the periodical profiles obtained from coherence scanning and phase shifting analysis differ only by the measured amplitude. However, at longer wavelength there is a 180° phase shift of the measured profiles obtained from phase analysis compared to coherence peak analysis. Increasing the evaluation wavelength improves the lateral resolution since the long wavelength contributions are related to electromagnetic waves of high angles of incidence. This behavior is to the best of our knowledge not documented in literature so far. It was first observed experimentally and could be confirmed by simulation results obtained from either Kirchhoff diffraction theory or an extended Richards-Wolf model developed in our group. Compared to original input profiles used for the simulation the profiles obtained from phase evaluation correspond quite well at longer wavelength, whereas the results obtained from coherence peak analysis are typically inverted with respect to height.

The group refractive index is important in length calibration of Fourier domain interferometers by transparent transfer standards. We demonstrate accurate group refractive index quantification using a Fourier domain short coherence Sagnac interferometer. Because of a justified linear length calibration function, the calibration constants cancel out in the evaluation of the group refractive index, which is then obtained accurately from two uncalibrated lengths. Measurements of two standard thickness coverslips revealed group indices of 1.5426±0.0042 and 1.5434±0.0046, with accuracies quoted at the 95% confidence level. This agreed with the dispersion data of the coverslip manufacturer and therefore validates our method. Our method provides a sample specific and accurate group refractive index quantification using the same Fourier domain interferometer that is to be calibrated for the length. This reduces significantly the requirements of the calibration transfer standard.

Soils and other geologic porous media often display layering and associated textural contrasts that may alter unsaturated flow and transport pathways. Such natural interfaces are usually represented empirically in continuum flow models with limited mechanistic account of the effect of adjusted pathways across layers on colloid transport and on the nature of unsaturated flow. In this study we present the soil foam drainage equation (SFDE) as alternative framework to simulate unsaturated flow in layered porous media., Hypothesis: In contrast to standard continuum flow models, the SFDE explicitly accounts for capillary flow pathways and their adjustment across textural interfaces that in turn define flow geometry for colloidal transport not predicted by continuum models., Experiments: Pore scale water distribution in a layered sand sample was measured using X-ray tomography to quantify capillary flow pathways. Literature values of measured saturation and capillary pressure profiles in layered porous columns were used to evaluate solutions based on the SFDE framework and to deduce velocity profiles and their effects for colloid transport., Findings: The SFDE framework provides new insights into capillary architecture in unsaturated layered media and opens a new way for using pore scale information (from imaging) to provide the necessary SFDE parameters and potentially improve on the standard continuum representation of capillary flows in layered media., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Capability to simulate the coherence function is important when tuning an interference microscope in an effort to reduce sidelobes in interference signals. The coherence function cannot directly be derived from the light source spectrum since the microscope's effective spectrum is affected by e.g. spatial coherence effects. We show this by comparing the true system spectrum measured using a spectrometer against the effective system spectrum obtained by Fourier analysis of the interference data. The results show that a modulation function that describes the scattering-induced spatial coherence dampening in the system is needed to correct the observed difference between these two spectra. The validity of this modulation function is further verified by quantifying the arithmetic mean roughness of two specified roughness standards. By providing a spectral transfer function for scattering, our method can simulate a sample specific coherence function, and thus shows promise to increase the quality of interference microscope images.

We present a passive vibration compensation approach in scanning white-light interferometry (SWLI). A pointwise distance measuring interferometer (DMI) obtains fast temporal distance changes during the white-light depth-scan of an aerial-measuring Michelson white-light interferometer for topography measurement. Both interferometers share a part of the optical path so that the measurement spot of the DMI is within the field of view of SWLI. With the real positions of the interferometer with respect to the measuring object during the depth scan known from DMI measurements, we can compensate for the influence of unintentional distance changes caused by environmental vibrations or scanner nonlinearities. By reordering of the captured image frames and improved correlogram interpolation, we are able to reconstruct correct signals from completely distorted (and unusable) SWLI signals. Although the basic idea of the system already has been published, we improved the signal reconstruction technique so that the specimen's topography measurement can be obtained with the same accuracy as without any vibrations or scan distortions influence. In addition, we demonstrate the feasibility of the approach by different practical measurements with and without vibrations.

Besides the illumination wavelength also the numerical aperture (NA) of a microscope objective affects the fringe spacing in interference microscopy. Therefore, at high NA values an effective wavelength should be obtained by calibration. At step height structures both, the effective wavelength and the batwing effect strongly depend on the height-to-wavelength-ratio (HWR). Therefore, changes of the effective wavelength considering temporal and spatial coherence enable us to estimate the batwing effect in measurement results. For high NA systems and broadband illumination two different theoretical approaches for signal modeling are introduced to study the influence of the center wavelength, the temporal, and the spatial coherence of the illuminating light on measurement results of a rectangular grating. In both models diffraction is considered. While the first simulation model (Kirchhoff) is mostly analytical the second one (Richards-Wolf) is primarily numerical. Simulation results of both models show a good agreement with experimental measurement results.

A general theoretical framework for quantifying the stomatal clustering effects on leaf gaseous diffusive conductance was developed and tested. The theory accounts for stomatal spacing and interactions among 'gaseous concentration shells'. The theory was tested using the unique measurements of Dow et al. (2014) that have shown lower leaf diffusive conductance for a genotype of Arabidopsis thaliana with clustered stomata relative to uniformly distributed stomata of similar size and density. The model accounts for gaseous diffusion: through stomatal pores; via concentration shells forming at pore apertures that vary with stomata spacing and are thus altered by clustering; and across the adjacent air boundary layer. Analytical approximations were derived and validated using a numerical model for 3D diffusion equation. Stomata clustering increases the interactions among concentration shells resulting in larger diffusive resistance that may reduce fluxes by 5-15%. A similar reduction in conductance was found for clusters formed by networks of veins. The study resolves ambiguities found in the literature concerning stomata end-corrections and stomatal shape, and provides a new stomata density threshold for diffusive interactions of overlapping vapor shells. The predicted reduction in gaseous exchange due to clustering, suggests that guard cell function is impaired, limiting stomatal aperture opening., (© 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.)

The PI3K/Akt signaling pathway is a major driving force in a variety of cellular functions. Dysregulation of this pathway has been implicated in many human diseases including cancer. While the activity of the cytoplasmic PI3K/Akt pathway has been extensively studied, the functions of these molecules and their effector proteins within the nucleus are poorly understood. Harboring key cellular processes such as DNA replication and repair as well as nascent messenger RNA transcription, the nucleus provides a unique compartmental environment for protein-protein and protein-DNA/RNA interactions required for cell survival, growth, and proliferation. Here we summarize recent advances made toward elucidating the nuclear PI3K/Akt signaling cascade and its key components within the nucleus as they pertain to cell growth and tumorigenesis. This review covers the spatial and temporal localization of the major nuclear kinases having PI3K activities and the counteracting phosphatases as well as the role of nuclear PI3K/Akt signaling in mRNA processing and exportation, DNA replication and repair, ribosome biogenesis, cell survival, and tumorigenesis.

We present a fast approach to the continuous measurement of rotational symmetric optical surfaces. This approach is based on a line scanning interferometer with sinusoidal modulation of the optical path length. The specimen is positioned with respect to the sensor and both are moved during measurement by use of a five axes system comprising a high precision rotational table. The calibration of both the line sensor as well as the scanning and positioning system is discussed. As proof of principle of the measurement and stitching concept results of a scan of a rotational symmetric sinusoidal structure and a spherical lens with a moderate slope are shown.

The current study addresses the validation of the Checklist of Controlling Behaviors (CCB), an 84-item domestic violence assessment instrument that can be used to address multiple levels of violence and coercive control in violent relationships. Derived from clinical observation and current theories, the CCB makes use of intimate partner violence survivor reports to identify the intensity and frequency of relationship violence. The instrument is divided into 10 subscales including (1) physical abuse, (2) sexual abuse, (3) male privilege, (4) isolation, (5) minimizing and denying, (6) blaming, (7) intimidation, (8) threats, (9) emotional abuse, and (10) economic abuse. To assess validity and reliability of the CCB, 2,135 female volunteers taking refuge at a domestic violence shelter were administered the instrument. Results of principal component analysis of the individual subscales revealed 10 factors having goodness-of-fit values above the desired normative level of .90.

White-light interferometers are widely used for high-accuracy topography measurement in industrial and scientific applications. A common way to characterize a white-light interferometer is to assume small surface amplitudes resulting in linear transfer characteristics described by the instrument transfer function (ITF). However, the well-known batwing effect gives rise to systematic errors, causing extra nonlinearity to the ITF. In this paper a model to simulate an interference pattern in the image plane as it is obtained by a vertical scanning white-light interferometer is introduced in order to overcome the limitation of small surface amplitudes. Repeating the simulation procedure for different height positions of the object results in an image stack that can be analyzed by the same algorithms as real measurement data. The simulation results agree with experimental observations: the batwing effect occurs in certain situations and the correct amplitude of a rectangular grating structure can be obtained as long as the structure is optically resolved. Both simulation, as well as experimental results, provide transfer characteristics of broader bandwidth than predicted by theoretical approaches based on linear system behavior.

In this Letter, the transfer characteristics of rectangular periodic phase objects are studied. It turns out that there are significant differences compared to amplitude objects. The imaging of an amplitude object can be understood as a linear process, whereas phase objects behave nonlinearly. It is shown that under certain conditions the correct shape of a rectangular phase grating can be obtained by an interference microscope as long as the first order diffraction component passes the optical imaging system. This result is in a good agreement with experimental observations and computer simulation results.

Group work with men who batter has traditionally consisted predominantly of psychoeducational programs that ignore concepts such as self-determination, goal setting, and positive engagement with men. More recently, this paradigm has begun to shift to include cognitive approaches and the utilization of strength-based strategies. The present sample included 42 men who were part of an ongoing batterer intervention program. Information for this study included assessment of each man's strengths, their goals, and their perceptions of the changes they felt they had already made prior to attending group treatment. Through a grounded theory analysis, a model was developed that highlights the pretherapeutic change processes that men experience due to their being arrested, charged with a misdemeanour domestic charge, and subsequently convicted of domestic violence. Particularly highlighted are changes in the ways that men view and navigate three distinct areas of their lives: their external world (including work and education); their internal world (perception of self, values, and skills); and their interpersonal relationships with their partner and children.

Exploring the relationship between parenting and women's use of violence the current study surveyed 106 mothers arrested for intimate partner violence (IPV) related crimes on parenting styles and attitudes toward when using violence against their partner is justified. Findings indicate parenting styles indicative of low belief in using physical discipline with their child/ children and an internal parental locus of control. However, a moderate to weak relationship between parenting styles and justification for using violence against a partner was also found. Although some support for the spillover theory is noted, results are far from conclusive.

Although white-light interferometers have become well-established tools for measuring smooth, rough, and microstructured surfaces, there are some limitations in certain applications, e.g., if tilted surface areas or small radii of curvature are to be measured. Since the correction of chromatic aberrations is not perfect over the total field of view or the total pupil plane, dispersion differences occur for different ray paths of the microscopic imaging system. The influence of these effects is discussed on the basis of the most commonly used Mirau interferometer, and the resulting systematic measuring errors are explained.

High and nearly constant evaporation rates from initially saturated porous media are sustained by capillary-driven flow from receding drying front below the evaporating surface. The spatial extent of continuous liquid pathways in homogeneous porous medium is defined by its hydraulically connected pore size distribution. We consider here evaporative losses from porous media consisting of two hydraulically coupled dissimilar domains each with own pore and particle size distributions separated by sharp vertical textural contrast. Evaporation experiments from texturally dissimilar media were monitored using neutron transmission and dye pattern imaging to quantify water distribution and drying front dynamics. Drying front invades exclusively coarse-textured domain while fine-textured domain remains saturated and its surface continuously coupled with the atmosphere. Results show that evaporation from fine-textured surface was supplied by liquid flow from adjacent coarse domain driven by capillary pressure differences between the porous media. A first characteristic length defining limiting drying front depth during which fine sand region remains saturated is deduced from difference in air-entry pressures of the two porous media. A second characteristic length defining the end of high evaporation rate includes the extent of continuous liquid films pinned in the crevices of the pore space and between particle contacts in the fine medium. We established numerically the lateral extent of evaporation-induced hydraulic coupling that is limited by viscous losses and gravity. For certain combinations of soil types the lateral extent of hydraulic coupling may exceed distances of 10 m. Results suggest that evaporative water losses from heterogeneous and coupled system are larger compared with uncoupled or homogenized equivalent systems.

Discrepancies exist in research examining substance problems within groups of women arrested for intimate partner violence (IPV). In some studies women IPV arrestees have been found to be at high risk for substance-related problems, whereas in others they are found to be at low risk for substance-related problems. The current study explores these discrepancies then compares a sample of women court ordered to a domestic violence diversion program (n = 78) to a matched sample of men (n = 78) in the same program using police report information, self-report measures, the Substance Abuse Subtle Screening Inventory-3, and the Millon Clinical Multiaxial Inventory-III alcohol and drug subscales. Women IPV arrestees had a low occurrence of substance use during the arresting incident, a low incidence of substance-related diagnoses, and fewer substance-related problems than did men IPV arrestees. However, women demonstrated personality structures susceptible to nondiagnosable, hazardous drinking patterns.

Evaporation from porous media involves mass and energy transport including phase change, vapor diffusion, and liquid flow, resulting in complex displacement patterns affecting drying rates. Force balance considering media properties yields characteristic lengths affecting the transition in the evaporation rate from a liquid-flow-based first stage limited only by vapor exchange with air to a second stage controlled by vapor diffusion through the medium. The characteristic lengths determine the extent of the hydraulically connected region between the receding drying front and evaporating surface (film region) and the onset of flow rate limitations through this film region. Water is displaced from large pores at the receding drying front to supply evaporation from hydraulically connected finer pores at the surface. Liquid flow is driven by a capillary pressure gradient spanned by the width of the pore size distribution and is sustained as long as the capillary gradient remains larger than gravitational forces and viscous dissipation. The maximum extent of the film region sustaining liquid flow is determined by a characteristic length L&#95;{C} combining the gravity characteristic length L&#95;{G} and viscous dissipation characteristic length L&#95;{V} . We used two sands with particle sizes 0.1-0.5 mm ("fine") and 0.3-0.9 mm ("coarse") to measure the evaporation from columns of different lengths under various atmospheric evaporative demands. The value of L&#95;{G} determined from capillary pressure-saturation relationships was 90 mm for the coarse sand and 140 mm for the fine sand. A significant decrease in drying rate occurred when the drying front reached the predicted L&#95;{G} value (viscous dissipation was negligibly small in sand and L&#95;{C} approximately L&#95;{G} ). The approach enables a prediction of the duration of first-stage evaporation with the highest water losses from soil to the atmosphere.

In an attempt to better understand the relationship between male use of the sex industry (i.e., pornography and strip clubs) and interpersonal violence (IPV), 2,135 female residents of an IPV shelter were surveyed regarding their batterer's use of both the sex industry and controlling behaviors in their relationship. Findings indicate that male domestic violence offenders who utilize the sex industry use more controlling behaviors than male domestic violence offenders who do not. Implications for policy, practice, and research are discussed.

The current descriptive study seeks to broaden empirical understanding about women charged with intimate partner violence by comparing a sample of women in a domestic violence diversion program (N = 78) to a matched sample of men (N = 78) in the same program on measurements of general risk factors, attitudes toward using violence, and readiness to change. Findings indicate that the women charged with intimate partner violence are a heterogeneous group, endorse risk factors that show an elevated likelihood they will continue to use violence, demonstrate a high level of tolerance for using violence in their relationship, and may be highly amenable to treatment opportunities. Implications for practice and future research are addressed.

White-light interferometry has turned into a standard tool in the field of high-accuracy topography measurements. Nevertheless, surfaces with relatively large local surface tilts or height steps often give rise to systematic measuring errors. The reasons are diffraction and dispersion effects, which cause deviations between height values obtained from the envelope maximum of the white-light interference signal and those obtained from the signal's phase. In certain cases this may result in ghost steps appearing in the measured topography. To identify and eliminate these ghost steps we use a second LED emitting light at a different mean wavelength. This now allows the measurement of curved or structured specular surfaces with high resolution, which up to now was restricted by the mentioned effects.

Domestic violence is not as simple as one partner physically harming another. Instead, it consists of a complex range of controlling behaviors including physical, emotional, sexual, and economic maltreatment as well as isolation, male privilege, blaming, intimidation, threats, and minimizing/denying behaviors. In addition to the controlling behaviors reported by women seeking shelter from violent relationships, a growing body of research indicates some individuals who abuse their intimate partner also abuse their pets. This study explores these connections using reports of 1,283 female pet owners seeking refuge from their male batterer in a domestic violence shelter. Findings indicate that batterers who also abuse their pet (a) use more forms of violence and (b) demonstrate greater use of controlling behaviors than batterers who do not abuse their pets. Likewise, positive correlations are found between specific controlling behaviors and cruelty to pets. Implications for practice and future research are discussed.

Fiber-optical sensors have some crucial advantages compared with rigid optical systems. They allow miniaturization and flexibility of system setups. Nevertheless, optical principles such as low-coherence interferometry can be realized by use of fiber optics. We developed and realized an approach for a fiber-optical sensor, which is based on the analysis of spatially modulated low-coherence interferograms. The system presented consists of three units, a miniaturized sensing probe, a broadband fiber-coupled light source, and an adapted Michelson interferometer, which is used as an optical receiver. Furthermore, the signal processing procedure, which was developed for the interferogram analysis in order to achieve nanometer measurement accuracy, is discussed. A system prototype has been validated thoroughly in different experiments. The results approve the accuracy of the sensor.

Aims: In this article the author--board-member of the European Network of (ex-) Users and Survivors of Psychiatry (ENUSP)--explains, what is needed to guarantee a minimal level of involvement of users and survivors of psychiatry into issues relating to psychiatric drugs., Methods: He reflects demands of their organisations, and compares these demands with the current involvement level. Considering the concrete circumstances in psychiatry, he reflects the risks and dangers of the administered drugs--especially the widely used neuroleptics--for example enhanced breast cancer risk in women, suicidal effects, receptor changes, tardive dyskinesia and other toxic reactions., Results: Considering the unique situation of psychiatric patients to receive treatment in general without informed consent and in a violent way or through bullying and threat, he argues for to provide their involvement in all aspects of psychiatric drug issues--especially registration and monitoring, for example by their involvement in creating and running a suicide register. And he argues for involvement in ethics committees, licensing processes and providing guidelines and decision making about effectiveness and reimbursement of costs., Conclusions: As first steps towards these aims he proposes independent and user-controlled research, independent and user-controlled education and independent and user-controlled information about the effects of psychiatric drugs.

Here polychromatic speckle patterns generated either by a polychromatic light source that emits at discrete frequencies or by a light source showing a continuous narrow-band spectral distribution are studied. The purpose here is the application of polychromatic speckle-pattern analysis to an in-process surface roughness characterization. To compare the coherence properties of the different polychromatic light sources, first a modified definition of the coherence length is introduced. Furthermore, the relevant optical phenomena, namely, the speckle elongation caused by the angular dispersion and the roughness-dependent speckle decorrelation, are summarized. It is shown that light sources with a continuous spectral distribution have essential advantages in comparison with discrete wavelength sources. The theoretical results are confirmed by experimental investigations based on a digital algorithm for the evaluation of CCD images of polychromatic speckle patterns, which are recorded in the Fourier plane of a Fourier-transforming lens.