Search

The escalating threat of emerging diseases, often stemming from contaminants and lethal pathogens, has precipitated a heightened demand for sophisticated diagnostic tools. Within this landscape, the functional nucleic acid (FNA) biosensor, harnessing the power of single-stranded DNA (ssDNA), has emerged as a preeminent choice for target analyte detection. However, the dependence on ssDNA has raised difficulties in realizing it in biological samples. Therefore, the production of high-quality ssDNA from biological samples is critical. This review aims to discuss strategies for generating ssDNA from biological samples for integration into biosensors. Several innovative strategies for ssDNA generation have been deployed, encompassing techniques, such as asymmetric PCR, Exonuclease-PCR, isothermal amplification, biotin-streptavidin PCR, transcription-reverse transcription, ssDNA overhang generation, and urea denaturation PAGE. These approaches have been seamlessly integrated with biosensors for biological sample analysis, ushering in a new era of disease detection and monitoring. This amalgamation of ssDNA generation techniques with biosensing applications holds significant promise, not only in improving the speed and accuracy of diagnostic processes but also in fortifying the global response to deadly diseases, thereby underlining the pivotal role of cutting-edge biotechnology in public health and disease prevention., (© 2024. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.)

Cargo molecule-encapsulated DNA capsules synthesized with a solid sacrificial template have elicited significant interest in the last decade and have been used for active materials in applications ranging from biosensors to drug delivery. However, the correlation between template properties and the subsequent assembly and triggered release behavior of the resultant carriers remain uninvestigated. In this study, ethylene glycol (EG) was added during the CaCO 3 precipitation synthesis to yield particles of various sizes and surface properties, and the adenosine triphosphate (ATP)-responsive release characteristics of the fabricated DNA capsules affected by these particle properties were investigated. The geometry, crystallization, and surface morphology of the CaCO 3 particles co-precipitated at various EG concentrations were characterized. We discuss the integrity of cross-linking hybridization, fluorescent molecule internalization, degree of leakage, and release efficiency of the resulting DNA capsules and their relevance brought by particle properties. To achieve efficient encapsulation and cargo release, the surface roughness of the CaCO 3 particles was explored and was deemed a key determinant of the compactness of the DNA shell after template removal. This effect was particularly strong in CaCO 3 particles in connection with high EG concentrations. The DNA capsules fabricated using 83% EG exhibited low leakage, high loading, and moderate release efficiencies as well as a greater apparent association constant with ATP due to their small particle size and the high-integrity DNA shells.

Microwave photonics has adopted a number of important concepts and technologies over the recent pasts, including photonic integration, versatile programmability, and techniques for enhancing key radio frequency performance metrics such as the noise figure and the dynamic range. However, to date, these aspects have not been achieved simultaneously in a single circuit. Here, we report a multi-functional photonic integrated circuit that enables programmable filtering functions with record-high performance. We demonstrate reconfigurable filter functions with record-low noise figure and a RF notch filter with ultra-high dynamic range. We achieve this unique feature using versatile complex spectrum tailoring enabled by an all integrated modulation transformer and a double injection ring resonator as a multi-function optical filtering component. Our work breaks the conventional and fragmented approach of integration, functionality and performance that currently prevents the adoption of integrated MWP systems in real applications., (© 2022. The Author(s).)

Coherent optomechanical interaction known as stimulated Brillouin scattering (SBS) can enable ultrahigh resolution signal processing and narrow-linewidth lasers. SBS has recently been studied extensively in integrated waveguides; however, many implementations rely on complicated fabrication schemes. The absence of SBS in standard and mature fabrication platforms prevents its large-scale circuit integration. Notably, SBS in the emerging silicon nitride (Si 3 N 4 ) photonic integration platform is currently out of reach because of the lack of acoustic guidance. Here, we demonstrate advanced control of backward SBS in multilayer Si 3 N 4 waveguides. By optimizing the separation between two Si 3 N 4 layers, we unlock acoustic waveguiding in this platform, potentially leading up to 15× higher Brillouin gain coefficient than previously possible in Si 3 N 4 waveguides. We use the enhanced SBS gain to demonstrate a high-rejection microwave photonic notch filter. This demonstration opens a path to achieving Brillouin-based photonic circuits in a standard, low-loss Si 3 N 4 platform.

The excessive amount of global plastic produced over the past century, together with poor waste management, has raised concerns about environmental sustainability. Plastic recycling has become a practical approach for diminishing plastic waste and maintaining sustainability among plastic waste management methods. Chemical and mechanical recycling are the typical approaches to recycling plastic waste, with a simple process, low cost, environmentally friendly process, and potential profitability. Several plastic materials, such as polypropylene, polystyrene, polyvinyl chloride, high-density polyethylene, low-density polyethylene, and polyurethanes, can be recycled with chemical and mechanical recycling approaches. Nevertheless, due to plastic waste's varying physical and chemical properties, plastic waste separation becomes a challenge. Hence, a reliable and effective plastic waste separation technology is critical for increasing plastic waste's value and recycling rate. Integrating recycling and plastic waste separation technologies would be an efficient method for reducing the accumulation of environmental contaminants produced by plastic waste, especially in industrial uses. This review addresses recent advances in plastic waste recycling technology, mainly with chemical recycling. The article also discusses the current recycling technology for various plastic materials.

There are a host of applications in communications, sensing, and science, in which analogue signal transmission is preferred over today's dominant digital transmission. In some of these applications, the advantage is in lower cost, while in others, it lies in superior performance. However, especially for longer analogue photonics links (up to 10 s of km), the performance is strongly limited by the impairments arising from using standard single-mode fibres (SSMF). Firstly, the three key metrics of analogue links (loss, noise figure, and dynamic range) tend to improve with received power, but this is limited by stimulated Brillouin scattering in SSMF. Further degradation is due to the chromatic dispersion of SSMF, which induces radio-frequency (RF) signal fading, increases even-order distortions, and causes phase-to-intensity-noise conversion. Further distortions still, are caused by the Kerr nonlinearity of SSMF. We propose to address all of these shortcomings by replacing SSMFs with hollow-core optical fibres, which have simultaneously six times lower chromatic dispersion and several orders of magnitude lower nonlinearity (Brillouin, Kerr). We demonstrate the advantages in this application using a 7.7 km long hollow-core fibre sample, significantly surpassing the performance of an SSMF link in virtually every metric, including 15 dB higher link gain and 6 dB lower noise figure., (© 2022. The Author(s).)

Integrated mode-locked lasers are useful tools in microwave photonic applications as a local oscillator. In particular, hybrid integrated lasers could easily be integrated with passive processing circuits. In this Letter, we report on the self-mode-locking of a hybrid integrated laser comprising two indium phosphide gain sections and a silicon nitride feedback circuit that filters light using two ring resonators. The hybrid laser is shown to mode-lock and to have a mostly frequency-modulated field in the cavity using a stepped-heterodyne optical complex spectrum analysis. A mostly frequency modulated field output is good for high powers per line due to a more continuous emission, compared with mode-locked lasers using a saturable absorber; additionally, the filter limits the bandwidth of the comb, condensing the power to the fewer comb lines.

We demonstrate for the first time, to the best of our knowledge, an on-chip microwave photonic (MWP) notch filter with high stopband rejection and integrated optical carrier suppression in a phase modulator-based system. The notch filter was achieved through phase modulation to intensity modulation (PM-to-IM) transformation and dual-sideband-processing using a network of three ring resonators (RRs) in a low-loss silicon nitride ( S i 3 N 4 ) platform. We show simultaneous PM-to-IM conversion and optical carrier processing for enhancing the filter performance using a single RR. We achieve filtering with a high stopband rejection of >55 d B , an optical carrier suppression up to 3 dB, a radio frequency link gain of 3 dB, a noise figure of 31 dB, and a spurious-free dynamic range of 100 d B ⋅ H z 2/3 . These experiments point to the importance of vectorial spectral shaping of an MWP spectrum for advanced functionalities.

An on-chip linearization method for phase modulated microwave photonic link based on integrated ring resonators is proposed. By properly tailoring the phase and amplitude of optical carrier band and second-order sidebands, the third-order intermodulation distortion (IMD3) components can be suppressed. Theoretical analysis are taken and a proof-of-concept experiment is carried out. Experimental results demonstrate that IMD3 is suppressed by 21.7 dB. When the noise of the link is properly optimized, an SFDR of 112.7 dB·Hz 2/3 can be achieved. This opens the possibility of integrating linearization into a functional photonic integrated circuit.

In this Letter, we demonstrate a ${{\rm Si}_3}{{\rm N}_4}$Si 3 N 4 -chip-based photonic approach to generate versatile radio frequency (RF) waveforms with a large tuning range of repetition rates. The amplitude and phase of the RF-phase-modulated signal are spectrally manipulated to synthesize Fourier coefficients of the desired RF waveforms by controlling the resonance conditions and frequencies of ${{\rm Si}_3}{{\rm N}_4}$Si 3 N 4 optical ring resonators. Full-duty-cycle triangular, square, and sawtooth waveforms with widely tunable repetition rates from 1 to 13 GHz were experimentally generated.

Microwave photonic bandpass filters (MPBPFs) are important building blocks in radio-frequency (RF) signal processing systems. However, most of the reported MPBPFs fail to satisfy the stringent real-world performance metrics, particularly low RF insertion loss. In this paper we report a novel MPBPF scheme using two cascaded integrated silicon nitride (Si 3 N 4 ) ring resonators, achieving a high link gain in the RF filter passband. In this scheme, one ring operates at an optimal over-coupling condition to enable a strong RF passband whilst an auxiliary ring is used to increase the detected RF signal power via tuning the optical carrier-to-sideband ratio. The unique combination of these two techniques enables compact size as well as high RF performance. Compared to previously reported ring-based MPBPFs, this work achieves a record-high RF gain of 1.8 dB in the passband, with a high spectral resolution of 260 MHz. Furthermore, a multi-band MPBPF with optimized RF gain, tunable central frequencies, and frequency spacing tunability is realized using additional ring resonators, highlighting the scalability and flexibility of this chip-based MPBPF scheme.

All programmable microwave photonic filters to date have been limited by the trade-off between the resolution and the operation bandwidth to construct arbitrary filter shapes. Here, we propose a new approach to synthesize a radio-frequency photonic filter with an arbitrary response and reconfigurable resolution through phase-only tailoring, which is implemented in a low-loss photonic chip. Based on an algorithm, incorporating the target transfer function of the filter optimum resolution can be intelligently chosen by tuning the coupling coefficients and the round-trip phase of cascaded ring resonators. We achieved filtering with tunable resolution from 300 MHz to 25 GHz along with various filtering shapes and multiple passbands.

In this Letter, for the first time, to the best of our knowledge, we harness on-chip Brillouin scattering for narrowband amplification and spectral purification of frequency comb lines for coherent optical communications. A parametrically generated optical frequency comb with a low carrier-to-noise power ratio was filtered through narrowband Brillouin amplification utilizing the same comb as the optical pump. This was achieved on a photonic chip to enable successful transmission of an advanced modulation format signal: 64-level quadrature amplitude modulation. 96 Gb/s data were modulated on two polarizations on multiple comb lines across 1532.9-1557.5 nm, demonstrating the scalability of this concept for operation in wavelength division multiplexing applications. The small form factor of the photonic chip reduces the polarization drifts when compared to optical fibers and paves the way for photonic integration.

We report a silicon nitride chip-based radio-frequency photonic notch filter with an unprecedented performance including an RF gain of 8 dB, a record-low noise figure of 15.6 dB, and a spurious-free dynamic range of 116  dB·Hz 2/3 , with a stop band rejection of 50 dB. This level of performance is achieved by using on-chip resonators' unique phase responses, and thorough optimizations of the photonic link. These record results will potentially stimulate future implementations of integrated microwave photonic subsystems for real-world applications.

Optical frequency comb lines with poor carrier to noise ratio (CNR) are significantly improved by Brillouin amplification using its extreme narrow bandwidth gain to suppress out of band noise, enabling higher quality signal modulation. Its application to spectral lines of narrow 10 GHz pitch and poor CNR is shown to suppress the otherwise strong phase distortion caused by poor CNR after encoding with 96 Gb/s DP-64-QAM signals and restore the bit error rate (BER) to below the limit for standard forward error correction (FEC). This is also achieved with the required frequency shifted optical pump for amplification obtained by seeding it from the comb itself, sparing the need for lasers and frequency locking. Simultaneous CNR improvement for 38 comb lines is also achieved with BER restored to below the FEC limit, enabled by a multi-line pump that is pre-dispersed to suppress its spectral distortion from the Kerr effect in the gain medium. Carrier performance at minimum BER shows minimal noise impact from the Brillouin amplifier itself. The results highlight the unique advantage of Brillouin gain for phase sensitive communications in transforming otherwise noisy spectral lines into useful high quality signal carriers.

Integrated microwave photonics has strongly emerged as a next-generation technology to address limitations of conventional RF electronics for wireless communications. High-resolution RF signal processing still remains a challenge due to limitations in technology that offer sub-GHz spectral resolution, in particular at high carrier frequencies. In this paper, we present an on-chip high-resolution RF signal processor, capable of providing high-suppression spectral filtering, large phase shifts and ns-scale time delays. This was achieved through tailoring of the Brillouin gain profiles using Stokes and anti-Stokes resonances combined with RF interferometry on a low-loss photonic chip with strong opto-acoustic interactions. Using an optical power of <40 mW, reconfigurable filters with a bandwidth of ~20 MHz and an extinction ratio in excess of 30 dB are synthesized. Through the concept of vector addition of RF signals we demonstrate, almost an order of magnitude amplification in the phase and delay compared to devices purely based upon the slow-light effect of Brillouin scattering. This concept allows for versatile and power-efficient manipulation of the amplitude and phase of RF signals on a photonic chip for applications in wireless communications including software defined radios and beam forming.

We demonstrate optical frequency conversion between telecom wavelengths using four-wave mixing Bragg scattering powered by two pump pulses polarized on orthogonal axes of a silicon waveguide. This allows conversion in a single frequency direction while, with co-polarized pumps, the signal is redshifted or blueshifted with similar efficiency. Our approach exploits the birefringence of the waveguide and its effect on the phase matching of the four-wave mixing process. The blue or red direction can be selected by the input polarization of the signal, and 20 dB extinction ratios are observed with the unintended direction. This technique will allow efficient and controlled conversion between specified wavelength channels in integrated photonic devices.

We report a chip-based true-time-delay unit based on stimulated Brillouin scattering that uses an on-off Brillouin gain of 52 dB to enable 4 ns delay over a bandwidth of 100 MHz and a phase shift of ∼200°. To verify these operations, we use a two-tap microwave filter configuration and observed changes in the free spectral range of the filter and shift in the spectrum of the filter. The realization of these functionalities on chip-scale devices is critical for phased-array antennas, multibeam satellites, delay lines, arbitrary waveform generation, and reconfigurable microwave photonic filters.

A novel technique to create a lossless and tunable RF photonic bandstop filter with an ultra-high suppression is demonstrated using the combination of an overcoupled optical ring resonator and tailored stimulated Brillouin scattering gain. The filter bandwidth narrowing is counterintuitively synthesized from two broad optical resonance responses. Through a precise amplitude and phase tailoring in the optical domain, the RF filter achieves a minimum insertion loss (<0  dB), a high isolation (>50  dB), and a tunable 3 dB bandwidth (60-220 MHz) simultaneously with wide frequency tunability (1-11 GHz). This ultra-low loss RF filter paves the way toward broadband advanced spectrum management with low loss, high selectivity, and improved signal-to-noise ratio.

In the microwave domain, signal interference bandstop filters with high extinction and wide stopbands are achieved through destructive interference of two signals. Implementation of this filtering concept using RF photonics will lead to unique filters with high performance, enhanced tuning range and reconfigurability. Here we demonstrate an RF photonic signal interference filter, achieved through the combination of precise synthesis of stimulated Brillouin scattering (SBS) loss with advanced phase and amplitude tailoring of RF modulation sidebands. We achieve a square-shaped, 20-dB extinction RF photonic filter over a tunable bandwidth of up to 1 GHz with a central frequency tuning range of 16 GHz using a low SBS loss of ~3 dB. Wideband destructive interference in this novel filter leads to the decoupling of the filter suppression from its bandwidth and shape factor. This allows the creation of a filter with all-optimized qualities.

We experimentally investigate four-wave mixing and nonlinear losses in low-loss 3 μm thick silicon strip waveguides. Adiabatic bends allow for single-mode operation in an ultra-compact 35 cm long spiral. The waveguides exhibited reduced nonlinear losses due to the large mode area of 2.75  μm 2 . The nonlinear coefficient γ was measured as 5.5  m -1   W -1 . These features, along with the low propagation loss of 0.17 dB/cm, enable large idler power generation at 1550 nm.

An unprecedented Brillouin gain of 44 dB in a photonic chip enables the realization of broadly tunable and reconfigurable integrated microwave photonic filters. More than a decade bandwidth reconfigurability from 30 up to 440 MHz, with a passband ripple <1.9  dB is achieved by tailoring the Brillouin pump. The filter central frequency is continuously tuned up to 30 GHz with no degradation of the passband response, which is a major improvement over electronic filters. Furthermore, we demonstrate pump tailoring to realize multiple bandpass filters with different bandwidths and central frequencies, paving the way for multiple on-chip microwave filters and channelizers.

Microwave photonic cancellation notch filters have been shown capable of achieving ultra-high suppressions independently from the strength of optical resonant filter they use, making them an attractive candidate for on-chip signal processing. Their operation, based on destructive interference in the electrical domain, requires precise control of the phase and amplitude of the optical modulation sidebands. To date, this was attainable only through the use of dual-parallel Mach-Zehnder modulators which suffer from bias drifts that prevent stable filter operation. Here we propose a new cancellation filter topology with ease of control and enhanced stability using a bias-free phase modulator and a reconfigurable optical processor as the modulation sidebands spectral shaper. We experimentally verify the long term stability of the novel filter topology through continuous real-time monitoring of the filter peak suppression over 24 hours.

We demonstrate the first, to the best of our knowledge, functional signal processing device based on stimulated Brillouin scattering in a silicon nanowire. We use only 1 dB of on-chip stimulated Brillouin scattering gain to create an RF photonic notch filter with 48 dB of suppression, 98 MHz linewidth, and 6 GHz frequency tuning. This device has potential applications in on-chip microwave signal processing and establishes the foundation for the first CMOS-compatible high-performance RF photonic filter.

We present the first microwave photonic phase shifter using stimulated Brillouin scattering (SBS) on-chip. The unique ability of SBS to generate both narrowband gain and loss resonances allows us to achieve low ±1.5 dB amplitude fluctuations, which is a record for integrated devices, along with 240° continuously tunable phase shift. Contrary to previous SBS-based approaches, the phase shift tuning mechanism relies on tuning the power, not the frequency, of two SBS pumps, making it more suited to on-chip implementations. We finally demonstrate that SBS pump depletion leads to amplitude response fluctuations, as well as increasing the insertion loss of the phase shifter. Advantageously, shorter integrated platforms possess higher pump depletion thresholds compared to long fibers, thus offering greater potential for reducing the insertion loss.

We report a novel class microwave photonic (MWP) notch filter with a very narrow isolation bandwidth (10 MHz), an ultrahigh stopband rejection (>60 dB), a wide frequency tuning (1-30 GHz), and flexible bandwidth reconfigurability (10-65 MHz). This performance is enabled by a new concept of sideband amplitude and phase controls using an electro-optic modulator and an optical filter. This concept enables energy efficient operation in active MWP notch filters, and opens up a pathway toward enabling low-power nanophotonic devices as high-performance RF filters.

We report a simple technique in microwave photonic (MWP) signal processing that allows the use of an optical filter with a shallow notch to exhibit a microwave notch filter with anomalously high rejection level. We implement this technique using a low-loss, tunable Si₃N₄ optical ring resonator as the optical filter, and achieved an MWP notch filter with an ultra-high peak rejection > 60 dB, a tunable high resolution bandwidth of 247-840 MHz, and notch frequency tuning of 2-8 GHz. To our knowledge, this is a record combined peak rejection and resolution for an integrated MWP filter.

We present an overview of several microwave photonic processing functionalities based on combinations of Mach-Zehnder and ring resonator filters using the high index contrast silicon nitride (TriPleX™) waveguide technology. All functionalities are built using the same basic building blocks, namely straight waveguides, phase tuning elements and directional couplers. We recall previously shown measurements on high spurious free dynamic range microwave photonic (MWP) link, ultra-wideband pulse generation, instantaneous frequency measurements, Hilbert transformers, microwave polarization networks and demonstrate new measurements and functionalities on a 16 channel optical beamforming network and modulation format transformer as well as an outlook on future microwave photonic platform integration, which will lead to a significantly reduced footprint and thereby enables the path to commercially viable MWP systems.

We report a photonic-chip-based scheme for all-optical ultra-wideband (UWB) pulse generation using a novel all-optical differentiator that exploits cross-phase modulation and birefringence in an As₂S₃ chalcogenide rib waveguide. Polarity-switchable UWB monocycles and doublets were simultaneously obtained with single optical carrier operation. Moreover, transmission over 40-km fiber of the generated UWB doublets is demonstrated with good dispersion tolerance. These results indicate that the proposed approach has potential applications in multi-shape, multi-modulation and long-distance UWB-over-fiber communication systems.

In this paper we describe the system integration and the experimental demonstration of a photonically beamformed four-element receiving array antenna for radio astronomy applications. To our knowledge, the work described here is the first demonstration of the squint-free, continuously tunable beamsteering capability offered by an integrated photonic beamformer based on optical ring resonator true-time-delay units, with measured radiation patterns. The integrated beamformer is realized in a low loss, complementary metal-oxide-semiconductor (CMOS) compatible optical waveguide technology. The measurements show a wideband, continuous beamsteering operation over a steering angle of 23.5 degrees and an instantaneous bandwidth of 500 MHz limited only by the measurement setup., (© 2012 Optical Society of America)

We report and experimentally demonstrate the generation of impulse radio ultrawideband (UWB) pulses using a photonic chip frequency discriminator. The discriminator consists of three add-drop optical ring resonators (ORRs) which are fully programmable using thermo-optical tuning. This discriminator chip in combination with a phase modulator forms a temporal differentiator where phase modulation is converted to intensity modulation (PM-IM conversion). By means of tailoring the discriminator response using either the individual or the cascade of drop and through responses of the ORRs, first-order or second-order temporal differentiations are obtained. Using this principle, the generation of UWB monocycle, doublet and modified doublet pulses are demonstrated. The use of this CMOS-compatible discriminator is promising for the realization of a compact and low cost UWB transmitter.

We report the design and characterization of Si₃N₄/SiO₂ optical waveguides which are specifically developed for optical delay lines in microwave photonics (MWP) signal processing applications. The waveguide structure consists of a stack of two Si₃N₄ stripes and SiO₂ as an intermediate layer. Characterization of the waveguide propagation loss was performed in race track-shaped optical ring resonators (ORRs) with a free-spectral range of 20 GHz and a bending radius varied from 50 μm to 125 μm. A waveguide propagation loss as low as 0.095 dB/cm was measured in the ORRs with bend radii ≥ 70 μm. Using the waveguide technology two types of RF-modulated optical sideband filters with high sideband suppression and small transition band consisting of an Mach-Zehnder interferometer and ORRs are also demonstrated. These results demonstrate the potential of the waveguide technology to be applied to construct compact on-chip MWP signal processors.

We report, for the first time, an integrated photonic signal processor consisting of a reconfigurable optical delay line (ODL) with a separate carrier tuning (SCT) unit and an optical sideband filter on a single CMOS compatible photonic chip. The processing functionalities are carried out with optical ring resonators as building blocks. We show that the integrated approach together with the use of SCT technique allows the implementation of a wideband, fully-tunable ODL with reduced complexity. To highlight the functionalities of the processor, we demonstrate a reconfigurable microwave photonic filter where the ODL has been configured in a bandwidth over 1 GHz., (© 2011 Optical Society of America)

We report a high performance phase modulation direct detection microwave photonic link employing a photonic chip as a frequency discriminator. The photonic chip consists of five optical ring resonators (ORRs) which are fully programmable using thermo-optical tuning. In this discriminator a drop-port response of an ORR is cascaded with a through response of another ORR to yield a linear phase modulation (PM) to intensity modulation (IM) conversion. The balanced photonic link employing the PM to IM conversion exhibits high second-order and third-order input intercept points of + 46 dBm and + 36 dBm, respectively, which are simultaneously achieved at one bias point.