8 results on '"Mesquita Filho, Paulo M."'
Search Results
2. Reply: Intracranial aneurysm diameter and risk of rupture.
- Author
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Lepski G, Lobão CAF, Taylor S, Mesquita Filho PM, and Tatagiba M
- Subjects
- Humans, Retrospective Studies, Aneurysm, Ruptured, Intracranial Aneurysm
- Published
- 2019
- Full Text
- View/download PDF
3. Bleeding risk of small intracranial aneurysms in a population treated in a reference center.
- Author
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Lepski G, Lobão CAF, Taylor S, Mesquita Filho PM, and Tatagiba M
- Subjects
- Adult, Aged, Aneurysm, Ruptured diagnostic imaging, Aneurysm, Ruptured pathology, Cerebral Angiography, Female, Humans, Hypertension complications, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm pathology, Intracranial Hemorrhages diagnostic imaging, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neck pathology, ROC Curve, Reference Values, Retrospective Studies, Risk Assessment methods, Risk Factors, Time Factors, Aneurysm, Ruptured complications, Intracranial Aneurysm complications, Intracranial Hemorrhages etiology
- Abstract
Objective: Large multicenter studies have shown that small intracranial aneurysms are associated with a minimal risk of bleeding. Nevertheless, other large series have shown that most ruptured aneurysms are, in fact, the smaller ones. In the present study, we questioned whether small aneurysms are indeed not dangerous., Methods: We enrolled 290 patients with newly-diagnosed aneurysms at our institution over a six-year period (43.7% ruptured). We performed multivariate analyses addressing epidemiological issues, cardiovascular diseases, and three angiographic parameters (largest aneurysm diameter, neck diameter and diameter of the nutrition vessel). Risk estimates were calculated using a logistic regression model. Aneurysm size parameters were stratified according to receiver operating characteristic (ROC) curves. Finally, we calculated odds ratios for rupture based on the ROC analysis., Results: The mean largest diameter for the ruptured versus unruptured groups was 13.3 ± 1.7 mm versus 22.2 ± 2.2 mm (p < 0.001). Multivariate analysis revealed a positive correlation between rupture and arterial hypertension (p < 0.001) and an inverse correlation with all three angiographic measurements (all p < 0.01). Aneurysms from the anterior cerebral artery bled more often (p < 0.05). According to the ROC curves, at the largest diameter of 15 mm, the sensitivity and specificity to predict rupture were 83% and 36%, respectively. Based on this stratification, we calculated the chance of rupture for aneurysms smaller than 15 mm as 46%, which dropped to 25% for larger aneurysms., Conclusion: In the population studied at our institution, small aneurysms were more prone to bleeding. Therefore, the need for intervention for small aneurysms should not be overlooked.
- Published
- 2019
- Full Text
- View/download PDF
4. Anatomic Nuances of the Ophthalmic Artery Origin from a Ventral Viewpoint: Considerations and Implications for Endoscopic Endonasal Surgery.
- Author
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Naudy CA, Yanez-Siller JC, Mesquita Filho PM, Gomez G M, Otto BA, Carrau RL, and Prevedello DM
- Subjects
- Cadaver, Carotid Artery, Internal diagnostic imaging, Cerebral Angiography methods, Humans, Nasal Cavity blood supply, Nasal Cavity diagnostic imaging, Ophthalmic Artery diagnostic imaging, Sphenoid Bone blood supply, Sphenoid Bone diagnostic imaging, Carotid Artery, Internal anatomy & histology, Nasal Cavity anatomy & histology, Neuroendoscopy methods, Ophthalmic Artery anatomy & histology, Sphenoid Bone anatomy & histology
- Abstract
Background: The origin of the ophthalmic artery is within the surgical field of endoscopic endonasal approaches (EEAs) to the suprasellar and parasellar regions. However, its anatomy from the endoscopic point-of-view has not been adequately elucidated., Objective: To highlight the anatomy of the ophthalmic artery origin from an endoscopic endonasal perspective., Methods: The origin of the ophthalmic artery was studied bilaterally under endoscopic visualization, after performing transplanum/transtubercular EEAs in 17 cadaveric specimens (34 arteries). Anatomic relationships relevant to surgery were evaluated. To complement the cadaveric findings, the ophthalmic artery origin was reviewed in 200 "normal" angiographic studies., Results: On the right side, 70.6% of ophthalmic arteries emerged from the superior aspect, while 17.6% and 11.8% emerged from the superomedial and superolateral aspects of the intradural internal carotid artery, respectively. On the left, 76.5%, 17.6%, and 5.9% of ophthalmic arteries emerged from the superior, superomedial, and superolateral aspects of the internal carotid, respectively. Similar findings were observed on angiography. All ophthalmic arteries emerged at the level of the medial opticocarotid recess. Overall, 47%, 26.5%, and 26.5% of ophthalmic arteries (right and left) were inferolateral, inferior, and inferomedial to the intracranial optic nerve segment, respectively. On both sides, the intracranial length of the ophthalmic artery ranged from 1.5 to 4.5 mm (mean: 2.90 ± standard deviation of 0.74 mm)., Conclusion: Awareness of the endoscopic nuances of the ophthalmic artery origin is paramount to minimize the risk of sight-threatening neurovascular injury during EEAs to the suprasellar and parasellar regions., (Copyright © 2018 by the Congress of Neurological Surgeons.)
- Published
- 2019
- Full Text
- View/download PDF
5. Initial Experience with a Flow Redirection Endoluminal Device Stent-A Brazilian Multicenter Study.
- Author
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Manzato LB, Santos RB, Teixeira DO, Mesquita Filho PM, Azambuja ND Jr, Frighetto L, and Vanzin JR
- Subjects
- Adult, Aged, Angiography, Aortic Aneurysm, Abdominal surgery, Brazil, Carotid Artery, Internal diagnostic imaging, Endovascular Procedures methods, Female, Humans, Imaging, Three-Dimensional, Intracranial Aneurysm pathology, Intracranial Aneurysm surgery, Male, Middle Aged, Retrospective Studies, Endovascular Procedures instrumentation, Intracranial Aneurysm therapy, Stents
- Published
- 2018
- Full Text
- View/download PDF
6. Optic Canal Decompression: Comparison of 2 Surgical Techniques.
- Author
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Mesquita Filho PM, Prevedello DM, Prevedello LM, Ditzel Filho LF, Fiore ME, Dolci RL, Buohliqah L, Otto BA, and Carrau RL
- Subjects
- Dissection methods, Humans, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Nerve Compression Syndromes diagnostic imaging, Ophthalmic Artery diagnostic imaging, Optic Nerve Diseases diagnostic imaging, Outcome and Process Assessment, Health Care, Tomography, X-Ray Computed, Craniotomy methods, Decompression, Surgical methods, Endoscopy methods, Nerve Compression Syndromes surgery, Ophthalmic Artery surgery, Optic Nerve Diseases surgery
- Abstract
Background: The optic canal is a bony channel that connects the anterior cranial fossa and orbit and contains the optic nerve and ophthalmic artery. It can be affected by several pathologies, leading to compression of the nerve nearby or inside the canal, leading to visual impairment. The usual technique to decompress the canal is through a craniotomy, but recently endoscopic endonasal approaches (EEAs) have surfaced as an interesting alternative due to direct access to the canal without the need for manipulation of neurovascular structures., Methods: Six specimens were dissected. The right optic canal was drilled on the right side via the EEA, and the left optic canal was drilled via frontotemporal craniotomy. The amount of decompression was measured using a 3-dimensional reconstruction on computed tomography scans and compared., Results: The EEA generated an average of 267.8 (221-294) degrees of decompression in the anterior portion of the canal versus 258.3 (219-300) degrees of decompression in the posterior portion of the canal, whereas the craniotomy generated an average of 229.3 (101-289) degrees of decompression in the anterior portion of the canal versus 250.3 (76-300) degrees of decompression in the posterior portion of the canal. There was no significant difference statistically., Conclusion: The decision for an approach for optic canal decompression should be based on the site of the pathology and localization of canal involvement. Both techniques are equivalent in terms of proportion of nerve decompression., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
7. Endoscopic endonasal anatomical study of the cavernous sinus segment of the ophthalmic nerve.
- Author
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Dolci RL, Carrau RL, Buohliqah L, Zoli M, Mesquita Filho PM, Lazarini PR, Ditzel Filho LF, and Prevedello DM
- Subjects
- Cadaver, Humans, Nose, Cavernous Sinus anatomy & histology, Endoscopy, Ophthalmic Nerve anatomy & histology
- Abstract
Objectives/hypothesis: This cadaveric study analyzes the endoscopic endonasal anatomy of the ophthalmic division of the trigeminal nerve (V1 ), from the middle fossa to its orbital entry via the superior orbital fissure. Anatomical relationships with the surrounding cranial nerves and blood vessels are described, with emphasis on their clinical correlation during surgery in this region. Our objective was to describe the anatomical relationships of the ophthalmic division of the trigeminal nerve., Study Design: Cadaveric study., Methods: Thirty middle cranial fossae, in adult human cadaveric specimens, were dissected endonasally under direct endoscopic visualization. During the dissection, we noted the relationships of the V1 nerve with the other trigeminal branches, as well as with the oculomotor and trochlear nerves, the paraclival and cavernous portions of the internal carotid artery, and the superior orbital fissure (SOF)., Results: The V1 nerve is the most superior trigeminal branch and runs upward and obliquely, along the middle portion of the lateral wall of the cavernous sinus. The V1 nerve joins the oculomotor and trochlear nerves to exit the cavernous sinus and enter the orbit through the SOF. Ten percent of the specimens displayed the trochlear nerve running along as a mate of the V1 nerve. The V1 nerve borders two key triangles in the lateral wall of the cavernous sinus, and the Parkinson's and anteromedial triangles., Conclusions: In this study, the V1 nerve was a constant and reliable landmark, thus allowing the identification of the anteromedial triangle. This potential space can serve as an adequate window to access the temporal lobe. Knowledge of this anatomy is essential when planning and executing endonasal surgery in this region., Level of Evidence: NA., (© 2014 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2015
- Full Text
- View/download PDF
8. Endoscopic endonasal surgical management of chondrosarcomas with cerebellopontine angle extension.
- Author
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Mesquita Filho PM, Ditzel Filho LF, Prevedello DM, Martinez CA, Fiore ME, Dolci RL, Otto BA, and Carrau RL
- Subjects
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurosurgical Procedures methods, Retrospective Studies, Cerebellopontine Angle pathology, Chondrosarcoma surgery, Endoscopy methods, Nose surgery, Skull Base Neoplasms surgery
- Abstract
Object: Skull base chondrosarcomas are slow-growing, locally invasive tumors that arise from the petroclival synchondrosis. These characteristics allow them to erode the clivus and petrous bone and slowly compress the contents of the posterior fossa progressively until the patient becomes symptomatic, typically from cranial neuropathies. Given the site of their genesis, surrounded by the petrous apex and the clival recess, these tumors can project to the middle fossa, cervical area, and posteriorly, toward the cerebellopontine angle (CPA). Expanded endoscopic endonasal approaches are versatile techniques that grant access to the petroclival synchondrosis, the core of these lesions. The ability to access multiple compartments, remove infiltrated bone, and achieve tumor resection without the need for neural retraction makes these techniques particularly appealing in the management of these complex lesions., Methods: Analysis of the authors' database yielded 19 cases of skull base chondrosarcomas; among these were 5 cases with predominant CPA involvement. The electronic medical records of the 5 patients were retrospectively reviewed for age, sex, presentation, pre- and postoperative imaging, surgical technique, pathology, and follow-up. These cases were used to illustrate the surgical nuances involved in the endonasal resection of CPA chondrosarcomas., Results: The male/female ratio was 1:4, and the patients' mean age was 55.2 ±11.2 years. All cases involved petrous bone and apex, with variable extensions to the posterior fossa and parapharyngeal space. The main clinical scenario was cranial nerve (CN) palsy, evidenced by diplopia (20%), ptosis (20%), CN VI palsy (20%), dysphagia (40%), impaired phonation (40%), hearing loss (20%), tinnitus (20%), and vertigo/dizziness (40%). Gross-total resection of the CPA component of the tumor was achieved in 4 cases (80%); near-total resection of the CPA component was performed in 1 case (20%). Two patients (40%) harbored high-grade chondrosarcomas. No patient experienced worsening neurological symptoms postoperatively. In 2 cases (40%), the symptoms were completely normalized after surgery., Conclusions: Expanded endoscopic endonasal approaches appear to be safe and effective in the resection of select skull base chondrosarcomas; those with predominant CPA involvement seem particularly amenable to resection through this technique. Further studies with larger cohorts are necessary to test these preliminary impressions and to compare their effectiveness with the results obtained with open approaches.
- Published
- 2014
- Full Text
- View/download PDF
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