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Quantum cascade lasers (QCLs) constitute an intriguing opportunity for the generation of on-chip optical dissipative Kerr solitons (DKSs). Originally demonstrated in passive microresonators, DKSs were recently observed in mid-infrared ring QCL paving the way for their achievement even at longer wavelengths. To this end, we realized defect-free terahertz ring QCLs featuring anomalous dispersion leveraging on a technological platform based on waveguide planarization. A concentric coupled waveguide approach is implemented for dispersion compensation, while a passive broadband bullseye antenna improves the device power extraction and far field. Comb spectra featuring sech 2 envelopes are presented for free-running operation. The presence of solitons is further supported by observing the highly hysteretic behavior, measuring the phase difference between the modes, and reconstructing the intensity time profile highlighting the presence of self-starting 12-picosecond-long pulses. These observations are in very good agreement with our numeric simulations based on a Complex Ginzburg-Landau Equation (CGLE).

Recently, there has been a growing interest in integrated THz photonics for various applications in communications, spectroscopy and sensing. We present a new integrated photonic platform based on active and passive elements integrated in a double-metal, high-confinement waveguide layout planarized with a low-loss polymer. An extended top metallization keeps waveguide losses low while improving dispersion, thermal and RF properties, as it enables to decouple the design of THz and microwave cavities. Free-running on-chip quantum cascade laser combs spanning 800 GHz, harmonic states with over 1.1 THz bandwidth and RF-injected broadband incoherent states spanning over nearly 1.6 THz are observed using a homogeneous quantum-cascade active core. With a strong external RF drive, actively mode-locked pulses as short as 4.4 ps can be produced, as measured by SWIFTS. We demonstrate as well passive waveguides with low insertion loss, enabling the tuning of the laser cavity boundary conditions and the co-integration of active and passive elements on the same THz photonic chip., (© 2022. The Author(s).)

The combination of electrophysiology and optogenetics enables the exploration of how the brain operates down to a single neuron and its network activity. Neural probes are in vivo invasive devices that integrate sensors and stimulation sites to record and manipulate neuronal activity with high spatiotemporal resolution. State-of-the-art probes are limited by tradeoffs involving their lateral dimension, number of sensors, and ability to access independent stimulation sites. Here, we realize a highly scalable probe that features three-dimensional integration of small-footprint arrays of sensors and nanophotonic circuits to scale the density of sensors per cross-section by one order of magnitude with respect to state-of-the-art devices. For the first time, we overcome the spatial limit of the nanophotonic circuit by coupling only one waveguide to numerous optical ring resonators as passive nanophotonic switches. With this strategy, we achieve accurate on-demand light localization while avoiding spatially demanding bundles of waveguides and demonstrate the feasibility with a proof-of-concept device and its scalability towards high-resolution and low-damage neural optoelectrodes., Competing Interests: Conflict of interestThe authors declare no competing interests., (© The Author(s) 2021.)

Poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles are loaded with curcumin and piperine by in situ emulsion polymerization using dodecyl benzene sulfonic acid both as a stabilizer and a doping agent. The loaded drugs affect the morphology, size, and colloidal stability of the nanoparticles. Furthermore, kinetics studies of nonstimulated drug release have evidenced that polymer···drug interactions are stronger for curcumin than for piperine. This observation suggests that drug delivery systems based on combination of the former drug with PEDOT are much appropriated to show an externally tailored release profile. This is demonstrated by comparing the release profiles obtained in presence and absence of electrical stimulus. Results indicate that controlled and time-programmed release of curcumin is achieved in a physiological medium by applying a negative voltage of -1.25 V to loaded PEDOT nanoparticles., (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)