11 results on '"Morrison, Ross"'
Search Results
2. The Patient Experience of Acute Lymphoblastic Leukemia and Its Treatment: Social Media Review.
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Crawford R, Sikirica S, Morrison R, Cappelleri JC, Russell-Smith A, Shah R, Chadwick H, and Doward L
- Abstract
Background: Adult patients with acute lymphoblastic leukemia (ALL) report substantial disease- and treatment-related impacts on their health-related quality of life (HRQOL). Patient-reported information (PRI) shared on social media may provide a distinct opportunity to understand the patient experience outside of formal research contexts and help inform the development of novel therapies., Objective: This qualitative social media review aimed to assess PRI shared on social media websites to gain a better understanding of the symptom, HRQOL, and treatment impacts on individuals with ALL., Methods: We identified English-language posts on 3 patient advocacy websites (Patient Power, The Patient Story, and Leukaemia Care) and YouTube that included PRI about experiences with ALL or ALL treatments shared by adults (aged ≥18 years) with a self-reported ALL diagnosis. Patients' demographic and disease characteristics were extracted from posts (where available), and the posts were analyzed thematically. A network analysis was conducted to delineate possible associations among ALL symptoms, HRQOL impacts, and treatment-related symptoms and impacts., Results: Of the 935 social media posts identified, 63 (7%) met the review criteria, including 40 (63%) videos, 5 (8%) comments posted in response to videos, and 18 (29%) blog posts. The 63 posts were contributed by 41 patients comprised of 21 (51%) males, 18 females (44%), and 2 (5%) whose gender was not reported. Among the patients, 13 (32%) contributed >1 source of data. Fatigue (n=20, 49%), shortness of breath (n=13, 32%), and bruising (n=12, 29%) were the symptoms prior to treatment most frequently discussed by patients. Patients also reported impacts on personal relationships (n=26, 63%), psychological and emotional well-being (n=25, 61%), and work (n=16, 39%). Although inpatient treatment reportedly restricted patients' independence and social functioning, it also provided a few patients with a sense of safety. Patients frequently relied on their doctors to drive their treatment decisions but were also influenced by family members. The network analysis indicated that disease-related symptoms were primarily associated with patients' physical functioning, activities of daily living, and ability to work, while treatment-related symptoms were primarily associated with emotional well-being., Conclusions: This social media review explored PRI through a thematic analysis of patient-contributed content on patient advocacy websites and YouTube to identify and contextualize emergent themes in patient experiences with ALL and its treatments. To our knowledge, this is the first study to leverage this novel tool to generate new insights into patients' experiences with ALL. Patients' social media posts suggest that inpatient care for ALL is associated with restricted independence and social functioning. However, inpatient care also provided a sense of safety for some patients. Studies such as this one that capture patients' experiences in their own words are valuable tools to further our knowledge of patient outcomes with ALL., (©Rebecca Crawford, Slaven Sikirica, Ross Morrison, Joseph C Cappelleri, Alexander Russell-Smith, Richa Shah, Helen Chadwick, Lynda Doward. Originally published in JMIR Cancer (https://cancer.jmir.org), 01.05.2023.)
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- 2023
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3. Patient Perceptions Regarding Ciltacabtagene Autoleucel Treatment: Qualitative Evidence From Interviews With Patients With Relapsed/Refractory Multiple Myeloma in the CARTITUDE-1 Study.
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Cohen AD, Hari P, Htut M, Berdeja JG, Usmani SZ, Madduri D, Olyslager Y, Goldberg JD, Schecter JM, Jackson CC, Gries KS, Fastenau JM, Valluri S, Deraedt W, Akram M, Crawford R, Morrison R, Doward L, Morgan K, Seldam ST, Jakubowiak A, and Jagannath S
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- Humans, Quality of Life, Immunotherapy, Adoptive methods, Fatigue, Pain etiology, Multiple Myeloma drug therapy
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Introduction: Ciltacabtagene autoleucel (cilta-cel), a novel chimeric antigen receptor T (CAR-T) cell therapy, has demonstrated early, deep, and durable clinical responses in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM), and improvements in health-related quality of life (HRQoL) in CARTITUDE-1 (NCT03548207). Patient perspectives on treatment provide context to efficacy outcomes and are an important aspect of therapeutic evaluation., Methods: Qualitative interviews were conducted in a subset of CARTITUDE-1 patients (n = 36) at screening, Day 100, and Day 184 post cilta-cel on living with MM, therapy expectations, and treatment experiences during the study., Results: Patients most wanted to see change in symptoms with the greatest impact on HRQoL: pain (85.2%) and fatigue (74.1%). The primary treatment expectation was achieving remission (40.7%), followed by extended life expectancy (14.8%). Patients most often defined meaningful change as improvement in symptoms (70.4%) and return to normalcy (40.7%). The percentage of patients reporting symptoms (pain, fatigue, bone fracture, gastrointestinal, neuropathy, and weakness) decreased from 85.2% to 22.2% across symptom types at baseline to 29.2% to 0% on Day 184 after cilta-cel. Improved symptoms and positive sentiments corresponded with improved perception of overall health status and reduced pain level, respectively. Most patients reported that their expectations of cilta-cel treatment had been met (70.8%) or exceeded (20.8%) at Day 184, and 70.8% of patients considered cilta-cel therapy better than their previous treatments., Conclusion: Overall HRQoL improvements and qualitative interviews showed cilta-cel met patient expectations of treatment and suggest the long treatment-free period also contributed to positive sentiments., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2023
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4. The patient experience of relapsed refractory multiple myeloma and perspectives on emerging therapies.
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Crawford R, Gries KS, Valluri S, Fastenau J, Morrison R, Yeh TM, Olyslager Y, Goldberg JD, Schecter JM, Jackson CC, Deraedt W, and Doward L
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- Adult, Humans, Female, Middle Aged, Male, Quality of Life, Antineoplastic Combined Chemotherapy Protocols adverse effects, Treatment Outcome, Patient Outcome Assessment, Multiple Myeloma drug therapy
- Abstract
Background: Relapsed refractory multiple myeloma (RRMM) is a disease that is nonresponsive or progressive on therapy, and although patients can achieve remission, relapse is common. As more treatment options become available for multiple myeloma (MM), it is important to understand patients' experiences of current and emerging therapies., Aims: This study aimed to better understand patient experiences with treatment and therapies for MM using qualitative interviews and patient-reported information (PRI) shared on social media., Methods: Semistructured qualitative interviews were conducted with adults with RRMM who resided in the United States. In addition to the interviews, PRI was collected from YouTube and a patient advocacy website. Key themes from the interviews and PRI were summarized, and illustrative quotes were extracted., Results: Twenty participants were interviewed; 11 were female, and mean (standard deviation) age was 60 (7.0) years. The PRI included 14 posts and 19 unique contributors (10 were female). Similar treatment-related symptoms were reported in the interviews and PRI. Fatigue and pain were the most frequently reported symptoms while receiving treatment in both the interviews and PRI. These symptoms had a meaningful impact on health-related quality of life (HRQOL); being off treatment and returning to normal living was described as an ideal treatment outcome. Nearly all interview participants (n = 18) preferred a treatment that would allow for a treatment-free interval, if it had the same efficacy and safety profile as a continuous treatment., Conclusion: The symptom experience reported in this study is consistent with known RRMM symptoms and HRQOL impacts. Additionally, this study highlighted that patients' treatment expectations are changing relative to their past treatment experience. Individuals living with RRMM strongly desire therapies with a treatment-free interval and minimal impact on their HRQOL., (© 2022 Janssen Pharmaceuticals. Cancer Reports published by Wiley Periodicals LLC.)
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- 2022
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5. Responsible agriculture must adapt to the wetland character of mid-latitude peatlands.
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Freeman BWJ, Evans CD, Musarika S, Morrison R, Newman TR, Page SE, Wiggs GFS, Bell NGA, Styles D, Wen Y, Chadwick DR, and Jones DL
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- Agriculture, Carbon Dioxide analysis, Greenhouse Effect, Soil, Greenhouse Gases analysis, Wetlands
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Drained, lowland agricultural peatlands are greenhouse gas (GHG) emission hotspots and a large but vulnerable store of irrecoverable carbon. They exhibit soil loss rates of ~2.0 cm yr
-1 and are estimated to account for 32% of global cropland emissions while producing only 1.1% of crop kilocalories. Carbon dioxide emissions account for >80% of their terrestrial GHG emissions and are largely controlled by water table depth. Reducing drainage depths is, therefore, essential for responsible peatland management. Peatland restoration can substantially reduce emissions. However, this may conflict with societal needs to maintain productive use, to protect food security and livelihoods. Wetland agriculture strategies will, therefore, be required to adapt agriculture to the wetland character of peatlands, and balance GHG mitigation against productivity, where halting emissions is not immediately possible. Paludiculture may substantially reduce GHG emissions but will not always be viable in the current economic landscape. Reduced drainage intensity systems may deliver partial reductions in the rate of emissions, with smaller modifications to existing systems. These compromise systems may face fewer hurdles to adoption and minimize environmental harm until societal conditions favour strategies that can halt emissions. Wetland agriculture will face agronomic, socio-economic and water management challenges, and careful implementation will be required. Diversity of values and priorities among stakeholders creates the potential for conflict. Successful implementation will require participatory research approaches and co-creation of workable solutions. Policymakers, private sector funders and researchers have key roles to play but adoption risks would fall predominantly on land managers. Development of a robust wetland agriculture paradigm is essential to deliver resilient production systems and wider environmental benefits. The challenge of responsible use presents an opportunity to rethink peatland management and create thriving, innovative and green wetland landscapes for everyone's future benefit, while making a vital contribution to global climate change mitigation., (© 2022 The Authors. Global Change Biology published by John Wiley & Sons Ltd.)- Published
- 2022
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6. Development of the Pulmonary Hypertension Functional Classification Self-Report: a patient version adapted from the World Health Organization Functional Classification measure.
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Highland KB, Crawford R, Classi P, Morrison R, Doward L, Nelsen AC, Castillo H, Mathai SC, and DuBrock HM
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- Humans, Interviews as Topic, Pulmonary Arterial Hypertension, Self Report, World Health Organization, Hypertension, Pulmonary classification, Quality of Life
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Background: Pulmonary arterial hypertension (PAH) is characterized by progressive limitations on physical activity, right heart failure, and premature death. The World Health Organization functional classification (WHO-FC) is a clinician-rated assessment used widely to assess PAH severity and functioning, but no equivalent patient-reported version of PAH symptoms and activity limitations exists. We developed a version of the WHO-FC for self-completion by patients: the Pulmonary Hypertension Functional Classification Self-Report (PH-FC-SR)., Methods: Semistructured interviews were conducted with three health care providers (HCPs) via telephone to inform development of the draft PH-FC-SR. Two rounds of semi-structured interviews were conducted with 14 US patients with a self-reported PAH diagnosis via telephone/online to elicit concepts and iteratively refine the PH-FC-SR., Results: HCPs reported that the WHO-FC was a useful tool for evaluating patients' PAH severity over time and for making treatment decisions but acknowledged that use of the measure is subjective. Patients in round 1 interviews (n = 6) reported PAH symptoms, including shortness of breath (n = 6), fatigue (n = 5), syncope (n = 5), chest pains (n = 3), and dizziness (n = 3). Round 1 patients identified challenges with the original WHO-FC, including comprehensibility of clinical terms and overlapping descriptions of class II and III, and preferred the Draft 1 PH-FC-SR over the original WHO-FC. After minor changes were made to Draft 2, round 2 interviews (n = 8) confirmed patients understood the PH-FC-SR class descriptions, interpreting them consistently., Conclusions: The HCP and patient interviews identified and confirmed certain limitations inherent within the clinician-rated WHO-FC, including subjective assessment and overlapping definitions for class II and III. The PH-FC-SR includes patient-appropriate language, symptoms, and physical activity impacts relevant to patients with PAH. Future research is recommended to validate the PH-FC-SR and explore its correlation with the physician-assessed WHO-FC and other outcomes., (© 2021. The Author(s).)
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- 2021
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7. Effect of a Scalable School-Based Intervention on Cardiorespiratory Fitness in Children: A Cluster Randomized Clinical Trial.
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Lonsdale C, Sanders T, Parker P, Noetel M, Hartwig T, Vasconcellos D, Lee J, Antczak D, Kirwan M, Morgan P, Salmon J, Moodie M, McKay H, Bennie A, Plotnikoff RC, Cinelli R, Greene D, Peralta L, Cliff D, Kolt G, Gore J, Gao L, Boyer J, Morrison R, Hillman C, Shigeta TT, Tan E, and Lubans DR
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- Child, Female, Humans, Male, New South Wales, Cardiorespiratory Fitness, Internet, Physical Education and Training organization & administration, School Health Services organization & administration
- Abstract
Importance: Cardiorespiratory fitness is an important marker of childhood health and low fitness levels are a risk factor for disease later in life. Levels of children's fitness have declined in recent decades. Whether school-based physical activity interventions can increase fitness at the population level remains unclear., Objective: To evaluate the effect of an internet-based intervention on children's cardiorespiratory fitness across a large number of schools., Design, Setting, and Participants: In this cluster randomized clinical trial, 22 government-funded elementary schools (from 137 providing consent) including 1188 students stratified from grades 3 and 4 in New South Wales, Australia, were randomized. The other schools received the intervention but were not included in the analysis. Eleven schools received the internet-based intervention and 11 received the control intervention. Recruitment and baseline testing began in 2016 and ended in 2017. Research assistants, blinded to treatment allocation, completed follow-up outcome assessments at 12 and 24 months. Data were analyzed from July to August 2020., Interventions: The internet-based intervention included standardized online learning for teachers and minimal in-person support from a project mentor (9-10 months)., Main Outcomes and Measures: Multistage 20-m shuttle run test for cardiorespiratory fitness., Results: Of 1219 participants (49% girls; mean [SD] age, 8.85 [0.71] years) from 22 schools, 1188 students provided baseline primary outcome data. At 12 months, the number of 20-m shuttle runs increased by 3.32 laps (95% CI, 2.44-4.20 laps) in the intervention schools and 2.11 laps (95% CI, 1.38-2.85 laps) in the control schools (adjusted difference = 1.20 laps; 95% CI, 0.17-2.24 laps). By 24 months, the adjusted difference was 2.22 laps (95% CI, 0.89-3.55 laps). The cost per student was AUD33 (USD26)., Conclusions and Relevance: In this study, a school-based intervention improved children's cardiorespiratory fitness when delivered in a large number of schools. The low cost and sustained effect over 24 months of the intervention suggests that it may have potential to be scaled at the population level., Trial Registration: http://anzctr.org.au Identifier: ACTRN12616000731493.
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- 2021
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8. A cluster randomised trial of an intervention to increase the implementation of physical activity practices in secondary schools: study protocol for scaling up the Physical Activity 4 Everyone (PA4E1) program.
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Sutherland R, Campbell E, Nathan N, Wolfenden L, Lubans DR, Morgan PJ, Gillham K, Oldmeadow C, Searles A, Reeves P, Williams M, Evans N, Bailey A, Morrison R, McLaughlin M, and Wiggers J
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- Adolescent, Cost-Benefit Analysis, Female, Humans, Male, New South Wales, Poverty Areas, Program Evaluation, Research Design, School Health Services economics, Schools, Students statistics & numerical data, Time Factors, Exercise physiology, Pediatric Obesity prevention & control, School Health Services organization & administration, Students psychology
- Abstract
Background: The implementation of interventions at-scale is required to maximise population health benefits. 'Physical Activity 4 Everyone (PA4E1)' was a multi-component school-based program targeting adolescents attending secondary schools in low socio-economic areas. An efficacy trial of the intervention demonstrated an increase in students' mean minutes of moderate-to-vigorous physical activity (MVPA) per day and lower weight gain at low incremental cost. This study aims to assess the effectiveness and cost effectiveness of a multi-component implementation support intervention to improve implementation, at-scale, of the evidence based school physical activity (PA) practices of the PA4E1 program. Impact on student PA levels and adiposity will also be assessed, in addition to the cost of implementation., Methods: A cluster randomised controlled trial, utilising an effectiveness-implementation hybrid design, will be conducted in up to 76 secondary schools located in lower socio-economic areas across four health districts in New South Wales (NSW), Australia. Schools will be randomly allocated to a usual practice control arm or a multi-component implementation support intervention to embed the seven school PA practices of the PA4E1 program. The implementation support intervention incorporates seven strategies including executive support, in-School Champion, teacher training, resources, prompts, audit and feedback and access to an external Support Officer. The primary trial outcome will be the proportion of schools meeting at least four of the seven physical activity practices of the program, assessed via surveys with Head Physical Education teachers at 12 and 24-months. Secondary outcomes will be assessed via a nested evaluation of student PA and adiposity at 12-months (Grade 8 students) and 24 months (Grade 9 students) undertaken in 30 schools (15 per group). Resource use associated with the implementation intervention will be measured prospectively. Linear mixed effects regression models will assess program effects on the primary outcome at each follow-up period., Discussion: This study is one of few evidence-based multi-component PA programs scaled-up to a large number of secondary schools and evaluated via randomised controlled trial. The use of implementation science theoretical frameworks to implement the evidence-based program and the rigorous evaluation design are strengths of the study., Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12617000681358 registered 12th May 2017. Protocol Version 1.
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- 2019
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9. Denial of long-term issues with agriculture on tropical peatlands will have devastating consequences.
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Wijedasa LS, Jauhiainen J, Könönen M, Lampela M, Vasander H, Leblanc MC, Evers S, Smith TE, Yule CM, Varkkey H, Lupascu M, Parish F, Singleton I, Clements GR, Aziz SA, Harrison ME, Cheyne S, Anshari GZ, Meijaard E, Goldstein JE, Waldron S, Hergoualc'h K, Dommain R, Frolking S, Evans CD, Posa MR, Glaser PH, Suryadiputra N, Lubis R, Santika T, Padfield R, Kurnianto S, Hadisiswoyo P, Lim TW, Page SE, Gauci V, Van Der Meer PJ, Buckland H, Garnier F, Samuel MK, Choo LN, O'Reilly P, Warren M, Suksuwan S, Sumarga E, Jain A, Laurance WF, Couwenberg J, Joosten H, Vernimmen R, Hooijer A, Malins C, Cochrane MA, Perumal B, Siegert F, Peh KS, Comeau LP, Verchot L, Harvey CF, Cobb A, Jaafar Z, Wösten H, Manuri S, Müller M, Giesen W, Phelps J, Yong DL, Silvius M, Wedeux BM, Hoyt A, Osaki M, Hirano T, Takahashi H, Kohyama TS, Haraguchi A, Nugroho NP, Coomes DA, Quoi LP, Dohong A, Gunawan H, Gaveau DL, Langner A, Lim FK, Edwards DP, Giam X, Van Der Werf G, Carmenta R, Verwer CC, Gibson L, Gandois L, Graham LL, Regalino J, Wich SA, Rieley J, Kettridge N, Brown C, Pirard R, Moore S, Capilla BR, Ballhorn U, Ho HC, Hoscilo A, Lohberger S, Evans TA, Yulianti N, Blackham G, Onrizal, Husson S, Murdiyarso D, Pangala S, Cole LE, Tacconi L, Segah H, Tonoto P, Lee JS, Schmilewski G, Wulffraat S, Putra EI, Cattau ME, Clymo RS, Morrison R, Mujahid A, Miettinen J, Liew SC, Valpola S, Wilson D, D'Arcy L, Gerding M, Sundari S, Thornton SA, Kalisz B, Chapman SJ, Su AS, Basuki I, Itoh M, Traeholt C, Sloan S, Sayok AK, and Andersen R
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- 2017
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10. Benefits and costs of ecological restoration: Rapid assessment of changing ecosystem service values at a U.K. wetland.
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Peh KS, Balmford A, Field RH, Lamb A, Birch JC, Bradbury RB, Brown C, Butchart SH, Lester M, Morrison R, Sedgwick I, Soans C, Stattersfield AJ, Stroh PA, Swetnam RD, Thomas DH, Walpole M, Warrington S, and Hughes FM
- Abstract
Restoration of degraded land is recognized by the international community as an important way of enhancing both biodiversity and ecosystem services, but more information is needed about its costs and benefits. In Cambridgeshire, U.K., a long-term initiative to convert drained, intensively farmed arable land to a wetland habitat mosaic is driven by a desire both to prevent biodiversity loss from the nationally important Wicken Fen National Nature Reserve (Wicken Fen NNR) and to increase the provision of ecosystem services. We evaluated the changes in ecosystem service delivery resulting from this land conversion, using a new Toolkit for Ecosystem Service Site-based Assessment (TESSA) to estimate biophysical and monetary values of ecosystem services provided by the restored wetland mosaic compared with the former arable land. Overall results suggest that restoration is associated with a net gain to society as a whole of $199 ha(-1)y(-1), for a one-off investment in restoration of $2320 ha(-1). Restoration has led to an estimated loss of arable production of $2040 ha(-1)y(-1), but estimated gains of $671 ha(-1)y(-1) in nature-based recreation, $120 ha(-1)y(-1) from grazing, $48 ha(-1)y(-1) from flood protection, and a reduction in greenhouse gas (GHG) emissions worth an estimated $72 ha(-1)y(-1). Management costs have also declined by an estimated $1325 ha(-1)y(-1). Despite uncertainties associated with all measured values and the conservative assumptions used, we conclude that there was a substantial gain to society as a whole from this land-use conversion. The beneficiaries also changed from local arable farmers under arable production to graziers, countryside users from towns and villages, and the global community, under restoration. We emphasize that the values reported here are not necessarily transferable to other sites.
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- 2014
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11. Policy perils of ignoring uncertainty in oil palm research.
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Paoli GD, Carlson KM, Hooijer A, Page SE, Curran LM, Wells PL, Morrison R, Jauhiainen J, Pittman AM, Gilbert D, and Lawrence D
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- Asia, Southeastern, Carbon metabolism, Humans, Plant Oils, Air Pollutants, Arecaceae, Climate Change, Environmental Policy, Models, Biological, Trees
- Published
- 2011
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