1. Neurotoxicity, antipsychotic and antidepressant screening of the fruit of Rosa moschata in mice.
- Author
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Muhammad Jamal -, Mujeebur Rehman -, Muhammad Nabi -, Zenat Fatima Khattak -, Abdul Aleem Awan -, Mudassir Shah -, Niaz Ali -, Iftekhar Hussain -, Muhammad Azhar Sherkheli -, and Rizwanul Haq -
- Subjects
- Animals, Mice, Plant Extracts toxicity, Fruit, Antidepressive Agents pharmacology, Swimming, Hindlimb Suspension methods, Depression chemically induced, Depression drug therapy, Rosa, Antipsychotic Agents toxicity
- Abstract
Extract of Rosa moschata (RM) fruits was evaluated for the anti-schizophrenic and antidepressant activities. We first determined the neurotoxic effect of hydro-methanolic extract of RM using inverted-screen test. Further, the extract was tested in the ketamine-induced schizophrenia model and its antidepressant effect was assessed by tail suspension and forced swim test in mice. Different doses of extract were administered once/day to the animals for 14 consecutive days. Behavioral parameters were investigated 24h after last administration of drug/extract by performing Y-maze test, forced swim test and open field test. Results showed that TD50 of the extract was ~1000mg/Kg. Moreover, extract significantly increased % alternations in YMT, reduced immobility time in FST and enhanced locomotion in OFT compared to saline group. Similarly, RM extract decreased time of immobility in FST and TST significantly showed antidepressant effect. Thus, it was concluded that extract of RM has antipsychotic and antidepressant properties.
- Published
- 2023