1. A novel thienothiophene-based "dual-responsive" probe for rapid, selective and sensitive detection of hypochlorite.
- Author
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Suna G, Erdemir E, Liv L, Karakus AC, Gunturkun D, Ozturk T, and Karakuş E
- Subjects
- Colorimetry methods, Water, Fluorescent Dyes chemistry, Hypochlorous Acid
- Abstract
Background: Hypochlorite/hypochlorous acid (ClO
- /HOCl) is a biologically crucial reactive oxygen species (ROS), produced in living organisms and has a critical role as an antimicrobial agent in the natural defense system. However, when ClO- is produced excessively, it can lead to the oxidative damage of biomolecules, resulting in organ damage and various diseases. Therefore, it is imperative to have a straightforward, quick and reliable method for over watching the minimum amount of ClO- in different environments., Results: Herein, a new probe TTM, containing thienothiophene and malononitrile units, was developed for exceptionally selective and sensitive hypochlorite (ClO- ) detection. TTM demonstrated a rapid "turn-on" fluorescence response (<30 s), naked-eye detection (colorimetric), voltammetric read-out with anodic scan, low detection limit (LOD = 0.58 μM and 1.43 μM for optical and electrochemical methods, respectively) and applicability in detecting ClO- in real water samples and living cells., Significance and Novelty: This study represents one of the rare examples of a small thienothiophene-based molecule for both optical and electrochemical detections of ClO- in an aqueous medium., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2024
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