1. Synthesis of highly stable bacterial cellulosic pocket for drug storage.
- Author
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Narh C, Charles F, Mensah A, and Qufu W
- Abstract
Inulin was introduced to the fructose permeates of Gluconacetobacter xylinus (ATCC 10,245) bacterial strain to successfully synthesize empty cellulosic pockets for possible drug storage. FTIR Spectroscopy analysis confirmed a slight variation in the hydrogen bonds at 2893 cm
-1 due to CH and CH2 stretching whiles Conformational analysis revealed that inulobiose extending all-trans conformation corresponded to φ = Ψ = ω = 180°. Fructofuranose moiety, the anomeric carbon was defined as C2. The definition of torsional angles φ = ϴ(C1-C2-0-CI'), Ψ = ϴ (C2-0-C 1'-C2'), and ω = ϴ(0-C1'-C2'-0') followed the proposed convention. Glycosidic angle C1'0 l'C2' was taken to be 114.0° and both O6 hydroxyl groups in inulobiose were fixed in a trans position, compelling the hydroxyl group to sterically favor comparison with the gauche orientation of sucrose structure. XRD analysis results indicated a typical cellulose type I. DSC and TGA analysis revealed a highly stable pocket until about 260°C., (Copyright © 2018 Elsevier Ltd. All rights reserved.)- Published
- 2019
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