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1. Limits on Active to Sterile Neutrino Oscillations from Disappearance Searches in the MINOS, Daya Bay, and Bugey-3 Experiments.

Author

Adamson P, An FP, Anghel I, Aurisano A, Balantekin AB, Band HR, Barr G, Bishai M, Blake A, Blyth S, Bock GJ, Bogert D, Cao D, Cao GF, Cao J, Cao SV, Carroll TJ, Castromonte CM, Cen WR, Chan YL, Chang JF, Chang LC, Chang Y, Chen HS, Chen QY, Chen R, Chen SM, Chen Y, Chen YX, Cheng J, Cheng JH, Cheng YP, Cheng ZK, Cherwinka JJ, Childress S, Chu MC, Chukanov A, Coelho JA, Corwin L, Cronin-Hennessy D, Cummings JP, de Arcos J, De Rijck S, Deng ZY, Devan AV, Devenish NE, Ding XF, Ding YY, Diwan MV, Dolgareva M, Dove J, Dwyer DA, Edwards WR, Escobar CO, Evans JJ, Falk E, Feldman GJ, Flanagan W, Frohne MV, Gabrielyan M, Gallagher HR, Germani S, Gill R, Gomes RA, Gonchar M, Gong GH, Gong H, Goodman MC, Gouffon P, Graf N, Gran R, Grassi M, Grzelak K, Gu WQ, Guan MY, Guo L, Guo RP, Guo XH, Guo Z, Habig A, Hackenburg RW, Hahn SR, Han R, Hans S, Hartnell J, Hatcher R, He M, Heeger KM, Heng YK, Higuera A, Holin A, Hor YK, Hsiung YB, Hu BZ, Hu T, Hu W, Huang EC, Huang HX, Huang J, Huang XT, Huber P, Huo W, Hussain G, Hylen J, Irwin GM, Isvan Z, Jaffe DE, Jaffke P, James C, Jen KL, Jensen D, Jetter S, Ji XL, Ji XP, Jiao JB, Johnson RA, de Jong JK, Joshi J, Kafka T, Kang L, Kasahara SM, Kettell SH, Kohn S, Koizumi G, Kordosky M, Kramer M, Kreymer A, Kwan KK, Kwok MW, Kwok T, Lang K, Langford TJ, Lau K, Lebanowski L, Lee J, Lee JH, Lei RT, Leitner R, Leung JK, Li C, Li DJ, Li F, Li GS, Li QJ, Li S, Li SC, Li WD, Li XN, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Lin SK, Lin YC, Ling JJ, Link JM, Litchfield PJ, Littenberg L, Littlejohn BR, Liu DW, Liu JC, Liu JL, Loh CW, Lu C, Lu HQ, Lu JS, Lucas P, Luk KB, Lv Z, Ma QM, Ma XB, Ma XY, Ma YQ, Malyshkin Y, Mann WA, Marshak ML, Martinez Caicedo DA, Mayer N, McDonald KT, McGivern C, McKeown RD, Medeiros MM, Mehdiyev R, Meier JR, Messier MD, Miller WH, Mishra SR, Mitchell I, Mooney M, Moore CD, Mualem L, Musser J, Nakajima Y, Naples D, Napolitano J, Naumov D, Naumova E, Nelson JK, Newman HB, Ngai HY, Nichol RJ, Ning Z, Nowak JA, O'Connor J, Ochoa-Ricoux JP, Olshevskiy A, Orchanian M, Pahlka RB, Paley J, Pan HR, Park J, Patterson RB, Patton S, Pawloski G, Pec V, Peng JC, Perch A, Pfützner MM, Phan DD, Phan-Budd S, Pinsky L, Plunkett RK, Poonthottathil N, Pun CS, Qi FZ, Qi M, Qian X, Qiu X, Radovic A, Raper N, Rebel B, Ren J, Rosenfeld C, Rosero R, Roskovec B, Ruan XC, Rubin HA, Sail P, Sanchez MC, Schneps J, Schreckenberger A, Schreiner P, Sharma R, Moed Sher S, Sousa A, Steiner H, Sun GX, Sun JL, Tagg N, Talaga RL, Tang W, Taychenachev D, Thomas J, Thomson MA, Tian X, Timmons A, Todd J, Tognini SC, Toner R, Torretta D, Treskov K, Tsang KV, Tull CE, Tzanakos G, Urheim J, Vahle P, Viaux N, Viren B, Vorobel V, Wang CH, Wang M, Wang NY, Wang RG, Wang W, Wang X, Wang YF, Wang Z, Wang ZM, Webb RC, Weber A, Wei HY, Wen LJ, Whisnant K, White C, Whitehead L, Whitehead LH, Wise T, Wojcicki SG, Wong HL, Wong SC, Worcester E, Wu CH, Wu Q, Wu WJ, Xia DM, Xia JK, Xing ZZ, Xu JL, Xu JY, Xu Y, Xue T, Yang CG, Yang H, Yang L, Yang MS, Yang MT, Ye M, Ye Z, Yeh M, Young BL, Yu ZY, Zeng S, Zhan L, Zhang C, Zhang HH, Zhang JW, Zhang QM, Zhang XT, Zhang YM, Zhang YX, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao QW, Zhao YB, Zhong WL, Zhou L, Zhou N, Zhuang HL, and Zou JH

Abstract

Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti)neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the Liquid Scintillator Neutrino Detector (LSND) and MiniBooNE experiments in a minimally extended four-neutrino flavor framework. Stringent limits on sin^{2}2θ&#95;{μe} are set over 6 orders of magnitude in the sterile mass-squared splitting Δm&#95;{41}^{2}. The sterile-neutrino mixing phase space allowed by the LSND and MiniBooNE experiments is excluded for Δm&#95;{41}^{2}<0.8  eV^{2} at 95%  CL&#95;{s}.

Published
2016
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2. Improved Search for a Light Sterile Neutrino with the Full Configuration of the Daya Bay Experiment.

Author

An FP, Balantekin AB, Band HR, Bishai M, Blyth S, Cao D, Cao GF, Cao J, Cen WR, Chan YL, Chang JF, Chang LC, Chang Y, Chen HS, Chen QY, Chen SM, Chen YX, Chen Y, Cheng JH, Cheng J, Cheng YP, Cheng ZK, Cherwinka JJ, Chu MC, Chukanov A, Cummings JP, de Arcos J, Deng ZY, Ding XF, Ding YY, Diwan MV, Dolgareva M, Dove J, Dwyer DA, Edwards WR, Gill R, Gonchar M, Gong GH, Gong H, Grassi M, Gu WQ, Guan MY, Guo L, Guo RP, Guo XH, Guo Z, Hackenburg RW, Han R, Hans S, He M, Heeger KM, Heng YK, Higuera A, Hor YK, Hsiung YB, Hu BZ, Hu T, Hu W, Huang EC, Huang HX, Huang XT, Huber P, Huo W, Hussain G, Jaffe DE, Jaffke P, Jen KL, Jetter S, Ji XP, Ji XL, Jiao JB, Johnson RA, Joshi J, Kang L, Kettell SH, Kohn S, Kramer M, Kwan KK, Kwok MW, Kwok T, Langford TJ, Lau K, Lebanowski L, Lee J, Lee JH, Lei RT, Leitner R, Leung JK, Li C, Li DJ, Li F, Li GS, Li QJ, Li S, Li SC, Li WD, Li XN, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Lin SK, Lin YC, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu DW, Liu JL, Liu JC, Loh CW, Lu C, Lu HQ, Lu JS, Luk KB, Lv Z, Ma QM, Ma XY, Ma XB, Ma YQ, Malyshkin Y, Martinez Caicedo DA, McDonald KT, McKeown RD, Mitchell I, Mooney M, Nakajima Y, Napolitano J, Naumov D, Naumova E, Ngai HY, Ning Z, Ochoa-Ricoux JP, Olshevskiy A, Pan HR, Park J, Patton S, Pec V, Peng JC, Pinsky L, Pun CS, Qi FZ, Qi M, Qian X, Raper N, Ren J, Rosero R, Roskovec B, Ruan XC, Steiner H, Sun GX, Sun JL, Tang W, Taychenachev D, Treskov K, Tsang KV, Tull CE, Viaux N, Viren B, Vorobel V, Wang CH, Wang M, Wang NY, Wang RG, Wang W, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wen LJ, Whisnant K, White CG, Whitehead L, Wise T, Wong HL, Wong SC, Worcester E, Wu CH, Wu Q, Wu WJ, Xia DM, Xia JK, Xing ZZ, Xu JY, Xu JL, Xu Y, Xue T, Yang CG, Yang H, Yang L, Yang MS, Yang MT, Ye M, Ye Z, Yeh M, Young BL, Yu ZY, Zeng S, Zhan L, Zhang C, Zhang HH, Zhang JW, Zhang QM, Zhang XT, Zhang YM, Zhang YX, Zhang YM, Zhang ZJ, Zhang ZY, Zhang ZP, Zhao J, Zhao QW, Zhao YB, Zhong WL, Zhou L, Zhou N, Zhuang HL, and Zou JH

Abstract

This Letter reports an improved search for light sterile neutrino mixing in the electron antineutrino disappearance channel with the full configuration of the Daya Bay Reactor Neutrino Experiment. With an additional 404 days of data collected in eight antineutrino detectors, this search benefits from 3.6 times the statistics available to the previous publication, as well as from improvements in energy calibration and background reduction. A relative comparison of the rate and energy spectrum of reactor antineutrinos in the three experimental halls yields no evidence of sterile neutrino mixing in the 2×10^{-4}≲|Δm&#95;{41}^{2}|≲0.3  eV^{2} mass range. The resulting limits on sin^{2}2θ&#95;{14} are improved by approx imately a factor of 2 over previous results and constitute the most stringent constraints to date in the |Δm&#95;{41}^{2}|≲0.2  eV^{2} region.

Published
2016
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3. Measurement of the Reactor Antineutrino Flux and Spectrum at Daya Bay.

Author

An FP, Balantekin AB, Band HR, Bishai M, Blyth S, Butorov I, Cao D, Cao GF, Cao J, Cen WR, Chan YL, Chang JF, Chang LC, Chang Y, Chen HS, Chen QY, Chen SM, Chen YX, Chen Y, Cheng JH, Cheng J, Cheng YP, Cherwinka JJ, Chu MC, Cummings JP, de Arcos J, Deng ZY, Ding XF, Ding YY, Diwan MV, Dove J, Draeger E, Dwyer DA, Edwards WR, Ely SR, Gill R, Gonchar M, Gong GH, Gong H, Grassi M, Gu WQ, Guan MY, Guo L, Guo XH, Hackenburg RW, Han R, Hans S, He M, Heeger KM, Heng YK, Higuera A, Hor YK, Hsiung YB, Hu BZ, Hu LM, Hu LJ, Hu T, Hu W, Huang EC, Huang HX, Huang XT, Huber P, Hussain G, Jaffe DE, Jaffke P, Jen KL, Jetter S, Ji XP, Ji XL, Jiao JB, Johnson RA, Kang L, Kettell SH, Kohn S, Kramer M, Kwan KK, Kwok MW, Kwok T, Langford TJ, Lau K, Lebanowski L, Lee J, Lei RT, Leitner R, Leung KY, Leung JK, Lewis CA, Li DJ, Li F, Li GS, Li QJ, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin PY, Lin SK, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu DW, Liu H, Liu JL, Liu JC, Liu SS, Lu C, Lu HQ, Lu JS, Luk KB, Ma QM, Ma XY, Ma XB, Ma YQ, Martinez Caicedo DA, McDonald KT, McKeown RD, Meng Y, Mitchell I, Monari Kebwaro J, Nakajima Y, Napolitano J, Naumov D, Naumova E, Ngai HY, Ning Z, Ochoa-Ricoux JP, Olshevski A, Pan HR, Park J, Patton S, Pec V, Peng JC, Piilonen LE, Pinsky L, Pun CS, Qi FZ, Qi M, Qian X, Raper N, Ren B, Ren J, Rosero R, Roskovec B, Ruan XC, Shao BB, Steiner H, Sun GX, Sun JL, Tang W, Taychenachev D, Tsang KV, Tull CE, Tung YC, Viaux N, Viren B, Vorobel V, Wang CH, Wang M, Wang NY, Wang RG, Wang W, Wang WW, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wen LJ, Whisnant K, White CG, Whitehead L, Wise T, Wong HL, Wong SC, Worcester E, Wu Q, Xia DM, Xia JK, Xia X, Xing ZZ, Xu JY, Xu JL, Xu J, Xu Y, Xue T, Yan J, Yang CG, Yang L, Yang MS, Yang MT, Ye M, Yeh M, Young BL, Yu GY, Yu ZY, Zang SL, Zhan L, Zhang C, Zhang HH, Zhang JW, Zhang QM, Zhang YM, Zhang YX, Zhang YM, Zhang ZJ, Zhang ZY, Zhang ZP, Zhao J, Zhao QW, Zhao YF, Zhao YB, Zheng L, Zhong WL, Zhou L, Zhou N, Zhuang HL, and Zou JH

Abstract

This Letter reports a measurement of the flux and energy spectrum of electron antineutrinos from six 2.9 GWth nuclear reactors with six detectors deployed in two near (effective baselines 512 and 561 m) and one far (1579 m) underground experimental halls in the Daya Bay experiment. Using 217 days of data, 296 721 and 41 589 inverse β decay (IBD) candidates were detected in the near and far halls, respectively. The measured IBD yield is (1.55±0.04) ×10(-18)  cm(2) GW(-1) day(-1) or (5.92±0.14) ×10(-43)  cm(2) fission(-1). This flux measurement is consistent with previous short-baseline reactor antineutrino experiments and is 0.946±0.022 (0.991±0.023) relative to the flux predicted with the Huber-Mueller (ILL-Vogel) fissile antineutrino model. The measured IBD positron energy spectrum deviates from both spectral predictions by more than 2σ over the full energy range with a local significance of up to ∼4σ between 4-6 MeV. A reactor antineutrino spectrum of IBD reactions is extracted from the measured positron energy spectrum for model-independent predictions.

Published
2016
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4. New measurement of antineutrino oscillation with the full detector configuration at Daya Bay.

Author

An FP, Balantekin AB, Band HR, Bishai M, Blyth S, Butorov I, Cao GF, Cao J, Cen WR, Chan YL, Chang JF, Chang LC, Chang Y, Chen HS, Chen QY, Chen SM, Chen YX, Chen Y, Cheng JH, Cheng J, Cheng YP, Cherwinka JJ, Chu MC, Cummings JP, de Arcos J, Deng ZY, Ding XF, Ding YY, Diwan MV, Draeger E, Dwyer DA, Edwards WR, Ely SR, Gill R, Gonchar M, Gong GH, Gong H, Grassi M, Gu WQ, Guan MY, Guo L, Guo XH, Hackenburg RW, Han R, Hans S, He M, Heeger KM, Heng YK, Higuera A, Hor YK, Hsiung YB, Hu BZ, Hu LM, Hu LJ, Hu T, Hu W, Huang EC, Huang HX, Huang XT, Huber P, Hussain G, Jaffe DE, Jaffke P, Jen KL, Jetter S, Ji XP, Ji XL, Jiao JB, Johnson RA, Kang L, Kettell SH, Kramer M, Kwan KK, Kwok MW, Kwok T, Langford TJ, Lau K, Lebanowski L, Lee J, Lei RT, Leitner R, Leung KY, Leung JK, Lewis CA, Li DJ, Li F, Li GS, Li QJ, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin PY, Lin SK, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu DW, Liu H, Liu JL, Liu JC, Liu SS, Lu C, Lu HQ, Lu JS, Luk KB, Ma QM, Ma XY, Ma XB, Ma YQ, Martinez Caicedo DA, McDonald KT, McKeown RD, Meng Y, Mitchell I, Monari Kebwaro J, Nakajima Y, Napolitano J, Naumov D, Naumova E, Ngai HY, Ning Z, Ochoa-Ricoux JP, Olshevski A, Park J, Patton S, Pec V, Peng JC, Piilonen LE, Pinsky L, Pun CS, Qi FZ, Qi M, Qian X, Raper N, Ren B, Ren J, Rosero R, Roskovec B, Ruan XC, Shao BB, Steiner H, Sun GX, Sun JL, Tang W, Taychenachev D, Themann H, Tsang KV, Tull CE, Tung YC, Viaux N, Viren B, Vorobel V, Wang CH, Wang M, Wang NY, Wang RG, Wang W, Wang WW, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wen LJ, Whisnant K, White CG, Whitehead L, Wise T, Wong HL, Wong SC, Worcester E, Wu Q, Xia DM, Xia JK, Xia X, Xing ZZ, Xu JY, Xu JL, Xu J, Xu Y, Xue T, Yan J, Yang CG, Yang L, Yang MS, Yang MT, Ye M, Yeh M, Yeh YS, Young BL, Yu GY, Yu ZY, Zang SL, Zhan L, Zhang C, Zhang HH, Zhang JW, Zhang QM, Zhang YM, Zhang YX, Zhang YM, Zhang ZJ, Zhang ZY, Zhang ZP, Zhao J, Zhao QW, Zhao YF, Zhao YB, Zheng L, Zhong WL, Zhou L, Zhou N, Zhuang HL, and Zou JH

Abstract

We report a new measurement of electron antineutrino disappearance using the fully constructed Daya Bay Reactor Neutrino Experiment. The final two of eight antineutrino detectors were installed in the summer of 2012. Including the 404 days of data collected from October 2012 to November 2013 resulted in a total exposure of 6.9×10^{5} GW&#95;{th}  ton days, a 3.6 times increase over our previous results. Improvements in energy calibration limited variations between detectors to 0.2%. Removal of six ^{241}Am-^{13}C radioactive calibration sources reduced the background by a factor of 2 for the detectors in the experimental hall furthest from the reactors. Direct prediction of the antineutrino signal in the far detectors based on the measurements in the near detectors explicitly minimized the dependence of the measurement on models of reactor antineutrino emission. The uncertainties in our estimates of sin^{2}2θ&#95;{13} and |Δm&#95;{ee}^{2}| were halved as a result of these improvements. An analysis of the relative antineutrino rates and energy spectra between detectors gave sin^{2}2θ&#95;{13}=0.084±0.005 and |Δm&#95;{ee}^{2}|=(2.42±0.11)×10^{-3}  eV^{2} in the three-neutrino framework.

Published
2015
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5. Search for a light sterile neutrino at Daya Bay.

Author

An FP, Balantekin AB, Band HR, Beriguete W, Bishai M, Blyth S, Butorov I, Cao GF, Cao J, Chan YL, Chang JF, Chang LC, Chang Y, Chasman C, Chen H, Chen QY, Chen SM, Chen X, Chen X, Chen YX, Chen Y, Cheng YP, Cherwinka JJ, Chu MC, Cummings JP, de Arcos J, Deng ZY, Ding YY, Diwan MV, Draeger E, Du XF, Dwyer DA, Edwards WR, Ely SR, Fu JY, Ge LQ, Gill R, Gonchar M, Gong GH, Gong H, Grassi M, Gu WQ, Guan MY, Guo XH, Hackenburg RW, Han GH, Hans S, He M, Heeger KM, Heng YK, Hinrichs P, Hor YK, Hsiung YB, Hu BZ, Hu LM, Hu LJ, Hu T, Hu W, Huang EC, Huang H, Huang XT, Huber P, Hussain G, Isvan Z, Jaffe DE, Jaffke P, Jen KL, Jetter S, Ji XP, Ji XL, Jiang HJ, Jiao JB, Johnson RA, Kang L, Kettell SH, Kramer M, Kwan KK, Kwok MW, Kwok T, Lai WC, Lau K, Lebanowski L, Lee J, Lei RT, Leitner R, Leung A, Leung JK, Lewis CA, Li DJ, Li F, Li GS, Li QJ, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin PY, Lin SK, Lin YC, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu DW, Liu H, Liu JL, Liu JC, Liu SS, Liu YB, Lu C, Lu HQ, Luk KB, Ma QM, Ma XY, Ma XB, Ma YQ, McDonald KT, McFarlane MC, McKeown RD, Meng Y, Mitchell I, Monari Kebwaro J, Nakajima Y, Napolitano J, Naumov D, Naumova E, Nemchenok I, Ngai HY, Ning Z, Ochoa-Ricoux JP, Olshevski A, Patton S, Pec V, Peng JC, Piilonen LE, Pinsky L, Pun CS, Qi FZ, Qi M, Qian X, Raper N, Ren B, Ren J, Rosero R, Roskovec B, Ruan XC, Shao BB, Steiner H, Sun GX, Sun JL, Tam YH, Tang X, Themann H, Tsang KV, Tsang RH, Tull CE, Tung YC, Viren B, Vorobel V, Wang CH, Wang LS, Wang LY, Wang M, Wang NY, Wang RG, Wang W, Wang WW, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Webber DM, Wei HY, Wei YD, Wen LJ, Whisnant K, White CG, Whitehead L, Wise T, Wong HL, Wong SC, Worcester E, Wu Q, Xia DM, Xia JK, Xia X, Xing ZZ, Xu JY, Xu JL, Xu J, Xu Y, Xue T, Yan J, Yang CC, Yang L, Yang MS, Yang MT, Ye M, Yeh M, Yeh YS, Young BL, Yu GY, Yu JY, Yu ZY, Zang SL, Zeng B, Zhan L, Zhang C, Zhang FH, Zhang JW, Zhang QM, Zhang Q, Zhang SH, Zhang YC, Zhang YM, Zhang YH, Zhang YX, Zhang ZJ, Zhang ZY, Zhang ZP, Zhao J, Zhao QW, Zhao Y, Zhao YB, Zheng L, Zhong WL, Zhou L, Zhou ZY, Zhuang HL, and Zou JH

Abstract

A search for light sterile neutrino mixing was performed with the first 217 days of data from the Daya Bay Reactor Antineutrino Experiment. The experiment's unique configuration of multiple baselines from six 2.9 GW(th) nuclear reactors to six antineutrino detectors deployed in two near (effective baselines 512 m and 561 m) and one far (1579 m) underground experimental halls makes it possible to test for oscillations to a fourth (sterile) neutrino in the 10(-3) eV(2)<|Δm(41)(2) |< 0.3 eV(2) range. The relative spectral distortion due to the disappearance of electron antineutrinos was found to be consistent with that of the three-flavor oscillation model. The derived limits on sin(2) 2θ(14) cover the 10(-3) eV(2) ≲ |Δm(41)(2)| ≲ 0.1 eV(2) region, which was largely unexplored.

Published
2014
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6. Spectral measurement of electron antineutrino oscillation amplitude and frequency at Daya Bay.

Author

An FP, Balantekin AB, Band HR, Beriguete W, Bishai M, Blyth S, Brown RL, Butorov I, Cao GF, Cao J, Carr R, Chan YL, Chang JF, Chang Y, Chasman C, Chen HS, Chen HY, Chen SJ, Chen SM, Chen XC, Chen XH, Chen Y, Chen YX, Cheng YP, Cherwinka JJ, Chu MC, Cummings JP, de Arcos J, Deng ZY, Ding YY, Diwan MV, Draeger E, Du XF, Dwyer DA, Edwards WR, Ely SR, Fu JY, Ge LQ, Gill R, Gonchar M, Gong GH, Gong H, Gornushkin YA, Gu WQ, Guan MY, Guo XH, Hackenburg RW, Hahn RL, Han GH, Hans S, He M, Heeger KM, Heng YK, Hinrichs P, Hor Y, Hsiung YB, Hu BZ, Hu LJ, Hu LM, Hu T, Hu W, Huang EC, Huang HX, Huang HZ, Huang XT, Huber P, Hussain G, Isvan Z, Jaffe DE, Jaffke P, Jetter S, Ji XL, Ji XP, Jiang HJ, Jiao JB, Johnson RA, Kang L, Kettell SH, Kramer M, Kwan KK, Kwok MW, Kwok T, Lai WC, Lai WH, Lau K, Lebanowski L, Lee J, Lei RT, Leitner R, Leung A, Leung JK, Lewis CA, Li DJ, Li F, Li GS, Li QJ, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin SK, Lin YC, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu DW, Liu H, Liu JC, Liu JL, Liu SS, Liu YB, Lu C, Lu HQ, Luk KB, Ma QM, Ma XB, Ma XY, Ma YQ, McDonald KT, McFarlane MC, McKeown RD, Meng Y, Mitchell I, Nakajima Y, Napolitano J, Naumov D, Naumova E, Nemchenok I, Ngai HY, Ngai WK, Ning Z, Ochoa-Ricoux JP, Olshevski A, Patton S, Pec V, Peng JC, Piilonen LE, Pinsky L, Pun CS, Qi FZ, Qi M, Qian X, Raper N, Ren B, Ren J, Rosero R, Roskovec B, Ruan XC, Shao BB, Steiner H, Sun GX, Sun JL, Tam YH, Tanaka HK, Tang X, Themann H, Trentalange S, Tsai O, Tsang KV, Tsang RH, Tull CE, Tung YC, Viren B, Vorobel V, Wang CH, Wang LS, Wang LY, Wang LZ, Wang M, Wang NY, Wang RG, Wang W, Wang WW, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Webber DM, Wei H, Wei YD, Wen LJ, Whisnant K, White CG, Whitehead L, Wise T, Wong HL, Wong SC, Worcester E, Wu Q, Xia DM, Xia JK, Xia X, Xing ZZ, Xu J, Xu JL, Xu JY, Xu Y, Xue T, Yan J, Yang CG, Yang L, Yang MS, Ye M, Yeh M, Yeh YS, Young BL, Yu GY, Yu JY, Yu ZY, Zang SL, Zhan L, Zhang C, Zhang FH, Zhang JW, Zhang QM, Zhang SH, Zhang YC, Zhang YH, Zhang YM, Zhang YX, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao QW, Zhao YB, Zheng L, Zhong WL, Zhou L, Zhou ZY, Zhuang HL, and Zou JH

Abstract

A measurement of the energy dependence of antineutrino disappearance at the Daya Bay reactor neutrino experiment is reported. Electron antineutrinos (ν¯(e)) from six 2.9  GW(th) reactors were detected with six detectors deployed in two near (effective baselines 512 and 561 m) and one far (1579 m) underground experimental halls. Using 217 days of data, 41 589 (203 809 and 92 912) antineutrino candidates were detected in the far hall (near halls). An improved measurement of the oscillation amplitude sin(2)2θ(13)=0.090(-0.009)(+0.008) and the first direct measurement of the ν¯(e) mass-squared difference |Δm(ee)2|=(2.59(-0.20)(+0.19))×10(-3)  eV2 is obtained using the observed ν¯(e) rates and energy spectra in a three-neutrino framework. This value of |Δm(ee)2| is consistent with |Δm(μμ)2| measured by muon neutrino disappearance, supporting the three-flavor oscillation model.

Published
2014
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7. Observation of electron-antineutrino disappearance at Daya Bay.

Author

An FP, Bai JZ, Balantekin AB, Band HR, Beavis D, Beriguete W, Bishai M, Blyth S, Boddy K, Brown RL, Cai B, Cao GF, Cao J, Carr R, Chan WT, Chang JF, Chang Y, Chasman C, Chen HS, Chen HY, Chen SJ, Chen SM, Chen XC, Chen XH, Chen XS, Chen Y, Chen YX, Cherwinka JJ, Chu MC, Cummings JP, Deng ZY, Ding YY, Diwan MV, Dong L, Draeger E, Du XF, Dwyer DA, Edwards WR, Ely SR, Fang SD, Fu JY, Fu ZW, Ge LQ, Ghazikhanian V, Gill RL, Goett J, Gonchar M, Gong GH, Gong H, Gornushkin YA, Greenler LS, Gu WQ, Guan MY, Guo XH, Hackenburg RW, Hahn RL, Hans S, He M, He Q, He WS, Heeger KM, Heng YK, Hinrichs P, Ho TH, Hor YK, Hsiung YB, Hu BZ, Hu T, Hu T, Huang HX, Huang HZ, Huang PW, Huang X, Huang XT, Huber P, Isvan Z, Jaffe DE, Jetter S, Ji XL, Ji XP, Jiang HJ, Jiang WQ, Jiao JB, Johnson RA, Kang L, Kettell SH, Kramer M, Kwan KK, Kwok MW, Kwok T, Lai CY, Lai WC, Lai WH, Lau K, Lebanowski L, Lee J, Lee MK, Leitner R, Leung JK, Leung KY, Lewis CA, Li B, Li F, Li GS, Li J, Li QJ, Li SF, Li WD, Li XB, Li XN, Li XQ, Li Y, Li ZB, Liang H, Liang J, Lin CJ, Lin GL, Lin SK, Lin SX, Lin YC, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu BJ, Liu C, Liu DW, Liu H, Liu JC, Liu JL, Liu S, Liu X, Liu YB, Lu C, Lu HQ, Luk A, Luk KB, Luo T, Luo XL, Ma LH, Ma QM, Ma XB, Ma XY, Ma YQ, Mayes B, McDonald KT, McFarlane MC, McKeown RD, Meng Y, Mohapatra D, Morgan JE, Nakajima Y, Napolitano J, Naumov D, Nemchenok I, Newsom C, Ngai HY, Ngai WK, Nie YB, Ning Z, Ochoa-Ricoux JP, Oh D, Olshevski A, Pagac A, Patton S, Pearson C, Pec V, Peng JC, Piilonen LE, Pinsky L, Pun CS, Qi FZ, Qi M, Qian X, Raper N, Rosero R, Roskovec B, Ruan XC, Seilhan B, Shao BB, Shih K, Steiner H, Stoler P, Sun GX, Sun JL, Tam YH, Tanaka HK, Tang X, Themann H, Torun Y, Trentalange S, Tsai O, Tsang KV, Tsang RH, Tull C, Viren B, Virostek S, Vorobel V, Wang CH, Wang LS, Wang LY, Wang LZ, Wang M, Wang NY, Wang RG, Wang T, Wang W, Wang X, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Webber DM, Wei YD, Wen LJ, Wenman DL, Whisnant K, White CG, Whitehead L, Whitten CA Jr, Wilhelmi J, Wise T, Wong HC, Wong HL, Wong J, Worcester ET, Wu FF, Wu Q, Xia DM, Xiang ST, Xiao Q, Xing ZZ, Xu G, Xu J, Xu J, Xu JL, Xu W, Xu Y, Xue T, Yang CG, Yang L, Ye M, Yeh M, Yeh YS, Yip K, Young BL, Yu ZY, Zhan L, Zhang C, Zhang FH, Zhang JW, Zhang QM, Zhang K, Zhang QX, Zhang SH, Zhang YC, Zhang YH, Zhang YX, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao QW, Zhao YB, Zheng L, Zhong WL, Zhou L, Zhou ZY, Zhuang HL, and Zou JH

Abstract

The Daya Bay Reactor Neutrino Experiment has measured a nonzero value for the neutrino mixing angle θ(13) with a significance of 5.2 standard deviations. Antineutrinos from six 2.9 GWth reactors were detected in six antineutrino detectors deployed in two near (flux-weighted baseline 470 m and 576 m) and one far (1648 m) underground experimental halls. With a 43,000 ton-GWth-day live-time exposure in 55 days, 10,416 (80,376) electron-antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to expected number of antineutrinos at the far hall is R=0.940±0.011(stat.)±0.004(syst.). A rate-only analysis finds sin(2)2θ(13)=0.092±0.016(stat.)±0.005(syst.) in a three-neutrino framework.

Published
2012
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8. 4D-Imaging of the lung: reproducibility of lesion size and displacement on helical CT, MRI, and cone beam CT in a ventilated ex vivo system.

Author

Biederer J, Dinkel J, Remmert G, Jetter S, Nill S, Moser T, Bendl R, Thierfelder C, Fabel M, Oelfke U, Bock M, Plathow C, Bolte H, Welzel T, Hoffmann B, Hartmann G, Schlegel W, Debus J, Heller M, and Kauczor HU

Subjects
Animals, Cone-Beam Computed Tomography methods, Equipment Design, Magnetic Resonance Imaging methods, Observer Variation, Particle Accelerators, Phantoms, Imaging, Reproducibility of Results, Swine, Tomography, Spiral Computed methods, Lung diagnostic imaging, Lung pathology, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology, Movement, Multiple Pulmonary Nodules diagnostic imaging, Multiple Pulmonary Nodules pathology, Respiration
Abstract

Purpose: Four-dimensional (4D) imaging is a key to motion-adapted radiotherapy of lung tumors. We evaluated in a ventilated ex vivo system how size and displacement of artificial pulmonary nodules are reproduced with helical 4D-CT, 4D-MRI, and linac-integrated cone beam CT (CBCT)., Methods and Materials: Four porcine lungs with 18 agarose nodules (mean diameters 1.3-1.9 cm), were ventilated inside a chest phantom at 8/min and subject to 4D-CT (collimation 24 x 1.2 mm, pitch 0.1, slice/increment 24 x 10(2)/1.5/0.8 mm, pitch 0.1, temporal resolution 0.5 s), 4D-MRI (echo-shared dynamic three-dimensional-flash; repetition/echo time 2.13/0.72 ms, voxel size 2.7 x 2.7 x 4.0 mm, temporal resolution 1.4 s) and linac-integrated 4D-CBCT (720 projections, 3-min rotation, temporal resolution approximately 1 s). Static CT without respiration served as control. Three observers recorded lesion size (RECIST-diameters x/y/z) and axial displacement. Interobserver- and interphase-variation coefficients (IO/IP VC) of measurements indicated reproducibility., Results: Mean x/y/z lesion diameters in cm were equal on static and dynamic CT (1.88/1.87; 1.30/1.39; 1.71/1.73; p > 0.05), but appeared larger on MRI and CBCT (2.06/1.95 [p < 0.05 vs. CT]; 1.47/1.28 [MRI vs. CT/CBCT p < 0.05]; 1.86/1.83 [CT vs. CBCT p < 0.05]). Interobserver-VC for lesion sizes were 2.54-4.47% (CT), 2.29-4.48% (4D-CT); 5.44-6.22% (MRI) and 4.86-6.97% (CBCT). Interphase-VC for lesion sizes ranged from 2.28% (4D-CT) to 10.0% (CBCT). Mean displacement in cm decreased from static CT (1.65) to 4D-CT (1.40), CBCT (1.23) and MRI (1.16)., Conclusions: Lesion sizes are exactly reproduced with 4D-CT but overestimated on 4D-MRI and CBCT with a larger variability due to limited temporal and spatial resolution. All 4D-modalities underestimate lesion displacement.

Published
2009
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9. Linac-integrated 4D cone beam CT: first experimental results.

Author

Dietrich L, Jetter S, Tücking T, Nill S, and Oelfke U

Subjects
Algorithms, Humans, Imaging, Three-Dimensional instrumentation, Models, Theoretical, Movement physiology, Phantoms, Imaging, Reproducibility of Results, Tomography, X-Ray Computed instrumentation, Imaging, Three-Dimensional methods, Radiographic Image Enhancement methods, Radiography, Thoracic methods, Respiratory Mechanics, Tomography, X-Ray Computed methods
Abstract

A new online imaging approach, linac-integrated cone beam CT (CBCT), has been developed over the past few years. It has the advantage that a patient can be examined in their treatment position directly before or during a radiotherapy treatment. Unfortunately, respiratory organ motion, one of the largest intrafractional organ motions, often leads to artefacts in the reconstructed 3D images. One way to take this into account is to register the breathing phase during image acquisition for a phase-correlated image reconstruction. Therefore, the main focus of this work is to present a system which has the potential to investigate the correlation between internal (movement of the diaphragm) and external (data of a respiratory gating system) information about breathing phase and amplitude using an inline CBCT scanner. This also includes a feasibility study about using the acquired information for a respiratory-correlated 4D CBCT reconstruction. First, a moving lung phantom was used to develop and to specify the required methods which are based on an image reconstruction using only projections belonging to a certain moving phase. For that purpose, the corresponding phase has to be detected for each projection. In the case of the phantom, an electrical signal allows one to track the movement in real time. The number of projections available for the image reconstruction depends on the breathing phase and the size of the position range from which projections should be used for the reconstruction. The narrower this range is, the better the inner structures can be located, but also the noise of the images increases due to the limited number of projections. This correlation has also been analysed. In a second step, the methods were clinically applied using data sets of patients with lung tumours. In this case, the breathing phase was detected by an external gating system (AZ-733V, Anzai Medical Co.) based on a pressure sensor attached to the patient's abdominal region with a fixation belt. The comparison of the reconstructed 4D CBCT images and the corresponding 4D CT images used for the treatment planning provides the required information for the calculation of possible setup errors. So, a repositioning of the patient is feasible even though the patient moves due to respiration. In addition to the external signal, the position of the diaphragm in the cranial-caudal direction could be extracted from each projection. Both independent sources of information show a very good agreement of the phase and even the amplitude of the movement and the external signal respectively. This suggests the usability of such a system for a gated dose delivery approach. However, more studies involving patients with different incidences have to be carried out to confirm these first results.

Published
2006
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10. Cryopreservation of peripheral blood progenitor cells: characteristics of suitable techniques.

Author

Sputtek A, Jetter S, Hummel K, and Kühnl P

Subjects
Cell Survival drug effects, Colony-Forming Units Assay, Cryoprotective Agents pharmacology, Dimethyl Sulfoxide pharmacology, Dose-Response Relationship, Drug, Granulocytes drug effects, Hematologic Neoplasms blood, Humans, Hydroxyethyl Starch Derivatives pharmacology, Macrophages drug effects, Blood Preservation methods, Cryopreservation methods, Hematopoietic Stem Cell Transplantation, Leukapheresis
Abstract

The influence of 6 different cooling rates (1.4, 5, 10, 15, 20, 160 K/min) and 5 different compositions of the suspensions to be frozen (% DMSO/% HES: 10/0, 7.5/2.5, 5/6, 2.5/7.5, 0/10) were investigated in 30 aliquots from each of 12 peripheral blood progenitor cells (PBSC) products which had been obtained by leukapheresis from 11 patients with hematological malignancies and solid tumors and 1 healthy donor treated with 5-24 micrograms/kg body weight/day granulocyte colony stimulating factor (G-CSF) over 5 days. The MNC concentration in the products obtained amounted to 4.51 +/- 1.55 x 10(7)/ml (mean +/- SEM), range: 2.10-7.65 x 10(7)/ml). For freezing, cooling rates were generated by means of a liquid nitrogen(LN2)-operated, computer-controlled freezer, a mechanical -80 degrees C freezer, in the vapor phase over LN2, and by submerging into LN2. The statistical analysis of the results clearly indicates that optimum results compared with the prefreeze values for numerical recovery (80.6 +/- 20.1%, Coulter counter), viability (membrane integrity by Trypan blue exclusion 91.6 +/- 4.1%), and colony-forming potential (56.2 +/- 45.8% erythroid burst-forming units [BFU-E], 63.4 +/- 72.8% myeloid colonies [CFU-GM]) were achieved at a cooling rate of 1.4 K/min with 10% DMSO being present. The values obtained at a cooling rate of 5 K/min (-80 degrees C mechanical refrigerator) in the presence of 5% DMSO and 6% HES did not differ significantly (i.e., membrane integrity 91.8 +/- 3.9%, BFU-E 53.0 +/- 37.4%, CFU-GM 47.8 +/- 58.2%). At cooling rates above 5 K/min and DMSO concentrations lower than 5% (in spite of higher HES concentrations) there was a significant drop of CFU recovery (CFU-GM plus BFU-E) to almost 0%. In parallel, numerical recovery and viability dropped as well, but less pronounced, indicating that both methods are unsuitable for the prediction of CFU recovery when different freezing protocols are applied. We need at least 5% DMSO (in the presence of 6% HES) in spite of the undesirable histamine-releasing effect of this compound. The cooling rate is not critical in the range from 1 to 5 K/min and can easily be achieved by -80 degrees C freezers.

Published
1997

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