1. Induction of Lumbar Disc Degeneration in Rabbits Through a Transabdominal Approach.
- Author
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Yang K, Li J, Rudd S, Zhao R, Song Z, Jia D, Ding W, Wu Z, and Yang S
- Subjects
- Animals, Rabbits, Reproducibility of Results, Disease Models, Animal, Spinal Puncture adverse effects, Intervertebral Disc Degeneration diagnostic imaging, Intervertebral Disc Degeneration surgery, Intervertebral Disc Degeneration pathology, Intervertebral Disc diagnostic imaging, Intervertebral Disc surgery, Low Back Pain pathology
- Abstract
Lower back pain is an extremely common medical issue in populations worldwide. One of the main contributors to lower back pain is intervertebral disc (IVD) degeneration. An ideal animal model of IVD degeneration is essential to study the pathophysiology of lower back pain and investigate potential therapeutic strategies. Rabbit models are reliable, economical, and easily established animal models. The retroperitoneal approach has been widely used to induce IVD degeneration in rabbit models. However, there are reported complications associated with this technique, such as the avulsion of segmental arteries and nerve root injury. In this paper, we aim to show a surgical protocol using needle puncture to establish rabbit lumbar disc degeneration via a transabdominal approach. Consequently, radiological checks and histological analyses indicated that lumbar disc degeneration was successfully established in rabbits. This surgical protocol presents the precise location of target discs and high reproducibility of IVD degeneration models with fewer complications.
- Published
- 2023
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