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The Late Devonian magmatism of the Dananhu arc belt in the Central Asian Orogenic Belt provides a critical geological record. This study provides new comprehensive geochronological, geochemical, and Sr-Nd isotopic data of granodioritic and dioritic intrusions in the Dananhu belt. These findings contribute to unraveling the regional tectonic history and constraining the geodynamic processes involved. Zircon U-Pb dating indicates that the granodiorites and diorites were formed at 382.7 ± 3.8Ma and 363.1 ± 4.3Ma, respectively. The granodiorites show characteristics similar to I-type granites with high SiO 2 , low MgO and Mg # and aluminium saturation index (<1.1), negligible Eu anomalies, low (K 2 O + Na 2 O)/CaO ratios and zircon saturation temperatures (average = 696 °C). Granodiorites also show depleted isotope signatures (ε Nd(t)  = +5.85 to +6.27 and low ( 87 Sr/ 86 Sr) i  = 0.704082-0.704583) and juvenile T DM ages (741-793Ma), indicating their origin from a juvenile crust. The diorites are characterized by enrichments in large ion lithophile elements, U and Pb, but depleted in Nb and Ta displaying typical geochemical features of a subduction-related origin, together with high ε Nd(t) (+6.10 to +6.84) and low initial Sr isotopes (0.703745-0.704601), suggesting that they originated from a subduction fluid modified depleted mantle. The petrogenesis of both granodiorites and diorites in the Dananhu arc provides evidence that they formed through magmatic processes in a subduction tectonic setting. Considering the adakites associated with slab melting from previous studies in the Dananhu arc, it is plausible that the north-dipping subduction of the North Tianshan oceanic lithosphere have contributed to the Dananhu arc magmatism during the Late Devonian., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Huifei Tao reports financial support was provided by National Natural Science Foundation of China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)