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The use of high-energy radiation generated by electron collisions with a laser pulse is an effective method to treat cancer. In this paper, the spatial properties of radiation produced by electron collisions with a tightly focused linearly polarized laser pulse are investigated. Theoretical derivations and numerical simulations within the framework of classical electrodynamics show that the stronger the laser intensity, the higher the initial electron energy, and the longer the laser pulse, which can produce greater radiation power. An increase in the laser intensity expands the range of electron radiation and therefore reduces the collimation of the radiation. The collimation in the radiation is better when colliding with an electron of higher initial energy. The phenomenon that the radiated power of the electron varies periodically with the initial phase of the laser is also found. The results of this paper have important implications to produce strongly radiating and highly collimated rays.

Using an ultra-high-energy ( γ ⩾1000) electron to collide with laser pulses to generate high-energy γ -rays is an important way to treat cancer. We investigate a method for modulating high-energy γ -rays with higher energy and more collimation using tightly focused circularly polarized laser pulses colliding with an ultra-high-energy electron. Theoretical derivation and numerical simulation within the framework of classical electrodynamics show that higher electron initial energy, stronger laser intensity, and a longer pulse can generate higher γ -ray energy. The high-energy γ -rays generated by an electron with higher initial energies are more collimated. The increase of the laser intensity and the increase of the pulse width will increase the angular range of the high-energy γ -rays. At the same time, the phenomenon of the "jumping point," in which the radiation energy varies with the laser intensity, was found. Our findings have important implications for modulating better high-energy γ -ray sources.

The radiation character of nonlinear Thomson scattering is investigated in the interaction of Lagueree-Gaussian circularly polarized laser pulses with a single electron in the angular plane. With theoretical analysis and numerical calculation, it is shown that the angular radiation distributions have annular structures with great fourfold or plane symmetry in pulses characterized by comparatively lower laser intensity (a 0 < 6), prolonged pulse duration (τ > 50fs)or wide beam waist (b 0 > 5μm). In other circumstances, a vortex radiation pattern is found for the first time on the basis of the electron dynamics. Further, by increasing the initial phase of laser pulse, the overall angular radiation has an interesting counter-clockwise rotating trend with a cycle of Δξ 0  = 2π. These results would help the understanding of nonlinear Thomson scattering and push forward the research of twisted X/γ-ray generation in optical laboratory.

Osteosarcoma is among the commonly observed malignancies worldwide. High-mobility group box 1 protein (HMGB1) is a highly conserved protein and is involved in the progression of various types of human cancer. The aim of the present study was to explore whether the level of HMGB1 was involved in the necrosis of osteosarcoma cells. Doxorubicin (DXR), as an inducer of necrosis, was administered to human osteosarcoma cell lines (MG63, Saos-2 and U2OS), and the results indicated that 0.5 µg/ml DXR significantly induced the necrosis of MG63 cells (P<0.01), while 0.5 and 1.0 µg/ml DXR suppressed the viability of MG63 and U2OS cells (P<0.05), relative to untreated controls. Additionally, treatment with DXR was observed by western blot analysis to markedly increase the expression levels of HMGB1 in MG63 cells, and to significantly increase the levels of secreted HMGB1 in the supernatants of MG63 and U2OS cells (P<0.01). In conclusion, cell necrosis increased the level of HMGB1 in osteosarcoma cells, as well as the level of secreted HMGB1 in cell supernatants. Therefore, HMGB1 may be a potential target in molecular therapy for patients with osteosarcoma.

Based on the scalar diffraction theory, the propagation and focusing properties of a hard-edged diffracted beam generated by a Gaussian mirror resonator were investigated. Explicit expressions for the field distribution of the truncated beam that propagates through a paraxial optical ABCD system were derived in detail. Numerical examples are given to illustrate our analytical results.

The far-field intensity distribution (FFID) of a beam generated by a phase-unifying mirror resonator was investigated based on scalar diffraction theory. Attention was paid to the parameters, such as obscuration ratio and reflectivity of the phase-unifying mirror, that determine the FFID. All analyses were limited to the TEM00 fundamental mode.