21 results on '"Topham, Christina"'
Search Results
2. A Patient-Reported Historical Disease Course and Flare Frequency in Adults With Moderate-to-Severe Atopic Dermatitis-A Pilot Study.
- Author
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Grinich EE, Dizon MP, Topham C, Chung J, and Simpson EL
- Subjects
- Humans, Adult, Pilot Projects, Disease Progression, Patient Reported Outcome Measures, Dermatitis, Atopic
- Abstract
Competing Interests: E.L.S. reports personal fees from AbbVie, Amgen, Arena Pharmaceuticals, Aslan Pharma, Boston Consulting Group, Collective Acumen, LLC (CA), Dermira, Eli Lilly, Evidera, ExcerptaMedica, Forte Bio RX, Galderma, GlaxoSmithKline, Incyte, Janssen, Kyowa Kirin Pharmaceutical Development, Leo Pharm, Medscape LLC, Pfizer, Physicians World LLC, Regeneron, Sanofi-Genzyme, Trevi therapeutics, and WebMD. These potential conflicts of interest have been reviewed and managed by OHSU. E.L.S. reports grants (or a principal investigator role) from AbbVie, Amgen, Arcutis, Aslan, Corevita, Dermira, Eli Lilly, Incyte, Kyowa Hakko Kirin, Leo Pharmaceuticals, Merck, Novartis, Pfizer, Regeneron, Sanofi, and TARGET-DERM. These potential conflicts of interest have been reviewed and managed by OHSU. The other authors have no funding or conflicts of interest to declare.
- Published
- 2022
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3. Validity of the Skindex Mini in Patients With Atopic Dermatitis.
- Author
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Dizon MP, Topham C, Haynes D, Brazil M, Chren MM, and Simpson E
- Subjects
- Humans, Surveys and Questionnaires, Quality of Life, Dermatitis, Atopic
- Abstract
Competing Interests: M.M.C. holds a copyright for the Skindex Mini. The remaining authors have no conflicts of interest to declare.
- Published
- 2022
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4. Painful thickened skin on the soles of the feet.
- Author
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Nicholson LT, Topham C, Curtis J, and Madigan LM
- Abstract
Competing Interests: None disclosed.
- Published
- 2022
- Full Text
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5. Paraneoplastic Dermatomyositis.
- Author
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Orton C, Topham C, and Madigan LM
- Subjects
- Autoantibodies, Humans, Dermatomyositis complications, Dermatomyositis diagnosis, Paraneoplastic Syndromes diagnosis, Paraneoplastic Syndromes etiology
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- 2022
- Full Text
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6. Low-dose methotrexate in dermatology: the utility of serological monitoring in a real-world cohort.
- Author
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Hajar T, Latour EJ, Haynes D, Topham C, Hill EE, Simpson EL, and Greiling TM
- Subjects
- Aspartate Aminotransferases, Cohort Studies, Humans, Retrospective Studies, Dermatology, Methotrexate adverse effects
- Abstract
When prescribing low-dose methotrexate, frequent serological testing is recommended in the dermatologic literature, although much of the supporting data is extrapolated from non-dermatologic conditions. We performed a retrospective cohort study to determine the cumulative incidence and timing of low-dose methotrexate-associated serological abnormalities over the first year of therapy, in a pragmatic cohort of patients with dermatologic compared to non-dermatologic diagnoses. Laboratory values recorded included white blood cell count, hemoglobin, platelet count, estimated glomerular filtration rate, alanine aminotransferase, and aspartate aminotransferase. Among 1376 patients, there were no cases of methotrexate-associated grade 4/very severe lab abnormality or fatality. Baseline risk factors associated with moderate-to-severe lab abnormalities included non-dermatologic diagnoses, low hemoglobin, low estimated glomerular filtration rate, and elevated transaminases. The incidence of moderate-to-severe lab abnormalities was 4.4% among all patients, 3.1% among patients with dermatologic diagnoses, and 2.3% among patients with normal baseline lab values. Lab abnormalities led to discontinuation of therapy in 0.8% of patients. Serious changes did not occur in the first two weeks of therapy. We conclude that the cumulative incidence of low-dose methotrexate-associated lab abnormality was lower in patients with dermatologic diagnoses or normal baseline testing and these factors may be used to adjust monitoring practices.
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- 2022
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7. Pityriasis Rubra Pilaris Response to IL-17A Inhibition Is Associated with IL-17C and CCL20 Protein Levels.
- Author
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Strunck JL, Cutler B, Rajpal B, Kent G, Haynes D, Topham CA, Ortega-Loayza AG, Yang D, Wang Z, Liu Y, Cassidy P, and Greiling TM
- Subjects
- Adult, Female, High-Throughput Screening Assays, Humans, Inflammation Mediators metabolism, Male, Middle Aged, Pityriasis Rubra Pilaris drug therapy, Proteomics, Anti-Inflammatory Agents therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Chemokine CCL20 metabolism, Interleukin-17 metabolism, Pityriasis Rubra Pilaris immunology, Skin pathology
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- 2022
- Full Text
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8. Patient Experience Surveys Reveal Gender-Biased Descriptions of Their Care Providers.
- Author
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Haynes D, Pampari A, Topham C, Schwarzenberger K, Heath M, Zou J, and Greiling TM
- Subjects
- Female, Humans, Male, Patient Outcome Assessment, Patient Satisfaction, Retrospective Studies, Surveys and Questionnaires, Delivery of Health Care, Health Personnel
- Abstract
Patient experience surveys (PES) are collected by healthcare systems as a surrogate marker of quality and published unedited online for the purpose of transparency, but these surveys may reflect gender biases directed toward healthcare providers. This retrospective study evaluated PES at a single university hospital between July 2016 and June 2018. Surveys were stratified by overall provider rating and self-identified provider gender. Adjectives from free-text survey comments were extracted using natural language processing techniques and applied to a statistical machine learning model to identify descriptors predictive of provider gender. 109,994 surveys were collected, 17,395 contained free-text comments describing 687 unique providers. The mean overall rating between male (8.84, n = 8558) and female (8.80, n = 8837) providers did not differ (p = 0.149). However, highly-rated male providers were more often described for their agentic qualities using adjectives such as "informative," "forthright," "superior," and "utmost" (OR 1.48, p < 0.01)-whereas highly-rated female providers were more often described by their communal qualities through adjectives such as "empathetic," "sweet," "warm," "attentive," and "approachable" (OR 2.11, p < 0.0001). PES may contain gender stereotypes, raising questions about their impact on physicians and their validity as a quality metric which must be balanced with the need for unedited transparency. Future prospective studies are needed to further characterize this trend across geographically and racially diverse healthcare providers., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2021
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9. Validation of a novel patient-operated device for measuring skin barrier function in atopic dermatitis.
- Author
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Grinich EE, Topham C, Haynes D, Chung J, Latour E, and Simpson EL
- Subjects
- Humans, Reproducibility of Results, Skin metabolism, Water Loss, Insensible, Dermatitis, Atopic diagnosis, Eczema
- Abstract
Background: Transepidermal water loss (TEWL) and capacitance are used in atopic dermatitis (AD) trials to provide objective data on clinical change and response to therapy. Many barrier devices are costly, limiting their utility. GPSkin is a novel low-cost, patient-operable device that measures both TEWL and capacitance via smartphone application., Objective: This validation study investigated the correlation of GPSkin with the AquaFlux and Corneometer, and the reliability of these devices, in patients with AD., Methods: Fifty AD patients with varying disease severity performed self-measurements with GPSkin, while investigators collected data with all 3 devices, on both nonlesional and lesional skin., Conclusion: GPSkin and AquaFlux demonstrated strong correlation for TEWL on nonlesional and lesional skin by Spearman's correlation (r
s ), independent of device user. For capacitance, GPSkin and the Corneometer showed moderate correlation when obtained by patients, yet a strong correlation when obtained by a clinician. Despite good correlation, GPSkin showed poor agreement with both the AquaFlux and Corneometer in Bland-Altman plots. GPSkin underestimated both TEWL and capacitance. Overall, the devices had good test-retest reliability. None of the devices could discriminate between AD severity states. While GPSkin marks an exciting advancement in barrier technology, further study is needed for validation on AD skin., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)- Published
- 2021
- Full Text
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10. Mucosal linear IgA disease with esophageal involvement responsive to ustekinumab.
- Author
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Jimenez A, Topham C, Varedi D, Leiferman KM, and Hull C
- Abstract
Competing Interests: None disclosed.
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- 2021
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11. Inverse Correlation of TRIM32 and Protein Kinase C ζ in T Helper Type 2-Biased Inflammation.
- Author
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Wang Z, Yoo YJ, De La Torre R, Topham C, Hanifin J, Simpson E, Messing RO, Kulesz-Martin M, and Liu Y
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- Animals, Cell Differentiation, Mice, Mice, Inbred C57BL, Th2 Cells cytology, Ubiquitination, Dermatitis, Atopic etiology, Protein Kinase C physiology, Th2 Cells immunology, Ubiquitin-Protein Ligases physiology
- Abstract
Atopic dermatitis (AD) is a T helper (Th)2-biased disease with elevated expression of Th2 cytokines that responds to Th2 signaling blockade. TRIM32 is an E3 ubiquitin ligase with innate antiviral activity. In our previous studies, we showed that Trim32 null mice developed Th2-biased skin inflammation in response to imiquimod and associated a low level of TRIM32 with AD. In this study, we provide evidence that TRIM32 deficiency contributes to enhanced Th2 cell differentiation in vitro. Analysis of TRIM32-associated proteins from public databases identified protein kinase C (PKC)ζ as a TRIM32-associated protein that contributes to the regulation of Th2 signaling. We demonstrated that PKCζ was specifically ubiquitinated by TRIM32 and, further, that PKCζ stability tended to be increased in Th2 cells with a Trim32 null background. Furthermore, Prkcz null mice showed compromised AD-like phenotypes in the MC903 AD model. Consistently, a high PKCζ and low TRIM32 ratio was associated with CD4+ cells in AD human skin compared with those in healthy controls. Taken together, these findings suggest that TRIM32 functions as a regulator of PKCζ that controls the differentiation of Th2 cells important for AD pathogenesis., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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12. Dupilumab-Associated Ocular Surface Disease: Clinical Characteristics, Treatment, and Follow-Up.
- Author
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Bohner A, Topham C, Strunck J, Haynes D, Brazil M, Clements J, Simpson E, and Chamberlain W
- Subjects
- Adolescent, Adult, Aged, Anti-Allergic Agents therapeutic use, Child, Conjunctivitis chemically induced, Conjunctivitis drug therapy, Eye Pain chemically induced, Eye Pain drug therapy, Female, Follow-Up Studies, Glucocorticoids therapeutic use, Humans, Keratitis chemically induced, Keratitis drug therapy, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Tacrolimus therapeutic use, Treatment Outcome, Antibodies, Monoclonal, Humanized adverse effects, Conjunctivitis diagnosis, Dermatitis, Atopic drug therapy, Eye Pain diagnosis, Keratitis diagnosis
- Abstract
Purpose: A consecutive case series of patients with dupilumab-associated ocular surface disease (DAOSD) that describes common ocular symptoms and signs, proposes a symptom disease severity grading system, and describes treatment strategies of DAOSD patients was evaluated., Methods: A retrospective chart review of patients with concomitant dupilumab-treated atopic dermatitis and DAOSD with ophthalmic evaluation between January 2014 and May 2019 was conducted., Results: Twenty-nine patients (mean age 46 years, M/F: 12/17) with 57 ophthalmic exams were identified. The most common ocular symptoms included irritation/pain (n = 28, 97%), redness (n = 24, 83%), pruritus (n = 18, 62%), discharge (n = 18, 62%), and light sensitivity (n = 6, 21%). The most frequent signs included conjunctival injection (n = 18, 62%), superficial punctate keratitis (n = 16, 55%), and papillary reaction (n = 8, 28%). Topical corticosteroids (TCS) (n = 23, 79%), tacrolimus (n = 6, 21%), and artificial tears (n = 7, 24%) were the most commonly used therapies. Of those with follow-up documentation (n = 21), 20 were noted to have partial or complete response with TCS based on symptoms and reduction of signs. Using our proposed symptom-based grading scale, scaled 1 to 5 based on the presence of common symptoms listed above, 66% (n = 19) requiring topical immunomodulating therapy were found in the 'severe' group (≥3 symptoms) and 17% (n = 5) were found in the 'mild' group (≤2 symptoms)., Conclusions: This study provides insight into the commonly presenting ocular signs and symptoms associated with DAOSD and highlights the efficacy of TCS and other immunomodulators in improving symptoms associated with DAOSD. Based on our findings, we propose a symptom-based grading system that can guide nonophthalmic physicians regarding ophthalmology consult., Competing Interests: Eric Simpson is a consultant and investigator for Regeneron and Sanofi. The remaining authors have no conflicts of interest to disclose., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
13. Association between halo nevi and melanoma in adults: A multicenter retrospective case series.
- Author
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Haynes D, Strunck JL, Said J, Tam I, Varedi A, Topham CA, Olamiju B, Wei BM, Erickson MK, Wang LL, Tan A, Stoner R, Hartman RI, Lilly E, Grossman D, Curtis JA, Westerdahl JS, Leventhal JS, Choi JN, Chu EY, Ming ME, Stein JA, Liebman TN, Berry E, and Greiling TM
- Subjects
- Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Young Adult, Melanoma diagnosis, Neoplasms, Second Primary diagnosis, Nevus, Halo diagnosis, Skin Neoplasms diagnosis
- Published
- 2021
- Full Text
- View/download PDF
14. Initial validation of the product of the signs global assessment and body surface area in atopic dermatitis.
- Author
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Topham C, Haynes D, Brazil M, and Simpson E
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Feasibility Studies, Female, Humans, Male, Middle Aged, Northwestern United States, Retrospective Studies, Tertiary Care Centers, Young Adult, Body Surface Area, Dermatitis, Atopic diagnosis, Severity of Illness Index
- Abstract
Background: Current valid instruments that measure the signs of atopic dermatitis in clinical trials may not be suitable for clinical practice because of their complexity. The product of a clinician-derived 5-point signs global assessment and body surface area (SGA × BSA) may represent a simple approach to quickly assess the severity of signs in patients with atopic dermatitis in clinical practice., Objectives: Evaluate the basic measurement properties of the SGA × BSA., Methods: Retrospective chart review of patients with atopic dermatitis treated in an outpatient dermatology clinic at Oregon Health & Science University from 2015 to 2018 who had a recorded BSA and SGA., Results: We identified 138 patients completing 325 clinic visits. SGA × BSA demonstrated strong and statistically significant (P < .001) correlations with the Eczema Area and Severity Index (r = 0.91, n = 19), average daily pruritus (r = 0.71, n = 177), patient global assessment (r = 0.74, n = 170), and a derived global scale composed of the average of 4 signs rated between 0 and 3 (r = 0.77, n = 282). Acceptability, responsiveness, and floor or ceiling effects of the measure were deemed adequate. Severity banding was maximized at 1, 21, and 87 (κ = 0.4902)., Limitations: The patient cohort was gathered exclusively from a tertiary care clinic setting in the Pacific Northwest and lacked ethnic diversity., Conclusions: The results from this study suggest that SGA × BSA is a valid and feasible instrument for atopic dermatitis signs in clinical practice., (Copyright © 2020. Published by Elsevier Inc.)
- Published
- 2021
- Full Text
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15. Evaluation of Ixekizumab Treatment for Patients With Pityriasis Rubra Pilaris: A Single-Arm Trial.
- Author
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Haynes D, Strunck JL, Topham CA, Ortega-Loayza AG, Kent G, Cassidy PB, Hu R, Choate K, Wang Z, Liu Y, and Greiling TM
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- Adult, Antibodies, Monoclonal, Humanized adverse effects, CARD Signaling Adaptor Proteins genetics, DNA Mutational Analysis, Dermatologic Agents adverse effects, Female, Follow-Up Studies, Gain of Function Mutation, Guanylate Cyclase genetics, Humans, Interleukin-17 analysis, Interleukin-17 antagonists & inhibitors, Interleukin-17 metabolism, Male, Membrane Proteins genetics, Middle Aged, Pityriasis Rubra Pilaris diagnosis, Pityriasis Rubra Pilaris genetics, Pityriasis Rubra Pilaris pathology, Quality of Life, Severity of Illness Index, Skin drug effects, Skin metabolism, Skin pathology, Treatment Outcome, Antibodies, Monoclonal, Humanized administration & dosage, Dermatologic Agents administration & dosage, Pityriasis Rubra Pilaris drug therapy
- Abstract
Importance: Pityriasis rubra pilaris is a rare and disabling cutaneous disease that is frequently recalcitrant to conventional therapies and appears to involve interleukin (IL)-17 overexpression., Objective: To investigate the clinical response and safety of ixekizumab in treating pityriasis rubra pilaris., Design, Setting, and Participants: Single-arm, investigator-initiated trial conducted in adult patients with moderate to severe pityriasis rubra pilaris at a single-center academic university from June 2018 to January 2020. A total of 41 patients were screened, 12 were enrolled, and 11 completed the full duration of therapy. A referred, consecutive sample was used during participant selection. The treatment period and primary outcome occurred over 24 weeks with additional patient follow-up through 36 weeks., Intervention: Subcutaneous administration of ixekizumab, a humanized IgG4 antibody that binds IL-17A, at the US Food and Drug Administration-approved dosing schedule for treatment of psoriasis for 24 weeks., Main Outcomes and Measures: The primary outcome was the mean change in Psoriasis Area and Severity Index at 24 weeks. Secondary outcomes included change in affected body surface area, quality of life, induction of sustained remission, and association of improvement with CARD14 genetic variations and cutaneous cytokine expression., Results: A total of 12 white patients (mean [SD] age, 49.8 [15.1] years; 8 male [67%]) were enrolled between June 2018 and April 2019, with 11 completing the full course of intervention. The mean (SEM) improvements in Psoriasis Area and Severity Index, affected body surface area, and Dermatology Life Quality Index were 15.2 (2.1) (P < .0001), 29.8% (9.3%) (P = .009), and 9.5 (2.5) (P = .004), respectively. The 4 participants with the most improvement in Psoriasis Area and Severity Index at week 24 stayed in remission at week 36 (defined as lack of increase in Psoriasis Area and Severity Index from week 24 through week 36), off therapy. Relative dermal IL-17A expression decreased by a 1.9 log-fold change. No participants had known pathogenic CARD14 variations. There were no serious adverse events., Conclusions and Relevance: In this single-armed trial, ixekizumab was associated with reduced clinical signs and symptoms of pityriasis rubra pilaris in a subset of patients, including those in whom other systemic therapies have failed., Trial Registration: ClinicalTrials.gov Identifier: NCT03485976.
- Published
- 2020
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- View/download PDF
16. Field Therapy in Solid Organ Transplant Recipients: Are We Initiating Early Enough?
- Author
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Topham C, Haynes D, Hopkins RS, and Leitenberger J
- Subjects
- Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell etiology, Female, Humans, Keratosis, Actinic epidemiology, Keratosis, Actinic etiology, Male, Middle Aged, Oregon epidemiology, Retrospective Studies, Skin Neoplasms etiology, Surveys and Questionnaires, Organ Transplantation, Skin Neoplasms epidemiology, Transplant Recipients
- Abstract
Organ transplant recipients (OTRs) are at increased risk for more aggressive non-melanoma skin cancer (NMSC). Recent emphasis on field therapy has complimented the canonical surgical treatment paradigm. This retrospective analysis of survey responses by patients seen at Oregon Health and Science University from 2013-2018 offers insights into patient trends and practice gaps in caring for OTRs. All patients completed a 57-point questionnaire at their first clinic visit, which included questions regarding demographics, transplant history, dermatologic history, and use of field therapy. Of the 295 patients (mean age, 56 years; M/F: 193/102) who completed the questionnaire, field therapy was reported by 31 (11%) patients. Field therapy patients noted an overall higher AK and SCC burden, with a greater proportion of patients reporting >20 AKs and >10 SCCs. Field therapy use was sparse in the low AK/low SCC group (n=25) when compared to those reporting high AK/high SCC (n=11) burden (n=4 (16%) vs n=8 (73%), P<0.01). This data suggests that OTRs with several clinically evident AKs and/or a low number of SCCs are less likely to have been treated with field therapy modalities compared to OTRs who have developed >10 AKs or ≥6 SCCs. A delay in initiation of preventative measures or field therapy in this population, however, may be a missed opportunity for intervention. Early intervention with field therapy in particularly high-risk OTRs with a low skin cancer burden may mitigate future skin cancer development.J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.4759.
- Published
- 2020
17. Tofacitinib for the treatment of recalcitrant palmoplantar pustulosis: A case report.
- Author
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Haynes D, Topham C, Hagstrom E, and Greiling T
- Subjects
- Female, Humans, Middle Aged, Piperidines therapeutic use, Protein Kinase Inhibitors therapeutic use, Psoriasis drug therapy, Pyrimidines therapeutic use, Pyrroles therapeutic use
- Published
- 2020
- Full Text
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18. Ulcerative C2 neurocutaneous dysesthesia (trigeminal trophic syndrome in an alternative distribution).
- Author
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Haynes D, Topham C, Hajar T, Ortega-Loayza AG, White KP, and Keller JJ
- Subjects
- Aged, 80 and over, Diagnosis, Differential, Facial Dermatoses complications, Female, Humans, Paresthesia complications, Pruritus pathology, Skin Ulcer pathology, Syndrome, Facial Dermatoses pathology, Paresthesia pathology, Skin Ulcer etiology, Trigeminal Nerve
- Abstract
Trigeminal trophic syndrome is an uncommon condition characterized by paresthesia, itch, and self-inflicted wounds following the trigeminal dermatome(s). Similar processes adhering to cervical nerve distributions have been reported, calling into question the specificity of trigeminal trophic syndrome for the trigeminal network. Herein, we report patient with trigeminal trophic syndrome adhering to the C2 dermatome, a previously unreported distribution.
- Published
- 2020
19. Localization and age distribution of telangiectases in children and adolescents with hereditary hemorrhagic telangiectasia: A retrospective cohort study.
- Author
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Gonzalez CD, Cipriano SD, Topham CA, Stevenson DA, Whitehead KJ, Vanderhooft S, Presson AP, and McDonald J
- Subjects
- Activin Receptors, Type II genetics, Adolescent, Age Distribution, Child, Child, Preschool, Endoglin genetics, Female, Humans, Infant, Infant, Newborn, Male, Mouth, Retrospective Studies, Telangiectasia, Hereditary Hemorrhagic genetics, Face, Hand, Telangiectasia, Hereditary Hemorrhagic pathology
- Abstract
Background: The location of telangiectases in hereditary hemorrhagic telangiectasia (HHT), as set forth in the consensus diagnostic (Curaçao) criteria, is based primarily on adults., Objective: Document the locations and numbers of telangiectases in a cohort of pediatric patients with HHT., Methods: A retrospective chart review using a standardized data collection form for site and number of telangiectases was performed for pediatric patients with HHT (age, 0-18 years) from 2005 to 2016., Results: Of 90 pediatric patients with HHT, 71% had one or more telangiectases. Of all the telangiectases counted (N = 319), cutaneous telangiectases were more common (73%) than oral telangiectases (27%). The hands were the most frequent site, accounting for 33% of all telangiectases. Adolescents were more likely than children to have cutaneous telangiectases (85% vs 50% [Q = 0.005]). The most frequent sites in children younger than 10 years were the hands excluding the fingers (27%), fingers (25%), and face (23%). Only 23% of subjects (21 of 90) presented with multiple (≥3) telangiectases at locations considered characteristic for the current consensus diagnosis guidelines (lips, oral cavity, and fingers)., Limitations: Ascertainment bias based on recruitment., Conclusions: In this pediatric population, telangiectases at sites not included as "characteristic" by the Curaçao diagnostic criteria were common. The Curaçao criteria in regard to both number and location of telangiectases may be inadequate in the pediatric HHT population., (Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
20. Linear amyopathic dermatomyositis with calcinosis cutis responsive to topical sodium thiosulfate.
- Author
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Topham C, Haynes D, Frigerio A, and Hull C
- Subjects
- Administration, Topical, Adolescent, Biopsy, Needle, Calcinosis complications, Chronic Disease, Dermatomyositis complications, Dermatomyositis diagnosis, Humans, Immunohistochemistry, Leg Dermatoses diagnosis, Leg Dermatoses etiology, Male, Skin Diseases drug therapy, Skin Diseases pathology, Treatment Outcome, Calcinosis diagnosis, Dermatomyositis drug therapy, Dermatomyositis pathology, Thiosulfates therapeutic use
- Abstract
A case of a 15-year-old male patient with a 3-year history of linear, segmental amyopathic dermatomyositis with calcinosis cutis is presented. The calcinosis was recalcitrant to treatment with topical steroids and hydroxychloroquine. Topical 10% sodium thiosulfate use for 8 weeks resulted in improvement. The use of topical sodium thiosulfate for patients in whom surgical extraction is not an option is detailed., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
21. More than goosebumps: A case of marked skin dimpling in an infant.
- Author
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Topham C, Deacon DC, Bowen A, and Cipriano SD
- Subjects
- Humans, Infant, Male, Muscle Contraction, Muscle, Smooth, Skin Diseases diagnosis, Skin Diseases etiology
- Published
- 2019
- Full Text
- View/download PDF
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