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Thirty-six patients received an intravenous bolus injection of 2 g cefoxitin over 5 min at various times before abdominal or vaginal hysterectomy. Cefoxitin levels in myometrium and salpinges were substantially higher than those in endometrium and almost as high as those in serum during the first two hours following the i. v. administration of the drug. Tissue concentrations of 8 micrograms/g could be maintained for two hours. The cefoxitin tissue concentrations attained in myometrium, endometrium and salpinges justify controlled prospective clinical studies on the prevention of postoperative wound infections with this antibiotic.

In 30 patients with genital infections of different etiology and high fever lamoxactam was used as a single agent antibiotic. In 90% of the cases the treatment was successful. The antibiotic did not need to be changed in any of the cases. The determination of the lamoxactam concentration in the uterus and the fallopian tubes after a single dose of 2 grams pre-operatively at various times showed high tissue levels for a prolonged period of time. The concentrations were still higher 6 hours after the single dose than the in vitro MHK values for most bacteria important in gynaecological infections.