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Background: There are several studies that indicate that cancer development may be conditioned by the activation of some biological systems that involve the interaction of different biomolecules, such as adenosine and vascular endothelial growth factor. These biomolecules have been targeted of some drugs for treat of cancer; however, there is little information on the interaction of purine derivatives with adenosine and vascular endothelial growth factor receptor (VEGF-R1)., Objective: The aim of this research was to determine the possible interaction of purine (1: ) and their derivatives (2-31: ) with A 1 , A 2 -adenosine receptors, and VEGF-R1., Methods: Theoretical interaction of purine and their derivatives with A 1 , A 2 -adenosine receptors and VEGF-R1 was carried out using the 5uen, 5mzj and 3hng proteins as theoretical tools. Besides, adenosine, cgs-15943, rolofylline, cvt-124, wrc-0571, luf-5834, cvt-6883, AZD-4635, cabozantinib, pazopanib, regorafenib, and sorafenib drugs were used as controls., Results: The results showed differences in the number of aminoacid residues involved in the interaction of purine and their derivatives with 5uen, 5mzj and 3hng proteins compared with the controls. Besides, the inhibition constants (Ki) values for purine and their derivatives 5: , 9: , 10: , 14: , 15: , 16: , and 20: were lower compared with the controls CONCLUSIONS: Theoretical data suggest that purine and their derivatives 5: , 9: , 10: , 14: , 15: , 16: , and 20: could produce changes in cancer cell growth through inhibition of A 1 , A 2 -adenosine receptors and VEGFR-1 inhibition. These data indicate that these purine derivatives could be a therapeutic alternative to treat some types of cancer., Competing Interests: The authors declare that they have no conflict of interest with any public or private institution., (Thieme. All rights reserved.)

We have previously shown that bilingual Spanish and English-learning infants can segment English iambs, two-syllable words with final stress (e.g., guiTAR), earlier than their monolingual peers. This is consistent with accelerated development in bilinguals and was attributed to bilingual infants' increased exposure to iambs through Spanish; about 10% of English content words start with an unstressed syllable, compared to 40% in Spanish. Here, we evaluated whether increased exposure to a stress pattern alone is sufficient to account for acceleration in bilingual infants. In English, 90% of content words start with a stressed syllable (e.g., KINGdom), compared to 60% in Spanish. However, we found no evidence for accelerated segmentation of Spanish trochees by Spanish-English bilingual infants compared to their monolingual Spanish-learning peers. Based on this finding, we argue that merely increased exposure to a linguistic feature in one language does not result in accelerated development in the other. Instead, only the acquisition of infrequent patterns in one language may be accelerated due to the additive effects of the other language.

Heart failure is a health problem worldwide. There are some drugs for it, including digoxin, spironolactone, captopril, and valsartan, but some of these drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia, hyponatremia and hypotension. The aim of this research was to evaluate the biological activity of coumarin (2H-chromen-2-one) and its derivatives (3BrAcet-C, 3-4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against ischemia/reperfusion injury as a therapeutic alternative for heart failure. In addition, the biological activity of the coumarin derivative 4-Me-7-Ph-C on left ventricular pressure (LVP) was determined in the absence or presence of ouabain and nifedipine at a dose of 1 nM using an isolated rat heart model. The results showed that i ) the coumarin derivative 4-Me-7-Ph-C significantly decreased the infarct area ( p +=+0.05) compared with 3BrAcet-C, 3-4Br-Ph-C, 4-CN-7D-C, and 6Br-3-D-C; and ii ) 4-Me-7-Ph-C increased LVP in a dose-dependent manner, which effect was inhibited by nifedipine. These data suggest that coumarin 4-Me-7-Ph-C may act as a type-L calcium channel activator, so it could be a good agent to treat heart failure., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)

The evolution of 5G and 6G networks has enhanced the ability of massive IoT devices to provide real-time monitoring and interaction with the surrounding environment. Despite recent advances, the necessary security services, such as immediate and continuous authentication, high scalability, and cybersecurity handling of IoT cannot be achieved in a single broadcast authentication protocol. This paper presents a new hybrid protocol called Hybrid Two-level µ-timed-efficient stream loss-tolerant authentication (Hybrid TLI-µTESLA) protocol, which maximizes the benefits of the previous TESLA protocol variants, including scalability support and immediate authentication of Multilevel-µTESLA protocol and continuous authentication with minimal computation overhead of enhanced Inf-TESLA protocol. The inclusion of three different keychains and checking criteria of the packets in the Hybrid TLI-µTESLA protocol enabled resistance against Masquerading, Modification, Man-in-the-Middle, Brute-force, and DoS attacks. A solution for the authentication problem in the first and last packets of the high-level and low-level keychains of the Multilevel-µTESLA protocol was also proposed. The simulation analysis was performed using Java, where we compared the Hybrid TLI-µTESLA protocol with other variants for time complexity and computation overhead at the sender and receiver sides. We also conducted a comparative analysis between two hash functions, SHA-2 and SHA-3, and assessed the feasibility of the proposed protocol in the forthcoming 6G technology. The results demonstrated the superiority of the proposed protocol over other variants in terms of immediate and continuous authentication, scalability, cybersecurity, lifetime, network performance, and compatibility with 5G and 6G IoT generations.

Yarkoni's analysis clearly articulates a number of concerns limiting the generalizability and explanatory power of psychological findings, many of which are compounded in infancy research. ManyBabies addresses these concerns via a radically collaborative, large-scale and open approach to research that is grounded in theory-building, committed to diversification, and focused on understanding sources of variation.

We asked whether increased exposure to iambs, two-syllable words with stress on the second syllable (e.g., guitar), by way of another language - Spanish - facilitates English learning infants' segmentation of iambs. Spanish has twice as many iambic words (40%) compared to English (20%). Using the Headturn Preference Procedure we tested bilingual Spanish and English learning 8-month-olds' ability to segment English iambs. Monolingual English learning infants succeed at this task only by 11 months. We showed that at 8 months, bilingual Spanish and English learning infants successfully segmented English iambs, and not simply the stressed syllable, unlike their monolingual English learning peers. At the same age, bilingual infants failed to segment Spanish iambs, just like their monolingual Spanish peers. These results cannot be explained by bilingual infants' reliance on transitional probability cues to segment words in both their native languages because statistical cues were comparable in the two languages. Instead, based on their accelerated development, we argue for autonomous but interdependent development of the two languages of bilingual infants., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)

From the earliest months of life, infants prefer listening to and learn better from infant-directed speech (IDS) than adult-directed speech (ADS). Yet, IDS differs within communities, across languages, and across cultures, both in form and in prevalence. This large-scale, multi-site study used the diversity of bilingual infant experiences to explore the impact of different types of linguistic experience on infants' IDS preference. As part of the multi-lab ManyBabies 1 project, we compared lab-matched samples of 333 bilingual and 385 monolingual infants' preference for North-American English IDS (cf. ManyBabies Consortium, 2020: ManyBabies 1), tested in 17 labs in 7 countries. Those infants were tested in two age groups: 6-9 months (the younger sample) and 12-15 months (the older sample). We found that bilingual and monolingual infants both preferred IDS to ADS, and did not differ in terms of the overall magnitude of this preference. However, amongst bilingual infants who were acquiring North-American English (NAE) as a native language, greater exposure to NAE was associated with a stronger IDS preference, extending the previous finding from ManyBabies 1 that monolinguals learning NAE as a native language showed a stronger preference than infants unexposed to NAE. Together, our findings indicate that IDS preference likely makes a similar contribution to monolingual and bilingual development, and that infants are exquisitely sensitive to the nature and frequency of different types of language input in their early environments., Competing Interests: Conflicts of Interest The authors declare that there were no conflicts of interest with respect to the authorship or the publication of this article.

Objective: To record which interventions produce the greatest variations in body composition in patients ≤19 years old with metabolic syndrome (MS)., Method: search dates between 2005 and 2017 in peer reviewed journals, following the PRISMA method (Preferred Reporting Items for Systematic reviews and Meta-Analyses). The selection criteria were: diagnostic for MS or at least a criterion for diagnosis; randomized clinical trials, ≤19 years of age; intervention programs that use diet and/or exercise as a tool (interventions showing an interest in body composition)., Results: 1781 clinical trials were identified under these criteria but only 0.51% were included. The most frequent characteristics of the selected clinical trials were that they used multidisciplinary interventions and were carried out in America. The most utilized parameters were BMI (body mass index) in kg/m² and BW (body weight) in kg., Conclusions: Most of the clinical trials included had been diagnosed through at least 2 diagnostic criteria for MS. Multidisciplinary interventions obtained greater changes in body composition in patients with MS. This change was especially prevalent in the combinations of dietary interventions and physical exercise. It is proposed to follow the guidelines proposed for patients who are overweight, obese, or have diabetes type 2, and extrapolate these strategies as recommendations for future clinical trials designed for patients with MS.

The most precise top quark mass measurements use kinematic reconstruction methods, determining the top mass parameter of a Monte Carlo event generator m_{t}^{MC}. Because of hadronization and parton-shower dynamics, relating m_{t}^{MC} to a field theory mass is difficult. We present a calibration procedure to determine this relation using hadron level QCD predictions for observables with kinematic mass sensitivity. Fitting e^{+}e^{-} 2-jettiness calculations at next-to-leading-logarithmic and next-to-next-to-leading-logarithmic order to pythia 8.205, m_{t}^{MC} differs from the pole mass by 900 and 600 MeV, respectively, and agrees with the MSR mass within uncertainties, m_{t}^{MC}≃m_{t,1  GeV}^{MSR}.