1. Leveraging circulating microbial DNA for early cancer detection.
- Author
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Kataria R, Shoaie S, Grigoriadis A, and Wan JCM
- Subjects
- Humans, DNA, Liquid Biopsy methods, Early Detection of Cancer, Cell-Free Nucleic Acids genetics, Neoplasms diagnosis, Neoplasms genetics
- Abstract
Microbial cell-free DNA (microbial cfDNA) offers a minimally invasive approach for profiling the microbiome. Despite technical and biological challenges, the potential of microbial cfDNA for cancer detection is increasingly being evaluated using deep sequencing, novel laboratory approaches, and computational methods. Targeting the microbiome using liquid biopsies could improve early cancer detection., Competing Interests: Declaration of interests J.C.M.W. is an inventor of patents for methods for ctDNA detection. He is a stockholder and a cofounder of cfdx. He has served as a consultant for Delfi Diagnostics and Cleary Gottlieb. The other authors declare no conflicts of interest., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
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