1. The antioxidative and immunostimulating properties of D-glucosamine.
- Author
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Yan Y, Wanshun L, Baoqin H, Changhong W, Chenwei F, Bing L, and Liehuan C
- Subjects
- Adjuvants, Immunologic chemistry, Animals, Antioxidants chemistry, Cell Proliferation drug effects, Chelating Agents chemistry, Erythrocytes immunology, Glucosamine chemistry, Hemolysis drug effects, Hypersensitivity, Delayed, Iron chemistry, Lymphocytes cytology, Lymphocytes drug effects, Macrophages, Peritoneal drug effects, Macrophages, Peritoneal immunology, Male, Mice, Mice, Inbred ICR, Oxidative Stress drug effects, Phagocytosis drug effects, Pinocytosis drug effects, Sheep, Spleen cytology, Spleen drug effects, Spleen growth & development, Thymus Gland drug effects, Thymus Gland growth & development, Adjuvants, Immunologic pharmacology, Antioxidants pharmacology, Glucosamine pharmacology
- Abstract
The objective of the present study was to investigate the antioxidant activity and immunostimulating property of glucosamine (GlcN) using various in vitro and in vivo tests. Results showed that GlcN possessed excellent antioxidant activities as manifested by strong chelating effect on ferrous ions and protection of macromolecules such as protein, lipid, and deoxyribose from oxidative damage induced by hydroxyl radicals. The immunostimulating effects of GlcN were further evaluated through various immunological tests. GlcN showed excellent activity of enhancing splenocyte proliferation. Neutral red pinocytosis and NO production in mouse peritoneal macrophages were significantly augmented. Oral administration of GlcN to mice for 20 days significantly enhanced the serum antibody level in mice in response to sheep red blood cells (SRBC), increased the relative organ weight of spleen and thymus tissue, and promoted the delayed-type hypersensitivity (DTH) against SRBC as compared with control group. In conclusion, the present investigation reveals GlcN is biologically functional in antioxidative activities and immunostimulating properties.
- Published
- 2007
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