1. Expert panel consensus recommendations on the utilization of nebulized budesonide for managing asthma and COPD in both stable and exacerbation stages in Thailand.
- Author
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Wongsurakiat P, Rattanawongpaibul A, Limsukon A, Chiewchalermsri C, Wiwatcharagoses K, Kornthatchapong K, Saiphoklang N, Sanguanwit P, Domthong P, Kawamatawong T, Sewatanon T, Reechaipichitkul W, and Maneechotesuwan K
- Subjects
- Humans, Thailand, Administration, Inhalation, Bronchodilator Agents administration & dosage, Bronchodilator Agents therapeutic use, Consensus, Budesonide administration & dosage, Budesonide therapeutic use, Asthma drug therapy, Pulmonary Disease, Chronic Obstructive drug therapy, Nebulizers and Vaporizers
- Abstract
Objective: This study investigated the utilization of nebulized budesonide for acute asthma and COPD exacerbations as well as for maintenance therapy in adults., Data Sources: We conducted a search on PubMed for nebulized budesonide treatment., Selected Studies: Selecting all English-language papers that utilize Mesh phrases "asthma," "COPD," "budesonide," "nebulized," "adult," "exacerbation," and "maintenance" without temporal restrictions, and narrowing down to clinical research such as RCTs, observational studies, and real-world studies., Results: Analysis of 25 studies was conducted to assess the effectiveness of nebulized budesonide in asthma ( n = 10) and COPD ( n = 15). The panel in Thailand recommended incorporating nebulized budesonide as an additional or alternative treatment option to the standard of care and systemic corticosteroids (SCS) based on the findings., Conclusion: Nebulized budesonide is effective and well-tolerated in treating asthma and COPD, with less systemic adverse effects compared to systemic corticosteroids. High-dose nebulized budesonide can enhance clinical outcomes for severe and mild exacerbations with slow systemic corticosteroid response. Nebulized budesonide can substitute systemic corticosteroids in some situations.
- Published
- 2024
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