1. Functional biomacromolecules-based microneedle patch for the treatment of diabetic wound.
- Author
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Zhao C, Wu Z, Pan B, Zhang R, Golestani A, Feng Z, Ge Y, and Yang H
- Subjects
- Humans, Administration, Cutaneous, Diabetes Mellitus, Transdermal Patch, Drug Delivery Systems methods, Needles, Wound Healing drug effects
- Abstract
Diabetic wounds are a common complication of diabetes. The prolonged exposure to high glucose and oxidative stress in the wound environment increases the risk of bacterial infection and abnormal angiogenesis, leading to amputation. Microneedle patches have shown promise in promoting the healing of diabetic wounds through transdermal drug delivery. These patches target the four main aspects of diabetic wound treatment: hypoglycemia, antibacterial action, inflammatory regulation, and tissue regeneration. By overcoming the limitations of traditional administration methods, microneedle patches enable targeted therapy for deteriorated tissues. The design of these patches extends beyond the selection of needle tip material and biomacromolecule encapsulated drugs; it can also incorporate near-infrared rays to facilitate cascade reactions and treat diabetic wounds. In this review, we comprehensively summarize the advantages of microneedle patches compared to traditional treatment methods. We focus on the design and mechanism of these patches based on existing experimental articles in the field and discuss the potential for future research on microneedle patches., Competing Interests: Declaration of competing interest All authors have disclosed any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. There is no use of any human and animal subjects in this work., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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