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Objective: To evaluate the efficacy of electroacupuncture (EA) intervention on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)., Methods: Eight databases, including PubMed, Embase, the Cochrane Library, Web of Science, Chinese BioMedical Literature Database, China National Knowledge Infrastructure Database, Wanfang Data, China Science and Technology Journal Database, and two clinical trial registries, were searched. All randomized controlled trials (RCTs) related to EA intervention in cardiac surgery with CPB were collected. Based on the inclusion and exclusion criteria, two researchers independently screened articles and extracted data. After the quality evaluation, RevMan 5.3 software was used for analysis., Results: Fourteen RCTs involving 836 patients were included. Compared with the control treatment, EA significantly increased the incidence of cardiac automatic rebeat after aortic unclamping [relative risk ( RR ) = 1.15, 95% confidence interval ( CI ) (1.01, 1.31), P < 0.05; moderate]. Twenty-four hours after aortic unclamping, EA significantly increased the superoxide dismutase [standardized mean difference ( SMD ) = 0.96, 95% CI (0.32, 1.61), P < 0.05; low], and interleukin (IL)-2 [ SMD = 1.33, 95% CI (0.19, 2.47), P < 0.05; very low] expression levels and decreased the malondialdehyde [ SMD =－1.62, 95% CI (－2.15, －1.09), P < 0.05; moderate], tumour necrosis factor-α [ SMD = －1.28, 95% CI (－2.37, －0.19), P < 0.05; moderate], and cardiac troponin I [SMD = －1.09, 95% CI (－1.85, －0.32), P < 0.05; low] expression levels as well as the inotrope scores [ SMD = －0.77, 95% CI (－1.22, －0.31), P < 0.05; high]. There was no difference in IL-6 and IL-10 expression levels. The amount of intraoperative sedative [ SMD = -0.31, 95% CI (－0.54, －0.09), P < 0.05; moderate] and opioid analgesic [ SMD = -0.96, 95% CI (－1.53, －0.38), P < 0.05; low] medication was significantly lower in the EA group than in the control group. Moreover, the postoperative tracheal intubation time [ SMD = －0.92, 95% CI (－1.40, －0.45), P < 0.05; low] and intensive care unit stay [ SMD = －1.71, 95% CI (－3.06, －0.36), P < 0.05; low] were significantly shorter in the EA group than in the control group. There were no differences in the time to get out of bed for the first time, total days of antibiotic use after surgery, or postoperative hospital stay. No adverse reactions related to EA were reported in any of the included studies., Conclusions: In cardiac surgery with CPB, EA may be a safe and effective strategy to reduce myocardial ischaemia-reperfusion injury and speed up the recovery of patients after surgery. These findings must be interpreted with caution, as most of the evidence was of low or moderate quality. More RCTs with larger sample sizes and higher quality are needed to provide more convincing evidence.