1. Sevoflurane preconditioning protects against acute MI/R injury via enhancing AdipoR1-Cav3 interaction and alleviating endoplasmic reticulum stress.
- Author
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Zhang YQ, Li R, Tian SY, Lv JP, Yang BZ, Wang J, Wang L, Bai XJ, Wang CH, and Wang Q
- Subjects
- Adiponectin genetics, Animals, Apoptosis, Endoplasmic Reticulum Stress, Mice, Mice, Knockout, Myocytes, Cardiac, Receptors, Adiponectin genetics, Sevoflurane pharmacology, Myocardial Reperfusion Injury prevention & control
- Abstract
Whether and how sevoflurane preconditioning (SevoPre) exerts protection against acute myocardial ischemia/reperfusion (MI/R) injury remains elusive. We observed significant myocardial injury, as evidenced by infarct size, cardiomyocyte apoptosis, and circulating troponin-I, at 3 h of MI/R in both wildtype and adiponectin knockout mice. The injury was significantly ameliorated by SevoPre in wildtype mice, but not in adiponectin knockout mice. In wildtype mice, we found that MI/R could increase endoplasmic reticulum stress of cardiomyocytes, and impair association of adiponectin receptor 1 and ceveolin-3, both of which processes were largely restored by SevoPre. In summary, we demonstrated that significant injury had already took place at 3 h of MI/R, which could be ameliorated by SevoPre via promoting affinity of adiponectin receptor 1 and ceveolin-3, and then attenuating endoplasmic reticulum stress of cardiomyocytes., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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