1. Phase III randomized trial of weekly cisplatin and irradiation versus cisplatin and tirapazamine and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical carcinoma limited to the pelvis: a Gynecologic Oncology Group study.
- Author
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DiSilvestro PA, Ali S, Craighead PS, Lucci JA, Lee YC, Cohn DE, Spirtos NM, Tewari KS, Muller C, Gajewski WH, Steinhoff MM, and Monk BJ
- Subjects
- Adenocarcinoma mortality, Adenocarcinoma pathology, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Canada, Carcinoma, Adenosquamous mortality, Carcinoma, Adenosquamous pathology, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Chi-Square Distribution, Cisplatin administration & dosage, Disease Progression, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Neoplasm Staging, Proportional Hazards Models, Prospective Studies, Time Factors, Tirapazamine, Treatment Outcome, Triazines administration & dosage, United States, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms pathology, Adenocarcinoma therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Adenosquamous therapy, Carcinoma, Squamous Cell therapy, Chemoradiotherapy adverse effects, Chemoradiotherapy mortality, Uterine Cervical Neoplasms therapy
- Abstract
Purpose: This prospective, randomized phase III intergroup trial of the Gynecologic Oncology Group and National Cancer Institute of Canada Clinical Trials Group was designed to test the effectiveness and safety of adding the hypoxic cell sensitizer tirapazamine (TPZ) to standard cisplatin (CIS) chemoradiotherapy in locally advanced cervix cancer., Patients and Methods: Patients with locally advanced cervix cancer were randomly assigned to CIS chemoradiotherapy versus CIS/TPZ chemoradiotherapy. Primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS) and tolerability., Results: PFS was evaluable in 387 of 402 patients randomly assigned over 36 months, with enrollment ending in September 2009. Because of the lack of TPZ supply, the study did not reach its original target accrual goal. At median follow-up of 28.3 months, PFS and OS were similar in both arms. Three-year PFS for the TPZ/CIS/RT and CIS/RT arms were 63.0% and 64.4%, respectively (log-rank P = .7869). Three-year OS for the TPZ/CIS/RT and CIS/RT arms were 70.5% and 70.6%, respectively (log-rank P = .8333). A scheduled interim safety analysis led to a reduction in the starting dose for the TPZ/CIS arm, with resulting tolerance in both treatment arms., Conclusion: TPZ/CIS chemoradiotherapy was not superior to CIS chemoradiotherapy in either PFS or OS, although definitive commentary was limited by an inadequate number of events (progression or death). TPZ/CIS chemoradiotherapy was tolerable at a modified starting dose.
- Published
- 2014
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