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Radio frequency identification (RFID) is a mature technology that allows contactless data readout via a wireless communication link. While numerous passive RFID tags are available on the market, accurate alignment between tags and readers is required in a vast majority of cases to mitigate polarization mismatches. We show that enhancing electromagnetic designs with additional mechanical degrees of freedom allows bypassing fundamental limitations and approach ideal performances. Here, we demonstrate a new miniature tag, accessible from any direction and immune to rotations in space. Our tag is made of a high permittivity ceramic resonator, inductively coupled to a metal ring, which contains an RFID chip. The structure is placed inside a spherical plastic holder. In this architecture, the ceramic resonator serves several functions. First, it allows reducing the device footprint without significant bandwidth degradation. Second, it acts as a bob, aligning the electromagnetic structure parallel to the ground, regardless of its initial orientation in space. The bob is designed to slide inside the plastic holder. This roly-poly effect relaxes the constraint on a mutual tag-reader orientation, including the polarization mismatch, and provides next to perfect long-range operation. Being only 55 mm in diameter, our device can be interrogated from a 12 m distance, regardless of the tag's orientation in space. Introducing mechanical degrees of freedom into electromagnetic designs allows obtaining new functionalities, contributing to applications where a mutual orientation between transvers is required., (© 2022. The Author(s).)

Hyperbolic metamaterials were initially proposed in optics to boost radiation efficiencies of quantum emitters. Adopting this concept for antenna design allows approaching long-standing contests in radio physics. For example, broadband impedance matching, accompanied with moderately high antenna gain, is among the existent challenges. Here we propose employing hyperbolic metamaterials for a broadband impedance matching, while a structured layer on top of a metamaterials slab ensures an efficient and directive energy outcoupling to a free space. In particular, a subwavelength loop antenna, placed underneath the matching layer, efficiently excites bulk metamaterial modes, which have well-resolved spatial-temporal separation owing to the hypebolicity of effective permeability tensor. Interplaying chromatic and modal dispersions enable to map different frequencies into non overlapping spatial locations within a compact subwavelength hyperbolic slab. The outcoupling of energy to the free space is obtained by patterning the slab with additional resonant elements, e.g. high index dielectric spheres. As the result, two-order of magnitude improvement in linear gain of the device is predicted. The proposed new architecture can find a use in applications, where multiband or broadband compact devices are required.

The healthy human body contains small amounts of metabolic formaldehyde (FA) that mainly results from methanol oxidation by pectin methylesterase, which is active in a vegetable diet and in the gastrointestinal microbiome. With age, the ability to maintain a low level of FA decreases, which increases the risk of Alzheimer's disease and dementia. It has been shown that 1,2-dithiolane-3-pentanoic acid or alpha lipoic acid (ALA), a naturally occurring dithiol and antioxidant cofactor of mitochondrial α-ketoacid dehydrogenases, increases glutathione (GSH) content and FA metabolism by mitochondrial aldehyde dehydrogenase 2 (ALDH2) thus manifests a therapeutic potential beyond its antioxidant property. We suggested that ALA can contribute to a decrease in the FA content of mammals by acting on ALDH2 expression. To test this assumption, we administered ALA in mice in order to examine the effect on FA metabolism and collected blood samples for the measurement of FA. Our data revealed that ALA efficiently eliminated FA in mice. Without affecting the specific activity of FA-metabolizing enzymes (ADH1, ALDH2, and ADH5), ALA increased the GSH content in the brain and up-regulated the expression of the FA-metabolizing ALDH2 gene in the brain, particularly in the hippocampus, but did not impact its expression in the liver in vivo or in rat liver isolated from the rest of the body. After ALA administration in mice and in accordance with the increased content of brain ALDH2 mRNA, we detected increased ALDH2 activity in brain homogenates. We hypothesized that the beneficial effects of ALA on patients with Alzheimer's disease may be associated with accelerated ALDH2-mediated FA detoxification and clearance.