1. Experimental study of the biological properties of nmHA-SiO 2 fiber materials prepared by electrospinning technology.
- Author
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Zhang W, Zheng Y, Yang C, Yu Z, Zhao Y, Yang L, Li Y, Liu Q, Xu C, Su J, and Yan T
- Subjects
- Animals, Rabbits, X-Ray Microtomography, Materials Testing, Mice, Bone Substitutes chemistry, Bone Substitutes pharmacology, Skull surgery, Skull diagnostic imaging, Surface Properties, Minerals, Silicon Dioxide chemistry, Durapatite chemistry, Durapatite pharmacology, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Bone Regeneration drug effects
- Abstract
To study the biocompatibility of nanohydroxyapatite (nmHA)-SiO
2 fiber material and its efficacy in guided bone regeneration. ① The cytotoxicity of the nmHA-SiO2 fiber material to MC3T3-E1 cells was determined by CCK-8 assay. The adhesion of cells on the surface of the material was observed. ② Bone defects were prepared in the skull of three groups of New Zealand white rabbits. The following treatments were administered: implantation of nmHA-SiO2 , implantation of Bio-Oss, and no treatment. The defects were then covered with nmHA-SiO2 membrane or Hai'ao oral repair membrane. Animal samples were analyzed by gross observation, micro-computed tomography, hematoxylin-eosin staining and Masson staining. The data were statistically analyzed by multivariate analysis of variance to evaluate the repair of bone defects. ① The nmHA-SiO2 fiber material has suitable biocompatibility. ② The nmHA-SiO2 fiber material performed more effectively as a barrier membrane than other bone substitute materials in GBR model rabbits.- Published
- 2024
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