7 results on '"Zhou, Beini"'
Search Results
2. Causal associations of tea consumption on risk of pancreatic adenocarcinoma and the mediating role of vascular endothelial growth factor D levels.
- Author
-
Ouyang Y, Zhou B, Chu L, Chen X, Hao Q, and Lei J
- Subjects
- Humans, Risk Factors, Pancreatic Neoplasms etiology, Tea, Adenocarcinoma etiology, Mendelian Randomization Analysis
- Abstract
Tea is one of the most widely consumed beverages in the world. However, the association between tea and risk of pancreatic adenocarcinoma remains controversial. This study aimed to investigate the causal relationship between tea consumption and risk of pancreatic adenocarcinoma and to explore their mediating effects. The two-sample Mendelian randomisation (MR) analysis showed an inverse causal relationship between tea intake and pancreatic adenocarcinoma (OR: 0·111 (0·02, 0·85), P < 0·04). To examine the mediating effects, we explored the potential mechanisms by which tea intake reduces the risk of pancreatic adenocarcinoma. Based on the oral bioavailability and drug-like properties in Traditional Chinese Medicine Systems Pharmacology database, we selected the main active ingredients of tea. We screened out the fifteen representative targeted genes by Pharmmapper database, and the gene ontology enrichment analysis showed that these targeted genes were related to vascular endothelial growth factor (VEGF) pathway. The two-step MR analysis of results showed that only VEGF-D played a mediating role, with a mediation ratio of 0·230 (0·066, 0·394). In conclusion, the findings suggest that VEGF-D mediates the effect of tea intake on the risk of pancreatic adenocarcinoma.
- Published
- 2024
- Full Text
- View/download PDF
3. Long sleep duration is associated with abdominal aortic calcification among male adults with chronic kidney disease: NHANES 2013-2014.
- Author
-
Wang Y, Liu X, Zhang J, Zhou B, Yue W, and Hu K
- Subjects
- Humans, Male, Middle Aged, Adult, Female, Risk Factors, Aged, Sleep Wake Disorders epidemiology, Sleep Wake Disorders complications, Aortic Diseases epidemiology, Aortic Diseases complications, Prevalence, Cross-Sectional Studies, Time Factors, Sleep Duration, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic physiopathology, Aorta, Abdominal pathology, Aorta, Abdominal diagnostic imaging, Sleep physiology, Vascular Calcification epidemiology, Vascular Calcification complications, Nutrition Surveys
- Abstract
There are no studies exploring the correlation between sleep duration and abdominal aortic calcification (AAC). This study aims to investigate this relationship and its significance. Additionally, given the higher prevalence of sleep disorders and AAC in patients with chronic kidney disease (CKD), we conducted further studies in this population. We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014. Sleep duration was assessed by a sleep questionnaire and categorized into 2-5, 6-8, and ≥ 9 h. The AAC-24 score is determined using the Kauppila scoring system and used for AAC assessment. Multivariable linear and logistic regression analysis were used to explore the relationship between sleep duration and AAC. Among the 2,996 participants, 14.29% reported nightly short sleep (2-5 h), 77.64% reported intermediate sleep (6-8 h), and 8.08% reported long sleep (≥ 9 h). After adjusting for potential confounding factors, among male participants with CKD, long sleep (≥ 9 h) significantly increased AAC-24 scores compared with intermediate sleep (6-8 h) (β: 2.12; 95% CI: 0.75, 3.50), and the risk of severe AAC (SAAC) was increased by 1.55 times (OR: 2.55; 95% CI: 1.02, 6.36). And among female CKD and non-CKD participants, sleep duration was not associated with AAC. Long sleep duration increases the risk of AAC among male adults with CKD. Prospective studies are needed to confirm this finding., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
4. Bioluminescence-optogenetics-mediated gene therapy in a sleep-disordered breathing mouse model.
- Author
-
Wang Y, Liu X, Zhang Q, Zhao D, Zhou B, Pan Z, Zha S, and Hu K
- Subjects
- Animals, Mice, Male, Mice, Inbred C57BL, Dependovirus genetics, Hypoglossal Nerve, Luminescent Measurements, Motor Neurons metabolism, Optogenetics methods, Disease Models, Animal, Genetic Therapy methods, Sleep Apnea Syndromes therapy, Sleep Apnea Syndromes genetics
- Abstract
Obstructive sleep apnea (OSA) incurs a huge individual, societal, and economic burden. Specific and selective targeting of hypoglossal motor neurons could be an effective means to treat OSA. Bioluminescent-optogenetics (BL-OG) is a novel genetic regulatory approach in which luminopsins, fusion proteins of light-generating luciferase and light-sensing ion channels, increase neuronal excitability when exposed to a suitable substrate. Here we develop and validate the feasibility of BL-OG for sleep-disordered breathing (SDB). Upon confirming that diet-induced obese mice represent an excellent SDB model, we employed a method of targeting the hypoglossal nucleus (12 N) by peripherally injecting retrogradely transported rAAV2/Retro. With AAV transduction, the eLMO3 protein is expressed in hypoglossal motor neurons (HMN); administration of CTZ results in production of bioluminescence that in turn activates the tethered channelrhodopsin, leading to an increase in the firing of HMN and a 2.7 ± 0.8-fold increase in phasic activity of the genioglossus muscle, a 7.6 ± 1.8-fold increase in tonic activity, and improvements in hypoventilation and apnea index without impacting sleep structure. This is therefore the first study to leverage the rAAV2/Retro vector to execute the BL-OG approach in SDB, which amplified genioglossus muscle discharge activity and increased airflow in mice after activation. This study marks the pioneering utilization of BL-OG in SDB research., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
5. Thyroid dysfunction in the wake of Omicron: understanding its role in COVID-19 severity and mortality.
- Author
-
Zhang Q, Zhang Z, Liu X, Wang Y, Chen H, Hao Y, Zha S, Zhang J, He Y, Zhou B, and Hu K
- Subjects
- Humans, Female, Male, Middle Aged, Retrospective Studies, China epidemiology, Adult, Aged, Thyroid Function Tests, Euthyroid Sick Syndromes epidemiology, Thyroid Gland physiopathology, Thyroid Gland virology, Thyroid Gland pathology, Risk Factors, Thyrotropin blood, Triiodothyronine blood, Thyroxine blood, Betacoronavirus isolation & purification, Pandemics, COVID-19 mortality, COVID-19 complications, COVID-19 epidemiology, SARS-CoV-2, Thyroid Diseases complications, Thyroid Diseases physiopathology, Thyroid Diseases virology, Severity of Illness Index
- Abstract
Purpose: SARS-CoV-2 can invade the thyroid gland. This study was to delineate the risk of thyroid dysfunction amidst the prevalence of the Omicron variant, and to investigate the correlation between thyroid function and Coronavirus disease 2019 (COVID-19) outcomes. The study also aimed to ascertain whether thyroid dysfunction persisted during COVID-19 recovery phase., Methods: This was a retrospective cohort study. COVID-19 patients from the Renmin Hospital of Wuhan University, China during the epidemic of Omicron variants were included, and their thyroid function were analyzed in groups., Results: A history of thyroid disease was not associated with COVID-19 outcomes. COVID-19 can lead to a bimodal distribution of thyroid dysfunction. The severity of COVID-19 was inversely proportional to the levels of thyroid- stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4), leading to a higher prevalence of thyroid dysfunction. Severe COVID-19 was a risk factor for euthyroid sick syndrome (ESS) (OR=22.5, 95% CI, 12.1 - 45.6). Neutrophil to lymphocyte ratio mediated the association between severe COVID-19 and ESS (mediation effect ratio = 41.3%, p < 0.001). ESS and decreased indicators of thyroid function were associated with COVID-19 mortality, while high levels of FT3 and FT4 exhibited a protective effect against death. This effect was more significant in women (p < 0.05). During the recovery period, hyperthyroidism was quite uncommon, while a small percentage of individuals (7.7%) continued to exhibit hypothyroidism., Conclusion: COVID-19 severity was linked to thyroid dysfunction. Severe COVID-19 increased the risk of ESS, which was associated with COVID-19 mortality. Post-recovery, hyperthyroidism was rare, but some individuals continued to have hypothyroidism., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhang, Zhang, Liu, Wang, Chen, Hao, Zha, Zhang, He, Zhou and Hu.)
- Published
- 2024
- Full Text
- View/download PDF
6. Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections.
- Author
-
Liu X, Zhang Q, Chen H, Hao Y, Zhang J, Zha S, Zhou B, Yi Y, Xiao R, and Hu K
- Subjects
- Adult, Child, Humans, Female, Child, Preschool, Male, Retrospective Studies, Parents, Anti-Bacterial Agents therapeutic use, Macrolides therapeutic use, Pneumonia, Mycoplasma epidemiology, Mycoplasma Infections, Quinolones
- Abstract
Background: Mycoplasma pneumoniae infections have increased in China recently, causing some evidence of familial clustering. The purpose of this study was to compare the clinical features of parents and children in cases of familial clustering of Mycoplasma pneumoniae infection., Methods: A retrospective analysis was performed on the cases of familial clustering of Mycoplasma pneumoniae infection, and the clinical characteristics of parents and children were compared., Results: We identified 63 families, of these, 57 (65.5%) adults and 65 (94.2%) children required hospitalization. Fifty-seven adults (mean age 35.1 ± 4.6 years, 80.7% female) and 55 children (mean age 6.3 ± 3.9 years, 54.5% female) were included in the analysis. The incidence of mycoplasma infection in adults had increased gradually over the past year, while the rate in children had spiked sharply since June 2023. The clinical symptoms were similar in the two groups, mainly fever and cough. The peak temperature of children was higher than that of adults (39.1 ± 0.7℃ vs 38.6 ± 0.7℃, p = 0.004). Elevated lactate dehydrogenase was more common in children than in adults (77.8% vs 11.3%, p < 0.001). Bronchial pneumonia and bilateral involvement were more common in children, while adults usually had unilateral involvement. Three (60%) adults and 21 (52.5%) children were macrolide-resistant Mycoplasma pneumoniae infected. Children were more likely to be co-infected (65.5% vs 22.8%, p < .001). Macrolides were used in most children and quinolones were used in most adults. Ten (18.2%) children were diagnosed with severe Mycoplasma pneumoniae pneumonia, whereas all adults had mild disease. Children had a significantly longer fever duration than adults ((5.6 ± 2.2) days vs (4.1 ± 2.2) days, p = 0.002). No patient required mechanical ventilation or died., Conclusions: Mycoplasma pneumoniae infection shows a familial clustering epidemic trend at the turn of summer and autumn, with different clinical characteristics between parents and children., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
7. Energy field-based lane changing behavior interaction model and risk evaluation in the weaving section of expressway.
- Author
-
Li Y, Yang F, Xuan Z, and Zhou B
- Subjects
- Humans, Computer Simulation, Risk-Taking, Accidents, Traffic, Automobile Driving
- Abstract
Objective: With the development of intelligent driving assistance systems, the evaluation of driving behavior risk has shifted from traditional single-vehicle studies to multi-vehicle studies. This study aimed to investigate the interaction mechanism between vehicles and to study the microscopic laws of traffic flow operation., Methods: Firstly, the concept of "driving interaction field" was proposed. The virtual interaction quality and distance were used to define the driving interaction field. The interaction angle distinguished the vehicle interaction between different lanes. Then, the risk mechanism in the interaction process was analyzed by driving risk index. Corresponding thresholds of 50% and 85% quantile values were determined. Finally, the process of the lane-changing simulation experiments was divided into three phases (preparation, execution and adjustment)., Results: The driving risk index of the execution phase was larger than the other phases. Meanwhile, the comparison with the classical driving risk indexes revealed that the proposed index was more accurate and intuitive in describing the interaction risks., Conclusions: The driving interaction model proposed in this study quantified the overall environmental pressure on the vehicle. It overcomes the previous limitation of kinetic interaction parameters. The research provides a new idea for the ITS and autonomous driving systems, contributing to the enhancement of traffic safety and efficiency.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.