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Background: Lead exposure reduces the cognitive development and future economic prospects of children. While previous studies in high-income settings have explored productivity losses associated with lead exposure, limited research has focused on low and middle-income countries like Mexico., Objectives: This study aims to provide a comprehensive assessment of the economic implications of lead exposure on Mexican children using, for the first time, nationally representative Blood Lead Levels (BLLs) measurements in children aged 1-4, specifically focusing on the costs of forgone lifetime income due to cognitive losses., Methods: BLLs of children aged 1-4 were extracted from the 2018-2019 National Health and Nutrition Survey (ENSANUT). Estimations of cognitive losses were derived from a log-linear relationship between BLLs and IQ loss. Lost lifetime economic productivity per child was calculated, assuming a 2% reduction in lifetime potential productivity for each IQ point lost due to lead exposure, based on previous literature (Attina and Trasande, 2013; Larsen and Sánchez-Triana, 2023). Productivity data were obtained from representative sources for Mexico., Results: The estimated economic loss amounted to US $33.02 billion, equivalent to 2.76% of Mexico's Gross Domestic Product (GDP) in 2019 (calculated for a 1-year cohort). On a national scale, the long-term loss of cognition for children 1-4 years old is 4.14 IQ points per child due to lead exposure, with significant variability across States (range: 3.26 to 5.26). Lead-poisoned children (≥5 μg/dL) suffered an average loss of 6.42 IQ points (range: 0 to 6.97). In terms of economic impact, some States like Chiapas experienced losses of 7.08% of its GDP, while others had losses as low as 0.67%. Intriguingly, states with lower Human Development Index (HDIs) exhibited relatively higher economic losses despite lower average blood lead levels., Discussion: The heterogeneous impact of lead exposure across Mexican states underscores the necessity for tailored regional policies. These findings emphasize the urgency for targeted interventions and informed policy measures to mitigate the socioeconomic consequences of lead exposure on Mexican children., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Martha M. Tellez-Rojo reports financial support was provided by Pure Earth Blacksmith Institute. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Comprehensive cow-calf production data was utilized to evaluate the impact of dam age on lifetime productivity of Angus replacement beef females. Cows used in this study were commercial Angus replacement females born between 2006 and 2020, ranging in age from 1 to 14-yr of age (n = 3568). To determine the impact of dam age on lifetime productivity, cows were classified by age groups, specifically 2-, 3-, 4-, 5-, 6/7-, and 8-yrs old and older. The 8-yr and older group consisted of females that were up to 14-yr of age. Cow BW at breeding exhibited a cow age × dam age interaction (p < 0.01). Cows at 5-yrs of age from 2-yr old dams weighed less at breeding than cows at 5-yrs of age from 3-, 4-, 5- and 8-years and older dams, with cows at 5-yr of age from 6/7-yr old dams being intermediate. The probability of remaining in the herd at the age of 5 was significant for dam age (p = 0.05) averaging 69.41%, but after further delineation, no significant impacts of dam age were observed. Productivity as a measure of total pounds of calf weaned through 5-yrs displayed a dam age effect (p = 0.01) with cows from 8-yrs or older dams weaning more total pounds of calf, than cows from 3-yr-old dams. In summary, the impact of dam age on lifetime productivity indicates that dam age can impact future productivity of their offspring.

The assessment of the operational stability of biocatalysts by conventional direct determination of the total turnover number (TTN), a useful indicator of lifetime biocatalyst productivity, via continuous isothermal experiments tends to be time-consuming, material-intensive, and prone to disturbances, especially in case of rather stable catalysts. In the present work, we present and validate two alternative methods for estimating the TTN of a biocatalyst for any desired operating temperature. The first method is a mechanistic approach, built upon mathematical derivation of enzyme deactivation models derived from first principles, in which TTN can be calculated from two straightforward isothermal biochemical batch measurements. The second method relies on a few non-isothermal, continuous-mode experiments in conjunction with mathematical modeling to determine the intrinsic deactivation parameters of the biocatalyst. We verify both methods on the test case of TEM-1 β-lactamase-catalyzed penicillin G (Pen G) hydrolysis. Both alternative methods provide estimates of TTN which are typically within a factor of two to five or less of the values measured directly via lengthy, costly, and error-prone conventional isothermal aging tests. Therefore, both the mechanistic approach and the non-isothermal continuous approach are extremely valuable tools to enable calculation of catalyst cost contribution in continuous processing and to eliminate underperforming candidates in search of the most stable biocatalyst., (© 2022 Wiley-VCH GmbH.)

To determine the optimal voluntary waiting period to first service after calving for maximizing the lifetime productivity of cows in a dairy herd, we simulated the changes in lifetime productivity due to increasing the number of days from calving to first service. We also assessed the effects of changes in the maximum number of services within a lactation, maximum number of calvings, and calf sale prices on lifetime productivity. We evaluated lifetime productivity as lifetime average productivity, that is, the sum of daily revenues from milk and calf sales from first calving to culling. The lifetime productivity at ≤65 days to first service was low because of the low conception rate during early lactation. In addition, lifetime productivity at ≥185 days to first service decreased as the number of days to first service increased. The number of days to first service for maximum lifetime productivity decreased as the maximum number of calvings increased. Furthermore, the decrease in lifetime productivity associated with decreasing the maximum number of services within a lactation from five to four was greater than that when the maximum number of calvings was decreased from six to five., (© 2022 Japanese Society of Animal Science.)

A total of 1338 high-yielding cows with five lactations from a large well-managed commercial dairy operation in a hot environment of northern Mexico were used to evaluate milk yield and reproductive performance of cows undergoing unplanned extended lactations (EL; > 450 days). The null hypothesis that cumulative milk yield during five consecutive lactations is the same in cows not having unplanned EL and cows with several EL was tested. All EL resulted from cows failing to become pregnant with ≥ 4 services. Cows were allocated to 1 of 6 groups according to the number of EL (EL0 for cows with no EL to EL5 for cows with 5 EL). Cumulative milk yield was highest (P < 0.01) for EL5 cows (95,499 kg) and lowest for EL0 cows (56,236 kg). Likewise, cumulative days in milk were greatest (P < 0.01) in EL5 (2968 days) and lowest in EL0 (1857 days) cows. Mean milk yield per lactation increased linearly with the increase in the number of extended lactations with a maximum of 19,099 kg of milk/lactation for EL5 cows. Mean daily milk yield/productive life was lowest (P < 0.01) for EL0 (30.2 kg) and highest for EL5 (32.1 kg). The percentage of days in milk relative to days from birth to the end of the fifth lactation was highest for EL5 (78.1%) and lowest for EL0 (59.6%), with EL2 to EL4 cows intermediate. Length of calving interval was longest (P < 0.01) for EL5 (24.7 months) and shortest for EL0 (15.5 months) cows. It was concluded that it is worthwhile maintaining high-yielding cows incapable to conceive before 230 days in milk because they did conceive again and produced considerable amounts of milk during their productive life, which substantially prolonged their permanence time in the herd.

Evaluation of lifetime productivity of individual animals in response to various interventions allows assessment of long-term investment opportunities for farmers. In order to gain a better understanding of promising feed interventions for improvement of small ruminant production in Southwestern Nigeria, a dynamic modelling approach was used to explore the effect of different feeding strategies on the lifetime productivity of West African Dwarf (WAD) goats. Modifications were made to the current version of Livestock Simulator developed for cattle production to simulate goat production systems particularly for WAD goats. Effects of changes in input parameters (quality of feed and potential adult weight) confirmed the sensitivity of the modelled weight development and reproductive performance. The values of simulated model outputs corresponded well with observed values for most of the variables, except for the pre-weaning mortality rate in the cut-and-carry system where a wide discrepancy between simulated (2.1%) and observed (23%) data was found. The scenario analysis showed that simulated goats in the free grazing system attained sexual maturity and kidded much later than those in the grazing with supplementation and the cut-and-carry systems. The simulated results suggested that goats require supplementation with protein and energy sources, in order to promote lifetime productivity, early sexual maturity and higher birth weight. In terms of economic returns based on feed cost alone, the moderately intense system produced the most profit. We therefore conclude that grazing with adequate supplementation using farm-generated feed resources offers an opportunity for improving smallholder goat production systems in West Africa.

Many opportunities exist to reduce enteric methane (CH4) and other greenhouse gas (GHG) emissions per unit of product from ruminant livestock. Research over the past century in genetics, animal health, microbiology, nutrition, and physiology has led to improvements in dairy production where intensively managed farms have GHG emissions as low as 1 kg of CO2 equivalents (CO2e)/kg of energy-corrected milk (ECM), compared with >7 kg of CO2 e/kg of ECM in extensive systems. The objectives of this review are to evaluate options that have been demonstrated to mitigate enteric CH4 emissions per unit of ECM (CH4/ECM) from dairy cattle on a quantitative basis and in a sustained manner and to integrate approaches in genetics, feeding and nutrition, physiology, and health to emphasize why herd productivity, not individual animal productivity, is important to environmental sustainability. A nutrition model based on carbohydrate digestion was used to evaluate the effect of feeding and nutrition strategies on CH4/ECM, and a meta-analysis was conducted to quantify the effects of lipid supplementation on CH4/ECM. A second model combining herd structure dynamics and production level was used to estimate the effect of genetic and management strategies that increase milk yield and reduce culling on CH4/ECM. Some of these approaches discussed require further research, but many could be implemented now. Past efforts in CH4 mitigation have largely focused on identifying and evaluating CH4 mitigation approaches based on nutrition, feeding, and modifications of rumen function. Nutrition and feeding approaches may be able to reduce CH4/ECM by 2.5 to 15%, whereas rumen modifiers have had very little success in terms of sustained CH4 reductions without compromising milk production. More significant reductions of 15 to 30% CH4/ECM can be achieved by combinations of genetic and management approaches, including improvements in heat abatement, disease and fertility management, performance-enhancing technologies, and facility design to increase feed efficiency and life-time productivity of individual animals and herds. Many of the approaches discussed are only partially additive, and all approaches to reducing enteric CH4 emissions should consider the economic impacts on farm profitability and the relationships between enteric CH4 and other GHG., (Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)

The objective of this study was to obtain heritability estimates for longevity (length of life, length of productive life, number of litters) and lifetime productivity traits (lifetime pig production, lifetime pig efficiency, lifetime litter efficiency) and genetic correlation between them and litter size at first farrowing, growth (ADG), backfat thickness (BF), loin depth, lean meat percentage (LMP), phenotypic selection index (PSI), and exterior in 19423 Polish Landrace (L) and 16049 Polish Large White (LW) sows. Heritabilities for longevity and lifetime productivity traits were 0.10-0.13 for L sows and 0.09-0.11 for LW sows depending on the trait definition. The genetic correlations among these traits were all high and positive, ranging from 0.76 to 0.99. Antagonistic genetic correlations (-0.21 to -0.26) were found between longevity traits and PSI and LMP in LW sows, while in L sows the respective parameters were lower and not significant for length of productive life. The number of live-born piglets in the first litter was positively correlated with lifetime pig production and lifetime pig efficiency in both breeds. The genetic correlations of longevity and lifetime pig production with ADG, BF, loin depth and exterior were small, and in most cases, not significant., (© 2013 Blackwell Verlag GmbH.)

Objective: To quantify the economic effects of a child conceived by in vitro fertilization (IVF) in terms of net tax revenue from the state's perspective in Greece., Methods: Based on previous international experience, a mathematical model was developed to assess the lifetime productivity of a single individual and his/her lifetime transactions with governmental agencies. The model distinguished among three periods in the economic life cycle of an individual: (1) early life, when the government primarily contributes resources through child tax credits, health care, and educational expenses; (2) employment, when individuals begin returning resources through taxes; and (3) retirement, when the government expends additional resources on pensions and health care. The cost of a live birth with IVF was based on the modification of a previously published model developed by the authors. All outcomes were discounted at a 3% discount rate. The data inputs - namely, the economic or demographic variables - were derived from the National Statistical Secretariat of Greece and other relevant sources. To deal with uncertainty, bias-corrected uncertainty intervals (UIs) were calculated based on 5000 Monte Carlo simulations. In addition, to examine the robustness of our results, other one-way sensitivity analyses were also employed., Results: The cost of IVF per birth was estimated at €17,015 (95% UI: €13,932-€20,200). The average projected income generated by an individual throughout his/her productive life was €258,070 (95% UI: €185,376-€339,831). In addition, his/her life tax contribution was estimated at €133,947 (95% UI: €100,126-€177,375), while the discounted governmental expenses for elderly and underage individuals were €67,624 (95% UI: €55,211-€83,930). Hence, the net present value of IVF was €60,435 (95% UI: €33,651-€94,330), representing a 182% net return on investment. Results remained constant under various assumptions for the main model parameters., Conclusion: State-funded IVF may represent good value for money in the Greek setting, since it has positive tax benefits for the government, notwithstanding its beneficial psychological effect on infertile couples.