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1. Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes

Author

Aterido, Adriá, López-Lasanta, María, Blanco García, Francico J, Juan-Mas, Antonio, García-Vivar, María Luz, Erra, Alba, Pérez-García, Carolina, Sánchez-Fernández, Simón Ángel, Sanmartí, Raimón, Fernández-Nebro, Antonio, Alperi-López, Mercedes, Tornero, Jesús, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Palau, Núria, Pan, Wenjing, Byrne-Steele, Miranda, Starenki, Dmytro, Weber, Daniel, Rodríguez-Nunez, Iván, Han, Jian, Myers, Richard M., Marsal, Sara, Juliá, Antonio, Aterido, Adriá, López-Lasanta, María, Blanco García, Francico J, Juan-Mas, Antonio, García-Vivar, María Luz, Erra, Alba, Pérez-García, Carolina, Sánchez-Fernández, Simón Ángel, Sanmartí, Raimón, Fernández-Nebro, Antonio, Alperi-López, Mercedes, Tornero, Jesús, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Palau, Núria, Pan, Wenjing, Byrne-Steele, Miranda, Starenki, Dmytro, Weber, Daniel, Rodríguez-Nunez, Iván, Han, Jian, Myers, Richard M., Marsal, Sara, and Juliá, Antonio

Published
2024

2. Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis

Author

Juliá, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco García, Francisco J, Erra, Alba, Fernández-Nebro, Antonio, Juan Mas, Antonio, Pérez-García, Carolina, García Vivar, María Luz, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Díaz-Torné, César, Moreno, Estefanía, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Tornero Molina, Jesús, Marsal, Sara, Juliá, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco García, Francisco J, Erra, Alba, Fernández-Nebro, Antonio, Juan Mas, Antonio, Pérez-García, Carolina, García Vivar, María Luz, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Díaz-Torné, César, Moreno, Estefanía, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Tornero Molina, Jesús, and Marsal, Sara

Abstract

[Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is associated with the response to tumor necrosis factor inhibitor (TNFi) therapy. Methods: Peripheral blood genome-wide DNA methylation profiles were analyzed in a discovery cohort of 62 RA patients at baseline and at week 12 of TNFi therapy. DNA methylation of individual CpG sites and enrichment of biological pathways were evaluated for their association with drug response. Using a novel cell deconvolution approach, altered DNA methylation associated with TNFi response was also tested in the six main immune cell types in blood. Validation of the results was performed in an independent longitudinal cohort of 60 RA patients. Findings: Treatment with TNFi was associated with significant longitudinal peripheral blood methylation changes in biological pathways related to RA (FDR<0.05). 139 biological functions were modified by therapy, with methylation levels changing systematically towards a signature similar to that of healthy controls. Differences in the methylation profile of T cell activation and differentiation, GTPase-mediated signaling, and actin filament organization pathways were associated with the clinical response to therapy. Cell type deconvolution analysis identified CpG sites in CD4+T, NK, neutrophils and monocytes that were significantly associated with the response to TNFi. Interpretation: Our results show that treatment with TNFi restores homeostatic blood methylation in RA. The clinical response to TNFi is associated to methylation variation in specific biological pathways, and it involves cells from both the innate and adaptive immune systems.

Published
2022

3. Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

Author

Julià, Antonio, López-Lasanta, María, Blanco, Francisco, Gómez, Antonio, Haro Villar, Isabel, Juan Mas, Antonio, Erra, Alba, García Vivar, M. Luz, Monfort, Jordi, Sánchez-Fernández, Simón, González, Isidoro, Alperi, Mercedes, Castellanos-Moreira, Raul, Fernández-Nebro, Antonio, Díaz-Torné, César, Palau, Núria, Lastra, Raquel, Lladós, Jordi, Sanmartí, Raimon, Marsal, Sara, Julià, Antonio, López-Lasanta, María, Blanco, Francisco, Gómez, Antonio, Haro Villar, Isabel, Juan Mas, Antonio, Erra, Alba, García Vivar, M. Luz, Monfort, Jordi, Sánchez-Fernández, Simón, González, Isidoro, Alperi, Mercedes, Castellanos-Moreira, Raul, Fernández-Nebro, Antonio, Díaz-Torné, César, Palau, Núria, Lastra, Raquel, Lladós, Jordi, Sanmartí, Raimon, and Marsal, Sara

Abstract

Background Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TNF therapy. Rheumatoid factor (RF) and anti-cyclic-citrullinated antibodies (anti-CCP) have been evaluated as biomarkers of response but the results have shown limited consistency. Anti-carbamylated protein (anti-CarP) and anti-peptidylarginine deiminase type 4 (anti-PAD4) antibodies have been much less studied. Despite being linked to common immune processes, the interaction between these markers has not been evaluated yet. Our aim was to analyze the interaction between these four antibodies in relation to the response to anti-TNF therapy. Methods For this objective, a prospective cohort of n = 80 RA patients starting anti-TNF therapy was recruited. Serum determinations at baseline were performed for RF, anti-CCP, anti-CarP and anti-PAD4 antibodies using enzyme-linked immunosorbent assays (ELISA). The clinical response to anti-TNF therapy was determined at week 12 using the change in DAS28 score. Association was performed using multivariate linear regression adjusting for baseline DAS28, sex and age. Results The interaction between pairs of antibodies was tested by the addition of an interaction term. We found two highly significant antibody interactions associated with treatment response: anti-CarP with anti-PAD4 (p = 0.0062), and anti-CCP with RF (p = 0.00068). The latter antibody interaction was replicated in an independent retrospective cohort of RA patients (n = 199, p = 0.04). Conclusions The results of this study suggest that antibody interaction effects are important factors in the response to anti-TNF therapy in RA.

Published
2021

4. Prevalence of symptomatic axial osteoarthritis phenotypes in Spain and associated socio-demographic, anthropometric, and lifestyle variables

Author

Silva-Díaz, María T., Blanco García, Francisco J, Quevedo Vila, Víctor, Seoane-Mato, Daniel, Pérez-Ruiz, Fernando, Juan-Mas, Antonio, Pego-Reigosa, José M., Narváez, Javier, Quilis, Neus, Cortés, Raúl, Romero-Pérez, Antonio, Fábregas Canales, Dolores, Font Gayá, Teresa, Bordoy Ferrer, Carolina, Prado-Galbarro, Francisco Javier, Sánchez-Piedra, Carlos, Díaz-González, Federico, Bustabad-Reyes, Sagrario, Silva-Díaz, María T., Blanco García, Francisco J, Quevedo Vila, Víctor, Seoane-Mato, Daniel, Pérez-Ruiz, Fernando, Juan-Mas, Antonio, Pego-Reigosa, José M., Narváez, Javier, Quilis, Neus, Cortés, Raúl, Romero-Pérez, Antonio, Fábregas Canales, Dolores, Font Gayá, Teresa, Bordoy Ferrer, Carolina, Prado-Galbarro, Francisco Javier, Sánchez-Piedra, Carlos, Díaz-González, Federico, and Bustabad-Reyes, Sagrario

Abstract

[Abstract] Objective. Axial osteoarthritis (OA) is a common cause of back and neck pain, however, few studies have examined its prevalence. The aim was to estimate the prevalence and the characteristics of symptomatic axial OA in Spain. Methods. EPISER2016 is a cross-sectional multicenter population-based study of people aged 40 years or older. Subjects were randomly selected using multistage stratified cluster sampling. Participants were contacted by telephone to complete rheumatic disease screening questionnaires. Two phenotypes were analyzed, patients with Non-exclusive axial OA (NEA-OA) and Exclusive axial OA (EA-OA). To calculate the prevalence and its 95% confidence interval (CI), the sample design was considered and weighting was calculated according to age, sex and geographic origin. Results. Prevalence of NEA-OA by clinical or clinical-radiographic criteria was 19.17% (95% CI: 17.82–20.59). The frequency of NEA-OA increased with age (being 3.6 times more likely in patients aged 80 s or more than in those between 40 and 49 years) and body mass index. It was significantly more frequent in women, as well as in the center of Spain. It was less frequent in those with a higher level of education. Lumbar OA was more frequent than cervical OA. This difference grew with increasing age and was not associated with gender. It was also greater in overweight and obese subjects. Conclusions. This is the first study on the prevalence of axial OA phenotypes in Europe describing the associated socio-demographic, anthropometric, and lifestyle variables.

Published
2021

5. Dark Matter benchmark models for early LHC Run-2 Searches:Report of the ATLAS/CMS Dark Matter Forum

Author

Abercrombie, D., Akchurin, N., Juan Mas, A, Allen, B., Alvarez, Barbara, Jeremy, Andrea, Arbey, Alexandre, Azuelos, G., Azzi, P., Backovic, Mihailo, Bai, Yang, Banerjee, S. M., Belyaev, Alexander, Boveia, Antonio, Brennan, A., Buchmueller, O., Zucchetta, Alberto, Shepherd, William Madsen, Abercrombie, D., Akchurin, N., Juan Mas, A, Allen, B., Alvarez, Barbara, Jeremy, Andrea, Arbey, Alexandre, Azuelos, G., Azzi, P., Backovic, Mihailo, Bai, Yang, Banerjee, S. M., Belyaev, Alexander, Boveia, Antonio, Brennan, A., Buchmueller, O., Zucchetta, Alberto, and Shepherd, William Madsen

Published
2020

6. Dark Matter benchmark models for early LHC Run-2 Searches:Report of the ATLAS/CMS Dark Matter Forum

Author

Abercrombie, D., Akchurin, N., Juan Mas, A, Allen, B., Alvarez, Barbara, Jeremy, Andrea, Arbey, Alexandre, Azuelos, G., Azzi, P., Backovic, Mihailo, Bai, Yang, Banerjee, S. M., Belyaev, Alexander, Boveia, Antonio, Brennan, A., Buchmueller, O., Zucchetta, Alberto, Shepherd, William Madsen, Abercrombie, D., Akchurin, N., Juan Mas, A, Allen, B., Alvarez, Barbara, Jeremy, Andrea, Arbey, Alexandre, Azuelos, G., Azzi, P., Backovic, Mihailo, Bai, Yang, Banerjee, S. M., Belyaev, Alexander, Boveia, Antonio, Brennan, A., Buchmueller, O., Zucchetta, Alberto, and Shepherd, William Madsen

Published
2020

7. Prevalencia de artrosis sintomática en España: estudio EPISER2016

Author

Blanco García, Francisco J, Silva-Díaz, María T., Quevedo Vila, Víctor, Seoane-Mato, Daniel, Pérez Ruiz, Fernando, Juan-Mas, Antonio, Pego-Reigosa, J., Narváez, Javier, Quilis, Neus, Cortés, Raúl, Romero Pérez, Antonio, Fábregas Canales, Dolores, Font Gayá, Teresa, Bordoy Ferrer, Carolina, Sánchez-Piedra, Carlos, Díaz-González, Federico, Bustabad, Sagrario, Blanco García, Francisco J, Silva-Díaz, María T., Quevedo Vila, Víctor, Seoane-Mato, Daniel, Pérez Ruiz, Fernando, Juan-Mas, Antonio, Pego-Reigosa, J., Narváez, Javier, Quilis, Neus, Cortés, Raúl, Romero Pérez, Antonio, Fábregas Canales, Dolores, Font Gayá, Teresa, Bordoy Ferrer, Carolina, Sánchez-Piedra, Carlos, Díaz-González, Federico, and Bustabad, Sagrario

Abstract

[Resumen] Introducción. La Sociedad Española de Reumatología elaboró en el año 2000 el estudio EPISER2000 para conocer la prevalencia de la artrosis y otras enfermedades reumáticas en España. Los cambios sociodemográficos y en los hábitos de vida ocurridos en los últimos años en España justifican actualizar los datos de las enfermedades reumáticas (EPISER2016). Objetivo. Estimar la prevalencia de artrosis sintomática de columna cervical, columna lumbar, cadera, rodilla y mano, en población adulta en España. Material y métodos. Estudio transversal de base poblacional. Se realizó un muestreo aleatorizado polietápico estratificado y por conglomerados. Los participantes fueron contactados por teléfono para cumplimentar un cuestionario de cribado de artrosis. El reumatólogo confirmaba o descartaba el diagnóstico. Se utilizaron los criterios-clínicos-ACR para diagnosticar artrosis de manos y los criterios clínico-radiológicos-ACR para diagnosticar la artrosis de rodilla y cadera. Resultados. La prevalencia de artrosis en España en una o más de las localizaciones estudiadas fue de 29,35%. La prevalencia de artrosis-cervical fue del 10,10% y de artrosis-lumbar del 15,52%. Ambas son más frecuentes en mujeres y a mayor edad, así como en personas con niveles de estudios bajos y obesidad. La prevalencia de artrosis de cadera fue del 5,13% y la de artrosis de rodilla del 13,83%; estas se asocian con el sexo femenino, sobrepeso y obesidad, menor frecuencia en nivel de estudios alto y con la edad. La prevalencia de la artrosis de mano fue del 7,73%. Es más frecuente en mujeres, obesas, con bajo nivel de estudios y mayor edad. Conclusiones. El estudio EPISER2016 es el primero que analiza la prevalencia de artrosis sintomática en 5 localizaciones (columna cervical, lumbar, rodilla, cadera y manos) en España. La artrosis de la columna lumbar es la más prevalente., [Abstract] Introduction. The Spanish Society of Rheumatology carried out the EPISER2000 study in 2000 to determine the prevalence of osteoarthritis and other rheumatic diseases in the Spanish population. Recent sociodemographic changes and lifestyle habits in Spain justified updating the epidemiological data on osteoarthritis and other rheumatic diseases (EPISER2016-study). Objective. To estimate the prevalence of symptomatic osteoarthritis of the cervical spine, lumbar spine, hip, knee and hand in the adult population in Spain. Material and methods. Cross-sectional population-based study. A multistage and stratified random cluster sampling was carried out. The participants were contacted by telephone to complete an osteoarthritis screening questionnaire. A rheumatologist confirmed or discarded the diagnosis. The ACR-clinical-criteria were used to diagnose hand-osteoarthritis and the ACR-clinical-radiological criteria to diagnose knee- and hip-osteoarthritis. To estimate the prevalence and its 95% confidence interval, weights were calculated according to the probability of selection in each of the sampling stages. Results. The prevalence of osteoarthritis in Spain in one or more of the locations studied was 29.35%. The prevalence of cervical-osteoarthritis was 10.10% and of lumbar-osteoarthritis 15.52%. Both are more frequent in women and at older ages, as well as in people with low levels of education and obesity. The prevalence of hip-osteoarthritis was 5.13%, that of knee-osteoarthritis 13.83%, these are associated with female sex, overweight and obesity. The prevalence of hand osteoarthritis was 7.73%. It is more frequent in women, who are obese, with a low educational level and who are older. Conclusion. The EPISER2016 study is the first to analyse the prevalence of symptomatic osteoarthritis in 5 locations (cervical, lumbar, knee, hip and hands) in Spain. Lumbar spine osteoarthritis is the most prevalent.

Published
2020

8. Caracterización de pacientes afectas de fibromialgia con o sin síndrome de hiperlaxitud articular

Author

Blanch Rubió, J., Juan Mas, Antonio, Carbonell i Abelló, Jordi, Pedro-Botet, Juan, López Núñez, Lilian María, Universitat Autònoma de Barcelona. Departament de Medicina., Blanch Rubió, J., Juan Mas, Antonio, Carbonell i Abelló, Jordi, Pedro-Botet, Juan, López Núñez, Lilian María, and Universitat Autònoma de Barcelona. Departament de Medicina.

Abstract

Departament responsable de la tesi: Departament de Medicina., La tesi presentada avalua la presència de la síndrome d'hiperlaxitud articular (SHA) en pacients que pateixen fibromiàlgia (FM) i si existeixen diferències entre les pacients que presenten SHA i les que no. Els resultats d'aquesta tesi, reflexen que el trastorn ansiós és més prevalent en les pacients amb FM i SHA, així mateix, aquestes pacients són més primes, amb menys massa grassa i massa muscular, així com menor densitat mineral òssia. El nostre treball ha aconseguit demostrar que els dos grups presenten certes similituds a nivell clínic i algunes diferències interessants a nivell de la composició corporal i del metabolisme ossi., La tesis presentada evalúa la presencia del síndrome de hiperlaxitud articular (SHA) en pacientes afectas de fibromialgia (FM) y si esta característica confiere diferencias entre ambos grupos. Encontramos que el trastorno ansioso fue más prevalente en las pacientes con FM y con SHA, estas pacientes son mas delgadas, con menor masa grasa y masa muscular; así como menor densidad mineral ósea. Nuestro trabajo ha logrado demostrar que ambos grupos presentan ciertas similitudes a nivel clínico y algunas diferencias interesantes a nivel de la composición corporal y del metabolismo óseo., The thesis presented evaluates the presence/absence of Joint Hypermobility Syndrome (JHS) in patients with Fibromyalgia (FM) and if this characteristic confers differences between both groups. We found that anxiety disorder was more prevalent in patients with FM and with JHS; these patients are thinner, with less fat and muscle mass; as well as lower bone mineral density. Our work has shown that both groups present certain similarities at a clinical level and some interesting differences in terms of body composition and bone metabolism.

Published
2019

9. Caracterización de pacientes afectas de fibromialgia con o sin síndrome de hiperlaxitud articular

Author

Blanch Rubió, J., Juan Mas, Antonio, Carbonell i Abelló, Jordi, Pedro-Botet, Juan, López Núñez, Lilian María, Universitat Autònoma de Barcelona. Departament de Medicina, Blanch Rubió, J., Juan Mas, Antonio, Carbonell i Abelló, Jordi, Pedro-Botet, Juan, López Núñez, Lilian María, and Universitat Autònoma de Barcelona. Departament de Medicina

Abstract

Departament responsable de la tesi: Departament de Medicina., La tesi presentada avalua la presència de la síndrome d'hiperlaxitud articular (SHA) en pacients que pateixen fibromiàlgia (FM) i si existeixen diferències entre les pacients que presenten SHA i les que no. Els resultats d'aquesta tesi, reflexen que el trastorn ansiós és més prevalent en les pacients amb FM i SHA, així mateix, aquestes pacients són més primes, amb menys massa grassa i massa muscular, així com menor densitat mineral òssia. El nostre treball ha aconseguit demostrar que els dos grups presenten certes similituds a nivell clínic i algunes diferències interessants a nivell de la composició corporal i del metabolisme ossi., La tesis presentada evalúa la presencia del síndrome de hiperlaxitud articular (SHA) en pacientes afectas de fibromialgia (FM) y si esta característica confiere diferencias entre ambos grupos. Encontramos que el trastorno ansioso fue más prevalente en las pacientes con FM y con SHA, estas pacientes son mas delgadas, con menor masa grasa y masa muscular; así como menor densidad mineral ósea. Nuestro trabajo ha logrado demostrar que ambos grupos presentan ciertas similitudes a nivel clínico y algunas diferencias interesantes a nivel de la composición corporal y del metabolismo óseo., The thesis presented evaluates the presence/absence of Joint Hypermobility Syndrome (JHS) in patients with Fibromyalgia (FM) and if this characteristic confers differences between both groups. We found that anxiety disorder was more prevalent in patients with FM and with JHS; these patients are thinner, with less fat and muscle mass; as well as lower bone mineral density. Our work has shown that both groups present certain similarities at a clinical level and some interesting differences in terms of body composition and bone metabolism.

Published
2019

10. The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Author

Gonzalez-Alvaro, Isidoro, Castrejon, Isabel, Carmona, Loreto, Dougados, M., Huizinga, T., Abu Shakra, M., Alberts, A., Alperi Lopez, M., Amital, H., Aringer, M., Aslanidis, S., Berenbaum, F., Bijlsma, H., Blanco Garcia, F. J., Bliddal, H., Borofsky, M., Brocq, O., Buldakov, S., Cantini, F., Carreno Perez, L., Chahade, W., Ciconelli, R., Codreanu, C., Dahlqvist, S. R., Damjanov, N., Diamantopoulos, A., Dimdina, L., Dimic, A., Dorokhov, A., Dubikov, A., Fadienko, G., Fano, N., Ferreira, G., Gabrielli, A., Gaffney, K., Gaudin, P., Gerlag, D. M., Gerli, R., Goncalves, C. R., Hansen, M. S., Hanvivadhanakul, P., Hoili, C., Hou, A., Hunter, J., Ilic, T., Ionescu, R., Kaine, J., Kakurina, N., Kamalova, R., Kelly, T., Knyazeva, L., Krumina, L., Kurthen, R., Lagrone, R. P., Lapadula, G., Lavrentjevs, V, Lawson, J. G., Lazic, Z., Lejnieks, A., Levy, Y., Lexberg, A., Mader, R., Mariette, X., Markovits, D., Mola, Martin E., Maugars, Y., Guarch, Maymo J., Mazurov, V., I, Mikkelsen, K., Vergles, Morovic J., Nabizadeh, S., Nanagara, R., Nasonov, E. L., Sarabia, Navarro F., Neumann, T., Novak, S., Olech, E., Oza, M., Paran, D., Parsik, E., Pegram, S., Suarez, Pombo M., Popova, T., Puechal, X., Raja, N., Ridley, D., Rosner, I, Rubbert-Roth, A., Rudin, A., Saraux, A., Saulite-Kandevica, D., Settas, L., Sfikakis, P., Sheeran, T., Sizikov, A., Stamenkovic, D., Stefanovic, D., Stolow, J. B., Tan, A. L., Tebib, J., Tishler, M., Tony, H. P., Troum, O. M., Uaratanawong, S., Ucar Angulo, E., Valenzuela, G., van der Laken, K., Van Laar, J., van Riel, P. L. C. M., Vasilopoulos, D., Veldi, T., Vinogradova, I, Vosse, D., Wassenberg, S., Weidmann, C., Weitz, M., Wollenhaupt, J., Xavier, R., Yakupova, S., Zagar, I, Zavgorodnaja, T., Zemerova, E., Zisman, D., Zonova, E., Camona, Loreto, Abasolo Alcazar, L., Alegre de Miguel, C., Andreu Sanchez, J. L., Aragon Diez, A., Balsa Criado, A., Batlle Gualda, E., Belmonte Serrano, M. A., Beltran Audera, J., Beltran Fabregat, J., Bonilla Hernan, G., Caro Fernandez, N., Casado, E., Cebrian Mendez, L., Corteguera Coro, M., Cuadra Diaz, J. L., Cuesta, E., Fiter Areste, J., Freire Gonzalez, M., Galindo Izquierdo, M., Garcia Meijide, J. A., Garcia Gomez, M. C., Gimenez Ubeda, E., Gomez Centeno, E., Gomez Vaquero, C., Gonzalez Fernandez, M. J., Gonzalez Gomez, M. L., Gonzalez Hernandez, T., Gonzalez-Alvaro, I, Gonzalez-Montagut Gomez, C., Grandal Delgado, Y., Gratacos Masmitja, J., Hernandez del Rio, A., Instxaurbe, A. R., Irigoyen Oyarzabal, M., V, Jimenez Palop, M., Juan Mas, A., Judez Navarro, E., Larrosa Padro, M., Lopez Longo, F. J., Loza Santamaria, E., Maese Manzano, J., Manero Ruiz, F. J., Mateo Bernardo, I, Mayordomo Gonzalez, L., Mazzucheli, R., Medrano San Idelfonso, M., Naranjo Hernandez, A., Pecondon Espanol, A., Peiro Callizo, E., Quiros Donate, J., Ramos Lopez, P., Rivera Redondo, J., Rodriguez Gomez, M., Rodriguez Lopez, M., Rosello Pardo, R., Sampedro Alvarez, J., Sanmarti Sala, R., Rey Rey, Santos J., Tena Marsa, X., Tenorio Martin, M., Torres Martin, M. C., Urena Garnica, I, Valdazo de Diego, J. P., Valls, M., Villaverde Garcia, V., Zarco Montejo, P., Zubieta Tabernero, J., Balsa, Alejandro, Sanmarti, Raimon, Cabezas, J. A., Cantalejo, M., Chamizo, E., Ciruelo, E., Corrales, A., Cruz, A., Diaz, C., Fiter, J., Freire, M. M., Galindo, M., Garcia de Vicuna, M. R., Gelman, S. M., Gonzalez Crespo, R., Gonzalez Fernandez, C., Gracia, A., Granados, J., Guzman, M. A., Irigoyen, M., V, Juan, A., Juanola, X., Laiz, A., Manero, F. J., Martinez, A., Martinez, F., Mata, C., Maymo, J., Navarro, F. J., Peiro, E., Perez, F., Perez, G., Perez, M., Pujol, M., Quiros, J., Ribas, B., Riera, M., Rivera, J., Rodriguez, J. M., Rosello, R., Tenorio, M., Toyos, F. J., Gonzalez-Alvaro, Isidoro, Castrejon, Isabel, Carmona, Loreto, Dougados, M., Huizinga, T., Abu Shakra, M., Alberts, A., Alperi Lopez, M., Amital, H., Aringer, M., Aslanidis, S., Berenbaum, F., Bijlsma, H., Blanco Garcia, F. J., Bliddal, H., Borofsky, M., Brocq, O., Buldakov, S., Cantini, F., Carreno Perez, L., Chahade, W., Ciconelli, R., Codreanu, C., Dahlqvist, S. R., Damjanov, N., Diamantopoulos, A., Dimdina, L., Dimic, A., Dorokhov, A., Dubikov, A., Fadienko, G., Fano, N., Ferreira, G., Gabrielli, A., Gaffney, K., Gaudin, P., Gerlag, D. M., Gerli, R., Goncalves, C. R., Hansen, M. S., Hanvivadhanakul, P., Hoili, C., Hou, A., Hunter, J., Ilic, T., Ionescu, R., Kaine, J., Kakurina, N., Kamalova, R., Kelly, T., Knyazeva, L., Krumina, L., Kurthen, R., Lagrone, R. P., Lapadula, G., Lavrentjevs, V, Lawson, J. G., Lazic, Z., Lejnieks, A., Levy, Y., Lexberg, A., Mader, R., Mariette, X., Markovits, D., Mola, Martin E., Maugars, Y., Guarch, Maymo J., Mazurov, V., I, Mikkelsen, K., Vergles, Morovic J., Nabizadeh, S., Nanagara, R., Nasonov, E. L., Sarabia, Navarro F., Neumann, T., Novak, S., Olech, E., Oza, M., Paran, D., Parsik, E., Pegram, S., Suarez, Pombo M., Popova, T., Puechal, X., Raja, N., Ridley, D., Rosner, I, Rubbert-Roth, A., Rudin, A., Saraux, A., Saulite-Kandevica, D., Settas, L., Sfikakis, P., Sheeran, T., Sizikov, A., Stamenkovic, D., Stefanovic, D., Stolow, J. B., Tan, A. L., Tebib, J., Tishler, M., Tony, H. P., Troum, O. M., Uaratanawong, S., Ucar Angulo, E., Valenzuela, G., van der Laken, K., Van Laar, J., van Riel, P. L. C. M., Vasilopoulos, D., Veldi, T., Vinogradova, I, Vosse, D., Wassenberg, S., Weidmann, C., Weitz, M., Wollenhaupt, J., Xavier, R., Yakupova, S., Zagar, I, Zavgorodnaja, T., Zemerova, E., Zisman, D., Zonova, E., Camona, Loreto, Abasolo Alcazar, L., Alegre de Miguel, C., Andreu Sanchez, J. L., Aragon Diez, A., Balsa Criado, A., Batlle Gualda, E., Belmonte Serrano, M. A., Beltran Audera, J., Beltran Fabregat, J., Bonilla Hernan, G., Caro Fernandez, N., Casado, E., Cebrian Mendez, L., Corteguera Coro, M., Cuadra Diaz, J. L., Cuesta, E., Fiter Areste, J., Freire Gonzalez, M., Galindo Izquierdo, M., Garcia Meijide, J. A., Garcia Gomez, M. C., Gimenez Ubeda, E., Gomez Centeno, E., Gomez Vaquero, C., Gonzalez Fernandez, M. J., Gonzalez Gomez, M. L., Gonzalez Hernandez, T., Gonzalez-Alvaro, I, Gonzalez-Montagut Gomez, C., Grandal Delgado, Y., Gratacos Masmitja, J., Hernandez del Rio, A., Instxaurbe, A. R., Irigoyen Oyarzabal, M., V, Jimenez Palop, M., Juan Mas, A., Judez Navarro, E., Larrosa Padro, M., Lopez Longo, F. J., Loza Santamaria, E., Maese Manzano, J., Manero Ruiz, F. J., Mateo Bernardo, I, Mayordomo Gonzalez, L., Mazzucheli, R., Medrano San Idelfonso, M., Naranjo Hernandez, A., Pecondon Espanol, A., Peiro Callizo, E., Quiros Donate, J., Ramos Lopez, P., Rivera Redondo, J., Rodriguez Gomez, M., Rodriguez Lopez, M., Rosello Pardo, R., Sampedro Alvarez, J., Sanmarti Sala, R., Rey Rey, Santos J., Tena Marsa, X., Tenorio Martin, M., Torres Martin, M. C., Urena Garnica, I, Valdazo de Diego, J. P., Valls, M., Villaverde Garcia, V., Zarco Montejo, P., Zubieta Tabernero, J., Balsa, Alejandro, Sanmarti, Raimon, Cabezas, J. A., Cantalejo, M., Chamizo, E., Ciruelo, E., Corrales, A., Cruz, A., Diaz, C., Fiter, J., Freire, M. M., Galindo, M., Garcia de Vicuna, M. R., Gelman, S. M., Gonzalez Crespo, R., Gonzalez Fernandez, C., Gracia, A., Granados, J., Guzman, M. A., Irigoyen, M., V, Juan, A., Juanola, X., Laiz, A., Manero, F. J., Martinez, A., Martinez, F., Mata, C., Maymo, J., Navarro, F. J., Peiro, E., Perez, F., Perez, G., Perez, M., Pujol, M., Quiros, J., Ribas, B., Riera, M., Rivera, J., Rodriguez, J. M., Rosello, R., Tenorio, M., and Toyos, F. J.

Abstract

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR's.

Published
2019

11. The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Author

Gonzalez-Alvaro, Isidoro, Castrejon, Isabel, Carmona, Loreto, Dougados, M., Huizinga, T., Abu Shakra, M., Alberts, A., Alperi Lopez, M., Amital, H., Aringer, M., Aslanidis, S., Berenbaum, F., Bijlsma, H., Blanco Garcia, F. J., Bliddal, H., Borofsky, M., Brocq, O., Buldakov, S., Cantini, F., Carreno Perez, L., Chahade, W., Ciconelli, R., Codreanu, C., Dahlqvist, S. R., Damjanov, N., Diamantopoulos, A., Dimdina, L., Dimic, A., Dorokhov, A., Dubikov, A., Fadienko, G., Fano, N., Ferreira, G., Gabrielli, A., Gaffney, K., Gaudin, P., Gerlag, D. M., Gerli, R., Goncalves, C. R., Hansen, M. S., Hanvivadhanakul, P., Hoili, C., Hou, A., Hunter, J., Ilic, T., Ionescu, R., Kaine, J., Kakurina, N., Kamalova, R., Kelly, T., Knyazeva, L., Krumina, L., Kurthen, R., Lagrone, R. P., Lapadula, G., Lavrentjevs, V, Lawson, J. G., Lazic, Z., Lejnieks, A., Levy, Y., Lexberg, A., Mader, R., Mariette, X., Markovits, D., Mola, Martin E., Maugars, Y., Guarch, Maymo J., Mazurov, V., I, Mikkelsen, K., Vergles, Morovic J., Nabizadeh, S., Nanagara, R., Nasonov, E. L., Sarabia, Navarro F., Neumann, T., Novak, S., Olech, E., Oza, M., Paran, D., Parsik, E., Pegram, S., Suarez, Pombo M., Popova, T., Puechal, X., Raja, N., Ridley, D., Rosner, I, Rubbert-Roth, A., Rudin, A., Saraux, A., Saulite-Kandevica, D., Settas, L., Sfikakis, P., Sheeran, T., Sizikov, A., Stamenkovic, D., Stefanovic, D., Stolow, J. B., Tan, A. L., Tebib, J., Tishler, M., Tony, H. P., Troum, O. M., Uaratanawong, S., Ucar Angulo, E., Valenzuela, G., van der Laken, K., Van Laar, J., van Riel, P. L. C. M., Vasilopoulos, D., Veldi, T., Vinogradova, I, Vosse, D., Wassenberg, S., Weidmann, C., Weitz, M., Wollenhaupt, J., Xavier, R., Yakupova, S., Zagar, I, Zavgorodnaja, T., Zemerova, E., Zisman, D., Zonova, E., Camona, Loreto, Abasolo Alcazar, L., Alegre de Miguel, C., Andreu Sanchez, J. L., Aragon Diez, A., Balsa Criado, A., Batlle Gualda, E., Belmonte Serrano, M. A., Beltran Audera, J., Beltran Fabregat, J., Bonilla Hernan, G., Caro Fernandez, N., Casado, E., Cebrian Mendez, L., Corteguera Coro, M., Cuadra Diaz, J. L., Cuesta, E., Fiter Areste, J., Freire Gonzalez, M., Galindo Izquierdo, M., Garcia Meijide, J. A., Garcia Gomez, M. C., Gimenez Ubeda, E., Gomez Centeno, E., Gomez Vaquero, C., Gonzalez Fernandez, M. J., Gonzalez Gomez, M. L., Gonzalez Hernandez, T., Gonzalez-Alvaro, I, Gonzalez-Montagut Gomez, C., Grandal Delgado, Y., Gratacos Masmitja, J., Hernandez del Rio, A., Instxaurbe, A. R., Irigoyen Oyarzabal, M., V, Jimenez Palop, M., Juan Mas, A., Judez Navarro, E., Larrosa Padro, M., Lopez Longo, F. J., Loza Santamaria, E., Maese Manzano, J., Manero Ruiz, F. J., Mateo Bernardo, I, Mayordomo Gonzalez, L., Mazzucheli, R., Medrano San Idelfonso, M., Naranjo Hernandez, A., Pecondon Espanol, A., Peiro Callizo, E., Quiros Donate, J., Ramos Lopez, P., Rivera Redondo, J., Rodriguez Gomez, M., Rodriguez Lopez, M., Rosello Pardo, R., Sampedro Alvarez, J., Sanmarti Sala, R., Rey Rey, Santos J., Tena Marsa, X., Tenorio Martin, M., Torres Martin, M. C., Urena Garnica, I, Valdazo de Diego, J. P., Valls, M., Villaverde Garcia, V., Zarco Montejo, P., Zubieta Tabernero, J., Balsa, Alejandro, Sanmarti, Raimon, Cabezas, J. A., Cantalejo, M., Chamizo, E., Ciruelo, E., Corrales, A., Cruz, A., Diaz, C., Fiter, J., Freire, M. M., Galindo, M., Garcia de Vicuna, M. R., Gelman, S. M., Gonzalez Crespo, R., Gonzalez Fernandez, C., Gracia, A., Granados, J., Guzman, M. A., Irigoyen, M., V, Juan, A., Juanola, X., Laiz, A., Manero, F. J., Martinez, A., Martinez, F., Mata, C., Maymo, J., Navarro, F. J., Peiro, E., Perez, F., Perez, G., Perez, M., Pujol, M., Quiros, J., Ribas, B., Riera, M., Rivera, J., Rodriguez, J. M., Rosello, R., Tenorio, M., Toyos, F. J., Gonzalez-Alvaro, Isidoro, Castrejon, Isabel, Carmona, Loreto, Dougados, M., Huizinga, T., Abu Shakra, M., Alberts, A., Alperi Lopez, M., Amital, H., Aringer, M., Aslanidis, S., Berenbaum, F., Bijlsma, H., Blanco Garcia, F. J., Bliddal, H., Borofsky, M., Brocq, O., Buldakov, S., Cantini, F., Carreno Perez, L., Chahade, W., Ciconelli, R., Codreanu, C., Dahlqvist, S. R., Damjanov, N., Diamantopoulos, A., Dimdina, L., Dimic, A., Dorokhov, A., Dubikov, A., Fadienko, G., Fano, N., Ferreira, G., Gabrielli, A., Gaffney, K., Gaudin, P., Gerlag, D. M., Gerli, R., Goncalves, C. R., Hansen, M. S., Hanvivadhanakul, P., Hoili, C., Hou, A., Hunter, J., Ilic, T., Ionescu, R., Kaine, J., Kakurina, N., Kamalova, R., Kelly, T., Knyazeva, L., Krumina, L., Kurthen, R., Lagrone, R. P., Lapadula, G., Lavrentjevs, V, Lawson, J. G., Lazic, Z., Lejnieks, A., Levy, Y., Lexberg, A., Mader, R., Mariette, X., Markovits, D., Mola, Martin E., Maugars, Y., Guarch, Maymo J., Mazurov, V., I, Mikkelsen, K., Vergles, Morovic J., Nabizadeh, S., Nanagara, R., Nasonov, E. L., Sarabia, Navarro F., Neumann, T., Novak, S., Olech, E., Oza, M., Paran, D., Parsik, E., Pegram, S., Suarez, Pombo M., Popova, T., Puechal, X., Raja, N., Ridley, D., Rosner, I, Rubbert-Roth, A., Rudin, A., Saraux, A., Saulite-Kandevica, D., Settas, L., Sfikakis, P., Sheeran, T., Sizikov, A., Stamenkovic, D., Stefanovic, D., Stolow, J. B., Tan, A. L., Tebib, J., Tishler, M., Tony, H. P., Troum, O. M., Uaratanawong, S., Ucar Angulo, E., Valenzuela, G., van der Laken, K., Van Laar, J., van Riel, P. L. C. M., Vasilopoulos, D., Veldi, T., Vinogradova, I, Vosse, D., Wassenberg, S., Weidmann, C., Weitz, M., Wollenhaupt, J., Xavier, R., Yakupova, S., Zagar, I, Zavgorodnaja, T., Zemerova, E., Zisman, D., Zonova, E., Camona, Loreto, Abasolo Alcazar, L., Alegre de Miguel, C., Andreu Sanchez, J. L., Aragon Diez, A., Balsa Criado, A., Batlle Gualda, E., Belmonte Serrano, M. A., Beltran Audera, J., Beltran Fabregat, J., Bonilla Hernan, G., Caro Fernandez, N., Casado, E., Cebrian Mendez, L., Corteguera Coro, M., Cuadra Diaz, J. L., Cuesta, E., Fiter Areste, J., Freire Gonzalez, M., Galindo Izquierdo, M., Garcia Meijide, J. A., Garcia Gomez, M. C., Gimenez Ubeda, E., Gomez Centeno, E., Gomez Vaquero, C., Gonzalez Fernandez, M. J., Gonzalez Gomez, M. L., Gonzalez Hernandez, T., Gonzalez-Alvaro, I, Gonzalez-Montagut Gomez, C., Grandal Delgado, Y., Gratacos Masmitja, J., Hernandez del Rio, A., Instxaurbe, A. R., Irigoyen Oyarzabal, M., V, Jimenez Palop, M., Juan Mas, A., Judez Navarro, E., Larrosa Padro, M., Lopez Longo, F. J., Loza Santamaria, E., Maese Manzano, J., Manero Ruiz, F. J., Mateo Bernardo, I, Mayordomo Gonzalez, L., Mazzucheli, R., Medrano San Idelfonso, M., Naranjo Hernandez, A., Pecondon Espanol, A., Peiro Callizo, E., Quiros Donate, J., Ramos Lopez, P., Rivera Redondo, J., Rodriguez Gomez, M., Rodriguez Lopez, M., Rosello Pardo, R., Sampedro Alvarez, J., Sanmarti Sala, R., Rey Rey, Santos J., Tena Marsa, X., Tenorio Martin, M., Torres Martin, M. C., Urena Garnica, I, Valdazo de Diego, J. P., Valls, M., Villaverde Garcia, V., Zarco Montejo, P., Zubieta Tabernero, J., Balsa, Alejandro, Sanmarti, Raimon, Cabezas, J. A., Cantalejo, M., Chamizo, E., Ciruelo, E., Corrales, A., Cruz, A., Diaz, C., Fiter, J., Freire, M. M., Galindo, M., Garcia de Vicuna, M. R., Gelman, S. M., Gonzalez Crespo, R., Gonzalez Fernandez, C., Gracia, A., Granados, J., Guzman, M. A., Irigoyen, M., V, Juan, A., Juanola, X., Laiz, A., Manero, F. J., Martinez, A., Martinez, F., Mata, C., Maymo, J., Navarro, F. J., Peiro, E., Perez, F., Perez, G., Perez, M., Pujol, M., Quiros, J., Ribas, B., Riera, M., Rivera, J., Rodriguez, J. M., Rosello, R., Tenorio, M., and Toyos, F. J.

Abstract

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR's.

Published
2019

12. Adherence to synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: results of the OBSERVAR study

Author

Juan Mas, Antonio, Castañeda, Santos, Cantero Santamaría, José I., Baquero, José L., De-Toro, Javier, Juan Mas, Antonio, Castañeda, Santos, Cantero Santamaría, José I., Baquero, José L., and De-Toro, Javier

Abstract

[Abstract] Background: Treatment compliance with disease-modifying antirheumatic drugs (DMARD) is essential to achieve the therapeutic goals in rheumatoid arthritis (RA). However, despite the need for good compliance, there is evidence that patients with RA frequently fail to use DMARD for the control of RA. Thus, the main objective of the OBSERVAR study is to evaluate the reasons for the lack of therapeutic adherence to synthetic DMARD in these patients. Patients and methods: A Delphi process involving 18 randomly selected Spanish rheumatologists determined the level of agreement with 66 causes of noncompliance selected from the literature in relation to synthetic DMARD in RA. Results: The reasons for noncompliance were consistent in 75.7%, although 3 reasons (4.5%) were highly consistent: 1) not knowing what to do in the case of an adverse event with DMARD; 2) not having undergone adherence screening by health personnel for early detection of "noncompliant patients"; and 3) not having undergone interventions or strategies that improve adherence. Conclusion: In order to improve adherence to RA treatment with synthetic DMARD, the patient should be adequately informed of each new treatment introduced, the patient's compliance profile should be incorporated into the clinical routine and the patient's motivation for therapeutic compliance be reinforced through the methods available to us., [Resumen] Introducción. La cumplimentación del tratamiento modificador de la enfermedad es esencial para alcanzar los objetivos terapéuticos en la artritis reumatoide (AR). Sin embargo, y a pesar de la necesidad de una buena adherencia, existe evidencia de que muchos pacientes con AR no cumplen adecuadamente con la prescripción del tratamiento indicado con fármacos moduladores de la enfermedad de acción lenta (FAME) sintéticos o convencionales. Conscientes de la importancia de este hecho, el estudio sobre observancia terapéutica en AR (estudio OBSERVAR) tiene como objetivo principal valorar los motivos de la falta de adherencia terapéutica a los FAME sintéticos en estos pacientes. Pacientes y métodos. Mediante un proceso Delphi entre 18 reumatólogos españoles seleccionados aleatoriamente se determinó el grado de acuerdo con 66 causas de incumplimiento seleccionadas de la bibliografía, en relación con los FAME sintéticos en la AR. Resultados. Los motivos de incumplimiento fueron consistentes en el 75,7%, si bien 3 razones (4,5%) destacaron como muy consistentes: 1) desconocer qué hacer cuando se sufre un acontecimiento adverso con el FAME; 2) no llevar a cabo métodos de cribado de la adherencia por el personal sanitario para detectar a los «pacientes incumplidores» de forma temprana y 3) no aplicar intervenciones o estrategias que mejoren la adherencia terapéutica. Conclusión. Para mejorar la adherencia al tratamiento de la AR con FAME sintéticos se debe informar al paciente de cada tratamiento nuevo introducido, incorporar el perfil de cumplimiento del paciente en la rutina clínica, y reforzar la motivación del paciente al cumplimiento terapéutico mediante los métodos a nuestro alcance.

Published
2019

13. Osteoporosi en població gran

Author

Juan Mas, Antoni, Ibáñez Barceló, Mònica, Melià Mesquida, Catalina, Ros Vilamajó, Inmaculada, Toniolo, Elide, Cacheda, Ana Paula, Juan Mas, Antoni, Ibáñez Barceló, Mònica, Melià Mesquida, Catalina, Ros Vilamajó, Inmaculada, Toniolo, Elide, and Cacheda, Ana Paula

Abstract

[cat]L’osteoporosi és la malaltia del metabolisme ossi més freqüent, i presenta unes característiques especials en la gent gran. La densitometria òssia, especialment la DXA, és l’element clau, segons les directrius de l’OMS, per al diagnòstic de l’OP relacionada amb la presència de fractures òssies. S’exposen unes escales de risc, entre les qual destaca el FRAX, que estimen la possibilitat de patir osteoporosi o de risc de fractures. L’osteoporosi comporta una repercussió enorme des del punt de vista clínic i econòmic, atès que provoca el nombre més important de fractures per fragilitat. La prevalença de l’osteoporosi és molt elevada en la població general, especialment en la població anciana i en les persones que presenten factors de risc específics de patir-ne. Hi ha uns factors de risc, variables clíniques i epidemiològiques, que s’associen específicament a la presència d’osteoporosi. El tractament consisteix en mesures higienicodietètiques, una correcta ingesta de calci i de vitamina D, exercici físic i fàrmacs específics: antiresortius, neoformadors o mixtos., [spa]La osteoporosis es la enfermedad del metabolismo óseo más frecuente, presentando unas características especiales en la gente mayor. La densitometría ósea, especialmente la DXA, es el elemento clave, según las directrices de la OMS, para el diagnóstico de la OP relacionada con la presencia de fracturas óseas. Se exponen unas escalas de riesgo, entre las que destaca el FRAX, que estiman la posibilidad de padecer osteoporosis o de riesgo de fracturas. Conlleva una repercusión enorme desde el punto de vista clínico y económico al provocar el mayor número de fracturas por fragilidad. La prevalencia de la osteoporosis es muy elevada en la población general, especialmente en la población anciana y en las personas que presentan factores de riesgo específicos de padecerla. Existen unos factores de riesgo, variables clínicas y epidemiológicas, que se asocian específicamente a la presencia de osteoporosis. El tratamiento consiste en medidas higiénico-dietéticas, una correcta ingesta de calcio y de vitamina D, ejercicio físico y fármacos específicos: antirresortivos, neoformadores o mixtos.

Published
2017

14. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

Author

Avouac, J. Walker, U. Tyndall, A. Kahan, A. Matucci-Cerinic, M. Allanore, Y. Miniati, I. Müller, A. Iannone, F. Giacomelli, R. Distler, O. Becvar, R. Sierakowsky, S. Kowal-Bielecka, O. Coelho, P. Cabane, J. Cutolo, M. Shoenfeld, Y. Valentini, G. Rovensky, J. Riemekasten, G. Nicoara, I. Vlachoyiannopoulos, P. Caporali, R. Jiri, S. Inanc, M. Gorska, I.Z. Carreira, P. Novak, S. Czirjak, L. Ramos, F.O. Jendro, M. Chizzolini, C. Kucharz, E.J. Richter, J. Cozzi, F. Rozman, B. Mallia, C.M. Gabrielli, A. Farge, D. Kiener, H.P. Schöffel, D. Sticherling, M. Airo, P. Wollheim, F. Martinovic, D. Trotta, F. Hunzelmann, N. Jablonska, S. Reich, K. Bombardieri, S. Siakka, P. Pellerito, R. Bambara, L.M. Morovic-Vergles, J. Denton, C. Hinrichs, R. Van Den Hoogen, F. Damjanov, N. Kötter, I. Ortiz, V. Heitmann, S. Krasowska, D. Seidel, M. Hasler, P. Van Laar, J.M. Kaltwasser, J.P. Foeldvari, I. Juan Mas, A. Bajocchi, G. Wislowska, M. Pereira Da Silva, J.A. Jacobsen, S. Worm, M. Graniger, W. Kuhn, A. Stankovic, A. Cossutta, R. Majdan, M. Rajcevska, L.D. Tikly, M. Nasonov, E.L. Steinbrink, K. Herrick, A. Müller-Ladner, U. Dinc, A. Scorza, R. Sondergaard, K. Indiveri, F. Nielsen, H. Szekanecz, Z. Silver, R.M. Antivalle, M. Espinosa, I.B. García De La Pena Lefebvre, P. Midtvedt, O. Launay, D. Valesini, F. Tuvik, P. Ionescu, R.M. Del Papa, N. Pinto, S. Wigley, F. Mihai, C. Capranu, M.S. Sunderkötter, C. Jun, J.B. Derk, C. Alhasani, S. Distler, J.H. Ton, E. Soukup, T. Seibold, J. Zeni, S. Nash, P. Mouthon, L. De Keyser, F. Duruöz, M.T. Cantatore, F.P. Strauss, G. Von Mülhen, C.A. Pozzi, M.R. Eyerich, K. Szechinski, J. Keiserman, M. Houssiau, F.A. Rom-Ivorra, J.A. Krummel-Lorenz, B. Aringer, M. Westhovens, R. Bellisai, F. Mayer, M. Stoeckl, F. Üprus, M. Volpe, A. Buslau, M. Yavuz, S. Granel, B. Feijó, A.V. Del Galdo, F. Popa, S. Zenone, T. Machado, X.R. Pileckyte, M. Stebbings, S. Mathieu, A. Tulli, A. Tourinho, T. Souza, R. Acayaba De Toledo, R. Stamp, L. Solanki, K. Veale, D. Neto, J.F.M. B and Avouac, J. Walker, U. Tyndall, A. Kahan, A. Matucci-Cerinic, M. Allanore, Y. Miniati, I. Müller, A. Iannone, F. Giacomelli, R. Distler, O. Becvar, R. Sierakowsky, S. Kowal-Bielecka, O. Coelho, P. Cabane, J. Cutolo, M. Shoenfeld, Y. Valentini, G. Rovensky, J. Riemekasten, G. Nicoara, I. Vlachoyiannopoulos, P. Caporali, R. Jiri, S. Inanc, M. Gorska, I.Z. Carreira, P. Novak, S. Czirjak, L. Ramos, F.O. Jendro, M. Chizzolini, C. Kucharz, E.J. Richter, J. Cozzi, F. Rozman, B. Mallia, C.M. Gabrielli, A. Farge, D. Kiener, H.P. Schöffel, D. Sticherling, M. Airo, P. Wollheim, F. Martinovic, D. Trotta, F. Hunzelmann, N. Jablonska, S. Reich, K. Bombardieri, S. Siakka, P. Pellerito, R. Bambara, L.M. Morovic-Vergles, J. Denton, C. Hinrichs, R. Van Den Hoogen, F. Damjanov, N. Kötter, I. Ortiz, V. Heitmann, S. Krasowska, D. Seidel, M. Hasler, P. Van Laar, J.M. Kaltwasser, J.P. Foeldvari, I. Juan Mas, A. Bajocchi, G. Wislowska, M. Pereira Da Silva, J.A. Jacobsen, S. Worm, M. Graniger, W. Kuhn, A. Stankovic, A. Cossutta, R. Majdan, M. Rajcevska, L.D. Tikly, M. Nasonov, E.L. Steinbrink, K. Herrick, A. Müller-Ladner, U. Dinc, A. Scorza, R. Sondergaard, K. Indiveri, F. Nielsen, H. Szekanecz, Z. Silver, R.M. Antivalle, M. Espinosa, I.B. García De La Pena Lefebvre, P. Midtvedt, O. Launay, D. Valesini, F. Tuvik, P. Ionescu, R.M. Del Papa, N. Pinto, S. Wigley, F. Mihai, C. Capranu, M.S. Sunderkötter, C. Jun, J.B. Derk, C. Alhasani, S. Distler, J.H. Ton, E. Soukup, T. Seibold, J. Zeni, S. Nash, P. Mouthon, L. De Keyser, F. Duruöz, M.T. Cantatore, F.P. Strauss, G. Von Mülhen, C.A. Pozzi, M.R. Eyerich, K. Szechinski, J. Keiserman, M. Houssiau, F.A. Rom-Ivorra, J.A. Krummel-Lorenz, B. Aringer, M. Westhovens, R. Bellisai, F. Mayer, M. Stoeckl, F. Üprus, M. Volpe, A. Buslau, M. Yavuz, S. Granel, B. Feijó, A.V. Del Galdo, F. Popa, S. Zenone, T. Machado, X.R. Pileckyte, M. Stebbings, S. Mathieu, A. Tulli, A. Tourinho, T. Souza, R. Acayaba De Toledo, R. Stamp, L. Solanki, K. Veale, D. Neto, J.F.M. B

Abstract

Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.

Published
2010

15. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database.

Author

Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P.C., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Vlachoyiannopoulos, P.G., Caporali, R., Jiri, S., Inanc, M., Zimmermann Gorska, I., Carreira, P., Novak, S., Czirjak, L., Oliveira Ramos, F., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H., Schoffel, D., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Hoogen, F.H.J. van den, Damjanov, N., Kotter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Laar, J.M. van, Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M.H.J.B., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Damjanovska Rajcevska, L., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Muller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., Garcia de la Pena Lefebvre, P., Midtvedt, O., Launay, D. de, Valesini, F., Tuvik, P., Vonk, M.C., et al., Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P.C., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Vlachoyiannopoulos, P.G., Caporali, R., Jiri, S., Inanc, M., Zimmermann Gorska, I., Carreira, P., Novak, S., Czirjak, L., Oliveira Ramos, F., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H., Schoffel, D., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Hoogen, F.H.J. van den, Damjanov, N., Kotter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Laar, J.M. van, Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M.H.J.B., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Damjanovska Rajcevska, L., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Muller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., Garcia de la Pena Lefebvre, P., Midtvedt, O., Launay, D. de, Valesini, F., Tuvik, P., Vonk, M.C., and et al.

Abstract

Contains fulltext : 87872.pdf (publisher's version ) (Closed access)

Published
2010

17. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database.

Author

Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P.C., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Vlachoyiannopoulos, P.G., Caporali, R., Jiri, S., Inanc, M., Zimmermann Gorska, I., Carreira, P., Novak, S., Czirjak, L., Oliveira Ramos, F., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H., Schoffel, D., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Hoogen, F.H.J. van den, Damjanov, N., Kotter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Laar, J.M. van, Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M.H.J.B., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Damjanovska Rajcevska, L., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Muller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., Garcia de la Pena Lefebvre, P., Midtvedt, O., Launay, D. de, Valesini, F., Tuvik, P., Vonk, M.C., et al., Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P.C., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Vlachoyiannopoulos, P.G., Caporali, R., Jiri, S., Inanc, M., Zimmermann Gorska, I., Carreira, P., Novak, S., Czirjak, L., Oliveira Ramos, F., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H., Schoffel, D., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Hoogen, F.H.J. van den, Damjanov, N., Kotter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Laar, J.M. van, Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M.H.J.B., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Damjanovska Rajcevska, L., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Muller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., Garcia de la Pena Lefebvre, P., Midtvedt, O., Launay, D. de, Valesini, F., Tuvik, P., Vonk, M.C., and et al.

Abstract

Contains fulltext : 87872.pdf (publisher's version ) (Closed access)

Published
2010

18. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database.

Author

Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P.C., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Vlachoyiannopoulos, P.G., Caporali, R., Jiri, S., Inanc, M., Zimmermann Gorska, I., Carreira, P., Novak, S., Czirjak, L., Oliveira Ramos, F., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H., Schoffel, D., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Hoogen, F.H.J. van den, Damjanov, N., Kotter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Laar, J.M. van, Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M.H.J.B., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Damjanovska Rajcevska, L., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Muller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., Garcia de la Pena Lefebvre, P., Midtvedt, O., Launay, D. de, Valesini, F., Tuvik, P., Vonk, M.C., et al., Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P.C., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J., Riemekasten, G., Vlachoyiannopoulos, P.G., Caporali, R., Jiri, S., Inanc, M., Zimmermann Gorska, I., Carreira, P., Novak, S., Czirjak, L., Oliveira Ramos, F., Jendro, M., Chizzolini, C., Kucharz, E.J., Richter, J., Cozzi, F., Rozman, B., Mallia, C.M., Gabrielli, A., Farge, D., Kiener, H., Schoffel, D., Airo, P., Wollheim, F., Martinovic, D., Trotta, F., Jablonska, S., Reich, K., Bombardieri, S., Siakka, P., Pellerito, R., Bambara, L.M., Morovic-Vergles, J., Denton, C., Hinrichs, R., Hoogen, F.H.J. van den, Damjanov, N., Kotter, I., Ortiz, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Laar, J.M. van, Kaltwasser, J.P., Foeldvari, I., Juan Mas, A., Bajocchi, G., Wislowska, M., Pereira Da Silva, J.A., Jacobsen, S., Worm, M.H.J.B., Graniger, W., Kuhn, A., Stankovic, A., Cossutta, R., Majdan, M., Damjanovska Rajcevska, L., Tikly, M., Nasonov, E.L., Steinbrink, K., Herrick, A., Muller-Ladner, U., Dinc, A., Scorza, R., Sondergaard, K., Indiveri, F., Nielsen, H., Szekanecz, Z., Silver, R.M., Antivalle, M., Espinosa, I.B., Garcia de la Pena Lefebvre, P., Midtvedt, O., Launay, D. de, Valesini, F., Tuvik, P., Vonk, M.C., and et al.

Abstract

Contains fulltext : 87872.pdf (publisher's version ) (Closed access)

Published
2010

20. Prevalencia de osteoporosis, detectada mediante densitometría de calcáneo, y su asociación a factores de riesgo en mujeres postmenopáusicas de Mallorca

Author

Juan Mas, Antonio, Tamborero Cao, Gaspar, Servera Gornals, Margarita, Cabanes Martín, Teodorico, Marí Solivellas, Bartolomé, Juan Mas, Antonio, Tamborero Cao, Gaspar, Servera Gornals, Margarita, Cabanes Martín, Teodorico, and Marí Solivellas, Bartolomé

Abstract

La osteoporosis es una enfermedad muy prevalente condicionando un aumento del riesgo de fractura. El diagnóstico habitualmente se realiza por densitometría, especialmente practicada en columna lumbar y / o cadera. El presente estudio pretende determinar la prevalencia de osteoporosis por densitometría en calcáneo de mujeres mayores de Mallorca. La prevalencia según la T-score utilizada oscila entre el 8,5 y 32,6% según el punto de corte del T-score utilizado. Se han encontrado factores de riesgo relacionados con la osteoporosis como la edad, el peso, el IMC, las fracturas osteoporóticas previas y la lactancia materna., Osteoporosis is a disease very frequent that rises the risk of bone fracture. Diagnosis is usually done by practicing a Bone Mineral Densitometry, usually located in the femoral neck and / or lumbar spine. This study wants to determine the prevalence of osteoporosis, by using a calcaneal densitometry, in old Mallorcan women. The results establish a prevalence between the 8,5 and 32,6% depending the T-score used. Osteoporosis is related to age, weigh, BMI, previous osteoporotic fractures and breastfeeding.

Published
2010

26. El himno de los artilleros [Música notada]

Author

Mas, Juan Mas del Rivero, Anguita Vega, Juan m. 1947, Mas, Juan Mas del Rivero, and Anguita Vega, Juan m. 1947

Abstract

Ded.: "A S.A.R. el Infante D. Jaime de Borbón, Artillero del cuarto regimiento Montado", Fecha de publicación basada en el año del estreno de la obra

Published
1914

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