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1. Outcomes in high-risk subgroups after fixed-duration ibrutinib + venetoclax for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Up to 5.5 years of follow-up in the phase 2 CAPTIVATE study.

Author: Wierda, William G, Wierda, William G, Jacobs, Ryan, Barr, Paul M, Allan, John N, Siddiqi, Tanya, Tedeschi, Alessandra, Kipps, Thomas J, O'Brien, Susan Mary, Badoux, Xavier C, Visentin, Andrea, Lasica, Masa, Carney, Dennis, Elinder Camburn, Anna, De La Serna Torroba, Javier, Szafer-Glusman, Edith, Zhou, Cathy, Szoke, Anita, Dean, James P, Ghia, Paolo, Tam, Constantine S, Wierda, William G, Wierda, William G, Jacobs, Ryan, Barr, Paul M, Allan, John N, Siddiqi, Tanya, Tedeschi, Alessandra, Kipps, Thomas J, O'Brien, Susan Mary, Badoux, Xavier C, Visentin, Andrea, Lasica, Masa, Carney, Dennis, Elinder Camburn, Anna, De La Serna Torroba, Javier, Szafer-Glusman, Edith, Zhou, Cathy, Szoke, Anita, Dean, James P, Ghia, Paolo, and Tam, Constantine S
Abstract: 7009 Background: The phase 2 CAPTIVATE study evaluated first-line ibrutinib (Ibr) + venetoclax (Ven) for CLL/SLL in 2 cohorts: minimal residual disease (MRD)-guided randomized discontinuation (MRD cohort) and Fixed Duration (FD cohort). Ibr±Ven retreatment was allowed in patients (pts) who had progressive disease (PD). Here, we report outcomes for pts with high-risk genomic features from the FD cohort and retreatment outcomes in pts from the FD cohort and MRD cohort placebo arm. Methods: Pts aged ≤70 y with previously untreated CLL/SLL without restriction on genomic risk factors received 3 cycles of Ibr, then 12 cycles of Ibr+Ven (Ibr, 420 mg/d orally; Ven, 5-wk ramp up to 400 mg/d orally). On-study retreatment included single-agent Ibr (FD cohort or MRD cohort placebo arm); pts with PD >2 y after end of treatment (EOT) could be retreated with FD Ibr+Ven (FD cohort). Results: In the FD cohort (n=159) with a median follow-up of 61.2 mo (range, 0.8–66.3), 5-y PFS and OS rates (95% CI) were 67% (59–74) and 96% (91–98), respectively. 5-y PFS rates were higher in pts with undetectable MRD at 3 mo after EOT in peripheral blood (83%) or bone marrow (84%) vs those without (48% and 50%, respectively). 5-y PFS rates (95% CI) in pts with genomic risk factors were: del(17p)/mutated TP53 41% (21–59), complex karyotype 57% (37–72), del(11q) 64% (30–85), and unmutated IGHV 68% (50–80) (Table). In total, 18 second malignancies occurred in 13 pts (10 events in 8 pts during FD Ibr+Ven, 6 events in 4 pts after EOT and before retreatment, and 2 events in 2 pts during retreatment). Of 202 pts who completed Ibr+Ven (FD cohort, n=159; MRD cohort placebo arm, n=43), 63 have had PD to date; PD occurred >2 y after EOT in 43/63 pts (68%). 32/63 (51%) pts initiated retreatment with Ibr (n=25) or Ibr+Ven (n=7). With a median time on Ibr retreatment of 21.9 mo (range, 0.03–50.4), ORR was 86% in 22 evaluable pts (best response: 1 CR; 1 nodular PR; 17 PR; 2 SD; 1 PD [Richter transformation])
Published: 2024

2. Entangled Photon Interferometry: Development of Photonic Systems Towards Quantum Spectroscopy

Author: Szoke, Szilard, Szoke, Szilard, Szoke, Szilard, and Szoke, Szilard
Abstract: Entangled photon spectroscopy is an emergent field offering the potential to perform nonlinear and non-classical measurements at low photon fluxes. The entangled photon pairs which are generated using a continuous-wave laser pumped spontaneous parametric downconversion (SPDC) process simultaneously display strong correlations in time and anti-correlations in frequency space. Measuring changes in these correlations provides classical and non-classical information about the underlying dynamics and fluctuations of the sample-system. Further, because these two variables are not Fourier conjugates, entangled photon spectroscopy makes it possible to exploit the spectral resolution of continuous-wave lasers, while leveraging the temporal relationship of the near-simultaneously generated photon pairs which effectively mimics an ultrafast pulsed laser experiment. Nonlinear and ultrafast measurements can therefore be performed with low-power sources while also achieving superior signal-to-noise ratios due to the underlying quantum statistics. As photons in a pair can be separately manipulated, spectroscopic setups using these quantum states of light have marked benefits in contrast to measurements performed using traditional single photon states. Here, we describe our efforts towards implementing quantum interferometers to test the abilities of entangled photon pairs in nonlinear spectroscopic studies. Specifically, we present work on the development of free-space, fiber-optic, and nanophotonic systems that leverage nonlinear materials to generate narrow to broadband entangled photon pairs via SPDC. The numerical methods used for designing and tailoring these entangled photon sources are outlined together with associated experimental limitations. The spectral-temporal correlations of the two-photon states are characterized using fourth-order interferometry, demonstrating Hong-Ou-Mandel interference with picoseconds to femtoseconds coherence times, and wavelengths ra
Published: 2022

3. Entangled Photon Interferometry: Development of Photonic Systems Towards Quantum Spectroscopy

Author: Szoke, Szilard, Szoke, Szilard, Szoke, Szilard, and Szoke, Szilard
Abstract: Entangled photon spectroscopy is an emergent field offering the potential to perform nonlinear and non-classical measurements at low photon fluxes. The entangled photon pairs which are generated using a continuous-wave laser pumped spontaneous parametric downconversion (SPDC) process simultaneously display strong correlations in time and anti-correlations in frequency space. Measuring changes in these correlations provides classical and non-classical information about the underlying dynamics and fluctuations of the sample-system. Further, because these two variables are not Fourier conjugates, entangled photon spectroscopy makes it possible to exploit the spectral resolution of continuous-wave lasers, while leveraging the temporal relationship of the near-simultaneously generated photon pairs which effectively mimics an ultrafast pulsed laser experiment. Nonlinear and ultrafast measurements can therefore be performed with low-power sources while also achieving superior signal-to-noise ratios due to the underlying quantum statistics. As photons in a pair can be separately manipulated, spectroscopic setups using these quantum states of light have marked benefits in contrast to measurements performed using traditional single photon states. Here, we describe our efforts towards implementing quantum interferometers to test the abilities of entangled photon pairs in nonlinear spectroscopic studies. Specifically, we present work on the development of free-space, fiber-optic, and nanophotonic systems that leverage nonlinear materials to generate narrow to broadband entangled photon pairs via SPDC. The numerical methods used for designing and tailoring these entangled photon sources are outlined together with associated experimental limitations. The spectral-temporal correlations of the two-photon states are characterized using fourth-order interferometry, demonstrating Hong-Ou-Mandel interference with picoseconds to femtoseconds coherence times, and wavelengths ra
Published: 2022

4. Entangled Photon Interferometry: Development of Photonic Systems Towards Quantum Spectroscopy

Author: Szoke, Szilard, Szoke, Szilard, Szoke, Szilard, and Szoke, Szilard
Abstract: Entangled photon spectroscopy is an emergent field offering the potential to perform nonlinear and non-classical measurements at low photon fluxes. The entangled photon pairs which are generated using a continuous-wave laser pumped spontaneous parametric downconversion (SPDC) process simultaneously display strong correlations in time and anti-correlations in frequency space. Measuring changes in these correlations provides classical and non-classical information about the underlying dynamics and fluctuations of the sample-system. Further, because these two variables are not Fourier conjugates, entangled photon spectroscopy makes it possible to exploit the spectral resolution of continuous-wave lasers, while leveraging the temporal relationship of the near-simultaneously generated photon pairs which effectively mimics an ultrafast pulsed laser experiment. Nonlinear and ultrafast measurements can therefore be performed with low-power sources while also achieving superior signal-to-noise ratios due to the underlying quantum statistics. As photons in a pair can be separately manipulated, spectroscopic setups using these quantum states of light have marked benefits in contrast to measurements performed using traditional single photon states. Here, we describe our efforts towards implementing quantum interferometers to test the abilities of entangled photon pairs in nonlinear spectroscopic studies. Specifically, we present work on the development of free-space, fiber-optic, and nanophotonic systems that leverage nonlinear materials to generate narrow to broadband entangled photon pairs via SPDC. The numerical methods used for designing and tailoring these entangled photon sources are outlined together with associated experimental limitations. The spectral-temporal correlations of the two-photon states are characterized using fourth-order interferometry, demonstrating Hong-Ou-Mandel interference with picoseconds to femtoseconds coherence times, and wavelengths ra
Published: 2022

5. Relapse after First-Line Fixed Duration Ibrutinib + Venetoclax: High Response Rates to Ibrutinib Retreatment and Absence of BTK Mutations in Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) with up to 5 Years of Follow-up in the Phase 2 Captivate Study

Author: Ghia, Paolo, Ghia, Paolo, Wierda, William G, Barr, Paul M, Kipps, Thomas J, Siddiqi, Tanya, Allan, John N, Hunter, Zoë, Zhou, Cathy, Szoke, Anita, Dean, James P, Tam, Constantine S, Ghia, Paolo, Ghia, Paolo, Wierda, William G, Barr, Paul M, Kipps, Thomas J, Siddiqi, Tanya, Allan, John N, Hunter, Zoë, Zhou, Cathy, Szoke, Anita, Dean, James P, and Tam, Constantine S
Abstract: Background: CAPTIVATE (PCYC-1142) is a multicenter phase 2 study of ibrutinib + venetoclax as first-line treatment for CLL/SLL in 2 cohorts: minimal residual disease (MRD)-guided randomized-discontinuation (MRD cohort) and Fixed Duration (FD cohort). Results from the FD cohort with 4 years of follow-up (Barr, ASCO 2023) showed 4-year progression-free survival (PFS) and overall survival (OS) rates of 79% and 98%, respectively. After completing fixed-duration treatment, ibrutinib-based retreatment was allowed per protocol in patients with an indication for treatment after experiencing progressive disease (PD). Here, we report retreatment outcomes in patients from the FD cohort or the MRD cohort placebo arm, as well as updated results with an additional year of follow-up (up to 5 years) from the FD cohort. Methods: Patients aged ≤70 years with previously untreated CLL/SLL received 3 cycles of ibrutinib, then 12 cycles of combined ibrutinib + venetoclax (ibrutinib, 420 mg/day orally; venetoclax, standard 5-week ramp up to 400 mg/day orally). Response was assessed by investigators per International Workshop on CLL (iwCLL) 2008 criteria. Duration of response (DOR), PFS, and OS were estimated using Kaplan-Meier methodology. Per protocol, on-study retreatment included single-agent ibrutinib; patients with PD >2 years after treatment completion could be retreated with the FD regimen (3 cycles of ibrutinib + 12 cycles of ibrutinib + venetoclax). Results: Of 202 patients treated with fixed-duration ibrutinib + venetoclax in the FD cohort (n=159) or the MRD cohort placebo arm (n=43), 53 have had PD to date (Table 1), with PD occurring >2 years after completion of treatment in the majority of patients (33/53 [62%]). Of the 40 patients with available samples at PD, one had an acquired resistance-associated mutation in BCL2 (A113G); no other patient had clinically relevant mutations in BTK, BCL2, or PLCG2. A total of 22 patients have initiated retreatment on study with singl
Published: 2023

6. Outcomes in Patients with High-Risk Features after Fixed-Duration Ibrutinib plus Venetoclax: Phase II CAPTIVATE Study in First-Line Chronic Lymphocytic Leukemia.

Author: Allan, John, Allan, John, Flinn, Ian, Siddiqi, Tanya, Ghia, Paolo, Tam, Constantine, Barr, Paul, Elinder Camburn, Anna, Tedeschi, Alessandra, Badoux, Xavier, Jacobs, Ryan, Kuss, Bryone, Trentin, Livio, Zhou, Cathy, Szoke, Anita, Abbazio, Christopher, Wierda, William, Kipps, Thomas, Allan, John, Allan, John, Flinn, Ian, Siddiqi, Tanya, Ghia, Paolo, Tam, Constantine, Barr, Paul, Elinder Camburn, Anna, Tedeschi, Alessandra, Badoux, Xavier, Jacobs, Ryan, Kuss, Bryone, Trentin, Livio, Zhou, Cathy, Szoke, Anita, Abbazio, Christopher, Wierda, William, and Kipps, Thomas
Abstract: PURPOSE: The CAPTIVATE study investigated first-line ibrutinib plus venetoclax for chronic lymphocytic leukemia in 2 cohorts: minimal residual disease (MRD)-guided randomized discontinuation (MRD cohort) and Fixed Duration (FD cohort). We report outcomes of fixed-duration ibrutinib plus venetoclax in patients with high-risk genomic features [del(17p), TP53 mutation, and/or unmutated immunoglobulin heavy chain (IGHV)] in CAPTIVATE. PATIENTS AND METHODS: Patients received three cycles of ibrutinib 420 mg/day then 12 cycles of ibrutinib plus venetoclax (5-week ramp-up to 400 mg/day). FD cohort patients (n = 159) received no further treatment. Forty-three MRD cohort patients with confirmed undetectable MRD (uMRD) after 12 cycles of ibrutinib plus venetoclax received randomized placebo treatment. RESULTS: Of 195 patients with known status of genomic risk features at baseline, 129 (66%) had ≥1 high-risk feature. Overall response rates were >95% regardless of high-risk features. In patients with and without high-risk features, respectively, complete response (CR) rates were 61% and 53%; best uMRD rates: 88% and 70% (peripheral blood) and 72% and 61% (bone marrow); 36-month progression-free survival (PFS) rates: 88% and 92%. In subsets with del(17p)/TP53 mutation (n = 29) and unmutated IGHV without del(17p)/TP53 mutation (n = 100), respectively, CR rates were 52% and 64%; uMRD rates: 83% and 90% (peripheral blood) and 45% and 80% (bone marrow); 36-month PFS rates: 81% and 90%. Thirty-six-month overall survival (OS) rates were >95% regardless of high-risk features. CONCLUSIONS: Deep, durable responses and sustained PFS seen with fixed-duration ibrutinib plus venetoclax are maintained in patients with high-risk genomic features, with similar PFS and OS to those without high-risk features. See related commentary by Rogers, p. 2561.
Published: 2023

7. Residual dynamic mode decomposition: robust and verified Koopmanism

Author: Colbrook, Matthew J. J., Ayton, Lorna J. J., Szoke, Mate, Colbrook, Matthew J. J., Ayton, Lorna J. J., and Szoke, Mate
Abstract: Dynamic mode decomposition (DMD) describes complex dynamic processes through a hierarchy of simpler coherent features. DMD is regularly used to understand the fundamental characteristics of turbulence and is closely related to Koopman operators. However, verifying the decomposition, equivalently the computed spectral features of Koopman operators, remains a significant challenge due to the infinite-dimensional nature of Koopman operators. Challenges include spurious (unphysical) modes and dealing with continuous spectra, which both occur regularly in turbulent flows. Residual dynamic mode decomposition (ResDMD), introduced by Colbrook & Townsend (Rigorous data-driven computation of spectral properties of Koopman operators for dynamical systems. 2021. arXiv:2111.14889), overcomes such challenges through the data-driven computation of residuals associated with the full infinite-dimensional Koopman operator. ResDMD computes spectra and pseudospectra of general Koopman operators with error control and computes smoothed approximations of spectral measures (including continuous spectra) with explicit high-order convergence theorems. ResDMD thus provides robust and verified Koopmanism. We implement ResDMD and demonstrate its application in various fluid dynamic situations at varying Reynolds numbers from both numerical and experimental data. Examples include vortex shedding behind a cylinder, hot-wire data acquired in a turbulent boundary layer, particle image velocimetry data focusing on a wall-jet flow and laser-induced plasma acoustic pressure signals. We present some advantages of ResDMD: the ability to resolve nonlinear and transient modes verifiably; the verification of learnt dictionaries; the verification of Koopman mode decompositions; and spectral calculations with reduced broadening effects. We also discuss how a new ordering of modes via residuals enables greater accuracy than the traditional modulus ordering (e.g. when forecasting) with a smaller dictionary. T
Published: 2023

8. Lessons Learned in ATCO2: 5000 hours of Air Traffic Control Communications for Robust Automatic Speech Recognition and Understanding

Author: Zuluaga-Gomez, Juan, Nigmatulina, Iuliia, Prasad, Amrutha, Motlicek, Petr, Khalil, Driss, Madikeri, Srikanth, Tart, Allan, Szoke, Igor, Lenders, Vincent, Rigault, Mickael, Choukri, Khalid, Zuluaga-Gomez, Juan, Nigmatulina, Iuliia, Prasad, Amrutha, Motlicek, Petr, Khalil, Driss, Madikeri, Srikanth, Tart, Allan, Szoke, Igor, Lenders, Vincent, Rigault, Mickael, and Choukri, Khalid
Abstract: Voice communication between air traffic controllers (ATCos) and pilots is critical for ensuring safe and efficient air traffic control (ATC). This task requires high levels of awareness from ATCos and can be tedious and error-prone. Recent attempts have been made to integrate artificial intelligence (AI) into ATC in order to reduce the workload of ATCos. However, the development of data-driven AI systems for ATC demands large-scale annotated datasets, which are currently lacking in the field. This paper explores the lessons learned from the ATCO2 project, a project that aimed to develop a unique platform to collect and preprocess large amounts of ATC data from airspace in real time. Audio and surveillance data were collected from publicly accessible radio frequency channels with VHF receivers owned by a community of volunteers and later uploaded to Opensky Network servers, which can be considered an "unlimited source" of data. In addition, this paper reviews previous work from ATCO2 partners, including (i) robust automatic speech recognition, (ii) natural language processing, (iii) English language identification of ATC communications, and (iv) the integration of surveillance data such as ADS-B. We believe that the pipeline developed during the ATCO2 project, along with the open-sourcing of its data, will encourage research in the ATC field. A sample of the ATCO2 corpus is available on the following website: https://www.atco2.org/data, while the full corpus can be purchased through ELDA at http://catalog.elra.info/en-us/repository/browse/ELRA-S0484. We demonstrated that ATCO2 is an appropriate dataset to develop ASR engines when little or near to no ATC in-domain data is available. For instance, with the CNN-TDNNf kaldi model, we reached the performance of as low as 17.9% and 24.9% WER on public ATC datasets which is 6.6/7.6% better than "out-of-domain" but supervised CNN-TDNNf model., Comment: Manuscript under review
Published: 2023

9. Fixed-duration (FD) ibrutinib (I) + venetoclax (V) for first-line (1L) treatment (tx) of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Three-year follow-up from the FD cohort of the phase 2 CAPTIVATE study.

Author: Wierda W.G., Barr P.M., Siddiqi T., Allan J.N., Kipps T.J., Trentin L., Jacobs R., Jackson S., Tedeschi A., Opat S., Bannerji R., Kuss B.J., Moreno C., Croner L.J., Szafer-Glusman E., Zhou C., Szoke A., Dean J.P., Ghia P., Tam C.S.L., Wierda W.G., Barr P.M., Siddiqi T., Allan J.N., Kipps T.J., Trentin L., Jacobs R., Jackson S., Tedeschi A., Opat S., Bannerji R., Kuss B.J., Moreno C., Croner L.J., Szafer-Glusman E., Zhou C., Szoke A., Dean J.P., Ghia P., and Tam C.S.L.
Abstract: Background: CAPTIVATE (PCYC-1142) is a multicenter phase 2 study of 1L I+V in CLL. The primary analysis (PA) evaluating FD tx with I+V was previously presented (Ghia et al., ASCO 2021). Here we present 3-y follow-up results from the FD cohort. . Method(s): Patients (pts) aged <=70 y with previously untreated CLL/SLL received 3 cycles of I then 12 cycles of I+V (I 420 mg/d orally; V ramp-up to 400 mg/d orally). Responses were investigator assessed per iwCLL 2008 criteria. Undetectable minimal residual disease (uMRD; <10-4) was measured by 8-color flow cytometry. Serious AEs (SAEs) deemed related to I reported >30 d after last dose of study drug were collected. Result(s): 159 pts were enrolled (median age 60 y), including pts with high-risk features of del(17p)/TP53 mutation (17%), unmutated IGHV (uIGHV; 56%), and complex karyotype (19%). 147 (92%) and 149 (94%) pts completed tx with I and V, respectively. With 1 y of additional follow-up since PA, median time on study was 39 mo (range 1-41). ORR was 96% and was consistent (96%-97%) in pts with high-risk features (Table).The primary endpoint of complete response (CR) including CR with incomplete bone marrow recovery (CRi) rate in pts without del(17p) (n=136) increased nominally from 56% (95% CI, 48-64) to 58% (95% CI 50-66); in all pts, CR rate increased from 55% (95% CI 48-63) to 57% (95% CI 50-65). In pts achieving CR, 93% had durable responses lasting >=12 mo post-tx. Of pts with uMRD in peripheral blood at 3 mo post-tx, 66/85 (78%) evaluable pts maintained uMRD through 12-mo post-tx. At 36 mo, PFS was 88% (95% CI 82-92) and OS was 98% (95% CI 94-99); similar rates were seen in pts with high-risk features (Table). All pts are off tx; no new SAEs of any kind have occurred since the PA. Available data on relevant mutations in BTK, PLC?2, or BCL-2 at time of PD will be presented. As of January 2022, 12 pts were retreated with single-agent I after PD (tx duration range 3-29 mo); of evaluated pts, 7/9 had partial respon
Published: 2022

10. Fixed-duration (FD) ibrutinib (I) + venetoclax (V) for first-line (1L) treatment (tx) of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Three-year follow-up from the FD cohort of the phase 2 CAPTIVATE study.

Author: Wierda W.G., Barr P.M., Siddiqi T., Allan J.N., Kipps T.J., Trentin L., Jacobs R., Jackson S., Tedeschi A., Opat S., Bannerji R., Kuss B.J., Moreno C., Croner L.J., Szafer-Glusman E., Zhou C., Szoke A., Dean J.P., Ghia P., Tam C.S.L., Wierda W.G., Barr P.M., Siddiqi T., Allan J.N., Kipps T.J., Trentin L., Jacobs R., Jackson S., Tedeschi A., Opat S., Bannerji R., Kuss B.J., Moreno C., Croner L.J., Szafer-Glusman E., Zhou C., Szoke A., Dean J.P., Ghia P., and Tam C.S.L.
Abstract: Background: CAPTIVATE (PCYC-1142) is a multicenter phase 2 study of 1L I+V in CLL. The primary analysis (PA) evaluating FD tx with I+V was previously presented (Ghia et al., ASCO 2021). Here we present 3-y follow-up results from the FD cohort. . Method(s): Patients (pts) aged <=70 y with previously untreated CLL/SLL received 3 cycles of I then 12 cycles of I+V (I 420 mg/d orally; V ramp-up to 400 mg/d orally). Responses were investigator assessed per iwCLL 2008 criteria. Undetectable minimal residual disease (uMRD; <10-4) was measured by 8-color flow cytometry. Serious AEs (SAEs) deemed related to I reported >30 d after last dose of study drug were collected. Result(s): 159 pts were enrolled (median age 60 y), including pts with high-risk features of del(17p)/TP53 mutation (17%), unmutated IGHV (uIGHV; 56%), and complex karyotype (19%). 147 (92%) and 149 (94%) pts completed tx with I and V, respectively. With 1 y of additional follow-up since PA, median time on study was 39 mo (range 1-41). ORR was 96% and was consistent (96%-97%) in pts with high-risk features (Table).The primary endpoint of complete response (CR) including CR with incomplete bone marrow recovery (CRi) rate in pts without del(17p) (n=136) increased nominally from 56% (95% CI, 48-64) to 58% (95% CI 50-66); in all pts, CR rate increased from 55% (95% CI 48-63) to 57% (95% CI 50-65). In pts achieving CR, 93% had durable responses lasting >=12 mo post-tx. Of pts with uMRD in peripheral blood at 3 mo post-tx, 66/85 (78%) evaluable pts maintained uMRD through 12-mo post-tx. At 36 mo, PFS was 88% (95% CI 82-92) and OS was 98% (95% CI 94-99); similar rates were seen in pts with high-risk features (Table). All pts are off tx; no new SAEs of any kind have occurred since the PA. Available data on relevant mutations in BTK, PLC?2, or BCL-2 at time of PD will be presented. As of January 2022, 12 pts were retreated with single-agent I after PD (tx duration range 3-29 mo); of evaluated pts, 7/9 had partial respon
Published: 2022

11. Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia.

Author: Barr, Paul M, Barr, Paul M, Owen, Carolyn, Robak, Tadeusz, Tedeschi, Alessandra, Bairey, Osnat, Burger, Jan A, Hillmen, Peter, Coutre, Steve E, Dearden, Claire, Grosicki, Sebastian, McCarthy, Helen, Li, Jian-Yong, Offner, Fritz, Moreno, Carol, Zhou, Cathy, Hsu, Emily, Szoke, Anita, Kipps, Thomas J, Ghia, Paolo, Barr, Paul M, Barr, Paul M, Owen, Carolyn, Robak, Tadeusz, Tedeschi, Alessandra, Bairey, Osnat, Burger, Jan A, Hillmen, Peter, Coutre, Steve E, Dearden, Claire, Grosicki, Sebastian, McCarthy, Helen, Li, Jian-Yong, Offner, Fritz, Moreno, Carol, Zhou, Cathy, Hsu, Emily, Szoke, Anita, Kipps, Thomas J, and Ghia, Paolo
Abstract: We report long-term follow-up from the RESONATE-2 phase 3 study of the once-daily Bruton's tyrosine kinase inhibitor ibrutinib, which is the only targeted therapy with significant progression-free survival (PFS) and overall survival (OS) benefit in multiple randomized chronic lymphocytic leukemia (CLL) studies. Patients (≥65 years) with previously untreated CLL, without del(17p), were randomly assigned 1:1 to once-daily ibrutinib 420 mg until disease progression/unacceptable toxicity (n = 136) or chlorambucil 0.5-0.8 mg/kg ≤12 cycles (n = 133). With up to 8 years of follow-up (range, 0.1-96.6 months; median, 82.7 months), significant PFS benefit was sustained for ibrutinib vs chlorambucil (hazard ratio [HR], 0.154; 95% confidence interval [CI], 0.108-0.220). At 7 years, PFS was 59% for ibrutinib vs 9% for chlorambucil. PFS benefit was also observed for ibrutinib- vs chlorambucil-randomized patients with high-risk genomic features: del(11q) (HR, 0.033; 95% CI, 0.010-0.107) or unmutated immunoglobulin heavy chain variable region (HR, 0.112; 95% CI, 0.065-0.192). OS at 7 years was 78% with ibrutinib. Prevalence of adverse events (AEs) was consistent with previous 5-year follow-up. Ibrutinib dosing was held (≥7 days) for 79 patients and reduced for 31 patients because of AEs; these AEs resolved or improved in 85% (67 of 79) and 90% (28 of 31) of patients, respectively. With up to 8 years of follow-up, 42% of patients remain on ibrutinib. Long-term RESONATE-2 data demonstrate sustained benefit with first-line ibrutinib treatment for CLL, including for patients with high-risk genomic features. These trials were registered at www.clinicaltrials.gov as #NCT01722487 and #NCT01724346.
Published: 2022

12. Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia.

Author: Barr, Paul M, Barr, Paul M, Owen, Carolyn, Robak, Tadeusz, Tedeschi, Alessandra, Bairey, Osnat, Burger, Jan A, Hillmen, Peter, Coutre, Steve E, Dearden, Claire, Grosicki, Sebastian, McCarthy, Helen, Li, Jian-Yong, Offner, Fritz, Moreno, Carol, Zhou, Cathy, Hsu, Emily, Szoke, Anita, Kipps, Thomas J, Ghia, Paolo, Barr, Paul M, Barr, Paul M, Owen, Carolyn, Robak, Tadeusz, Tedeschi, Alessandra, Bairey, Osnat, Burger, Jan A, Hillmen, Peter, Coutre, Steve E, Dearden, Claire, Grosicki, Sebastian, McCarthy, Helen, Li, Jian-Yong, Offner, Fritz, Moreno, Carol, Zhou, Cathy, Hsu, Emily, Szoke, Anita, Kipps, Thomas J, and Ghia, Paolo
Abstract: We report long-term follow-up from the RESONATE-2 phase 3 study of the once-daily Bruton's tyrosine kinase inhibitor ibrutinib, which is the only targeted therapy with significant progression-free survival (PFS) and overall survival (OS) benefit in multiple randomized chronic lymphocytic leukemia (CLL) studies. Patients (≥65 years) with previously untreated CLL, without del(17p), were randomly assigned 1:1 to once-daily ibrutinib 420 mg until disease progression/unacceptable toxicity (n = 136) or chlorambucil 0.5-0.8 mg/kg ≤12 cycles (n = 133). With up to 8 years of follow-up (range, 0.1-96.6 months; median, 82.7 months), significant PFS benefit was sustained for ibrutinib vs chlorambucil (hazard ratio [HR], 0.154; 95% confidence interval [CI], 0.108-0.220). At 7 years, PFS was 59% for ibrutinib vs 9% for chlorambucil. PFS benefit was also observed for ibrutinib- vs chlorambucil-randomized patients with high-risk genomic features: del(11q) (HR, 0.033; 95% CI, 0.010-0.107) or unmutated immunoglobulin heavy chain variable region (HR, 0.112; 95% CI, 0.065-0.192). OS at 7 years was 78% with ibrutinib. Prevalence of adverse events (AEs) was consistent with previous 5-year follow-up. Ibrutinib dosing was held (≥7 days) for 79 patients and reduced for 31 patients because of AEs; these AEs resolved or improved in 85% (67 of 79) and 90% (28 of 31) of patients, respectively. With up to 8 years of follow-up, 42% of patients remain on ibrutinib. Long-term RESONATE-2 data demonstrate sustained benefit with first-line ibrutinib treatment for CLL, including for patients with high-risk genomic features. These trials were registered at www.clinicaltrials.gov as #NCT01722487 and #NCT01724346.
Published: 2022

13. Single Photon Scattering Can Account for the Discrepancies Between Entangled Two-Photon Measurement Techniques

Author: Hickam, Bryce P., He, Manni, Harper, Nathan, Szoke, Szilard, Cushing, Scott, Hickam, Bryce P., He, Manni, Harper, Nathan, Szoke, Szilard, and Cushing, Scott
Abstract: Entangled photon pairs are predicted to linearize and increase the efficiency of two-photon absorption, allowing continuous wave laser diodes to drive ultrafast time-resolved spectroscopy and nonlinear processes. Despite a range of theoretical studies and experimental measurements, inconsistencies persist about the value of the entanglement enhanced interaction cross section. A spectrometer is constructed that can temporally and spectrally characterize the entangled photon state before, during, and after any potential two-photon excitation event. For the molecule Rhodamine 6G, which has a virtual state pathway, any entangled two-photon interaction is found to be equal to or lower than classical, single photon scattering events. This result can account for the discrepancies between the wide variety of entangled two-photon absorption cross sections reported from different measurement techniques. The reported instrumentation can unambiguously separate classical and entangled effects and therefore is of importance for the growing field of nonlinear and multiphoton entangled spectroscopy.
Published: 2022

14. Fusarium: more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In
Published: 2021

15. The CHEOPS mission

Author: Benz, W., Broeg, C., Fortier, A., Rando, N., Beck, T., Beck, M., Queloz, D., Ehrenreich, D., Maxted, P. F. L., Isaak, K. G., Billot, N., Alibert, Y., Alonso, R., Antonio, C., Asquier, J., Bandy, T., Barczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Bekkelien, A., Bergomi, M., Biondi, F., Bonfils, X., Borsato, L., Brandeker, Alexis, Busch, M.-D., Cabrera, J., Cessa, V., Charnoz, S., Chazelas, B., Collier Cameron, A., Corral Van Damme, C., Cortes, D., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O., Demory, B. O., Erikson, A., Farinato, J., Fossati, L., Fridlund, M., Futyan, D., Gandolfi, D., Garcia Munoz, A., Gillon, M., Guterman, P., Gutierrez, A., Hasiba, J., Heng, K., Hernandez, E., Hoyer, S., Kiss, L. L., Kovacs, Z., Kuntzer, T., Laskar, J., Lecavelier des Etangs, A., Lendl, M., Lopez, A., Lora, I., Lovis, C., Lueftinger, T., Magrin, D., Malvasio, L., Marafatto, L., Michaelis, H., de Miguel, D., Modrego, D., Munari, M., Nascimbeni, V., Olofsson, Göran, Ottacher, H., Ottensamer, R., Pagano, I., Palacios, R., Pall, E., Peter, G., Piazza, D., Piotto, G., Pizarro, A., Pollaco, D., Ragazzoni, R., Ratti, F., Rauer, H., Ribas, I., Rieder, M., Rohlfs, R., Safa, F., Salatti, M., Santos, N. C., Scandariato, G., Segransan, D., Simon, A. E., Smith, A. M. S., Sordet, M., Sousa, S. G., Steller, M., Szabo, G. M., Szoke, J., Thomas, N., Tschentscher, M., Udry, S., Van Grootel, V., Viotto, V., Walter, I., Walton, N. A., Wildi, F., Wolter, D., Benz, W., Broeg, C., Fortier, A., Rando, N., Beck, T., Beck, M., Queloz, D., Ehrenreich, D., Maxted, P. F. L., Isaak, K. G., Billot, N., Alibert, Y., Alonso, R., Antonio, C., Asquier, J., Bandy, T., Barczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Bekkelien, A., Bergomi, M., Biondi, F., Bonfils, X., Borsato, L., Brandeker, Alexis, Busch, M.-D., Cabrera, J., Cessa, V., Charnoz, S., Chazelas, B., Collier Cameron, A., Corral Van Damme, C., Cortes, D., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O., Demory, B. O., Erikson, A., Farinato, J., Fossati, L., Fridlund, M., Futyan, D., Gandolfi, D., Garcia Munoz, A., Gillon, M., Guterman, P., Gutierrez, A., Hasiba, J., Heng, K., Hernandez, E., Hoyer, S., Kiss, L. L., Kovacs, Z., Kuntzer, T., Laskar, J., Lecavelier des Etangs, A., Lendl, M., Lopez, A., Lora, I., Lovis, C., Lueftinger, T., Magrin, D., Malvasio, L., Marafatto, L., Michaelis, H., de Miguel, D., Modrego, D., Munari, M., Nascimbeni, V., Olofsson, Göran, Ottacher, H., Ottensamer, R., Pagano, I., Palacios, R., Pall, E., Peter, G., Piazza, D., Piotto, G., Pizarro, A., Pollaco, D., Ragazzoni, R., Ratti, F., Rauer, H., Ribas, I., Rieder, M., Rohlfs, R., Safa, F., Salatti, M., Santos, N. C., Scandariato, G., Segransan, D., Simon, A. E., Smith, A. M. S., Sordet, M., Sousa, S. G., Steller, M., Szabo, G. M., Szoke, J., Thomas, N., Tschentscher, M., Udry, S., Van Grootel, V., Viotto, V., Walter, I., Walton, N. A., Wildi, F., and Wolter, D.
Abstract: The CHaracterising ExOPlanet Satellite (CHEOPS) was selected on October 19, 2012, as the first small mission (S-mission) in the ESA Science Programme and successfully launched on December 18, 2019, as a secondary passenger on a Soyuz-Fregat rocket from Kourou, French Guiana. CHEOPS is a partnership between ESA and Switzerland with important contributions by ten additional ESA Member States. CHEOPS is the first mission dedicated to search for transits of exoplanets using ultrahigh precision photometry on bright stars already known to host planets. As a follow-up mission, CHEOPS is mainly dedicated to improving, whenever possible, existing radii measurements or provide first accurate measurements for a subset of those planets for which the mass has already been estimated from ground-based spectroscopic surveys. The expected photometric precision will also allow CHEOPS to go beyond measuring only transits and to follow phase curves or to search for exo-moons, for example. Finally, by unveiling transiting exoplanets with high potential for in-depth characterisation, CHEOPS will also provide prime targets for future instruments suited to the spectroscopic characterisation of exoplanetary atmospheres. To reach its science objectives, requirements on the photometric precision and stability have been derived for stars with magnitudes ranging from 6 to 12 in the V band. In particular, CHEOPS shall be able to detect Earth-size planets transiting G5 dwarf stars (stellar radius of 0.9R(circle dot)) in the magnitude range 6 <= V <= 9 by achieving a photometric precision of 20 ppm in 6 hours of integration time. In the case of K-type stars (stellar radius of 0.7R(circle dot)) of magnitude in the range 9 <= V <= 12, CHEOPS shall be able to detect transiting Neptune-size planets achieving a photometric precision of 85 ppm in 3 hours of integration time. This precision has to be maintained over continuous periods of observation for up to 48 hours. This precision and stab
Published: 2021
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16. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study

Author: Pignon, B., Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.R., Baudin, G., Tosato, S., Jongsma, H., de Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuan, J., Selten, J.P., Tortelli, A., Llorca, P.M., van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szoke, A., Schurhoff, F., Pignon, B., Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.R., Baudin, G., Tosato, S., Jongsma, H., de Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuan, J., Selten, J.P., Tortelli, A., Llorca, P.M., van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szoke, A., and Schurhoff, F.
Abstract: The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (beta for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E x E interactions.
Published: 2021

17. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author: Velthorst, Eva, Mollon, Josephine, Murray, Robin M., de Haan, Lieuwe, Germeys, Inez Myin, Glahn, David C., Arango, Celso, van der Ven, Els, Di Forti, Marta, Bernardo, Miguel, Guloksuz, Sinan, Delespaul, Philippe, Mezquida, Gisela, Amoretti, Silvia, Bobes, Julio, Saiz, Pilar A., Garcia-Portilla, Maria Paz, Santos, Jose Luis, Jimenez-Lopez, Estela, Sanjuan, Julio, Aguilar, Eduardo J., Arrojo, Manuel, Carracedo, Angel, Lopez, Gonzalo, Gonzalez-Penas, Javier, Parellada, Mara, Atbasoglu, Cem, Saka, Meram Can, Ucok, Alp, Alptekin, Koksal, Akdede, Berna, Binbay, Tolga, Altinyazar, Vesile, Ulas, Halis, Yalincetin, Berna, Gumus-Akay, Guvem, Beyaz, Burcin Cihan, Soygur, Haldun, Cankurtaran, Eylem Sahin, Kaymak, Semra Ulusoy, Maric, Nadja P., Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Del-Ben, Cristina Marta, Ferraro, Laura, Gayer-Anderson, Charlotte, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Morgan, Craig, Quattrone, Diego, Menchetti, Marco, Selten, Jean-Paul, Szoke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, McGorry, Patrick, Pantelis, Chris, Krebs, Marie-Odile, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, van Beveren, Nico J., Luykx, Jurjen J., Cahn, Wiepke, Simons, Claudia J. P., Kahn, Rene S., Schirmbeck, Frederike, van Winkel, Ruud, Reichenberg, Abraham, Velthorst, Eva, Mollon, Josephine, Murray, Robin M., de Haan, Lieuwe, Germeys, Inez Myin, Glahn, David C., Arango, Celso, van der Ven, Els, Di Forti, Marta, Bernardo, Miguel, Guloksuz, Sinan, Delespaul, Philippe, Mezquida, Gisela, Amoretti, Silvia, Bobes, Julio, Saiz, Pilar A., Garcia-Portilla, Maria Paz, Santos, Jose Luis, Jimenez-Lopez, Estela, Sanjuan, Julio, Aguilar, Eduardo J., Arrojo, Manuel, Carracedo, Angel, Lopez, Gonzalo, Gonzalez-Penas, Javier, Parellada, Mara, Atbasoglu, Cem, Saka, Meram Can, Ucok, Alp, Alptekin, Koksal, Akdede, Berna, Binbay, Tolga, Altinyazar, Vesile, Ulas, Halis, Yalincetin, Berna, Gumus-Akay, Guvem, Beyaz, Burcin Cihan, Soygur, Haldun, Cankurtaran, Eylem Sahin, Kaymak, Semra Ulusoy, Maric, Nadja P., Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Del-Ben, Cristina Marta, Ferraro, Laura, Gayer-Anderson, Charlotte, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Morgan, Craig, Quattrone, Diego, Menchetti, Marco, Selten, Jean-Paul, Szoke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, McGorry, Patrick, Pantelis, Chris, Krebs, Marie-Odile, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, van Beveren, Nico J., Luykx, Jurjen J., Cahn, Wiepke, Simons, Claudia J. P., Kahn, Rene S., Schirmbeck, Frederike, van Winkel, Ruud, and Reichenberg, Abraham
Abstract: Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.
Published: 2021

18. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author: Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
Published: 2021

19. Perspectives on automated composition of workflows in the life sciences

Author: Lamprecht, Anna-Lena, Palmblad, Magnus, Ison, Jon, Schwämmle, Veit, Al Manir, Mohammad Sadnan, Altintas, Ilkay, Baker, Christopher J O, Ben Hadj Amor, Ammar, Capella-Gutierrez, Salvador, Charonyktakis, Paulos, Crusoe, Michael R, Gil, Yolanda, Goble, Carole, Griffin, Timothy J, Groth, Paul, Ienasescu, Hans, Jagtap, Pratik, Kalaš, Matúš, Kasalica, Vedran, Khanteymoori, Alireza, Kuhn, Tobias, Mei, Hailiang, Ménager, Hervé, Möller, Steffen, Richardson, Robin A, Robert, Vincent, Soiland-Reyes, Stian, Stevens, Robert, Szaniszlo, Szoke, Verberne, Suzan, Verhoeven, Aswin, Wolstencroft, Katherine, Lamprecht, Anna-Lena, Palmblad, Magnus, Ison, Jon, Schwämmle, Veit, Al Manir, Mohammad Sadnan, Altintas, Ilkay, Baker, Christopher J O, Ben Hadj Amor, Ammar, Capella-Gutierrez, Salvador, Charonyktakis, Paulos, Crusoe, Michael R, Gil, Yolanda, Goble, Carole, Griffin, Timothy J, Groth, Paul, Ienasescu, Hans, Jagtap, Pratik, Kalaš, Matúš, Kasalica, Vedran, Khanteymoori, Alireza, Kuhn, Tobias, Mei, Hailiang, Ménager, Hervé, Möller, Steffen, Richardson, Robin A, Robert, Vincent, Soiland-Reyes, Stian, Stevens, Robert, Szaniszlo, Szoke, Verberne, Suzan, Verhoeven, Aswin, and Wolstencroft, Katherine
Abstract: Scientific data analyses often combine several computational tools in automated pipelines, or workflows. Thousands of such workflows have been used in the life sciences, though their composition has remained a cumbersome manual process due to a lack of standards for annotation, assembly, and implementation. Recent technological advances have returned the long-standing vision of automated workflow composition into focus. This article summarizes a recent Lorentz Center workshop dedicated to automated composition of workflows in the life sciences. We survey previous initiatives to automate the composition process, and discuss the current state of the art and future perspectives. We start by drawing the "big picture" of the scientific workflow development life cycle, before surveying and discussing current methods, technologies and practices for semantic domain modelling, automation in workflow development, and workflow assessment. Finally, we derive a roadmap of individual and community-based actions to work toward the vision of automated workflow development in the forthcoming years. A central outcome of the workshop is a general description of the workflow life cycle in six stages: 1) scientific question or hypothesis, 2) conceptual workflow, 3) abstract workflow, 4) concrete workflow, 5) production workflow, and 6) scientific results. The transitions between stages are facilitated by diverse tools and methods, usually incorporating domain knowledge in some form. Formal semantic domain modelling is hard and often a bottleneck for the application of semantic technologies. However, life science communities have made considerable progress here in recent years and are continuously improving, renewing interest in the application of semantic technologies for workflow exploration, composition and instantiation. Combined with systematic benchmarking with reference data and large-scale deployment of production-stage workflows, such technologies enable a more systematic pro
Published: 2021

20. Fusarium: more than a node or a foot-shaped basal cell

Author: Sub Molecular Microbiology, Sub Molecular Plant Physiology, Sub Ecology and Biodiversity, Molecular Microbiology, Molecular Plant Physiology, Ecology and Biodiversity, Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Sub Molecular Microbiology, Sub Molecular Plant Physiology, Sub Ecology and Biodiversity, Molecular Microbiology, Molecular Plant Physiology, Ecology and Biodiversity, Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Published: 2021

21. Fusarium: more than a node or a foot-shaped basal cell

Author: Crous, P.W., Lombard, L., Sandoval-Denis, M., Seifert, K.A., Schroers, H.-J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G.H.J., Lamprecht, S.C., Cai, L., Rossman, A.Y., Stadler, M., Summerbell, R.C., Taylor, J.W., Ploch, S., Visagie, C.M., Yilmaz, N., Frisvad, J.C., Abdel-Azeem, A.M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J.F., Araújo, J.P.M., Ariyawansa, H.A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J.D.P., Boekhout, T., Câmara, M.P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R.F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C.A., Vries, R.P. de, Ezekiel, C.N., Fan, X.L., Fernández, N.B., Gaya, E., González, C.D., Gramaje, D., Groenewald, J.Z., Grube, M., Guevara-Suarez, M., Gupta, V.K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K.D., Iturriaga, T., Jeewon, R., Johnston, P.R., Jurjević, Ž., Karalti, İ., Korsten, L., Kuramae, E.E., Kušan, I., Labuda, R., Lawrence, D.P., Lee, H.B., Lechat, C., Li, H.Y., Litovka, Y.A., Maharachchikumbura, S.S.N., Marin-Felix, Y., Kemkuignou, B. Matio, Matočec, N., McTaggart, A.R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R.H., Noumeur, S.R., Pavlov, I.N., Peralta, M.P., Phillips, A.J.L., Pitt, J.I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K.C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A.M., Salgado-Salazar, C., Samson, R.A., Santos, A.C.S., Shivas, R.G., Souza-Motta, C.M., Sun, G.Y., Swart, W.J., Szoke, S., Tan, Y.P., Taylor, J.E., Taylor, P.W.J., Tiago, P.V., Váczy, K.Z., Wiele, N. van de, Merwe, N.A. van der, Verkley, G.J.M., Vieira, W.A.S., Vizzini, A., Weir, B.S., Wijayawardene, N.N., Xia, J.W., Yáñez-Morales, M.J., Yurkov, A., Zamora, J.C., Zare, R., Zhang, C.L., Thines, M., Crous, P.W., Lombard, L., Sandoval-Denis, M., Seifert, K.A., Schroers, H.-J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G.H.J., Lamprecht, S.C., Cai, L., Rossman, A.Y., Stadler, M., Summerbell, R.C., Taylor, J.W., Ploch, S., Visagie, C.M., Yilmaz, N., Frisvad, J.C., Abdel-Azeem, A.M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J.F., Araújo, J.P.M., Ariyawansa, H.A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J.D.P., Boekhout, T., Câmara, M.P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R.F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C.A., Vries, R.P. de, Ezekiel, C.N., Fan, X.L., Fernández, N.B., Gaya, E., González, C.D., Gramaje, D., Groenewald, J.Z., Grube, M., Guevara-Suarez, M., Gupta, V.K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K.D., Iturriaga, T., Jeewon, R., Johnston, P.R., Jurjević, Ž., Karalti, İ., Korsten, L., Kuramae, E.E., Kušan, I., Labuda, R., Lawrence, D.P., Lee, H.B., Lechat, C., Li, H.Y., Litovka, Y.A., Maharachchikumbura, S.S.N., Marin-Felix, Y., Kemkuignou, B. Matio, Matočec, N., McTaggart, A.R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R.H., Noumeur, S.R., Pavlov, I.N., Peralta, M.P., Phillips, A.J.L., Pitt, J.I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K.C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A.M., Salgado-Salazar, C., Samson, R.A., Santos, A.C.S., Shivas, R.G., Souza-Motta, C.M., Sun, G.Y., Swart, W.J., Szoke, S., Tan, Y.P., Taylor, J.E., Taylor, P.W.J., Tiago, P.V., Váczy, K.Z., Wiele, N. van de, Merwe, N.A. van der, Verkley, G.J.M., Vieira, W.A.S., Vizzini, A., Weir, B.S., Wijayawardene, N.N., Xia, J.W., Yáñez-Morales, M.J., Yurkov, A., Zamora, J.C., Zare, R., Zhang, C.L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021

22. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author: Velthorst, E, Mollon, J, Murray, RM, de Haan, L, Germeys, IM, Glahn, DC, Arango, C, van der Ven, E, Di Forti, M, Bernardo, M, Guloksuz, S, Delespaul, P, Mezquida, G, Amoretti, S, Bobes, J, Saiz, PA, Garcia-Portilla, MP, Santos, JL, Jimenez-Lopez, E, Sanjuan, J, Aguilar, EJ, Arrojo, M, Carracedo, A, Lopez, G, Gonzalez-Penas, J, Parellada, M, Atbasoglu, C, Saka, MC, Ucok, A, Alptekin, K, Akdede, B, Binbay, T, Altinyazar, V, Ulas, H, Yalincetin, B, Gumus-Akay, G, Beyaz, BC, Soygur, H, Cankurtaran, ES, Kaymak, SU, Maric, NP, Mihaljevic, MM, Petrovic, SA, Mirjanic, T, Del-Ben, CM, Ferraro, L, Gayer-Anderson, C, Jones, PB, Jongsma, HE, Kirkbride, JB, La Cascia, C, Lasalvia, A, Tosato, S, Llorca, P-M, Menezes, PR, Morgan, C, Quattrone, D, Menchetti, M, Selten, J-P, Szoke, A, Tarricone, I, Tortelli, A, McGuire, P, Valmaggia, L, Kempton, MJ, van der Gaag, M, Riecher-Rossler, A, Bressan, RA, Barrantes-Vidal, N, Nelson, B, McGorry, P, Pantelis, C, Krebs, M-O, Ruhrmann, S, Sachs, G, Rutten, BPF, van Os, J, Alizadeh, BZ, van Amelsvoort, T, Bartels-Velthuis, AA, Bruggeman, R, van Beveren, NJ, Luykx, JJ, Cahn, W, Simons, CJP, Kahn, RS, Schirmbeck, F, van Winkel, R, Reichenberg, A, Velthorst, E, Mollon, J, Murray, RM, de Haan, L, Germeys, IM, Glahn, DC, Arango, C, van der Ven, E, Di Forti, M, Bernardo, M, Guloksuz, S, Delespaul, P, Mezquida, G, Amoretti, S, Bobes, J, Saiz, PA, Garcia-Portilla, MP, Santos, JL, Jimenez-Lopez, E, Sanjuan, J, Aguilar, EJ, Arrojo, M, Carracedo, A, Lopez, G, Gonzalez-Penas, J, Parellada, M, Atbasoglu, C, Saka, MC, Ucok, A, Alptekin, K, Akdede, B, Binbay, T, Altinyazar, V, Ulas, H, Yalincetin, B, Gumus-Akay, G, Beyaz, BC, Soygur, H, Cankurtaran, ES, Kaymak, SU, Maric, NP, Mihaljevic, MM, Petrovic, SA, Mirjanic, T, Del-Ben, CM, Ferraro, L, Gayer-Anderson, C, Jones, PB, Jongsma, HE, Kirkbride, JB, La Cascia, C, Lasalvia, A, Tosato, S, Llorca, P-M, Menezes, PR, Morgan, C, Quattrone, D, Menchetti, M, Selten, J-P, Szoke, A, Tarricone, I, Tortelli, A, McGuire, P, Valmaggia, L, Kempton, MJ, van der Gaag, M, Riecher-Rossler, A, Bressan, RA, Barrantes-Vidal, N, Nelson, B, McGorry, P, Pantelis, C, Krebs, M-O, Ruhrmann, S, Sachs, G, Rutten, BPF, van Os, J, Alizadeh, BZ, van Amelsvoort, T, Bartels-Velthuis, AA, Bruggeman, R, van Beveren, NJ, Luykx, JJ, Cahn, W, Simons, CJP, Kahn, RS, Schirmbeck, F, van Winkel, R, and Reichenberg, A
Abstract: Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.
Published: 2021

23. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author: Berendsen, S, Kapitein, P, Schirmbeck, F, van Tricht, MJ, McGuire, P, Morgan, C, Gayer-Anderson, C, Kempton, MJ, Valmaggia, L, Quattrone, D, di Forti, M, van der Gaag, M, Kirkbride, JB, Jongsma, HE, Jones, PB, Parellada, M, Arango, C, Arrojo, M, Bernardo, M, Sanjuan, J, Santos, JL, Szoke, A, Tortelli, A, Llorca, P-M, Tarricone, I, Tripoli, G, Ferraro, L, La Cascia, C, Lasalvia, A, Tosato, S, Menezes, PR, Del-Ben, CM, Nelson, B, Riecher-Rossler, A, Bressan, R, Barrantes-Vidal, N, Krebs, M-O, Nordentoft, M, Ruhrmann, S, Sachs, G, Rutten, BPF, van Os, J, Velthorst, E, de Haan, L, Berendsen, S, Kapitein, P, Schirmbeck, F, van Tricht, MJ, McGuire, P, Morgan, C, Gayer-Anderson, C, Kempton, MJ, Valmaggia, L, Quattrone, D, di Forti, M, van der Gaag, M, Kirkbride, JB, Jongsma, HE, Jones, PB, Parellada, M, Arango, C, Arrojo, M, Bernardo, M, Sanjuan, J, Santos, JL, Szoke, A, Tortelli, A, Llorca, P-M, Tarricone, I, Tripoli, G, Ferraro, L, La Cascia, C, Lasalvia, A, Tosato, S, Menezes, PR, Del-Ben, CM, Nelson, B, Riecher-Rossler, A, Bressan, R, Barrantes-Vidal, N, Krebs, M-O, Nordentoft, M, Ruhrmann, S, Sachs, G, Rutten, BPF, van Os, J, Velthorst, E, and de Haan, L
Published: 2021

24. Fusarium : more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021
Full Text: View/download PDF

25. Fusarium : more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021
Full Text: View/download PDF

26. Fusarium : more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021
Full Text: View/download PDF

27. Fusarium: more than a node or a foot-shaped basal cell

Author: Sub Molecular Microbiology, Sub Molecular Plant Physiology, Sub Ecology and Biodiversity, Molecular Microbiology, Molecular Plant Physiology, Ecology and Biodiversity, Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Sub Molecular Microbiology, Sub Molecular Plant Physiology, Sub Ecology and Biodiversity, Molecular Microbiology, Molecular Plant Physiology, Ecology and Biodiversity, Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Published: 2021

28. Fusarium : more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021
Full Text: View/download PDF

29. Fusarium: more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D. P., Boekhout, T., Câmara, M. P. S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Ž, Karalti, İ, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Yu Pei, Taylor, J. E., Taylor, P. W. J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D. P., Boekhout, T., Câmara, M. P. S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Ž, Karalti, İ, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Yu Pei, Taylor, J. E., Taylor, P. W. J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021

30. Fusarium: more than a node or a foot-shaped basal cell

Author: Sub Molecular Microbiology, Sub Molecular Plant Physiology, Sub Ecology and Biodiversity, Molecular Microbiology, Molecular Plant Physiology, Ecology and Biodiversity, Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Sub Molecular Microbiology, Sub Molecular Plant Physiology, Sub Ecology and Biodiversity, Molecular Microbiology, Molecular Plant Physiology, Ecology and Biodiversity, Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Published: 2021

31. Perspectives on automated composition of workflows in the life sciences

Author: Lamprecht, Anna-Lena, Palmblad, Magnus, Ison, Jon, Schwämmle, Veit, Al Manir, Mohammad Sadnan, Altintas, Ilkay, Baker, Christopher J O, Ben Hadj Amor, Ammar, Capella-Gutierrez, Salvador, Charonyktakis, Paulos, Crusoe, Michael R, Gil, Yolanda, Goble, Carole, Griffin, Timothy J, Groth, Paul, Ienasescu, Hans, Jagtap, Pratik, Kalaš, Matúš, Kasalica, Vedran, Khanteymoori, Alireza, Kuhn, Tobias, Mei, Hailiang, Ménager, Hervé, Möller, Steffen, Richardson, Robin A, Robert, Vincent, Soiland-Reyes, Stian, Stevens, Robert, Szaniszlo, Szoke, Verberne, Suzan, Verhoeven, Aswin, Wolstencroft, Katherine, Lamprecht, Anna-Lena, Palmblad, Magnus, Ison, Jon, Schwämmle, Veit, Al Manir, Mohammad Sadnan, Altintas, Ilkay, Baker, Christopher J O, Ben Hadj Amor, Ammar, Capella-Gutierrez, Salvador, Charonyktakis, Paulos, Crusoe, Michael R, Gil, Yolanda, Goble, Carole, Griffin, Timothy J, Groth, Paul, Ienasescu, Hans, Jagtap, Pratik, Kalaš, Matúš, Kasalica, Vedran, Khanteymoori, Alireza, Kuhn, Tobias, Mei, Hailiang, Ménager, Hervé, Möller, Steffen, Richardson, Robin A, Robert, Vincent, Soiland-Reyes, Stian, Stevens, Robert, Szaniszlo, Szoke, Verberne, Suzan, Verhoeven, Aswin, and Wolstencroft, Katherine
Abstract: Scientific data analyses often combine several computational tools in automated pipelines, or workflows. Thousands of such workflows have been used in the life sciences, though their composition has remained a cumbersome manual process due to a lack of standards for annotation, assembly, and implementation. Recent technological advances have returned the long-standing vision of automated workflow composition into focus. This article summarizes a recent Lorentz Center workshop dedicated to automated composition of workflows in the life sciences. We survey previous initiatives to automate the composition process, and discuss the current state of the art and future perspectives. We start by drawing the "big picture" of the scientific workflow development life cycle, before surveying and discussing current methods, technologies and practices for semantic domain modelling, automation in workflow development, and workflow assessment. Finally, we derive a roadmap of individual and community-based actions to work toward the vision of automated workflow development in the forthcoming years. A central outcome of the workshop is a general description of the workflow life cycle in six stages: 1) scientific question or hypothesis, 2) conceptual workflow, 3) abstract workflow, 4) concrete workflow, 5) production workflow, and 6) scientific results. The transitions between stages are facilitated by diverse tools and methods, usually incorporating domain knowledge in some form. Formal semantic domain modelling is hard and often a bottleneck for the application of semantic technologies. However, life science communities have made considerable progress here in recent years and are continuously improving, renewing interest in the application of semantic technologies for workflow exploration, composition and instantiation. Combined with systematic benchmarking with reference data and large-scale deployment of production-stage workflows, such technologies enable a more systematic pro
Published: 2021

32. Fusarium: more than a node or a foot-shaped basal cell

Author: Crous, P.W., Lombard, L., Sandoval-Denis, M., Seifert, K.A., Schroers, H.-J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G.H.J., Lamprecht, S.C., Cai, L., Rossman, A.Y., Stadler, M., Summerbell, R.C., Taylor, J.W., Ploch, S., Visagie, C.M., Yilmaz, N., Frisvad, J.C., Abdel-Azeem, A.M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J.F., Araújo, J.P.M., Ariyawansa, H.A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J.D.P., Boekhout, T., Câmara, M.P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R.F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C.A., Vries, R.P. de, Ezekiel, C.N., Fan, X.L., Fernández, N.B., Gaya, E., González, C.D., Gramaje, D., Groenewald, J.Z., Grube, M., Guevara-Suarez, M., Gupta, V.K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K.D., Iturriaga, T., Jeewon, R., Johnston, P.R., Jurjević, Ž., Karalti, İ., Korsten, L., Kuramae, E.E., Kušan, I., Labuda, R., Lawrence, D.P., Lee, H.B., Lechat, C., Li, H.Y., Litovka, Y.A., Maharachchikumbura, S.S.N., Marin-Felix, Y., Kemkuignou, B. Matio, Matočec, N., McTaggart, A.R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R.H., Noumeur, S.R., Pavlov, I.N., Peralta, M.P., Phillips, A.J.L., Pitt, J.I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K.C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A.M., Salgado-Salazar, C., Samson, R.A., Santos, A.C.S., Shivas, R.G., Souza-Motta, C.M., Sun, G.Y., Swart, W.J., Szoke, S., Tan, Y.P., Taylor, J.E., Taylor, P.W.J., Tiago, P.V., Váczy, K.Z., Wiele, N. van de, Merwe, N.A. van der, Verkley, G.J.M., Vieira, W.A.S., Vizzini, A., Weir, B.S., Wijayawardene, N.N., Xia, J.W., Yáñez-Morales, M.J., Yurkov, A., Zamora, J.C., Zare, R., Zhang, C.L., Thines, M., Crous, P.W., Lombard, L., Sandoval-Denis, M., Seifert, K.A., Schroers, H.-J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G.H.J., Lamprecht, S.C., Cai, L., Rossman, A.Y., Stadler, M., Summerbell, R.C., Taylor, J.W., Ploch, S., Visagie, C.M., Yilmaz, N., Frisvad, J.C., Abdel-Azeem, A.M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J.F., Araújo, J.P.M., Ariyawansa, H.A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J.D.P., Boekhout, T., Câmara, M.P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R.F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C.A., Vries, R.P. de, Ezekiel, C.N., Fan, X.L., Fernández, N.B., Gaya, E., González, C.D., Gramaje, D., Groenewald, J.Z., Grube, M., Guevara-Suarez, M., Gupta, V.K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K.D., Iturriaga, T., Jeewon, R., Johnston, P.R., Jurjević, Ž., Karalti, İ., Korsten, L., Kuramae, E.E., Kušan, I., Labuda, R., Lawrence, D.P., Lee, H.B., Lechat, C., Li, H.Y., Litovka, Y.A., Maharachchikumbura, S.S.N., Marin-Felix, Y., Kemkuignou, B. Matio, Matočec, N., McTaggart, A.R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R.H., Noumeur, S.R., Pavlov, I.N., Peralta, M.P., Phillips, A.J.L., Pitt, J.I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K.C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A.M., Salgado-Salazar, C., Samson, R.A., Santos, A.C.S., Shivas, R.G., Souza-Motta, C.M., Sun, G.Y., Swart, W.J., Szoke, S., Tan, Y.P., Taylor, J.E., Taylor, P.W.J., Tiago, P.V., Váczy, K.Z., Wiele, N. van de, Merwe, N.A. van der, Verkley, G.J.M., Vieira, W.A.S., Vizzini, A., Weir, B.S., Wijayawardene, N.N., Xia, J.W., Yáñez-Morales, M.J., Yurkov, A., Zamora, J.C., Zare, R., Zhang, C.L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021

33. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author: Velthorst, Eva, Mollon, Josephine, Murray, Robin M., de Haan, Lieuwe, Germeys, Inez Myin, Glahn, David C., Arango, Celso, van der Ven, Els, Di Forti, Marta, Bernardo, Miguel, Guloksuz, Sinan, Delespaul, Philippe, Mezquida, Gisela, Amoretti, Silvia, Bobes, Julio, Saiz, Pilar A., Garcia-Portilla, Maria Paz, Santos, Jose Luis, Jimenez-Lopez, Estela, Sanjuan, Julio, Aguilar, Eduardo J., Arrojo, Manuel, Carracedo, Angel, Lopez, Gonzalo, Gonzalez-Penas, Javier, Parellada, Mara, Atbasoglu, Cem, Saka, Meram Can, Ucok, Alp, Alptekin, Koksal, Akdede, Berna, Binbay, Tolga, Altinyazar, Vesile, Ulas, Halis, Yalincetin, Berna, Gumus-Akay, Guvem, Beyaz, Burcin Cihan, Soygur, Haldun, Cankurtaran, Eylem Sahin, Kaymak, Semra Ulusoy, Maric, Nadja P., Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Del-Ben, Cristina Marta, Ferraro, Laura, Gayer-Anderson, Charlotte, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Morgan, Craig, Quattrone, Diego, Menchetti, Marco, Selten, Jean-Paul, Szoke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, McGorry, Patrick, Pantelis, Chris, Krebs, Marie-Odile, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, van Beveren, Nico J., Luykx, Jurjen J., Cahn, Wiepke, Simons, Claudia J. P., Kahn, Rene S., Schirmbeck, Frederike, van Winkel, Ruud, Reichenberg, Abraham, Velthorst, Eva, Mollon, Josephine, Murray, Robin M., de Haan, Lieuwe, Germeys, Inez Myin, Glahn, David C., Arango, Celso, van der Ven, Els, Di Forti, Marta, Bernardo, Miguel, Guloksuz, Sinan, Delespaul, Philippe, Mezquida, Gisela, Amoretti, Silvia, Bobes, Julio, Saiz, Pilar A., Garcia-Portilla, Maria Paz, Santos, Jose Luis, Jimenez-Lopez, Estela, Sanjuan, Julio, Aguilar, Eduardo J., Arrojo, Manuel, Carracedo, Angel, Lopez, Gonzalo, Gonzalez-Penas, Javier, Parellada, Mara, Atbasoglu, Cem, Saka, Meram Can, Ucok, Alp, Alptekin, Koksal, Akdede, Berna, Binbay, Tolga, Altinyazar, Vesile, Ulas, Halis, Yalincetin, Berna, Gumus-Akay, Guvem, Beyaz, Burcin Cihan, Soygur, Haldun, Cankurtaran, Eylem Sahin, Kaymak, Semra Ulusoy, Maric, Nadja P., Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Del-Ben, Cristina Marta, Ferraro, Laura, Gayer-Anderson, Charlotte, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Morgan, Craig, Quattrone, Diego, Menchetti, Marco, Selten, Jean-Paul, Szoke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, McGorry, Patrick, Pantelis, Chris, Krebs, Marie-Odile, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, van Beveren, Nico J., Luykx, Jurjen J., Cahn, Wiepke, Simons, Claudia J. P., Kahn, Rene S., Schirmbeck, Frederike, van Winkel, Ruud, and Reichenberg, Abraham
Abstract: Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.
Published: 2021

34. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author: Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
Published: 2021

35. Ariel: Enabling planetary science across light-years

Author: Tinetti, Giovanna, Eccleston, Paul, Haswell, Carole, Lagage, Pierre-Olivier, Leconte, Jérémy, Lüftinger, Theresa, Micela, Giusi, Min, Michel, Pilbratt, Göran, Puig, Ludovic, Swain, Mark, Testi, Leonardo, Turrini, Diego, Vandenbussche, Bart, Osorio, Maria Rosa Zapatero, Aret, Anna, Beaulieu, Jean-Philippe, Buchhave, Lars, Ferus, Martin, Griffin, Matt, Guedel, Manuel, Hartogh, Paul, Machado, Pedro, Malaguti, Giuseppe, Pallé, Enric, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Szabó, Robert, Tan, Jonathan, Werner, Stephanie, Ratti, Francesco, Scharmberg, Carsten, Salvignol, Jean-Christophe, Boudin, Nathalie, Halain, Jean-Philippe, Haag, Martin, Crouzet, Pierre-Elie, Kohley, Ralf, Symonds, Kate, Renk, Florian, Caldwell, Andrew, Abreu, Manuel, Alonso, Gustavo, Amiaux, Jerome, Berthé, Michel, Bishop, Georgia, Bowles, Neil, Carmona, Manuel, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Désjonqueres, Lucile, Díaz, José J., Drummond, Rachel, Focardi, Mauro, Gómez, Jose M., Holmes, Warren, Krijger, Matthijs, Kovacs, Zsolt, Hunt, Tom, Machado, Richardo, Morgante, Gianluca, Ollivier, Marc, Ottensamer, Roland, Pace, Emanuele, Pagano, Teresa, Pascale, Enzo, Pearson, Chris, Pedersen, Søren Møller, Pniel, Moshe, Roose, Stéphane, Savini, Giorgio, Stamper, Richard, Szirovicza, Peter, Szoke, Janos, Tosh, Ian, Vilardell, Francesc, Barstow, Joanna, Borsato, Luca, Casewell, Sarah, Changeat, Quentin, Charnay, Benjamin, Civiš, Svatopluk, Foresto, Vincent Coudé du, Coustenis, Athena, Cowan, Nicolas, Danielski, Camilla, Demangeon, Olivier, Drossart, Pierre, Edwards, Billy N., Gilli, Gabriella, Encrenaz, Therese, Kiss, Csaba, Kokori, Anastasia, Ikoma, Masahiro, Morales, Juan Carlos, Mendonça, João, Moneti, Andrea, Mugnai, Lorenzo, Muñoz, Antonio García, Helled, Ravit, Kama, Mihkel, Miguel, Yamila, Nikolaou, Nikos, Pagano, Isabella, Panic, Olja, Rengel, Miriam, Rickman, Hans, Rocchetto, Marco, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Tsiaras, Angelos, Venot, Olivia, Vida, Krisztián, Waldmann, Ingo P., Yurchenko, Sergey, Szabó, Gyula, Zellem, Rob, Al-Refaie, Ahmed, Alvarez, Javier Perez, Anisman, Lara, Arhancet, Axel, Ateca, Jaume, Baeyens, Robin, Barnes, John R., Bell, Taylor, Benatti, Serena, Biazzo, Katia, Błęcka, Maria, Bonomo, Aldo Stefano, Bosch, José, Bossini, Diego, Bourgalais, Jeremy, Brienza, Daniele, Brucalassi, Anna, Bruno, Giovanni, Caines, Hamish, Calcutt, Simon, Campante, Tiago, Canestrari, Rodolfo, Cann, Nick, Casali, Giada, Casas, Albert, Cassone, Giuseppe, Cara, Christophe, Carone, Ludmila, Carrasco, Nathalie, Chioetto, Paolo, Cortecchia, Fausto, Czupalla, Markus, Chubb, Katy L., Ciaravella, Angela, Claret, Antonio, Claudi, Riccardo, Codella, Claudio, Comas, Maya Garcia, Cracchiolo, Gianluca, Cubillos, Patricio, Da Peppo, Vania, Decin, Leen, Dejabrun, Clemence, Delgado-Mena, Elisa, Di Giorgio, Anna, Diolaiti, Emiliano, Dorn, Caroline, Doublier, Vanessa, Doumayrou, Eric, Dransfield, Georgina, Dumaye, Luc, Dunford, Emma, Escobar, Antonio Jimenez, Van Eylen, Vincent, Farina, Maria, Fedele, Davide, Fernández, Alejandro, Fleury, Benjamin, Fonte, Sergio, Fontignie, Jean, Fossati, Luca, Funke, Bernd, Galy, Camille, Garai, Zoltán, García, Andrés, García-Rigo, Alberto, Garufi, Antonio, Sacco, Giuseppe Germano, Giacobbe, Paolo, Gómez, Alejandro, Gonzalez, Arturo, Gonzalez-Galindo, Francisco, Grassi, Davide, Griffith, Caitlin, Guarcello, Mario Giuseppe, Goujon, Audrey, Gressier, Amélie, Grzegorczyk, Aleksandra, Guillot, Tristan, Guilluy, Gloria, Hargrave, Peter, Hellin, Marie-Laure, Herrero, Enrique, Hills, Matt, Horeau, Benoit, Ito, Yuichi, Jessen, Niels Christian, Kabath, Petr, Kálmán, Szilárd, Kawashima, Yui, Kimura, Tadahiro, Knížek, Antonín, Kreidberg, Laura, Kruid, Ronald, Kruijssen, Diederik J. M., Kubelík, Petr, Lara, Luisa, Lebonnois, Sebastien, Lee, David, Lefevre, Maxence, Lichtenberg, Tim, Locci, Daniele, Lombini, Matteo, Lopez, Alejandro Sanchez, Lorenzani, Andrea, MacDonald, Ryan, Magrini, Laura, Maldonado, Jesus, Marcq, Emmanuel, Migliorini, Alessandra, Modirrousta-Galian, Darius, Molaverdikhani, Karan, Molinari, Sergio, Mollière, Paul, Moreau, Vincent, Morello, Giuseppe, Morinaud, Gilles, Morvan, Mario, Moses, Julianne I., Mouzali, Salima, Nakhjiri, Nariman, Naponiello, Luca, Narita, Norio, Nascimbeni, Valerio, Nikolaou, Athanasia, Noce, Vladimiro, Oliva, Fabrizio, Palladino, Pietro, Papageorgiou, Andreas, Parmentier, Vivien, Peres, Giovanni, Pérez, Javier, Perez-Hoyos, Santiago, Perger, Manuel, Pestellini, Cesare Cecchi, Petralia, Antonino, Philippon, Anne, Piccialli, Arianna, Pignatari, Marco, Piotto, Giampaolo, Podio, Linda, Polenta, Gianluca, Preti, Giampaolo, Pribulla, Theodor, Puertas, Manuel Lopez, Rainer, Monica, Reess, Jean-Michel, Rimmer, Paul, Robert, Séverine, Rosich, Albert, Rossi, Loic, Rust, Duncan, Saleh, Ayman, Sanna, Nicoletta, Schisano, Eugenio, Schreiber, Laura, Schwartz, Victor, Scippa, Antonio, Seli, Bálint, Shibata, Sho, Simpson, Caroline, Shorttle, Oliver, Skaf, N., Skup, Konrad, Sobiecki, Mateusz, Sousa, Sergio, Sozzetti, Alessandro, Šponer, Judit, Steiger, Lukas, Tanga, Paolo, Tackley, Paul, Taylor, Jake, Tecza, Matthias, Terenzi, Luca, Tremblin, Pascal, Tozzi, Andrea, Triaud, Amaury, Trompet, Loïc, Tsai, Shang-Min, Tsantaki, Maria, Valencia, Diana, Vandaele, Ann Carine, Van der Swaelmen, Mathieu, Vardan, Adibekyan, Vasisht, Gautam, Vazan, Allona, Del Vecchio, Ciro, Waltham, Dave, Wawer, Piotr, Widemann, Thomas, Wolkenberg, Paulina, Yip, Gordon Hou, Yung, Yuk, Zilinskas, Mantas, Zingales, Tiziano, Zuppella, Paola, Tinetti, Giovanna, Eccleston, Paul, Haswell, Carole, Lagage, Pierre-Olivier, Leconte, Jérémy, Lüftinger, Theresa, Micela, Giusi, Min, Michel, Pilbratt, Göran, Puig, Ludovic, Swain, Mark, Testi, Leonardo, Turrini, Diego, Vandenbussche, Bart, Osorio, Maria Rosa Zapatero, Aret, Anna, Beaulieu, Jean-Philippe, Buchhave, Lars, Ferus, Martin, Griffin, Matt, Guedel, Manuel, Hartogh, Paul, Machado, Pedro, Malaguti, Giuseppe, Pallé, Enric, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Szabó, Robert, Tan, Jonathan, Werner, Stephanie, Ratti, Francesco, Scharmberg, Carsten, Salvignol, Jean-Christophe, Boudin, Nathalie, Halain, Jean-Philippe, Haag, Martin, Crouzet, Pierre-Elie, Kohley, Ralf, Symonds, Kate, Renk, Florian, Caldwell, Andrew, Abreu, Manuel, Alonso, Gustavo, Amiaux, Jerome, Berthé, Michel, Bishop, Georgia, Bowles, Neil, Carmona, Manuel, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Désjonqueres, Lucile, Díaz, José J., Drummond, Rachel, Focardi, Mauro, Gómez, Jose M., Holmes, Warren, Krijger, Matthijs, Kovacs, Zsolt, Hunt, Tom, Machado, Richardo, Morgante, Gianluca, Ollivier, Marc, Ottensamer, Roland, Pace, Emanuele, Pagano, Teresa, Pascale, Enzo, Pearson, Chris, Pedersen, Søren Møller, Pniel, Moshe, Roose, Stéphane, Savini, Giorgio, Stamper, Richard, Szirovicza, Peter, Szoke, Janos, Tosh, Ian, Vilardell, Francesc, Barstow, Joanna, Borsato, Luca, Casewell, Sarah, Changeat, Quentin, Charnay, Benjamin, Civiš, Svatopluk, Foresto, Vincent Coudé du, Coustenis, Athena, Cowan, Nicolas, Danielski, Camilla, Demangeon, Olivier, Drossart, Pierre, Edwards, Billy N., Gilli, Gabriella, Encrenaz, Therese, Kiss, Csaba, Kokori, Anastasia, Ikoma, Masahiro, Morales, Juan Carlos, Mendonça, João, Moneti, Andrea, Mugnai, Lorenzo, Muñoz, Antonio García, Helled, Ravit, Kama, Mihkel, Miguel, Yamila, Nikolaou, Nikos, Pagano, Isabella, Panic, Olja, Rengel, Miriam, Rickman, Hans, Rocchetto, Marco, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Tsiaras, Angelos, Venot, Olivia, Vida, Krisztián, Waldmann, Ingo P., Yurchenko, Sergey, Szabó, Gyula, Zellem, Rob, Al-Refaie, Ahmed, Alvarez, Javier Perez, Anisman, Lara, Arhancet, Axel, Ateca, Jaume, Baeyens, Robin, Barnes, John R., Bell, Taylor, Benatti, Serena, Biazzo, Katia, Błęcka, Maria, Bonomo, Aldo Stefano, Bosch, José, Bossini, Diego, Bourgalais, Jeremy, Brienza, Daniele, Brucalassi, Anna, Bruno, Giovanni, Caines, Hamish, Calcutt, Simon, Campante, Tiago, Canestrari, Rodolfo, Cann, Nick, Casali, Giada, Casas, Albert, Cassone, Giuseppe, Cara, Christophe, Carone, Ludmila, Carrasco, Nathalie, Chioetto, Paolo, Cortecchia, Fausto, Czupalla, Markus, Chubb, Katy L., Ciaravella, Angela, Claret, Antonio, Claudi, Riccardo, Codella, Claudio, Comas, Maya Garcia, Cracchiolo, Gianluca, Cubillos, Patricio, Da Peppo, Vania, Decin, Leen, Dejabrun, Clemence, Delgado-Mena, Elisa, Di Giorgio, Anna, Diolaiti, Emiliano, Dorn, Caroline, Doublier, Vanessa, Doumayrou, Eric, Dransfield, Georgina, Dumaye, Luc, Dunford, Emma, Escobar, Antonio Jimenez, Van Eylen, Vincent, Farina, Maria, Fedele, Davide, Fernández, Alejandro, Fleury, Benjamin, Fonte, Sergio, Fontignie, Jean, Fossati, Luca, Funke, Bernd, Galy, Camille, Garai, Zoltán, García, Andrés, García-Rigo, Alberto, Garufi, Antonio, Sacco, Giuseppe Germano, Giacobbe, Paolo, Gómez, Alejandro, Gonzalez, Arturo, Gonzalez-Galindo, Francisco, Grassi, Davide, Griffith, Caitlin, Guarcello, Mario Giuseppe, Goujon, Audrey, Gressier, Amélie, Grzegorczyk, Aleksandra, Guillot, Tristan, Guilluy, Gloria, Hargrave, Peter, Hellin, Marie-Laure, Herrero, Enrique, Hills, Matt, Horeau, Benoit, Ito, Yuichi, Jessen, Niels Christian, Kabath, Petr, Kálmán, Szilárd, Kawashima, Yui, Kimura, Tadahiro, Knížek, Antonín, Kreidberg, Laura, Kruid, Ronald, Kruijssen, Diederik J. M., Kubelík, Petr, Lara, Luisa, Lebonnois, Sebastien, Lee, David, Lefevre, Maxence, Lichtenberg, Tim, Locci, Daniele, Lombini, Matteo, Lopez, Alejandro Sanchez, Lorenzani, Andrea, MacDonald, Ryan, Magrini, Laura, Maldonado, Jesus, Marcq, Emmanuel, Migliorini, Alessandra, Modirrousta-Galian, Darius, Molaverdikhani, Karan, Molinari, Sergio, Mollière, Paul, Moreau, Vincent, Morello, Giuseppe, Morinaud, Gilles, Morvan, Mario, Moses, Julianne I., Mouzali, Salima, Nakhjiri, Nariman, Naponiello, Luca, Narita, Norio, Nascimbeni, Valerio, Nikolaou, Athanasia, Noce, Vladimiro, Oliva, Fabrizio, Palladino, Pietro, Papageorgiou, Andreas, Parmentier, Vivien, Peres, Giovanni, Pérez, Javier, Perez-Hoyos, Santiago, Perger, Manuel, Pestellini, Cesare Cecchi, Petralia, Antonino, Philippon, Anne, Piccialli, Arianna, Pignatari, Marco, Piotto, Giampaolo, Podio, Linda, Polenta, Gianluca, Preti, Giampaolo, Pribulla, Theodor, Puertas, Manuel Lopez, Rainer, Monica, Reess, Jean-Michel, Rimmer, Paul, Robert, Séverine, Rosich, Albert, Rossi, Loic, Rust, Duncan, Saleh, Ayman, Sanna, Nicoletta, Schisano, Eugenio, Schreiber, Laura, Schwartz, Victor, Scippa, Antonio, Seli, Bálint, Shibata, Sho, Simpson, Caroline, Shorttle, Oliver, Skaf, N., Skup, Konrad, Sobiecki, Mateusz, Sousa, Sergio, Sozzetti, Alessandro, Šponer, Judit, Steiger, Lukas, Tanga, Paolo, Tackley, Paul, Taylor, Jake, Tecza, Matthias, Terenzi, Luca, Tremblin, Pascal, Tozzi, Andrea, Triaud, Amaury, Trompet, Loïc, Tsai, Shang-Min, Tsantaki, Maria, Valencia, Diana, Vandaele, Ann Carine, Van der Swaelmen, Mathieu, Vardan, Adibekyan, Vasisht, Gautam, Vazan, Allona, Del Vecchio, Ciro, Waltham, Dave, Wawer, Piotr, Widemann, Thomas, Wolkenberg, Paulina, Yip, Gordon Hou, Yung, Yuk, Zilinskas, Mantas, Zingales, Tiziano, and Zuppella, Paola
Abstract: Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution., Comment: Ariel Definition Study Report, 147 pages. Reviewed by ESA Science Advisory Structure in November 2020. Original document available at: https://www.cosmos.esa.int/documents/1783156/3267291/Ariel_RedBook_Nov2020.pdf
Published: 2021

36. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study

Author: Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.R., Baudin, G., Tosato, S., Jongsma, H., de Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuan, J., Selten, J.P., Tortelli, A., Llorca, P.M., van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szoke, A., Schurhoff, F., Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.R., Baudin, G., Tosato, S., Jongsma, H., de Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuan, J., Selten, J.P., Tortelli, A., Llorca, P.M., van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szoke, A., and Schurhoff, F.
Abstract: The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (beta for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E x E interactions.
Published: 2021

37. Fusarium: more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Željko, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H.J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P.M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D.P., Boekhout, T., Câmara, M. P.S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Željko, Karalti, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S.N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J.L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C.S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, P. W.J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J.M., Vieira, W. A.S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with
Published: 2021

38. Perspectives on automated composition of workflows in the life sciences

Author: Lamprecht, Anna-Lena, Palmblad, Magnus, Ison, Jon, Schwämmle, Veit, Al Manir, Mohammad Sadnan, Altintas, Ilkay, Baker, Christopher J.O., Ben Hadj Amor, Ammar, Capella-Gutierrez, Salvador, Charonyktakis, Paulos, Crusoe, Michael R., Gil, Yolanda, Goble, Carole, Griffin, Timothy J., Groth, Paul, Ienasescu, Hans, Jagtap, Pratik, Kalaš, Matúš, Kasalica, Vedran, Khanteymoori, Alireza, Kuhn, Tobias, Mei, Hailiang, Ménager, Hervé, Möller, Steffen, Richardson, Robin A., Robert, Vincent, Soiland-Reyes, Stian, Stevens, Robert, Szaniszlo, Szoke, Verberne, Suzan, Verhoeven, Aswin, Wolstencroft, Katherine, Lamprecht, Anna-Lena, Palmblad, Magnus, Ison, Jon, Schwämmle, Veit, Al Manir, Mohammad Sadnan, Altintas, Ilkay, Baker, Christopher J.O., Ben Hadj Amor, Ammar, Capella-Gutierrez, Salvador, Charonyktakis, Paulos, Crusoe, Michael R., Gil, Yolanda, Goble, Carole, Griffin, Timothy J., Groth, Paul, Ienasescu, Hans, Jagtap, Pratik, Kalaš, Matúš, Kasalica, Vedran, Khanteymoori, Alireza, Kuhn, Tobias, Mei, Hailiang, Ménager, Hervé, Möller, Steffen, Richardson, Robin A., Robert, Vincent, Soiland-Reyes, Stian, Stevens, Robert, Szaniszlo, Szoke, Verberne, Suzan, Verhoeven, Aswin, and Wolstencroft, Katherine
Abstract: Scientific data analyses often combine several computational tools in automated pipelines, or workflows. Thousands of such workflows have been used in the life sciences, though their composition has remained a cumbersome manual process due to a lack of standards for annotation, assembly, and implementation. Recent technological advances have returned the long-standing vision of automated workflow composition into focus. This article summarizes a recent Lorentz Center workshop dedicated to automated composition of workflows in the life sciences. We survey previous initiatives to automate the composition process, and discuss the current state of the art and future perspectives. We start by drawing the 'big picture' of the scientific workflow development life cycle, before surveying and discussing current methods, technologies and practices for semantic domain modelling, automation in workflow development, and workflow assessment. Finally, we derive a roadmap of individual and community-based actions to work toward the vision of automated workflow development in the forthcoming years. A central outcome of the workshop is a general description of the workflow life cycle in six stages: 1) scientific question or hypothesis, 2) conceptual workflow, 3) abstract workflow, 4) concrete workflow, 5) production workflow, and 6) scientific results. The transitions between stages are facilitated by diverse tools and methods, usually incorporating domain knowledge in some form. Formal semantic domain modelling is hard and often a bottleneck for the application of semantic technologies. However, life science communities have made considerable progress here in recent years and are continuously improving, renewing interest in the application of semantic technologies for workflow exploration, composition and instantiation. Combined with systematic benchmarking with reference data and large-scale deployment of production-stage workflows, such technologies enable a more systematic proces
Published: 2021

39. Fusarium : more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H-J, Chaverri, P., Gene, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araujo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Amor, A. Ben Hadj, Bezerra, J. D. P., Boekhout, T., Camara, M. P. S., Carbia, M., Cardinali, G., Castaneda-Ruiz, R. F., Celis, A., Chaturvedi, V, Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernandez, N. B., Gaya, E., Gonzalez, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V, Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernandez-Restrepo, M., Houbraken, J., Hubka, V, Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjevic, Z., Karalti, I, Korsten, L., Kuramae, E. E., Kusan, I, Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Kemkuignou, B. Matio, Matocec, N., McTaggart, A. R., Mlcoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. , I, Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V, Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Y. P., Taylor, J. E., Taylor, P. W. J., Tiago, P. , V, Vaczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yanez-Morales, M. J., Yurkov, A., Zamora, Juan Carlos, Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021
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40. Fusarium: more than a node or a foot-shaped basal cell

Author: Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D. P., Boekhout, T., Câmara, M. P. S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Ž, Karalti, İ, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Yu Pei, Taylor, J. E., Taylor, P. W. J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., Thines, M., Crous, P. W., Lombard, L., Sandoval-Denis, M., Seifert, K. A., Schroers, H. J., Chaverri, P., Gené, J., Guarro, J., Hirooka, Y., Bensch, K., Kema, G. H. J., Lamprecht, S. C., Cai, L., Rossman, A. Y., Stadler, M., Summerbell, R. C., Taylor, J. W., Ploch, S., Visagie, C. M., Yilmaz, N., Frisvad, J. C., Abdel-Azeem, A. M., Abdollahzadeh, J., Abdolrasouli, A., Akulov, A., Alberts, J. F., Araújo, J. P. M., Ariyawansa, H. A., Bakhshi, M., Bendiksby, M., Ben Hadj Amor, A., Bezerra, J. D. P., Boekhout, T., Câmara, M. P. S., Carbia, M., Cardinali, G., Castañeda-Ruiz, R. F., Celis, A., Chaturvedi, V., Collemare, J., Croll, D., Damm, U., Decock, C. A., de Vries, R. P., Ezekiel, C. N., Fan, X. L., Fernández, N. B., Gaya, E., González, C. D., Gramaje, D., Groenewald, J. Z., Grube, M., Guevara-Suarez, M., Gupta, V. K., Guarnaccia, V., Haddaji, A., Hagen, F., Haelewaters, D., Hansen, K., Hashimoto, A., Hernández-Restrepo, M., Houbraken, J., Hubka, V., Hyde, K. D., Iturriaga, T., Jeewon, R., Johnston, P. R., Jurjević, Ž, Karalti, İ, Korsten, L., Kuramae, E. E., Kušan, I., Labuda, R., Lawrence, D. P., Lee, H. B., Lechat, C., Li, H. Y., Litovka, Y. A., Maharachchikumbura, S. S. N., Marin-Felix, Y., Matio Kemkuignou, B., Matočec, N., McTaggart, A. R., Mlčoch, P., Mugnai, L., Nakashima, C., Nilsson, R. H., Noumeur, S. R., Pavlov, I. N., Peralta, M. P., Phillips, A. J. L., Pitt, J. I., Polizzi, G., Quaedvlieg, W., Rajeshkumar, K. C., Restrepo, S., Rhaiem, A., Robert, J., Robert, V., Rodrigues, A. M., Salgado-Salazar, C., Samson, R. A., Santos, A. C. S., Shivas, R. G., Souza-Motta, C. M., Sun, G. Y., Swart, W. J., Szoke, S., Tan, Yu Pei, Taylor, J. E., Taylor, P. W. J., Tiago, P. V., Váczy, K. Z., van de Wiele, N., van der Merwe, N. A., Verkley, G. J. M., Vieira, W. A. S., Vizzini, A., Weir, B. S., Wijayawardene, N. N., Xia, J. W., Yáñez-Morales, M. J., Yurkov, A., Zamora, J. C., Zare, R., Zhang, C. L., and Thines, M.
Abstract: Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera in the terminal fusarioid clade of the family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept of the genus Fusarium was proposed. In doing so, however, a significant body of data that supports distinct genera in Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA phylogeny based on 19 orthologous protein-coding genes was presented to support a very broad concept of Fusarium at the F1 node in Nectriaceae. Here, we demonstrate that re-analyses of this dataset show that all 19 genes support the F3 node that represents Fusarium sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone of the phylogeny is resolved by the concatenated alignment, but only six of the 19 genes fully support the F1 node, representing the broad circumscription of Fusarium. Furthermore, a re-analysis of the concatenated dataset revealed alternate topologies in different phylogenetic algorithms, highlighting the deep divergence and unresolved placement of various Nectriaceae lineages proposed as members of Fusarium. Species of Fusarium s. str. are characterised by Gibberella sexual morphs, asexual morphs with thin- or thick-walled macroconidia that have variously shaped apical and basal cells, and trichothecene mycotoxin production, which separates them from other fusarioid genera. Here we show that the Wollenweber concept of Fusarium presently accounts for 20 segregate genera with clear-cut synapomorphic traits, and that fusarioid macroconidia represent a character that has been gained or lost multiple times throughout Nectriaceae. Thus, the very broad circumscription of Fusarium is blurry and without apparent synapomorphies, and does not include all genera with fusarium-like macroconidia, which are spread throughout Nectriaceae (e.g., Cosmosporella, Macroconia, Microcera). In th
Published: 2021

41. Fusarium: more than a node or a foot-shaped basal cell

Author: Universitat Rovira i Virgili, Crous, P. W.; Lombard, L.; Sandoval-Denis, M.; Seifert, K. A.; Schroers, H-J; Chaverri, P.; Gene, J.; Guarro, J.; Hirooka, Y.; Bensch, K.; Kema, G. H. J.; Lamprecht, S. C.; Cai, L.; Rossman, A. Y.; Stadler, M.; Summerbell, R. C.; Taylor, J. W.; Ploch, S.; Visagie, C. M.; Yilmaz, N.; Frisvad, J. C.; Abdel-Azeem, A. M.; Abdollahzadeh, J.; Abdolrasouli, A.; Akulov, A.; Alberts, J. F.; Araujo, J. P. M.; Ariyawansa, H. A.; Bakhshi, M.; Bendiksby, M.; Amor, A. Ben Hadj; Bezerra, J. D. P.; Boekhout, T.; Camara, M. P. S.; Carbia, M.; Cardinali, G.; Castaneda-Ruiz, R. F.; Celis, A.; Chaturvedi, V; Collemare, J.; Croll, D.; Damm, U.; Decock, C. A.; de Vries, R. P.; Ezekiel, C. N.; Fan, X. L.; Fernandez, N. B.; Gaya, E.; Gonzalez, C. D.; Gramaje, D.; Groenewald, J. Z.; Grube, M.; Guevara-Suarez, M.; Gupta, V. K.; Guarnaccia, V; Haddaji, A.; Hagen, F.; Haelewaters, D.; Hansen, K.; Hashimoto, A.; Hernandez-Restrepo, M.; Houbraken, J.; Hubka, V; Hyde, K. D.; Iturriaga, T.; Jeewon, R.; Johnston, P. R.; Jurjevic, Z.; Karalti, I; Korsten, L.; Kuramae, E. E.; Kusan, I; Labuda, R.; Lawrence, D. P.; Lee, H. B.; Lechat, C.; Li, H. Y.; Litovka, Y. A.; Maharachchikumbura, S. S. N.; Marin-Felix, Y.; Kemkuignou, B. Matio; Matocec, N.; McTaggart, A. R.; Mlcoch, P.; Mugnai, L.; Nakashima, C.; Nilsson, R. H.; Noumeur, S. R.; Pavlov, I. N.; Peralta, M. P.; Phillips, A. J. L.; Pitt, J., I; Polizzi, G.; Quaedvlieg, W.; Rajeshkumar, K. C.; Restrepo, S.; Rhaiem, A.; Robert, J.; Robert, V; Rodrigues, A. M.; Salgado-Salazar, C.; Samson, R. A.; Santos, A. C. S.; Shivas, R. G.; Souza-Motta, C. M.; Sun, G. Y.; Swart, W. J.; Szoke, S.; Tan, Y. P.; Taylor, J. E.; Taylor, P. W. J.; Tiago, P., V; Vaczy, K. Z.; van de Wiele, N.; van der Merwe, N. A.; Verkley, G. J. M.; Vieira, W. A. S.; Vizzini, A.; Weir, B. S., Universitat Rovira i Virgili, and Crous, P. W.; Lombard, L.; Sandoval-Denis, M.; Seifert, K. A.; Schroers, H-J; Chaverri, P.; Gene, J.; Guarro, J.; Hirooka, Y.; Bensch, K.; Kema, G. H. J.; Lamprecht, S. C.; Cai, L.; Rossman, A. Y.; Stadler, M.; Summerbell, R. C.; Taylor, J. W.; Ploch, S.; Visagie, C. M.; Yilmaz, N.; Frisvad, J. C.; Abdel-Azeem, A. M.; Abdollahzadeh, J.; Abdolrasouli, A.; Akulov, A.; Alberts, J. F.; Araujo, J. P. M.; Ariyawansa, H. A.; Bakhshi, M.; Bendiksby, M.; Amor, A. Ben Hadj; Bezerra, J. D. P.; Boekhout, T.; Camara, M. P. S.; Carbia, M.; Cardinali, G.; Castaneda-Ruiz, R. F.; Celis, A.; Chaturvedi, V; Collemare, J.; Croll, D.; Damm, U.; Decock, C. A.; de Vries, R. P.; Ezekiel, C. N.; Fan, X. L.; Fernandez, N. B.; Gaya, E.; Gonzalez, C. D.; Gramaje, D.; Groenewald, J. Z.; Grube, M.; Guevara-Suarez, M.; Gupta, V. K.; Guarnaccia, V; Haddaji, A.; Hagen, F.; Haelewaters, D.; Hansen, K.; Hashimoto, A.; Hernandez-Restrepo, M.; Houbraken, J.; Hubka, V; Hyde, K. D.; Iturriaga, T.; Jeewon, R.; Johnston, P. R.; Jurjevic, Z.; Karalti, I; Korsten, L.; Kuramae, E. E.; Kusan, I; Labuda, R.; Lawrence, D. P.; Lee, H. B.; Lechat, C.; Li, H. Y.; Litovka, Y. A.; Maharachchikumbura, S. S. N.; Marin-Felix, Y.; Kemkuignou, B. Matio; Matocec, N.; McTaggart, A. R.; Mlcoch, P.; Mugnai, L.; Nakashima, C.; Nilsson, R. H.; Noumeur, S. R.; Pavlov, I. N.; Peralta, M. P.; Phillips, A. J. L.; Pitt, J., I; Polizzi, G.; Quaedvlieg, W.; Rajeshkumar, K. C.; Restrepo, S.; Rhaiem, A.; Robert, J.; Robert, V; Rodrigues, A. M.; Salgado-Salazar, C.; Samson, R. A.; Santos, A. C. S.; Shivas, R. G.; Souza-Motta, C. M.; Sun, G. Y.; Swart, W. J.; Szoke, S.; Tan, Y. P.; Taylor, J. E.; Taylor, P. W. J.; Tiago, P., V; Vaczy, K. Z.; van de Wiele, N.; van der Merwe, N. A.; Verkley, G. J. M.; Vieira, W. A. S.; Vizzini, A.; Weir, B. S.
Abstract: Microbiology, Forestry and Agricultural Biotechnology Institute (FABI), Faculty of Natural and Agricultural Sciences, University of Pretoria, P. Bag X20, Hatfield, 0028, Pretoria, South Africa; 20Department of Biotechnology and Biomedicine, DTU-Bioengineering, Technical University of Denmark, 2800, Kongens Lyngby, Denmark; 21Systematic Mycology Lab., Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt; 22Department of Plant Protection, Faculty of Agriculture, University of Kurdistan, P.O. Box 416, Sanandaj, Iran; 23Department of Medical Microbiology, King's College Hospital, London, UK;24Department of Infectious Diseases, Imperial College London, London, UK;25Department of Mycology and Plant Resistance, V. N. Karazin Kharkiv National University, Maidan Svobody 4, 61022, Kharkiv, Ukraine; 26Department of Food Science and Technology, Cape Peninsula University of Technology, P.O. Box 1906, Bellville, 7535, South Africa; 27School of Forest Resources and Conservation, University of Florida, Gainesville, FL, USA; 28Department of Plant Pathology and Microbiology, College of Bio-Resources and Agriculture, National Taiwan University, No.1, Sec.4, Roosevelt Road, Taipei, 106, Taiwan, ROC
Published: 2021

42. Layer-resolved ultrafast extreme ultraviolet measurement of hole transport in a Ni-TiO2-Si photoanode.

Author: Cushing, Scott K, Cushing, Scott K, Porter, Ilana J, de Roulet, Bethany R, Lee, Angela, Marsh, Brett M, Szoke, Szilard, Vaida, Mihai E, Leone, Stephen R, Cushing, Scott K, Cushing, Scott K, Porter, Ilana J, de Roulet, Bethany R, Lee, Angela, Marsh, Brett M, Szoke, Szilard, Vaida, Mihai E, and Leone, Stephen R
Abstract: Metal oxide semiconductor junctions are central to most electronic and optoelectronic devices, but ultrafast measurements of carrier transport have been limited to device-average measurements. Here, charge transport and recombination kinetics in each layer of a Ni-TiO2-Si junction is measured using the element specificity of broadband extreme ultraviolet (XUV) ultrafast pulses. After silicon photoexcitation, holes are inferred to transport from Si to Ni ballistically in ~100 fs, resulting in characteristic spectral shifts in the XUV edges. Meanwhile, the electrons remain on Si. After picoseconds, the transient hole population on Ni is observed to back-diffuse through the TiO2, shifting the Ti spectrum to a higher oxidation state, followed by electron-hole recombination at the Si-TiO2 interface and in the Si bulk. Electrical properties, such as the hole diffusion constant in TiO2 and the initial hole mobility in Si, are fit from these transient spectra and match well with values reported previously.
Published: 2020

43. Layer-resolved ultrafast extreme ultraviolet measurement of hole transport in a Ni-TiO2-Si photoanode.

Author: Cushing, Scott K, Cushing, Scott K, Porter, Ilana J, de Roulet, Bethany R, Lee, Angela, Marsh, Brett M, Szoke, Szilard, Vaida, Mihai E, Leone, Stephen R, Cushing, Scott K, Cushing, Scott K, Porter, Ilana J, de Roulet, Bethany R, Lee, Angela, Marsh, Brett M, Szoke, Szilard, Vaida, Mihai E, and Leone, Stephen R
Abstract: Metal oxide semiconductor junctions are central to most electronic and optoelectronic devices, but ultrafast measurements of carrier transport have been limited to device-average measurements. Here, charge transport and recombination kinetics in each layer of a Ni-TiO2-Si junction is measured using the element specificity of broadband extreme ultraviolet (XUV) ultrafast pulses. After silicon photoexcitation, holes are inferred to transport from Si to Ni ballistically in ~100 fs, resulting in characteristic spectral shifts in the XUV edges. Meanwhile, the electrons remain on Si. After picoseconds, the transient hole population on Ni is observed to back-diffuse through the TiO2, shifting the Ti spectrum to a higher oxidation state, followed by electron-hole recombination at the Si-TiO2 interface and in the Si bulk. Electrical properties, such as the hole diffusion constant in TiO2 and the initial hole mobility in Si, are fit from these transient spectra and match well with values reported previously.
Published: 2020

44. The CHEOPS mission

Author: Benz, Willy, Broeg, Christopher, Fortier, Andrea, Rando, Nicola, Beck, Thomas, Beck, Mathias, Queloz, Didier, Ehrenreich, David, Maxted, Pierre, Isaak, Kate, Billot, Nicolas, Alibert, Yann, Alonso, Roi, António, Carlos, Asquier, Joel, Bandy, Timothy, Bárczy, Tamas, Barrado, David, Barros, Susana, Baumjohann, Wolfgang, Bekkelien, Anja, Bergomi, Maria, Biondi, Federico, Bonfils, Xavier, Borsato, Luca, Brandeker, Alexis, Busch, Martin-Diego, Cabrera, Juan, Cessa, Virginie, Charnoz, Sébastien, Chazelas, Bruno, Cameron, Andrew Collier, Van Damme, Carlos Corral, Cortes, David, Davies, Melvyn, Deleuil, Magali, Deline, Adrien, Delrez, Laetitia, Demangeon, Olivier, Demory, Brice-Olivier, Erikson, Anders, Farinato, Jacopo, Fossati, Luca, Fridlund, Malcolm, Futyan, David, Gandolfi, Davide, Munoz, Antonio Garcia, Gillon, Michaël, Guterman, Pascal, Gutierrez, Antonio, Hasiba, Johann, Heng, Kevin, Hernandez, Eduardo, Hoyer, Sergio, Kiss, Laszlo, Kovacs, Zsolt, Kuntzer, Thibault, Laskar, Jacques, Etangs, Alain Lecavelier des, Lendl, Monika, López, Amador, Lora, Ivan, Lovis, Christophe, Lüftinger, Theresa, Magrin, Demetrio, Malvasio, Luca, Marafatto, Luca, Michaelis, Harald, de Miguel, Diana, Modrego, David, Munari, Matteo, Nascimbeni, Valerio, Olofsson, Göran, Ottacher, Harald, Ottensamer, Roland, Pagano, Isabella, Palacios, Roberto, Pallé, Enric, Peter, Gisbert, Piazza, Daniele, Piotto, Giampaolo, Pizarro, Alberto, Pollaco, Don, Ragazzoni, Roberto, Ratti, Francesco, Rauer, Heike, Ribas, Ignasi, Rieder, Martin, Rohlfs, Reiner, Safa, Frederic, Salatti, Mario, Santos, Nuno, Scandariato, Gaetano, Ségransan, Damien, Simon, Attila, Smith, Alexis, Sordet, Michael, Sousa, Sergio, Steller, Manfred, Szabó, Gyula, Szoke, Janos, Thomas, Nicolas, Tschentscher, Matthias, Udry, Stéphane, Van Grootel, Valérie, Viotto, Valentina, Walter, Ingo, Walton, Nicholas, Wildi, François, Wolter, David, Benz, Willy, Broeg, Christopher, Fortier, Andrea, Rando, Nicola, Beck, Thomas, Beck, Mathias, Queloz, Didier, Ehrenreich, David, Maxted, Pierre, Isaak, Kate, Billot, Nicolas, Alibert, Yann, Alonso, Roi, António, Carlos, Asquier, Joel, Bandy, Timothy, Bárczy, Tamas, Barrado, David, Barros, Susana, Baumjohann, Wolfgang, Bekkelien, Anja, Bergomi, Maria, Biondi, Federico, Bonfils, Xavier, Borsato, Luca, Brandeker, Alexis, Busch, Martin-Diego, Cabrera, Juan, Cessa, Virginie, Charnoz, Sébastien, Chazelas, Bruno, Cameron, Andrew Collier, Van Damme, Carlos Corral, Cortes, David, Davies, Melvyn, Deleuil, Magali, Deline, Adrien, Delrez, Laetitia, Demangeon, Olivier, Demory, Brice-Olivier, Erikson, Anders, Farinato, Jacopo, Fossati, Luca, Fridlund, Malcolm, Futyan, David, Gandolfi, Davide, Munoz, Antonio Garcia, Gillon, Michaël, Guterman, Pascal, Gutierrez, Antonio, Hasiba, Johann, Heng, Kevin, Hernandez, Eduardo, Hoyer, Sergio, Kiss, Laszlo, Kovacs, Zsolt, Kuntzer, Thibault, Laskar, Jacques, Etangs, Alain Lecavelier des, Lendl, Monika, López, Amador, Lora, Ivan, Lovis, Christophe, Lüftinger, Theresa, Magrin, Demetrio, Malvasio, Luca, Marafatto, Luca, Michaelis, Harald, de Miguel, Diana, Modrego, David, Munari, Matteo, Nascimbeni, Valerio, Olofsson, Göran, Ottacher, Harald, Ottensamer, Roland, Pagano, Isabella, Palacios, Roberto, Pallé, Enric, Peter, Gisbert, Piazza, Daniele, Piotto, Giampaolo, Pizarro, Alberto, Pollaco, Don, Ragazzoni, Roberto, Ratti, Francesco, Rauer, Heike, Ribas, Ignasi, Rieder, Martin, Rohlfs, Reiner, Safa, Frederic, Salatti, Mario, Santos, Nuno, Scandariato, Gaetano, Ségransan, Damien, Simon, Attila, Smith, Alexis, Sordet, Michael, Sousa, Sergio, Steller, Manfred, Szabó, Gyula, Szoke, Janos, Thomas, Nicolas, Tschentscher, Matthias, Udry, Stéphane, Van Grootel, Valérie, Viotto, Valentina, Walter, Ingo, Walton, Nicholas, Wildi, François, and Wolter, David
Abstract: The CHaracterising ExOPlanet Satellite (CHEOPS) was selected in 2012, as the first small mission in the ESA Science Programme and successfully launched in December 2019. CHEOPS is a partnership between ESA and Switzerland with important contributions by ten additional ESA Member States. CHEOPS is the first mission dedicated to search for transits of exoplanets using ultrahigh precision photometry on bright stars already known to host planets. As a follow-up mission, CHEOPS is mainly dedicated to improving, whenever possible, existing radii measurements or provide first accurate measurements for a subset of those planets for which the mass has already been estimated from ground-based spectroscopic surveys and to following phase curves. CHEOPS will provide prime targets for future spectroscopic atmospheric characterisation. Requirements on the photometric precision and stability have been derived for stars with magnitudes ranging from 6 to 12 in the V band. In particular, CHEOPS shall be able to detect Earth-size planets transiting G5 dwarf stars in the magnitude range between 6 and 9 by achieving a photometric precision of 20 ppm in 6 hours of integration. For K stars in the magnitude range between 9 and 12, CHEOPS shall be able to detect transiting Neptune-size planets achieving a photometric precision of 85 ppm in 3 hours of integration. This is achieved by using a single, frame-transfer, back-illuminated CCD detector at the focal plane assembly of a 33.5 cm diameter telescope. The 280 kg spacecraft has a pointing accuracy of about 1 arcsec rms and orbits on a sun-synchronous dusk-dawn orbit at 700 km altitude. The nominal mission lifetime is 3.5 years. During this period, 20% of the observing time is available to the community through a yearly call and a discretionary time programme managed by ESA., Comment: Submitted to Experimental Astronomy
Published: 2020
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45. Ariel: Enabling planetary science across light-years

Author: Tinetti, Giovanna, Eccleston, Paul, Haswell, Carole, Lagage, Pierre-Olivier, Leconte, Jérémy, Lüftinger, Theresa, Micela, Giusi, Min, Michel, Pilbratt, Göran, Puig, Ludovic, Swain, Mark, Testi, Leonardo, Turrini, Diego, Vandenbussche, Bart, Osorio, Maria Rosa Zapatero, Aret, Anna, Beaulieu, Jean-Philippe, Buchhave, Lars, Ferus, Martin, Griffin, Matt, Guedel, Manuel, Hartogh, Paul, Machado, Pedro, Malaguti, Giuseppe, Pallé, Enric, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Szabó, Robert, Tan, Jonathan, Werner, Stephanie, Ratti, Francesco, Scharmberg, Carsten, Salvignol, Jean-Christophe, Boudin, Nathalie, Halain, Jean-Philippe, Haag, Martin, Crouzet, Pierre-Elie, Kohley, Ralf, Symonds, Kate, Renk, Florian, Caldwell, Andrew, Abreu, Manuel, Alonso, Gustavo, Amiaux, Jerome, Berthé, Michel, Bishop, Georgia, Bowles, Neil, Carmona, Manuel, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Désjonqueres, Lucile, Díaz, José J., Drummond, Rachel, Focardi, Mauro, Gómez, Jose M., Holmes, Warren, Krijger, Matthijs, Kovacs, Zsolt, Hunt, Tom, Machado, Richardo, Morgante, Gianluca, Ollivier, Marc, Ottensamer, Roland, Pace, Emanuele, Pagano, Teresa, Pascale, Enzo, Pearson, Chris, Pedersen, Søren Møller, Pniel, Moshe, Roose, Stéphane, Savini, Giorgio, Stamper, Richard, Szirovicza, Peter, Szoke, Janos, Tosh, Ian, Vilardell, Francesc, Barstow, Joanna, Borsato, Luca, Casewell, Sarah, Changeat, Quentin, Charnay, Benjamin, Civiš, Svatopluk, Foresto, Vincent Coudé du, Coustenis, Athena, Cowan, Nicolas, Danielski, Camilla, Demangeon, Olivier, Drossart, Pierre, Edwards, Billy N., Gilli, Gabriella, Encrenaz, Therese, Kiss, Csaba, Kokori, Anastasia, Ikoma, Masahiro, Morales, Juan Carlos, Mendonça, João, Moneti, Andrea, Mugnai, Lorenzo, Muñoz, Antonio García, Helled, Ravit, Kama, Mihkel, Miguel, Yamila, Nikolaou, Nikos, Pagano, Isabella, Panic, Olja, Rengel, Miriam, Rickman, Hans, Rocchetto, Marco, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Tsiaras, Angelos, Venot, Olivia, Vida, Krisztián, Waldmann, Ingo P., Yurchenko, Sergey, Szabó, Gyula, Zellem, Rob, Al-Refaie, Ahmed, Alvarez, Javier Perez, Anisman, Lara, Arhancet, Axel, Ateca, Jaume, Baeyens, Robin, Barnes, John R., Bell, Taylor, Benatti, Serena, Biazzo, Katia, Błęcka, Maria, Bonomo, Aldo Stefano, Bosch, José, Bossini, Diego, Bourgalais, Jeremy, Brienza, Daniele, Brucalassi, Anna, Bruno, Giovanni, Caines, Hamish, Calcutt, Simon, Campante, Tiago, Canestrari, Rodolfo, Cann, Nick, Casali, Giada, Casas, Albert, Cassone, Giuseppe, Cara, Christophe, Carone, Ludmila, Carrasco, Nathalie, Chioetto, Paolo, Cortecchia, Fausto, Czupalla, Markus, Chubb, Katy L., Ciaravella, Angela, Claret, Antonio, Claudi, Riccardo, Codella, Claudio, Comas, Maya Garcia, Cracchiolo, Gianluca, Cubillos, Patricio, Peppo, Vania Da, Decin, Leen, Dejabrun, Clemence, Delgado-Mena, Elisa, Giorgio, Anna Di, Diolaiti, Emiliano, Dorn, Caroline, Doublier, Vanessa, Doumayrou, Eric, Dransfield, Georgina, Dumaye, Luc, Dunford, Emma, Escobar, Antonio Jimenez, Eylen, Vincent Van, Farina, Maria, Fedele, Davide, Fernández, Alejandro, Fleury, Benjamin, Fonte, Sergio, Fontignie, Jean, Fossati, Luca, Funke, Bernd, Galy, Camille, Garai, Zoltán, García, Andrés, García-Rigo, Alberto, Garufi, Antonio, Sacco, Giuseppe Germano, Giacobbe, Paolo, Gómez, Alejandro, Gonzalez, Arturo, Gonzalez-Galindo, Francisco, Grassi, Davide, Griffith, Caitlin, Guarcello, Mario Giuseppe, Goujon, Audrey, Gressier, Amélie, Grzegorczyk, Aleksandra, Guillot, Tristan, Guilluy, Gloria, Hargrave, Peter, Hellin, Marie-Laure, Herrero, Enrique, Hills, Matt, Horeau, Benoit, Ito, Yuichi, Jessen, Niels Christian, Kabath, Petr, Kálmán, Szilárd, Kawashima, Yui, Kimura, Tadahiro, Knížek, Antonín, Kreidberg, Laura, Kruid, Ronald, Kruijssen, Diederik J. M., Kubelík, Petr, Lara, Luisa, Lebonnois, Sebastien, Lee, David, Lefevre, Maxence, Lichtenberg, Tim, Locci, Daniele, Lombini, Matteo, Lopez, Alejandro Sanchez, Lorenzani, Andrea, MacDonald, Ryan, Magrini, Laura, Maldonado, Jesus, Marcq, Emmanuel, Migliorini, Alessandra, Modirrousta-Galian, Darius, Molaverdikhani, Karan, Molinari, Sergio, Mollière, Paul, Moreau, Vincent, Morello, Giuseppe, Morinaud, Gilles, Morvan, Mario, Moses, Julianne I., Mouzali, Salima, Nakhjiri, Nariman, Naponiello, Luca, Narita, Norio, Nascimbeni, Valerio, Nikolaou, Athanasia, Noce, Vladimiro, Oliva, Fabrizio, Palladino, Pietro, Papageorgiou, Andreas, Parmentier, Vivien, Peres, Giovanni, Pérez, Javier, Perez-Hoyos, Santiago, Perger, Manuel, Pestellini, Cesare Cecchi, Petralia, Antonino, Philippon, Anne, Piccialli, Arianna, Pignatari, Marco, Piotto, Giampaolo, Podio, Linda, Polenta, Gianluca, Preti, Giampaolo, Pribulla, Theodor, Puertas, Manuel Lopez, Rainer, Monica, Reess, Jean-Michel, Rimmer, Paul, Robert, Séverine, Rosich, Albert, Rossi, Loic, Rust, Duncan, Saleh, Ayman, Sanna, Nicoletta, Schisano, Eugenio, Schreiber, Laura, Schwartz, Victor, Scippa, Antonio, Seli, Bálint, Shibata, Sho, Simpson, Caroline, Shorttle, Oliver, Skaf, N., Skup, Konrad, Sobiecki, Mateusz, Sousa, Sergio, Sozzetti, Alessandro, Šponer, Judit, Steiger, Lukas, Tanga, Paolo, Tackley, Paul, Taylor, Jake, Tecza, Matthias, Terenzi, Luca, Tremblin, Pascal, Tozzi, Andrea, Triaud, Amaury, Trompet, Loïc, Tsai, Shang-Min, Tsantaki, Maria, Valencia, Diana, Vandaele, Ann Carine, Swaelmen, Mathieu Van der, Vardan, Adibekyan, Vasisht, Gautam, Vazan, Allona, Vecchio, Ciro Del, Waltham, Dave, Wawer, Piotr, Widemann, Thomas, Wolkenberg, Paulina, Yip, Gordon Hou, Yung, Yuk, Zilinskas, Mantas, Zingales, Tiziano, Zuppella, Paola, Tinetti, Giovanna, Eccleston, Paul, Haswell, Carole, Lagage, Pierre-Olivier, Leconte, Jérémy, Lüftinger, Theresa, Micela, Giusi, Min, Michel, Pilbratt, Göran, Puig, Ludovic, Swain, Mark, Testi, Leonardo, Turrini, Diego, Vandenbussche, Bart, Osorio, Maria Rosa Zapatero, Aret, Anna, Beaulieu, Jean-Philippe, Buchhave, Lars, Ferus, Martin, Griffin, Matt, Guedel, Manuel, Hartogh, Paul, Machado, Pedro, Malaguti, Giuseppe, Pallé, Enric, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Szabó, Robert, Tan, Jonathan, Werner, Stephanie, Ratti, Francesco, Scharmberg, Carsten, Salvignol, Jean-Christophe, Boudin, Nathalie, Halain, Jean-Philippe, Haag, Martin, Crouzet, Pierre-Elie, Kohley, Ralf, Symonds, Kate, Renk, Florian, Caldwell, Andrew, Abreu, Manuel, Alonso, Gustavo, Amiaux, Jerome, Berthé, Michel, Bishop, Georgia, Bowles, Neil, Carmona, Manuel, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Désjonqueres, Lucile, Díaz, José J., Drummond, Rachel, Focardi, Mauro, Gómez, Jose M., Holmes, Warren, Krijger, Matthijs, Kovacs, Zsolt, Hunt, Tom, Machado, Richardo, Morgante, Gianluca, Ollivier, Marc, Ottensamer, Roland, Pace, Emanuele, Pagano, Teresa, Pascale, Enzo, Pearson, Chris, Pedersen, Søren Møller, Pniel, Moshe, Roose, Stéphane, Savini, Giorgio, Stamper, Richard, Szirovicza, Peter, Szoke, Janos, Tosh, Ian, Vilardell, Francesc, Barstow, Joanna, Borsato, Luca, Casewell, Sarah, Changeat, Quentin, Charnay, Benjamin, Civiš, Svatopluk, Foresto, Vincent Coudé du, Coustenis, Athena, Cowan, Nicolas, Danielski, Camilla, Demangeon, Olivier, Drossart, Pierre, Edwards, Billy N., Gilli, Gabriella, Encrenaz, Therese, Kiss, Csaba, Kokori, Anastasia, Ikoma, Masahiro, Morales, Juan Carlos, Mendonça, João, Moneti, Andrea, Mugnai, Lorenzo, Muñoz, Antonio García, Helled, Ravit, Kama, Mihkel, Miguel, Yamila, Nikolaou, Nikos, Pagano, Isabella, Panic, Olja, Rengel, Miriam, Rickman, Hans, Rocchetto, Marco, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Tsiaras, Angelos, Venot, Olivia, Vida, Krisztián, Waldmann, Ingo P., Yurchenko, Sergey, Szabó, Gyula, Zellem, Rob, Al-Refaie, Ahmed, Alvarez, Javier Perez, Anisman, Lara, Arhancet, Axel, Ateca, Jaume, Baeyens, Robin, Barnes, John R., Bell, Taylor, Benatti, Serena, Biazzo, Katia, Błęcka, Maria, Bonomo, Aldo Stefano, Bosch, José, Bossini, Diego, Bourgalais, Jeremy, Brienza, Daniele, Brucalassi, Anna, Bruno, Giovanni, Caines, Hamish, Calcutt, Simon, Campante, Tiago, Canestrari, Rodolfo, Cann, Nick, Casali, Giada, Casas, Albert, Cassone, Giuseppe, Cara, Christophe, Carone, Ludmila, Carrasco, Nathalie, Chioetto, Paolo, Cortecchia, Fausto, Czupalla, Markus, Chubb, Katy L., Ciaravella, Angela, Claret, Antonio, Claudi, Riccardo, Codella, Claudio, Comas, Maya Garcia, Cracchiolo, Gianluca, Cubillos, Patricio, Peppo, Vania Da, Decin, Leen, Dejabrun, Clemence, Delgado-Mena, Elisa, Giorgio, Anna Di, Diolaiti, Emiliano, Dorn, Caroline, Doublier, Vanessa, Doumayrou, Eric, Dransfield, Georgina, Dumaye, Luc, Dunford, Emma, Escobar, Antonio Jimenez, Eylen, Vincent Van, Farina, Maria, Fedele, Davide, Fernández, Alejandro, Fleury, Benjamin, Fonte, Sergio, Fontignie, Jean, Fossati, Luca, Funke, Bernd, Galy, Camille, Garai, Zoltán, García, Andrés, García-Rigo, Alberto, Garufi, Antonio, Sacco, Giuseppe Germano, Giacobbe, Paolo, Gómez, Alejandro, Gonzalez, Arturo, Gonzalez-Galindo, Francisco, Grassi, Davide, Griffith, Caitlin, Guarcello, Mario Giuseppe, Goujon, Audrey, Gressier, Amélie, Grzegorczyk, Aleksandra, Guillot, Tristan, Guilluy, Gloria, Hargrave, Peter, Hellin, Marie-Laure, Herrero, Enrique, Hills, Matt, Horeau, Benoit, Ito, Yuichi, Jessen, Niels Christian, Kabath, Petr, Kálmán, Szilárd, Kawashima, Yui, Kimura, Tadahiro, Knížek, Antonín, Kreidberg, Laura, Kruid, Ronald, Kruijssen, Diederik J. M., Kubelík, Petr, Lara, Luisa, Lebonnois, Sebastien, Lee, David, Lefevre, Maxence, Lichtenberg, Tim, Locci, Daniele, Lombini, Matteo, Lopez, Alejandro Sanchez, Lorenzani, Andrea, MacDonald, Ryan, Magrini, Laura, Maldonado, Jesus, Marcq, Emmanuel, Migliorini, Alessandra, Modirrousta-Galian, Darius, Molaverdikhani, Karan, Molinari, Sergio, Mollière, Paul, Moreau, Vincent, Morello, Giuseppe, Morinaud, Gilles, Morvan, Mario, Moses, Julianne I., Mouzali, Salima, Nakhjiri, Nariman, Naponiello, Luca, Narita, Norio, Nascimbeni, Valerio, Nikolaou, Athanasia, Noce, Vladimiro, Oliva, Fabrizio, Palladino, Pietro, Papageorgiou, Andreas, Parmentier, Vivien, Peres, Giovanni, Pérez, Javier, Perez-Hoyos, Santiago, Perger, Manuel, Pestellini, Cesare Cecchi, Petralia, Antonino, Philippon, Anne, Piccialli, Arianna, Pignatari, Marco, Piotto, Giampaolo, Podio, Linda, Polenta, Gianluca, Preti, Giampaolo, Pribulla, Theodor, Puertas, Manuel Lopez, Rainer, Monica, Reess, Jean-Michel, Rimmer, Paul, Robert, Séverine, Rosich, Albert, Rossi, Loic, Rust, Duncan, Saleh, Ayman, Sanna, Nicoletta, Schisano, Eugenio, Schreiber, Laura, Schwartz, Victor, Scippa, Antonio, Seli, Bálint, Shibata, Sho, Simpson, Caroline, Shorttle, Oliver, Skaf, N., Skup, Konrad, Sobiecki, Mateusz, Sousa, Sergio, Sozzetti, Alessandro, Šponer, Judit, Steiger, Lukas, Tanga, Paolo, Tackley, Paul, Taylor, Jake, Tecza, Matthias, Terenzi, Luca, Tremblin, Pascal, Tozzi, Andrea, Triaud, Amaury, Trompet, Loïc, Tsai, Shang-Min, Tsantaki, Maria, Valencia, Diana, Vandaele, Ann Carine, Swaelmen, Mathieu Van der, Vardan, Adibekyan, Vasisht, Gautam, Vazan, Allona, Vecchio, Ciro Del, Waltham, Dave, Wawer, Piotr, Widemann, Thomas, Wolkenberg, Paulina, Yip, Gordon Hou, Yung, Yuk, Zilinskas, Mantas, Zingales, Tiziano, and Zuppella, Paola
Abstract: The concept of a mission devoted to atmospheric characterization of exoplanets through transit spectroscopy was first considered in Europe in 2007, shortly after the DARWIN proposal submitted to ESA for the first Cosmic Vision call for L-class missions was rejected because of the need for further scientific and technical developments. Following the decision, both ESA (EP-RAT panel report, October 2010) and the Exoplanetary Community (Blue Dot Team – Barcelona conference, September 2009) started a discussion to define a roadmap for exoplanetary research. Both groups concluded that an intermediate step was needed, both scientifically and technically, before the characterisation of Earth-like planets could be tackled, and recommended a transit spectroscopy mission as a first step to atmospheric characterisation. A short study was undertaken at ESTEC in the context of the ExoPlanet Roadmap Advisory Team mandate under the name ESM (Exoplanet Spectroscopy Mission). Following this study the Exoplanet Characterisation Observatory (EChO) was proposed and accepted for assessment phase study in the context of the ESA Cosmic Vision 2015-2025 programme M3 medium class mission opportunity. Although eventually not selected, the EChO study1 allowed further development of the technical building blocks and the science case for an eventual transit spectroscopy mission. In response to the call for the next medium class opportunity, Cosmic Vision M4, a proposal was submitted in January 2015: the Atmospheric Remote-sensing InfraRed Large-survey (ARIEL). The mission was one of the three selected in June 2015 for study in a Phase 0/A, a competitive assessment phase2. ARIEL was eventually selected as M4 in March 2018, and went into Phase B1, the definition study phase. The name of the mission has been changed to Ariel after selection. During Phase B1, the science case was studied in depth and consolidated under auspices of the Science Advisory Team, the bulk of the work be
Published: 2020

46. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme

Author: Hersenen-Medisch 1, Brain, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szoke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Hersenen-Medisch 1, Brain, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szoke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., and Morgan, Craig
Published: 2020

47. Final analysis from RESONATE: Up to six years of follow-up on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma.

Author: Munir, Talha, Munir, Talha, Brown, Jennifer R, O'Brien, Susan, Barrientos, Jacqueline C, Barr, Paul M, Reddy, Nishitha M, Coutre, Steven, Tam, Constantine S, Mulligan, Stephen P, Jaeger, Ulrich, Kipps, Thomas J, Moreno, Carol, Montillo, Marco, Burger, Jan A, Byrd, John C, Hillmen, Peter, Dai, Sandra, Szoke, Anita, Dean, James P, Woyach, Jennifer A, Munir, Talha, Munir, Talha, Brown, Jennifer R, O'Brien, Susan, Barrientos, Jacqueline C, Barr, Paul M, Reddy, Nishitha M, Coutre, Steven, Tam, Constantine S, Mulligan, Stephen P, Jaeger, Ulrich, Kipps, Thomas J, Moreno, Carol, Montillo, Marco, Burger, Jan A, Byrd, John C, Hillmen, Peter, Dai, Sandra, Szoke, Anita, Dean, James P, and Woyach, Jennifer A
Abstract: Ibrutinib, a once-daily oral inhibitor of Bruton's tyrosine kinase, is approved in the United States and Europe for treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The phase 3 RESONATE study showed improved efficacy of single-agent ibrutinib over ofatumumab in patients with relapsed/refractory CLL/SLL, including those with high-risk features. Here we report the final analysis from RESONATE with median follow-up on study of 65.3 months (range, 0.3-71.6) in the ibrutinib arm. Median progression-free survival (PFS) remained significantly longer for patients randomized to ibrutinib vs ofatumumab (44.1 vs 8.1 months; hazard ratio [HR]: 0.148; 95% confidence interval [CI]: 0.113-0.196; P˂.001). The PFS benefit with ibrutinib vs ofatumumab was preserved in the genomic high-risk population with del(17p), TP53 mutation, del(11q), and/or unmutated IGHV status (median PFS 44.1 vs 8.0 months; HR: 0.110; 95% CI: 0.080-0.152), which represented 82% of patients. Overall response rate with ibrutinib was 91% (complete response/complete response with incomplete bone marrow recovery, 11%). Overall survival, censored for crossover, was better with ibrutinib than ofatumumab (HR: 0.639; 95% CI: 0.418-0.975). With up to 71 months (median 41 months) of ibrutinib therapy, the safety profile remained consistent with prior reports; cumulatively, all-grade (grade ≥3) hypertension and atrial fibrillation occurred in 21% (9%) and 12% (6%) of patients, respectively. Only 16% discontinued ibrutinib because of adverse events (AEs). These long-term results confirm the robust efficacy of ibrutinib in relapsed/refractory CLL/SLL irrespective of high-risk clinical or genomic features, with no unexpected AEs. This trial is registered at www.clinicaltrials.gov (NCT01578707).
Published: 2019

48. Transdiagnostic dimensions of psychopathology at first episode psychosis : findings from the multinational EU-GEI study

Author: Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Olmeda, Ma Soledad, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schurhoff, Franck, Jamain, Stephane, Baudin, Gregoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Olmeda, Ma Soledad, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schurhoff, Franck, Jamain, Stephane, Baudin, Gregoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, and Cristofalo, Doriana
Published: 2019

49. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI) : a multicentre case-control study

Author: Di Forti, Marta, Quattrone, Diego, Freeman, Tom P., Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E., Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Rutten, Bart P. F., de Haan, Lieuwe, Sham, Pak C., van Os, Jim, Lewis, Cathryn M., Lynskey, Michael, Morgan, Craig, Murray, Robin M., Di Forti, Marta, Quattrone, Diego, Freeman, Tom P., Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E., Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Rutten, Bart P. F., de Haan, Lieuwe, Sham, Pak C., van Os, Jim, Lewis, Cathryn M., Lynskey, Michael, Morgan, Craig, and Murray, Robin M.
Published: 2019

50. Transdiagnostic dimensions of psychopathology at first episode psychosis : findings from the multinational EU-GEI study

Author: Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Olmeda, Ma Soledad, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schurhoff, Franck, Jamain, Stephane, Baudin, Gregoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Olmeda, Ma Soledad, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schurhoff, Franck, Jamain, Stephane, Baudin, Gregoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, and Cristofalo, Doriana
Published: 2019

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